In the twenty-first century, the interaction between humans and their ecological, sociocultural, and technological environment poses significant challenges, particularly regarding health and well-being. This paper contends that understanding these dynamics requires an interdisciplinary approach, drawing on the humanities, arts, social sciences, and health sciences. The "Composing Worlds" project addresses these issues by fostering interdisciplinary research, training, and cultural innovation, adopting a participatory approach, involving experts from different fields to uncover perspectives on crucial issues. The thematic analysis identifies collective correspondences covering critical thinking in health, environmental sustainability, technological advances, and bioethics. These axes guide transdisciplinary research and cultural activities to address 21st-century concerns. By promoting critical thinking and meaningful research, it aims to create a global narrative with a relational ethical connotation that encourages dialogue and reflection on changing societal paradigms.