Abstract Background: Racial disparities in cervical cancer deaths are longstanding, with African American and Latina women more likely to die from the disease. The advent of HPV vaccine created an opportunity to reduce or end these disparities, but only if uptake was either uniformly high across all females or higher among minority than non-minority females. Thus, interest in racial disparities in HPV vaccine coverage has been understandably high. Findings: Data from several sources show racial disparities and “reverse disparities” in HPV vaccination coverage. First, the most reliable national data are from the National Immunization Survey Teen, a national survey of parents of adolescents with vaccination doses confirmed by physician records. NIS-Teen data show, depending on the year, higher initiation among Black and Latina teen girls. HPV vaccine completion rates in some years have been lower among these groups. Second, several large studies of insured women have shown lower rates of HPV vaccine initiation among Black women. Finally, many national surveys using self-reported data have shown no reliable pattern with respect to disparities in HPV vaccine initiation. Another source of data is ecological analyses, comparing HPV vaccine coverage in states with lower and higher proportions of minority women. These analyses by Moss, Reiter and Brewer show that states with more African American residents had lower rates of HPV vaccine initiation among adolescent girls. However, we saw no disparities for completion or for proportion of Latina women. A last source of data are studies of awareness, knowledge, beliefs and attitudes. These studies show a more regular pattern of lower awareness of and lower knowledge related to HPV vaccine among minority women compared to non-minority women. However, racial disparities are not universal across studies and not routinely present for other outcomes. Commentary: Despite our best efforts to find racial disparities in HPV vaccination coverage, data from various sources suggest no clear pattern of ethnic or racial disparities for outcomes other than 3-dose series completion. Future studies should emphasize HPV vaccine initiation, which likely has a larger public health impact than series completion. Citation Format: Noel T. Brewer, Jennifer L. Moss, Paul L. Reiter. In search of racial disparities in HPV vaccination. [abstract]. In: Proceedings of the Seventh AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 9-12, 2014; San Antonio, TX. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2015;24(10 Suppl):Abstract nr IA07.