National Guidelines For Prevention Research Articles

Foreign body aspiration in children: A review of prevention guidelines by analyzing choking episodes in Eastern Québec from 2006 to 2020

BACKGROUND Many associations have published prevention guidelines to advise parents and health professionals about the risks of choking episodes and their complications. Yet, every year, many children are admitted following a choking episode that requires a bronchoscopy under general anesthesia. OBJECTIVES The objective was to identify the risks factors associated with choking episodes in children and compare them with actual prevention guidelines to determine if they are still adequate. METHODS This retrospective study included all patients, from 0 to 17 years old, who presented to the Center Mère-Enfant Soleil du CHU de Québec - Université Laval, between April 2006 and December 2020 and underwent a bronchoscopy under general anesthesia for a suspicion of foreign body aspiration. Data on demographic characteristics of the patients, the circumstances of the episodes and on severity criteria were collected and compared to the prevention guidelines. RESULTS Of the 101 patients included, 64.9% of them were boys with a mean age at presentation of 31.5 months. Food was the most common type of foreign body (73.3%) involving mostly nuts, seeds or raw vegetables. Choking episodes happened mostly at home (84.5%) and the majority (79.4%) happened under parental surveillance. A general increase in the number of admissions for choking episodes was noted. CONCLUSION Choking episodes requiring hospital admission were on the rise mostly due to a lack of adherence or knowledge of national prevention guidelines. These findings highlight the need for better parental education by addressing choking hazards during medical visits.

Optimised prevention of postnatal HIV transmission in Zambia and Burkina Faso (PROMISE-EPI): a phase 3, open-label, randomised controlled trial

Transmission through breastfeeding accounts for more than half of the unacceptably high number of new paediatric HIV infections worldwide. We hypothesised that, in addition to maternal antiretroviral therapy (ART), extended postnatal prophylaxis with lamivudine, guided by point-of-care assays for maternal viral load, could reduce postnatal transmission. We did a phase 3, open-label, randomised controlled trial at four health-care facilities in Zambia and four health-care facilities in Burkina Faso. Mothers with HIV and their breastfed infants without HIV attending the second visit of the Expanded Programme of Immunisation (EPI-2; infant age 6-8 weeks) were randomly assigned 1:1 to intervention or control groups. In the intervention group, maternal viral load was measured using Xpert HIV viral load assay at EPI-2 and at 6 months, with results provided immediately. Infants whose mothers had a viral load of 1000 copies per mL or higher were started on lamivudine syrup twice per day for 12 months or 1 month after breastfeeding discontinuation. The control group followed national guidelines for prevention of postnatal transmission of HIV. The primary outcome assessed by modified intention to treat was infant HIV infection at age 12 months, with HIV DNA point-of-care testing at 6 months and at 12 months. This trial is registered with ClinicalTrials.gov (NCT03870438). Between Dec 12, 2019 and Sept 30, 2021, 34 054 mothers were screened for HIV. Among them, 1506 mothers with HIV and their infants without HIV, including 1342 mother and infant pairs from Zambia and 164 from Burkina Faso, were eligible and randomly assigned 1:1 to the intervention (n=753) or control group (n=753). At baseline, the median age of the mothers was 30·6 years (IQR 26·0-34·7), 1480 (98·4%) of 1504 were receiving ART, and 169 (11·5%) of 1466 had a viral load ≥1000 copies/mL. There was one case of HIV transmission in the intervention group and six in the control group, resulting in a transmission incidence of 0·19 per 100 person-years (95% CI 0·005-1·04) in the intervention group and 1·16 per 100 person-years (0·43-2·53) in the control group, which did not reach statistical significance (p=0·066). HIV-free survival and serious adverse events were similar in both groups. Our intervention, initiated at EPI-2 and based on extended single-drug postnatal prophylaxis guided by point-of-care maternal viral load could be an important strategy for paediatric HIV elimination. The EDCTP2 programme with the support of the UK Department of Health & Social Care.

Preeclampsia prevention: a survey study on knowledge and practice among prenatal care providers in Ethiopia

BackgroundKnowledge and practice gap among providers has been cited among factors behind underutilization of aspirin for preeclampsia prevention, globally. ObjectiveTo determine the knowledge and practice level of prenatal care providers at a national tertiary referral hospital in Ethiopia and it's catchment health institutions. Study DesignThis was a cross-sectional survey on the knowledge and practice of preeclampsia prevention through ASA prophylaxis among prenatal care providers at St. Paul's Hospital Millennium Medical College (Ethiopia) and it's catchment health institutions. Data were collected prospectively using a structured questionnaire on ODK. The primary objective of our study was determining the knowledge and practice level among the prenatal care providers. Data were analyzed using SPSS version 23. Simple descriptive analysis were employed to analyze the data. Proportions and percentages were used to present the results. ResultsA total of 92 prenatal care providers working at 17 health institutions were approached and 78 of them agreed to participate in the study, constituting a response rate of 84.8%. The mean score of knowledge and practice of prevention for pre-eclampsia using Aspirin was 42.9(±0.13) and 45.8(±0.07) respectively. Most of the providers had poor knowledge (score less than 50%) and poor practice (score less than 50). Only 23.8% (19/78) and 36.3% (29/78) had good knowledge and good practice, respectively. More than half (61.3%, 49/78) of the respondents mentioned “lack of national guidelines for use of aspirin in pregnancy” as the main factor that impacted their practice on Aspirin for preeclampsia prevention in pregnant women. Among the resources utilized as a reference for practice of use of aspirin for pre-eclampsia prevention, FIGO or WHO guidelines (56.3%, 45/78), followed by ACOG (45%, 36/78) and clinical judgment (45%, 36/78) were the most frequently used resources. ConclusionResults of this study support previous reports of significant knowledge-to-practice gap in the use of ASA prophylaxis for prevention of preeclampsia, among prenatal care providers. It underscores the need for immediate action in narrowing this gap among the providers through availing practical national guidelines for prevention of pre-eclampsia and in-service trainings.

81 IMPROVING THE ASSESSMENT AND PREVENTION OF FALLS AND FRACTURES ON A REHABILITATION WARD

Abstract Background The National Steering Group and The National Institute for Health and Care Excellence provide guidelines on medical assessment and prevention of falls and fractures. This audit assesses and compares quality of practice on an Age-Related rehabilitation ward against these guidelines. Methods A retrospective audit, including all patients (n=31) on an off-site, Age-Related rehabilitation ward was completed. Data on falls and fractures at emergency department presentation and during admission was obtained through chart review. Following education and implementation of a falls pro-forma, a re-audit was completed at four months including all patients (n=40). Results In cycle 1, mean age of patients was 80 years (range 56-94), 39 Percent (%) (n=12) were admitted with a fall of whom 66.7% (n=8) had a resulting fracture. In cycle 2, mean age was 82 years (range 63–95), 48% (n=19) were admitted due to a fall, of whom 53% (n=10) had a fracture. A falls assessment and bone health review was completed in 39% (n=12) of all patients in cycle 1, and in 37% (n=3) admitted with a fall. This increased to 83% (n=33) of all patients in cycle 2 and 100% (n=40) of those admitted with a fall. Pre-intervention, 23% (n=7) had an inpatient fall compared to 18% (n=7) post-intervention; of these, 43% (n=3) and 14% (n=1) resulted in fractures respectively. Conclusion Compliance with national guidelines for prevention of falls and fractures improved with education and implementation of a falls pro-forma. This resulted in a reduction in falls, particularly injurious falls, on a rehabilitation ward. In future, this pro-forma may be implemented in other hospital wards.

Unintentional Fall-Related Mortality among the Elderly in Serbia: Importance of Death Reporting Quality.

Falls have been one of the leading causes of injury-related deaths among the elderly, having an increasing trend in many countries. We investigated trends of fall-related mortality among people aged ≥65 yr in Serbia. Based on official data, we calculated unintentional fall-related mortality rate (MR) from 1998 to 2017, using join point regression analysis to determine annual percentage changes (APC). Starting from 2005, doctors from Serbian Public Health Institute have been controlling the quality of death certificates. In the 1998-2004 period, MR decreased in men and women aged 65-74 and men aged ≥85 (by -12.4; -13.0; and -15.1% yearly) followed by an upward trend in men and women aged 65-74 (by 76.3 vs.40.2%yearly) from 2004 to 2007 and men aged ≥85 (by 13.7% yearly) from 2004 to 2017. MR decreased among women aged ≥85 (by -9.8% yearly) from 1998 to 2008 and then increased (by 9.0% yearly) from 2008 to 2017. In men and women aged 75-84, an increase of MR (by 7.4 vs.3.1%) was observed during the entire study period. In all age groups, except women aged ≥85, significant negative correlation was found between fall-related deaths and ill-defined and unknown causes of deaths. Control of death certificates by physicians from the Institute of Public Health led to the better reporting of the increasing trend of fall-related mortality among the elderly. Policy makers must investigate risk factors for fall and then adopt national guidelines for prevention and treatment of fall-related injury.

An analysis of the vitamin D overtesting in a tertiary healthcare centre.

IntroductionVitamin D testing is excessively used in clinical practice, despite of the clinical guidelines statements against population screening for vitamin D deficiency. This study aimed to assess an annual number of performed 25-hydroxy vitamin D (25(OH)D) tests that were unsupported by the national guidelines for prevention, detection and therapy of vitamin D deficiency in adults and to calculate associated financial burden for the publicly funded healthcare.Materials and methodsA representative sample of requested 25(OH)D tests in 2018 (N = 474) was formed after selection and randomisation of data set (N = 5298) collected from the laboratory information system database of the Clinical Department for Laboratory Diagnostics, the Clinical Hospital Centre Rijeka. Records were classified in two groups depending on associated medical condition(s) according to the national guidelines. An annual cost of the total and group specific vitamin D testing was calculated on the base of a single test price reimbursed by the Croatian Healthcare Insurance Fund (CHIF).ResultsMedical conditions with high-risk for vitamin D deficiency were detected in 43% (206/474) of vitamin D requests (group 1). Conditions not associated with vitamin D deficiency were detected in 57% (268/474) requests (group 2). A total cost of 25(OH)D testing for the CHIF was 58,729.50 EUR (25,523.79 EUR in the group 1 and 33,205.71 EUR in the group 2).ConclusionsMore than half of all 25(OH)D tests performed in the clinical laboratory represent avoidable cost for the public healthcare. Prevention of population screening by vitamin D testing is needed.

Knowledge, Attitudes and Practice towards COVID-19 Vaccinations: A Cross Sectional Community Survey in Sudan

Background: Several prophylactic vac¬cines against COVID-19 have already been developed in various countries. However, general community knowledge, attitudes and practice towards COVID-19 vaccinations are needed to investigate. Thus, the study aimed to investigate community knowledge, attitudes and perceptions towards COVID-19 vaccinations in Sudan. Methodology: prospective, cross sectional, online survey study through a self-administered questionnaire was carried out during the period between March 2021 to August 2021 in Khartoum, Sudan among 3310 Sudanese participants. The questionnaire included informed consent along with five sections (i.e., socio-demographics, knowledge, attitudes, Behavior toward COVID-19 national prevention guidelines and vaccine acceptance) was utilized during data collection. Results: The majority of the participants were female (64.35%). More than half (55.92%) of the participants were Adult (>25years). The majority of the respondents are knowledgeable about the approved COVID-19 vaccines (55.55%). The study also revealed that majority of respondents was believed that COVID-19 vaccination could not protect them from infection with COVID-19 (58.70%). The majority of the respondents are knowledgeable about the approved COVID-19 vaccines (55.55%). Conclusions: The findings reflect Good knowledge but more negative attitudes towards COVID-19 vaccine among the general population Sudan. Before and during vaccine rollout, practical ways to eliminate vaccination barriers in Sudanese populations must be implemented, including effective communication and supervision.

Knowledge and Perception of COVID-19 Pandemic during the First Wave (Feb-May 2020): A Cross-Sectional Study among Italian Healthcare Workers.

Italy was the first country in Europe to face the coronavirus pandemic. The aim of the study was to analyze healthcare workers’ (HCWs) level of information, practice, and risk perception towards COVID-19. We set up a cross-sectional study through SurveyMonkey® and distributed the link through Facebook and Whatsapp closed groups. The research instrument was a 31 items questionnaire distributed using Facebook and Whatsapp. It was conducted in Italy from February to May 2020. The study participants were general practitioners, pediatricians and other health professionals. A total of 958 participants were included: 320 (33.4%) general practitioners, 248 (25.9%) pediatricians and 390 (40.7%) other health professionals. The highest response rate was from Northern Italy (48.1%), followed by Central Italy (29.9%) and Southern Italy (22.0%). Less than a half (46%) of respondents felt they had a good level of information of COVID-19 case definition and of national prevention guidelines. Respondents reported to have changed their clinical practice; particularly, they increased the use of masks (87.1%, p < 0.001), disinfection and sanitization of doctors’ offices (75.8%, p < 0.001), the use of protective glasses (71.2%, p < 0.001), alcoholic hand solution (71.2%, p < 0.001), and hand washing (31.8%, p = 0.028). HCWs are at high risk of infection; less than a half of them felt adequately prepared to face COVID-19 pandemic, so they need extensive information and awareness of the disease to take adequate precautionary measures, and they are crucial to disseminate good practices.

A service evaluation of the dental and oral health of 5-year-old patients attending a specialised cleft centre

Introduction It is well recognised that cleft lip and/or palate carries an increased risk of developing dental caries. This article describes a service evaluation that was undertaken at the South Thames cleft service to analyse whether the five-year-old cohort of patients attending the clinic were following preventative advice as well as whether they were registered with a general dental practitioner and attending for regular recall. Methods A total of 96 patients were assessed. Data from a 24-month period were collected retrospectively using a data collection sheet. Results The vast majority (92%) of the patients included in this service evaluation were registered with a general dentist. Despite this, 40% had a decayed/missing/filled teeth score of &gt;0, only 73% were having fluoride varnish applied regularly and 79% were using toothpaste containing the recommended fluoride content. More than half (57%) of the patients had developmental defects of enamel. Conclusions There needs to be increased emphasis on following national prevention guidelines given that this group of patients is known to be at a higher risk of dental caries. Parents and carers must be made aware of the requirement for shared care between general dental practitioners and secondary care.

Racial/Ethnic Parity in Low-Dose Aspirin for Women With History of Preeclampsia After National Recommendations [26C

INTRODUCTION: Hypertensive disorders of pregnancy are associated with severe maternal morbidity and maternal mortality, particularly for non-white women. Our goal was to investigate the effect of race/ethnicity on low-dose aspirin use following release of national guidelines for prevention of preeclampsia. METHODS: This is a retrospective cohort study of women with a history of preeclampsia delivering in a single institution from 1/1/2015 to 9/30/2017 following publication of “Low-Dose Aspirin for the Prevention of Morbidity and Mortality From Preeclampsia: U.S. Preventative Services Task Force Recommendation Statement.” Billing codes were used to identify women with indications for low-dose aspirin during pregnancy. A history of preeclampsia was then confirmed by chart abstraction. Race/Ethnicity as documented in the medical record and reported use of low-dose aspirin was abstracted from the electronic medical record. A one-way ANOVA was used to compare aspirin use in women identified as “white,” “Hispanic,” “black or African American,” and “other.” RESULTS: We identified 110 women eligible to receive low-dose aspirin based on a history of preeclampsia. 25.5% (n=28) of women with a history of preeclampsia were documented as receiving low-dose aspirin during the study period. 39.1% of women were identified as “white” (n=43), 30.9% (n=30.9) were identified as “Hispanic or Latina” (n=34), 21.8% were identified as “black or African American,” and 8.2% were identified as “Other” (n=9). There was no statistically significant difference in low-dose aspirin by race/ethnicity (P=.52). CONCLUSION: Immediately following recommendations for low-dose aspirin use for prevention of preeclampsia, aspirin use did not vary by reported race/ethnicity.

Swedish national guideline for prevention and treatment of neonatal hypoglycaemia in newborn infants with gestational age ≥35weeks.

Postnatal hypoglycaemia in newborn infants remains an important clinical problem where prolonged periods of hypoglycaemia are associated with poor neurodevelopmental outcome. The aim was to develop an evidence-based national guideline with the purpose to optimise prevention, diagnosis and treatment of hypoglycaemia in newborn infants with a gestational age ≥35+0weeks. A PubMed search-based literature review was used to find actual and applicable evidence for all incorporated recommendations. The GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach was used for grading the evidence of the recommendations. Recommendations for the prevention of neonatal hypoglycaemia were extended and updated, focusing on promotion of breastfeeding as one prevention strategy. Oral dextrose gel as a novel supplemental therapy was incorporated in the treatment protocol. A new threshold-based screening and treatment protocol presented as a flow chart was developed. An updated and evidence-based national guideline for screening and treatment of neonatal hypoglycaemia will support standardised regimes, which may prevent hypoglycaemia and the risk for hypoglycaemia-related long-term sequelae.

The dental health of cleft patients attending the 18-month-old clinic at a specialised cleft centre.

Background Cleft lip and/or palate (CLP) patients are at high risk of developing dental caries and show a greater prevalence of dental defects.Aims To establish if CLP patients who attended the 18-month clinic had local dentists, were complying with oral hygiene instruction and had stopped bottle-feeding as per guidelines.Design Data were collected retrospectively over a 24-month period in which a total of 62 records were assessed.Results Data analyses revealed that 42% of patients who attended the clinic were registered with a dentist. Fifty percent of patients had stopped bottle-feeding and 67% were brushing two or more times a day. Although all patients reviewed on the clinic were caries free, 57% presented with a dental anomaly (hypodontia, hypomineralisation or hypoplasia).Conclusion Despite CLP patients being at high risk for developing dental caries, results showed that significant proportions of parents/carers were not following national guidelines for prevention. This evaluation highlights that shared preventive support between primary care dentists and specialist cleft dentists is not being achieved in the majority of cases. It also recognises that parents of CLP patients are either not receiving, or are failing to implement, preventive care advice.

Group B streptococcal disease in UK and Irish infants younger than 90 days, 2014–15: a prospective surveillance study

Group B streptococcus is a leading cause of serious infection in young infants in many countries worldwide. We aimed to define the burden and clinical features of invasive group B streptococcal disease in infants younger than 90 days in the UK and Ireland, together with the characteristics of disease-causing isolates. Prospective, active national surveillance of invasive group B streptococcal disease in infants younger than 90 days was done from April 1, 2014, to April 30, 2015, through the British Paediatric Surveillance Unit, microbiology reference laboratories, and national public health agencies in the UK and Ireland. Early onset was defined as disease in the first 6 days of life and late onset was defined as 7-89 days of life. Incidence was calculated using livebirths in 2014 (after adjustment for the 13-month surveillance period). Isolates were characterised by serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. 856 cases of group B streptococcus were identified in 2014-15, an incidence of 0·94 per 1000 livebirths (95% CI 0·88-1·00). Incidence for early-onset disease (n=517) was 0·57 per 1000 livebirths (95% CI 0·52-0·62), and for late-onset disease (n=339) was 0·37 per 1000 livebirths (0·33-0·41). 53 infants died (case fatality rate 6·2%), of whom 27 had early-onset disease (case fatality rate 5·2%) and 26 had late-onset disease (case fatality rate 7·7%). The predominant serotypes were III (241 [60%] of 402 serotyped isolates) and Ia (69 [17%]); five serotypes (Ia, Ib, II, III, V) accounted for 377 (94%) of all serotyped isolates. The incidence of invasive infant group B streptococcal disease in the UK and Ireland has increased since a comparable study done in 2000-01. The burden of early-onset disease has not declined despite the introduction of national prevention guidelines. New strategies for prevention are required. Meningitis Now.

Determinants of sporadic Campylobacter infections in Denmark: a nationwide case-control study among children and young adults.

BackgroundEach year more than 4,000 cases of campylobacteriosis are reported in Denmark, making it the most common bacterial gastrointestinal infection. Here we describe a case-control study to identify sources of infection with a focus on environmental factors.MethodsFrom January to December 2016, we conducted a prospective case-control study among Danish persons aged 1–30 years. Participants were invited by letter to complete an online questionnaire. Crude and adjusted ORs were calculated and final parsimonious multivariate models developed using logistic regression.ResultsThe study recruited 1366 cases and 4,418 controls, of whom 65% and 66%, respectively, completed the questionnaire. A multivariate model for domestically acquired cases showed, among others, increased risk of infection with bathing in fresh water (OR=5.1), contact to beach sand (OR=1.8), owning a pet dog with diarrhea (OR=4.6), and eating minced beef (OR=2.6) or chicken (OR=2.5). The model for children highlighted similar risk factors but also included bathing in a paddling pool (OR=13.6) and eating fresh strawberries (OR=5.3). A separate analysis for persons reporting foreign travel showed increased infection risk when traveling to Asia, Africa, or Turkey and that eating from street kitchens and having contact to water during traveling were also risk factors.ConclusionEnvironmental factors and animal contact account for a sizeable proportion of domestic Campylobacter infections in the age group studied. The study also re-confirmed handling/consumption of chicken as an important risk factor while highlighting minced beef as a potential new risk factor. Overall, these results contribute to a better understanding of the transmission dynamics of Campylobacter and will be used to improve national guidelines for prevention of infection.

National Guidelines for Prevention and Control of Iron Deficiency Anemia in India

Anaemia is a serious public health challenge in India with more than 50% prevalence across vulnerable groups such as pregnant women, infants, young children and adolescents. It has adverse effects on health, physical and mental productivity affecting quality of life. Guideline is any document containing recommendations about health interventions, whether these are clinical, public health or policy recommendations. The National Anemia Prevention and control guidelines have been developed taking cognizance of the current scientific evidence. The National Iron+ Initiative guidelines have been developed by the Adolescent Division of the Ministry of Health and Family Welfare (MoHFW), Government of India. Prevention and control of anaemia is one of the key strategies of the Health, Nutrition and Population Sector Programmes for reducing maternal, neonatal and childhood mortality and improving maternal, adolescent and childhood health status. It is estimated that anaemia causes 20 per cent of maternal deaths in India.

Former suicidal inpatients’ experiences of treatment and care in psychiatric wards in Norway

ABSTRACTPurpose: The purpose of this study is to explore how former suicidal inpatients experienced treatment and care in psychiatric wards in Norway following the implementation of the National guidelines for prevention of suicide in mental health care. The focus of the analysis was on aspects of treatment and care with potential for improvement. Method: We interviewed five former inpatients and analysed the data by means of Interpretative Phenomenological Analysis. Results: Experiencing a sense of companionship with the staff and receiving individualized treatment and care was important for the participants. This involved establishing trusting connections with mental health workers who treated them with respect, made them feel valued, and who recognized their suffering and needs. The formerly suicidal patients experienced being in a recovery process, which was promoted by the support of mental health workers. Although the participants reported mostly positive experiences, there were examples of insufficient care. Sometimes, they felt that their suffering and suicidality were not sufficiently recognized. Conclusion: Our study indicates that although there has been increased focus on suicidality in the mental health services, among other through clinical guidelines, some mental health workers still lack competence and should focus more fully on how to provide individualized care for suicidal inpatients.

Maternal mortality audit in Suriname between 2010 and 2014, a reproductive age mortality survey

BackgroundThe fifth Millennium Development Goal (MDG-5) aimed to improve maternal health, targeting a maternal mortality ratio (MMR) reduction of 75% between 1990 and 2015. The objective of this study was to identify all maternal deaths in Suriname, determine the extent of underreporting, estimate the reduction, audit the maternal deaths and assess underlying causes and substandard care factors.MethodsA reproductive age mortality survey was conducted in Suriname (South-American upper-middle income country) between 2010 and 2014 to identify all maternal deaths in the country. MMR was compared to vital statistics and a previous confidential enquiry from 1991 to 1993 with a MMR 226. A maternal mortality committee audited the maternal deaths and identified underlying causes and substandard care factors.ResultsIn the study period 65 maternal deaths were identified in 50,051 live births, indicating a MMR of 130 per 100.000 live births and implicating a 42% reduction of maternal deaths in the past 25 years. Vital registration indicated a MMR of 96, which marks underreporting of 26%. Maternal deaths mostly occurred in the urban hospitals (84%) and the causes were classified as direct (63%), indirect (32%) or unspecified (5%). Major underlying causes were obstetric and non-obstetric sepsis (27%) and haemorrhage (20%). Substandard care factors (95%) were mostly health professional related (80%) due to delay in diagnosis (59%), delay or wrong treatment (78%) or inadequate monitoring (59%). Substandard care factors most likely led to death in 47% of the cases.ConclusionDespite the reduction in maternal mortality, Suriname did not reach MDG-5 in 2015. Steps to reach the Sustainable Development Goal in 2030 (MMR ≤ 70 per 100.000 live births) and eliminate preventable deaths include improving data surveillance, installing a maternal death review committee, and implementing national guidelines for prevention and management of major complications of pregnancy, childbirth and puerperium.

Introduction to the Centers for Disease Control and Prevention and Healthcare Infection Control Practices Advisory Committee Guideline for Prevention of Surgical Site Infection: Prosthetic Joint Arthroplasty Section.

Peri-prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty that appears to be increasing as more of these procedures are performed. Numerous risk factors for incisional (superficial and deep) and organ/space (e.g., PJI) surgical site infections (SSIs) have been identified. A better understanding and reversal of modifiable risk factors may lead to a reduction in the incidence of incisional SSI and PJI. The Centers for Disease Control and Prevention (CDC) and the Healthcare Infection Control Practices Advisory Committee (HICPAC) recently updated the national Guideline for Prevention of Surgical Site Infection. The updated guideline applies evidence-based methodology, presents recommendations for potential strategies to reduce the risk of SSI, and includes an arthroplasty-specific section. This article serves to introduce the guideline development process and to complement the Prosthetic Joint Arthroplasty section with background information on PJI-specific economic burden, epidemiology, pathogenesis and microbiology, and risk factor information.

Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015.

In 2012, the European Centre for Disease Prevention and Control (ECDC) launched the 'European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE)' project to gain insights into the occurrence and epidemiology of carbapenemase-producing Enterobacteriaceae (CPE), to increase the awareness of the spread of CPE, and to build and enhance the laboratory capacity for diagnosis and surveillance of CPE in Europe. Data collected through a post-EuSCAPE feedback questionnaire in May 2015 documented improvement compared with 2013 in capacity and ability to detect CPE and identify the different carbapenemases genes in the 38 participating countries, thus contributing to their awareness of and knowledge about the spread of CPE. Over the last two years, the epidemiological situation of CPE worsened, in particular with the rapid spread of carbapenem-hydrolysing oxacillinase-48 (OXA-48)- and New Delhi metallo-beta-lactamase (NDM)-producing Enterobacteriaceae. In 2015, 13/38 countries reported inter-regional spread of or an endemic situation for CPE, compared with 6/38 in 2013. Only three countries replied that they had not identified one single case of CPE. The ongoing spread of CPE represents an increasing threat to patient safety in European hospitals, and a majority of countries reacted by establishing national CPE surveillances systems and issuing guidance on control measures for health professionals. However, 14 countries still lacked specific national guidelines for prevention and control of CPE in mid-2015.

Japanese encephalitis: a review of clinical guidelines and vaccine availability in Asia.

Travelers to Asia are at risk for acquiring Japanese Encephalitis (JEV), an arbovirus with high rates of morbidity and mortality. Recent advances in vaccination resulting in vaccines with low rates of side effects have strengthened the rationale to vaccinate more travelers to this region, as reflected in many updated national guidelines for prevention of disease in travelers. Vaccines however still require a complex pre-travel schedule and are costly, often leading to a requirement or desire for a vaccination option in the destination country. We explore current national guidelines for prevention of Japanese Encephalitis and seek to provide information on availability of JEV vaccines in various Asian countries.