Remote sensing can provide an alternative solution to quantify Dissolved Organic Carbon (DOC) in inland waters. Sensors embedded on Unmanned Aerial Vehicles (UAV) and satellites that can capture the DOC have already shown good relationships between DOC and the Colored Dissolved Organic Matter absorption (aCDOM.) coefficients in specific spectral regions. However, since the signal recorded by the sensors is reflectance-based, DOC estimates accuracy decreases when inverting the aCDOM. coefficients to reflectance. Thus, the main objective is to study the potential of a UAV-borne hyperspectral camera to retrieve the DOC in inland waters and to develop reflectance-based models using UAV and satellite (Landsat-8 OLI and Sentinel-2 MSI) data. Ensemble based systems (EBS) were favored in this study. The EBSUAV calibration results showed that six spectral regions (543.5, 564.5, 580.5, 609.5, 660, and 684 nm) are sensitive to DOC in waters. The EBSUAV test results showed a good concordance between measured and estimated DOC with an R2 = Nash-criterion (NASH) = 0.86, and RMSE (Root Mean Squares Error) = 0.68 mg C/L. The EBSSAT test results also showed a strong concordance between measured and estimated DOC with R2 = NASH = 0.92 and RMSE = 0.74 mg C/L. The spatial distribution of DOC estimates showed no dependency to other optically active elements. Nevertheless, estimates were sensitive to haze and sun glint.