Several decades of research and monitoring in the northern Gulf of Alaska (NGA) have revealed climate-related shifts in ocean temperature and salinity. Accompanying these shifts have been changes in the abundance and diversity of species, from single-celled plankton to fish, seabirds, and marine mammals. Research is documenting long-term change in the region and revealing the mechanisms by which recent marine heatwaves affect the ability of higher trophic levels to survive in these waters. Heatwaves in the northern Gulf of Alaska are likely to become longer, more frequent, and more intense, making long-term monitoring of ecosystem changes critical to understanding and predicting effects on valuable commercial fisheries and culturally significant native harvesting. In addition, documentation of change is necessary for projecting regional and global future climate scenarios and for informing climate-related policy decisions.