Purpose. To determine the relationship between innovation and infrastructure to support entrepreneurship as factors of growth of economic opportunities, based on the results of empirical research. Methodology. The case method and modern tools of econometric research were used to create an economic-mathematical model that assesses the relationship between economic opportunities and indicators of economic innovation. The research is based on the results of the Gallup 75 Years Anniversary Survey on current and future economic opportunities, as well as Global Innovation Index (GII) indicators. Findings. Creating favorable conditions for doing business and developing entrepreneurship is critically important for the economic recovery of Ukraine. The high level of entrepreneurial activity among Ukrainians emphasizes the importance of the development of innovative infrastructure and business support. The developed models can be used to forecast the economic capabilities of the population, which will contribute to the return of citizens and the development of the national economy. Thus, innovations and an effective infrastructure to support entrepreneurship play a key role in ensuring sustainable economic growth and social well-being in Ukraine. The results of the study can become the basis for developing strategies for economic development and solving migration problems in the post-war period. Determinants of the growth of economic opportunities of the population (human capital) are determined. The suggested GII parameters most correlate to positive feedback on economic opportunities and growth over the next 25 years. Originality. For the first time, the relationship between economic opportunities, the development of innovations and the development of infrastructure at the enterprise has been empirically proven. Statistically significant predictors of current and future economic opportunities of the population are substantiated and relevant economic and mathematical models for their evaluation and forecasting are developed. Practical value. The results of the study are particularly relevant in the context of solving the migration crisis caused by Russia’s military aggression against Ukraine. The return of citizens who have left the country depends on the creation of favorable conditions for business and the development of entrepreneurship. The developed models can be used to forecast the economic opportunities of the population in different countries, which will allow effective management of migration processes and promote the development of national economies. This will ensure the creation of a favorable business environment, which is critical for sustainable economic growth and social well-being.