The potential local toxicity of glycofurol 75 and 30% acetylsalicylic acid in glycofurol 75 for nasal application has been evaluated in rabbits. The commercially available 1% ephedrine nose drops were used as a clinical relevant standard. Acetylsalicylic acid may be of potential use in acute myocardial infarction, where the cost/benefit of an instant nasal application may be favourable. 4 h after application of nasal solutions, 50 μl into each nostril, the mucosa of septae and conchae were examined with respect to gross and histopathological changes. All solutions tested resulted in lesions that exceeded normal variations. Most of the inflammatory reactions in the acetylsalicylic acid group seemed reversible within 7 days, at which time, however, osteoblast and osteoblast activity and formation of osteoid were pronounced.