Width Narrowing Research Articles

Resonant tunneling properties of laser dressed hyperbolic Pöschl-Teller double barrier potential

We examine the resonant tunneling properties of the laser-dressed hyperbolic Pöschl-Teller double quantum barrier structure. We use the non-equilibrium Green's function method to investigate structure parameters and electric field bias on the transmission properties of the system. The transmission probabilities and resonance energy levels are significantly influenced by the well widths and barrier heights. The barrier height increases, resonance energy levels shift toward higher values, and the resonance peak width narrows, leading to sharper and more selective tunneling behavior. Our results show that increasing the electric field bias leads to a decrease in the transmission probability at the first resonance peak, but this effect is not as strong for the subsequent peaks. Moreover, we find that changes in the laser field's parameter and structure parameters allow for fine control over the electronic spectra, allowing for modifications like red or blue shifts based on particular needs. The significance of comprehending the interaction among structural factors, external fields, and transmission qualities in quantum barrier structures is highlighted by our research, providing valuable information for the development and enhancement of electronic and optoelectronic systems with customized functionality. Our findings show the laser field has a considerable impact on resonant tunneling properties, opening the door to new device applications.

Synthesis, Optical Spectroscopy, and Laser and Biomedical Imaging Application Potential of 2,4,6-Triphenylpyrylium Tetrachloroferrate and Its Derivatives.

Synthesis, optical spectroscopic properties, two-photon (TP) absorption-induced fluorescence, and laser and bioimaging application potentials of 2,4,6-triphenylpyrylium tetrachloroferrate (1),4-(4-methoxyphenyl)-2,6-diphenylpyrylium tetrachloroferrate (2), 2,6-bis(4-methoxyphenyl)-4-phenylpyrylium tetrachloroferrate (3), and 2,4,6-tris(4-methoxyphenyl)pyrylium tetrachloroferrate (4) are presented. The synthesis involves the conversion of pyrylium tosylates to pyrylium chlorides, followed by transformation into 1-4 on heating to reflux with FeCl3 in acetonitrile. They are characterized using 1H and 13C NMR spectra in CD3OD, and FTIR and Raman spectroscopic techniques. The salts dissolve in organic solvents and water (pH = 7 to 3) even at high concentrations (10-3 M). These solutions absorb light strongly from 500-300 nm. Solutions of 1, 3, and 4 fluoresce with high quantum yield in the 500-700 nm spectral range. Salts 1 and 4 exhibit fluorescence lifetime shortening, line width narrowing, and free-running laser action under intense pulsed laser excitation. Toxicity and cell imaging studies using human cancer cell lines reveal that salts 1 and 3 function as cellular fluorophores in vitro and have no adverse effects on cellular viability at nanomolar ranges. Furthermore, acetonitrile and methanol solutions of salts 1, 3, and 4 exhibit strong two-photon absorption-induced fluorescence, opening potential applications in biomedical imaging and microscopy.

Hydrogen bond symmetrisation in D2O ice observed by neutron diffraction

Hydrogen bond symmetrisation is the phenomenon where a hydrogen atom is located at the centre of a hydrogen bond. Theoretical studies predict that hydrogen bonds in ice VII eventually undergo symmetrisation upon increasing pressure, involving nuclear quantum effect with significant isotope effect and drastic changes in the elastic properties through several intermediate states with varying hydrogen distribution. Despite numerous experimental studies conducted, the location of hydrogen and hence the transition pressures reported up to date remain inconsistent. Here we report the atomic distribution of deuterium in D2O ice using neutron diffraction above 100 GPa and observe the transition from a bimodal to a unimodal distribution of deuterium at around 80 GPa. At the transition pressure, a significant narrowing of the peak widths of 110 is also observed, attributed to the structural relaxation by the change of elastic properties.

Channel width-dependent viscosity and slip length in nanoslits and effect of surface wettability

The channel width-dependent behaviors of viscosity (μ) and slip length (ls) in nanoslits are investigated using many-body dissipative particle dynamics simulation in both Poiseuille and Couette flow systems. In both systems, the viscosity and slip length increase as the channel width (w) grows in smaller channels, while they reach bulk values in larger channels. Moreover, as the surface wettability decreases, the slip length is found to increase, while the viscosity remains the same. The channel width-dependent behavior in nanoslits can be explained by the unique structure of the confined fluid. As the channel width narrows, the uniform density profile in the central region diminishes, and an oscillation pattern appears throughout the system. The change in the microstructure with the channel width alters friction between layers of fluid in laminar flow and fluid-solid friction, leading to a w-dependent μ and ls. Nonetheless, the alteration of surface wettability influences only fluid–solid interactions but not the friction between layers of fluid.

Dynamic Morphological Growth Trajectory of Crouzon Population: A Geometric Morphometric Analysis.

This study is to visualize the morphological growth trajectory of the Crouzon population and provide a more comprehensive and perceptual understanding of pathologic aggregation in terms of maxillofacial and soft tissue surfaces. Twenty-two patients with Crouzon syndrome were included in this retrospective surgery. Preoperative computed tomography was segmented into maxillofacial and soft tissue surface morphologies. Fifty-two anatomical landmarks and a standardized template were used to extract the morphological phenotypes and transform them into spatial coordinates. Geometric morphometrics (GM) were applied to visualize the growth trajectory and estimate the morphological variation of the Crouzon population. Cephalometric analysis was conducted to validate the growth trajectory in a clinical aspect. It was found that both maxillofacial and soft tissue surface morphologies were strongly covaried with age. Morphological development of the Crouzon population was characterized by (1) maxillary retrusion and clockwise rotation, (2) mandibular counterclockwise rotation, (3) facial width narrowing and aggregated concave face, and (4) sunken nasal bone. Pathologic maxillary retrusion continuously existed from infancy to adulthood, and rapid aggravation took place at 3 to 6 years old. In conclusion, this study is the first to visualize the dynamic growth trajectories on both maxillofacial and soft tissue surface morphologies. More attention and monitoring of breathing, snoring, intelligence, and global development should be cast on Crouzon patients between 3 and 6 years old in family care. If any functional abnormalities occur during this period, professional consultations and evaluations should be conducted timely to avoid pathologic aggravation. Consistency between GMs and cephalometry validates the reliability of GM potentials in the clinical field, allowing a promising and revolutionary methodology for dynamically and qualitatively analyzing pathologic changes in some rare congenital diseases.

Single-Particle Spectroelectrochemistry: Promoting the Electrocatalytic Activity of Gold Nanorods via Oxygen Plasma Treatment without Structural Deformation.

Understanding of the electrocatalytic activity enhancement in gold nanoparticles is still limited. Herein, we present the effect of the oxygen plasma treatment on the electrochemical activity of gold nanorods (AuNRs). Oxygen plasma treatment resulted in the blueshift and line width narrowing of the localized surface plasmon resonance (LSPR) spectra obtained from individual AuNRs immobilized on an indium tin oxide (ITO) surface. These changes can be attributed to increases in the surface charges of the AuNRs. The formation of a Au-ITO heterojunction provided structural stability to the immobilized AuNRs regardless of the duration of oxygen plasma exposure. The electrocatalytic oxidation of hydrogen peroxide (H2O2) was induced by increases in the free-electron densities on the surfaces of these AuNRs owing to oxygen plasma treatment, and Au did not dissolve under the experimental conditions. However, the potential-dependent LSPR spectra of the individual AuNRs showed similar patterns of LSPR behavior, irrespective of the duration of oxygen plasma treatment and the concentration of H2O2. Therefore, this study based on single-particle spectroelectrochemistry and cyclic voltammetry improves the understanding of the role of oxygen plasma treatment in promoting the catalytic activity of structurally stable AuNRs immobilized on an ITO surface.

Tuning Chemical Interface Damping: Competition between Surface Damping Pathways in Amalgamated Gold Nanorods Coated with Mesoporous Silica Shells.

The mechanism of mercury (Hg) amalgamation in gold nanorods coated with a mesoporous silica shell (AuNRs@mSiO2) and the effect of chemical treatments on the localized surface plasmon resonance (LSPR) spectral changes in single amalgamated AuNRs@mSiO2 remains unclear. In this study, we investigated Hg amalgamation and inward Hg diffusion in single AuNRs@mSiO2 without structural deformation via dark-field scattering spectroscopy and X-ray photoelectron spectroscopy. Then, we investigated the chemisorption of thiol molecules on single amalgamated AuNRs@Hg-mSiO2. Unlike previous studies on single AuNRs, the thiolation on single AuNRs@Hg-mSiO2 resulted in a redshift and line width narrowing of the LSPR peak within 1 h. To determine the chemical effect, we investigated the competition between two surface damping pathways: metal interface damping (MID) and chemical interface damping (CID). When we exposed amalgamated AuNRs@Hg-mSiO2 to 1-alkanethiols with three different carbon chain lengths for 1 h, we observed an increase in the line width broadening with longer chain lengths owing to enhanced CID, demonstrating the tunability of CID and LSPR properties upon chemical treatments. We also investigated the competition between the two surface damping pathways as a function of the time-dependent Au-Hg surface properties in AuNRs@Hg-mSiO2. The 24-h Hg treatment resulted in increased line width broadening compared to the 1-h treatment for the same thiols, which was attributed to the predominance of CID. This was in contrast to the predominance of MID under the 1-h treatment, which formed a core-shell structure. Therefore, this study provides new insights into the Hg amalgamation process, the effect of chemical treatments, competition between surface decay pathways, and LSPR control in AuNRs@mSiO2.

Bearing capacity of lunar soil ground under extraterrestrial environmental effects

Lunar environment features a low gravity field and ultra-high vacuum which shows significant effects on the bearing behavior of lunar soil ground for future lunar habitation. Therefore, the 2D Discrete Element Method was employed to simulate the plate load tests under different gravity fields in non-vacuum (i.e., excluding the van der Waals force) and high-vacuum (i.e., including the van der Waals force) environments, analyzing the bearing behavior and soil response under extraterrestrial environmental effects. The results show that a bilinear line bounded by 1g can be employed to describe the gravity effect on the gravity factors for ultimate bearing capacity and coefficient of subgrade reaction. The slopes are different in low and high-gravity fields, indicating that the high-gravity effect in a centrifuge cannot be directly applied to predict the bearing behavior of lunar soil ground in a low-gravity field. The affected area becomes deeper in depth and narrower in width with the decreasing gravity level in non-vacuum environment, while the affected area becomes deeper in depth and wider in width with the decreasing gravity level in high-vacuum environment. Such observations can provide advice for developing analytical models for the bearing capacity of lunar soil ground considering the extraterrestrial environmental effects.

Alternatives for sustainable weed control in single‐ and double‐cropped soybean: A case study for Mediterranean irrigated conditions

AbstractThe irrigated cropping systems in South Europe could benefit from soybean [Glycine max (L.) Merr.] introduction in their maize (Zea mays L.)‐based crop rotations. However, sustainable weed management strategies are needed for soybean growers under Mediterranean irrigated conditions. This work aimed to assess the weed control efficacy, and the soybean performance, of alternative management practices for single‐ and double‐cropped soybean. Two field experiments were carried out in northeast Spain in the period 2019–2021. Row width narrowing (75–37.5 cm), herbicide application (yes/no), and roller‐crimped rye [Secale cereal (L.) M.Bieb.] cover crop (yes/no) were assessed in the single cropping system experiment (SCS). In the barley‐soybean double cropping system experiment (DCS), row width narrowing and herbicide application were assessed. In the SCS, the presence of rye cover crop reduced weed biomass up to 92% compared to the controls without herbicide and cover crop in 2020. In 2021, no effect of the cover crop on weed pressure was found due to the low amount of rye biomass accumulated (11.8 and 3.4 ton DM ha−1 in 2020 and 2021, respectively). In the DCS, herbicide application attained the expected weed control. Row width narrowing to 37.5 cm did not have an impact on weed pressure nor on soybean yield in either experiment. We concluded that herbicide reduction for single‐cropped soybean under Mediterranean irrigated conditions can be achieved by roller‐crimping a rye cover crop, provided enough rye biomass is accumulated. In the DCS, our results indicated that further research is needed to find alternatives to chemical weed control.

MicroRNA-224-5p nanoparticles balance homeostasis via inhibiting cartilage degeneration and synovial inflammation for synergistic alleviation of osteoarthritis

MicroRNAs play a crucial role in regulating cartilage extracellular matrix (ECM) metabolism and are being explored as potential therapeutic targets for osteoarthritis (OA). The present study indicated that microRNA-224-5p (miR-224-5p) could balance the homeostasis of OA via regulating cartilage degradation and synovium inflammatory simultaneously. Multifunctional polyamidoamine dendrimer with amino acids used as efficient vector to deliver miR-224-5p. The vector could condense miR-224-5p into transfected nanoparticles, which showed higher cellular uptake and transfection efficiency compared to lipofectamine 3000, and also protected miR-224-5p from RNase degradation. After treatment with the nanoparticles, the chondrocytes showed an increase in autophagy rate and ECM anabolic components, as evidenced by the upregulation of autophagy-related proteins and OA-related anabolic mediators. This led to a corresponding inhibition of cell apoptosis and ECM catabolic proteases, ultimately resulting in the alleviation of ECM degradation. In addition, miR-224-5p also inhibited human umbilical vein endothelial cells angiogenesis and fibroblast-like synoviocytes inflammatory hyperplasia. Integrating the above synergistic effects of miR-224-5p in regulating homeostasis, intra-articular injection of nanoparticles performed outstanding therapeutic effect by reducing articular space width narrowing, osteophyte formation, subchondral bone sclerosis and inhibiting synovial hypertrophy and proliferation in the established mouse OA model. The present study provides a new therapy target and an efficient intra-articular delivery method for improving OA therapy. Statement of significanceOsteoarthritis (OA) is the most prevalent joint disease worldwide. Gene therapy, which involves delivering microRNAs, has the potential to treat OA. In this study, we demonstrated that miR-224-5p can simultaneously regulate cartilage degradation and synovium inflammation, thereby restoring homeostasis in OA gene therapy. Moreover, compared to traditional transfection reagents such as lipofectamine 3000, G5-AHP showed better efficacy in both microRNA transfection and protection against degradation due to its specific surface structure. In summary, G5-AHP/miR-224-5p was developed to meet the clinical needs of OA patients and the high requirement of gene transfection efficiency, providing a promising paradigm for the future application and development of gene therapy.

Opening of Lymphatic Outflow after Traumatic Cyclodialysis

After blunt trauma, a 24-year-old man presented with an inferior cyclodialysis cleft (A) and hypotony. Indocyanine green angiography (PMID: 28461013) on FLEX Spectralis revealed dilated, irregular, blind-tipped channels with variegated contrast (B, arrow), akin to lymphatics reported on angiographic imaging after trabeculectomy (PMID: 35005679). This was contrary to the traditional aqueous (PMIDs: 28461013, 35005679) outflow channels that are seen as acutely branching, more uniform, and narrower in width (C, arrow). As a result, after cyclodialysis, tracer imaging in this patient shows potential access to ocular lymphatics, most likely through the uveo-lymphatic pathway (PMID: 19729007), which could contribute to hypotony. Subconjunctival lymphatic trypan blue-assisted staining in the cleft region has previously shown lymphatic over-drain after cyclodialysis (PMID: 31090997) (Magnified version of Figure A-C is available online at www.aaojournal.org).

The Impact of Alar Flare Reduction Goes Beyond Just the Ala.

Alar flare reduction (AFR) is a widely used technique in rhinoplasty. Although the impact of AFR on the alar base has been well studied, its effect on the surrounding tissues is largely unknown. This study aims to elucidate the potential effect of AFR on the overall nasal and perinasal anatomy. AFR was performed on cadavers ( n = 7) with sequential crescent-shaped alar excisions of 2, 4, and 6 mm. Two- and three-dimensional photographs were obtained at baseline and subsequent intervals. Analysis was performed with Adobe Photoshop and Vectra. Standardized landmarks were placed at the nasal tip point (NTP) and alar base point to quantify NTP vector distances, NTP surface distances, and alar crease angle. The surface and vector distances between the NTP and alar base point decreased for increasing AFR intervals. AFR created a surface decrease of 1.90 ± 1.60, 3.54 ± 1.85, and 4.91 ± 1.89 mm, respectively. AFR created a vector decrease of 1.50 ± 1.14, 2.83 ± 1.37, and 3.97 ± 1.38 mm, respectively. NTP projection decreased by 0.54 ± 0.31 mm for 6-mm excision. AFR led to cheek elevation of 0.87 ± 0.70, 1.25 ± 0.60, and 1.96 ± 0.48 mm, respectively. This alar crease elevation blunted the transition between the cheek and upper lip skin at the level of the alar rim with the angle of this transition increasing 26.62 ± 12.78 degrees from baseline to 6 mm. Three-dimensional analysis demonstrates the influence of AFR on the alar base and surrounding perinasal contour. AFR results in nasal tip deprojection, alar crease elevation, and alar flare width narrowing. Further investigation into the impact of modifying the alar base on surrounding structures is warranted.

Enhancing Alkyne-Based Raman Tags with a Sulfur Linker.

Alkyne-based Raman tags have proven their utility for biological imaging. Although the alkynyl stretching mode is a relatively strong Raman scatterer, the detection sensitivity of alkyne-tagged compounds is ultimately limited by the magnitude of the probe's Raman response. In order to improve the performance of alkyne-based Raman probes, we have designed several tags that benefit from π-π conjugation as well as from additional n-π conjugation with a sulfur linker. We show that the sulfur linker provides additional enhancement and line width narrowing, offering a simple yet effective strategy for improving alkyne-based Raman tags. We validate the utility of various sulfur-linked alkyne tags for cellular imaging through stimulated Raman scattering microscopy.

Jet flow control by synchronous drive of two DBD-PAs in nozzle and on bluff body

In this study, two dielectric barrier discharge plasma actuators (DBD-PAs) are driven at different times to control a circular jet flow. DBD-PA was installed inside a nozzle and on a disk-shaped bluff body above the nozzle. A vortex was generated in the jet using DBD-PA in the nozzle, and the development of the vortex was controlled using the DBD-PA installed in the disk-shaped bluff body above the nozzle. The two DBD-PAs were driven with a time lag based on the time the vortex reached the bluff body. The findings reveal that the vortices did not pair with each other when the DBD-PA of the bluff body was slightly delayed from the timing of the occurrence of the vortex on the circulating flow side. When the vortices did not pair, the flow was not entrained in the circulating flow, causing the jet width to widen. The vortices paired with each other when the DBD-PA of the bluff body was driven at the same time as or long after the occurrence of the vortex on the circulating flow side. When the vortex pair with each other, they collapse quickly after pairing, and the jet width narrows, as the flow is entrained in the circulating flow. The difference in jet width downstream of the bluff body was found by driving the two DBD-PAs installed inside the nozzle and on the bluff body at different times.

Mechanism of MnSOD removing peroxy radical for inhibiting coal spontaneous combustion

• The pathways of free radical small and large cyclic chain reactions were analyzed; • The disproportionation reaction of MnSOD and peroxy radical was analyzed; • The mechanism of MnSOD scavenging peroxy radical was revealed; • The effect of MnSOD inhibiting coal spontaneous combustion was verified. Superoxide dismutase (MnSOD) was proposed as an inhibitor to inhibit coal spontaneous combustion (CSC). The pathways of free radical cyclic chain reaction were analysed. The mechanism of MnSOD removing peroxy radical (–OO·) was calculated by quantum chemical method, and the effect of MnSOD inhibiting CSC was verified by electron paramagnetic resonance experiment. Results showed that –OO· is the key to triggering free radical small and large cyclic chain reactions. The Mn ion is the active site of the MnSOD. MnSOD disproportionates –OO· in four steps: firstly, –OO· undergoes an addition reaction with MnSOD, and a new coordination bond –OO attaching to the Mn ion is generated; secondly, Mn 3+ is reduced to Mn 2+ by –OO· with the –OO bond broken to release O 2 ; thirdly, Mn 2+ is oxidised to Mn 3+ by –OO·, and a new coordination bond –OOH is formed with the reaction of H + and –OO·, which is attached to the Mn ion; lastly, H 2 O 2 is formed when H + reacts with the broken –OOH bond. In the first step, only covalent bonds are formed with no bond breaking and energy barriers. The energy barriers for the second to fourth reactions are 52.51, 78.77 and 183.79 kJ/mol, and the reaction rates are 3.848 × 10 5 , 9.601 and 3.760 × 10 −18 s −1 M −1 , respectively. In this four-step reaction, the heat release values are 131.28, –78.77, 472.59 and –210 kJ/mol. The –OO· is consumed during the reduction and oxidation reactions of Mn ions to generate O 2 and H 2 O 2 , respectively. The g value of the MnSOD coal sample decreases, the line width narrows, and the free radical concentration decreases, indicating that MnSOD can effectively inhibit CSC.

The Impact of Extreme Low Temperatures on Raman Spectra of Amino Acids Relevant for the Search for Life on Europa.

Raman spectroscopy, an emerging technology for in situ space exploration, has been suggested for life detection for the Europa Lander Mission. However, obtaining spectra of samples from the europan icy shell requires measurements at temperatures down to -233°C, which will affect the Raman spectra of any potential biosignatures. In this study, we obtained Raman spectra of amino acids using a 785 nm Raman system at temperatures ranging down to -196°C, analogous to Europa's surface and near subsurface. Significant Raman band width narrowing and decreasing variance were observed at lower temperatures leading to higher-precision Raman measurements, which required higher spectral resolution that could be as high as 2 cm-1 for full identification of amino acids. Such spectral resolution is much higher than the resolution of contemporary Raman instruments for planetary exploration and may be particularly problematic for miniaturized instruments. Shifting of Raman bands to both higher and lower frequencies by as much as ∼25 cm-1 together with changes in the Raman band intensity were recorded. The emergence of new bands and diminishing of the original bands also occurred for some amino acids. A significantly increased fluorescence background was observed in spectra of fluorescent molecules (i.e., tryptophan). A link between the type of vibrational modes associated with Raman bands and the change in their Raman shift at extreme low temperatures was identified and described. This link offers an exciting new method of molecule identification solely based on the comparison of spectra collected at two different temperatures and could greatly improve the identification capabilities in Raman spectroscopy for a wide array of applications.

Correlation analysis between looper system and strip width narrowing in hot strip rolling

Correlation analysis between looper system and strip width narrowing in hot strip rolling

Successful Management of Post-Traumatic Residual Orbital Roof Defects with Cosmetic Disfigurement and Functional Deficits Using Innovative Titanium Plate Orbitoplasty.

Late presentations of post-traumatic residual orbital roof deformities ensuing from old, unaddressed orbital injuries, can be extremely challenging to manage and quite complicated to correct, owing to proximity of the brain and frontal sinus, malunion or bony fusion of the displaced, delicate orbital fracture fragments, necrosis of entrapped extraocular muscles and progressive intraorbital soft tissue fibrosis and adhesions. There exists a paucity in literature on delayed repair of displaced and comminuted orbital roof fractures and late reconstruction of the three-dimensional architecture of the orbital frame and internal orbit. To present an unusual case of severe post-traumatic residual orbital roof deformity, resulting in longstanding aesthetic disfigurement and persisting functional deficits, and its successful management. The patient had sustained orbital injuries sixteen months ago, on being punched in the face at a boxing tournament. The increased orbital volume produced by an impure blowout fracture of the left orbital roof, with comminution of the upper and lower orbital rims, had resulted in considerable cosmetic deformity, discomfort as well as functional debility, all of which were successfully and efficaciously managed by an innovative use of a Titanium Orbital Plate for orbital roof reconstruction. Overlooked, undetected or ignored derangements in intraorbital volume and contour, can lead to severe cosmetic disfigurement in the form of enophthalmos, hypoglobus, entropion, telecanthus, palpebral fissure width narrowing and ptosis; in addition to crippling functional deficits, such as diplopia, blurred vision, levator dysfunction, restricted ocular motility and reduced visual range and acuity. An innovative Titanium mesh orbitoplasty enabled achievement of both, the aesthetic and functional goals of reconstruction of the distorted bony orbit, with successful correction of severe functional and aesthetic deficits.

The immediate meniscal allograft transplantation achieved better chondroprotection and less meniscus degeneration than the conventional delayed transplantation in the long-term.

The purpose of this study was to compare the long-term clinical and radiological outcomes between the immediate and delayed meniscus allograft transplantation (MAT). Nine menisci were transplanted immediately after total meniscectomy (immediate group, IM), and 10 menisci were delayed transplanted in patients with the median of 35months (range 9-92months) after total meniscectomy (delayed group, DE). Patient's subjective clinical outcomes including VAS, IKDC, Lysholm and Tegner scores as well as muscle strength measures were compared. Joint degeneration was evaluated by both radiographs to assess joint space width narrowing, Kellegren-Lawrence (KL) grade and MRI with T2 mapping sequences to quantitatively analyze both cartilage and meniscal allograft degeneration. The median follow-up time was 10.8years (range 10-14years). The IKDC (IM vs DE, 89.8 vs 80.9, n.s.) and Lysholm scores (IM vs DE, 87.7 vs 78.0, n.s.) were close in two groups, while the IM group showed slightly lower VAS (IM vs DE, 0.2 vs 1.5, p = 0.031), higher Tegner score (IM vs DE, 7 vs 3.5 p = 0.021) and better quadriceps muscle strength. The IM group had less joint space narrowing (IM vs DE, 0.35mm vs 0.71mm, n.s.), less KL grade progression (IM vs DE, 0.6 vs 1.7, p = 0.041) on radiographs and less chondral lesions development on MRIs (Cartilage Degeneration Index, IM vs DE, 252 vs 2038, p = 0.025). All meniscal grafts exhibited degeneration by showing grade 3 signal on MRI, and 4 (4/9) in the IM group and 8 (8/10) cases in the DE group. The T2 value of cartilage and meniscal allograft in the IM group was close to that of the healthy control and was significantly lower than that of the DE group. Compared to the conventional delayed MAT, the immediate MAT achieved better cartilage and meniscus protection in the long-term, while its superiority in patient-reported outcomes was limited. IV.

Single-Particle Study on Hg Amalgamation Mechanism and Slow Inward Diffusion in Mesoporous Silica-Coated Gold Nanorods without Structural Deformation.

This paper presents the structural and spectral variations of individual mesoporous silica-coated gold nanorods (AuNRs@mSiO2) compared to bare AuNRs upon Hg-Au amalgamation. First, the aspect ratio of AuNRs@mSiO2 exposed to Hg solutions was unchanged because the deformation related to the cores of AuNR was suppressed by the silica shell. Second, dark-field microscopy and spectroscopy revealed a blue shift of the localized surface plasmon resonance (LSPR) wavelength peak and strong plasmon damping in the individual AuNRs@mSiO2 scattering spectra, exposed to Hg solutions. Furthermore, we investigated time-dependent adsorption kinetics and spectral changes during the formation of Au-Hg amalgam in single AuNRs@mSiO2 over a long time frame without any disturbance from the structural deformation. The inward Hg diffusion into the AuNR core caused a gradual red shift and line width narrowing of the LSPR peak when AuNRs@mSiO2 were withdrawn from Hg solution. Thus, this paper provides new insights into the relationship among amalgamation process, morphological change, the role of silica shell, Hg inward diffusion, LSPR peak, and line width at the single-particle level.