Nanomaterials For Drug Delivery Research Articles

Advances in Nano-Functional Materials in Targeted Thrombolytic Drug Delivery.

Thrombotic disease has been listed as the third most fatal vascular disease in the world. After decades of development, clinical thrombolytic drugs still cannot avoid the occurrence of adverse reactions such as bleeding. A number of studies have shown that the application of various nano-functional materials in thrombus-targeted drug delivery, combined with external stimuli, such as magnetic, near-infrared light, ultrasound, etc., enrich the drugs in the thrombus site and use the properties of nano-functional materials for collaborative thrombolysis, which can effectively reduce adverse reactions such as bleeding and improve thrombolysis efficiency. In this paper, the research progress of organic nanomaterials, inorganic nanomaterials, and biomimetic nanomaterials for drug delivery is briefly reviewed.

Role of vacancy defects and nanopumping on drug transport efficiency in boron nitride nanotubes

AbstractBoron nitride nanotubes (BNNTs) are promising nanomaterials for drug delivery due to their remarkable mechanical and electrical properties. BNNTs use nanopumping technique to transport drug molecules to target sites when subjected to an external force, such as an electric field or mechanical forces. Despite numerous efforts to investigate BNNTs/biomolecules interactions, the impact of atomic‐scale intrinsic characteristics of BNNT on drug delivery efficiency and delivery time is not well understood. To investigate this, we use molecular dynamics simulations (MD) to develop two simulation models: one with defective BNNT and another with a non‐defective (pristine) BNNT. Here, the fullerene molecule (C20) is introduced into BNNT and transported towards target cells. Our results show that vacancy defects can significantly impact the effectiveness of the nanopumping process. In pristine BNNTs, drug molecules move primarily by translation motion. However, the presence of vacancy defects and their concentration in BNNTs can affect the translation motion of drug molecules. We show that the judicious selection of oscillation frequency and amplitude of Cu tips is important to achieve efficient drug transport. This work provides new insights into the role of structural defects and oscillation on the drug transport efficiency of C20 molecules in BNNT using the nanopumping mechanism.

Recent developments in the Darcy-Forchheimer model of magnetized tetra hybrid nanofluid activation energy/joule heating in a stenotic artery

The impact of heat generation and activation energy on the Darcy-Forchheimer flow of magnetized fluid with nanoparticles in the condition of blood flowing arteries is being investigated by researchers from all over the world in an effort to understand the heat transmission component for the treatment of numerous diseases. The assessment of heat transmission has been made with the enclosure of influence like the viscous dissipation, heat source, Joules heating, and thermal radiation. Utilized is a tetra hybrid nanofluid made up of silver (Ag), gold (Au), titanium oxide (TiO2), coper (Cu), and Blood as the base fluid. The main justification for the use of gold, copper, and silver nanoparticles as drug delivery nanomaterials is their potential for drug transport and imaging. The purpose of the presented model is to assess the performance of the well-known tetra hybrid nanofluid models developed by Yamada-Ota and Xue. The main PDE are transformed into ODE via similarity renovations, and these ODE are then numerically solved using the MATLAB built-in bvp4c scheme. The arteries' internal temperature rises as a result of thermal radiation and viscous dissipation. The velocity and thermal distributions show an increasing behavior with greater variations in the flow parameter. The Yamada-Ota model outperforms the Xue tetra hybrid nanofluid model in terms of heat transmission effectiveness.

Nanotechnology in Orthodontics: Unveiling Pain Mechanisms, Innovations, and Future Prospects of Nanomaterials in Drug Delivery.

Orthodontic pain is characterized by sensations of tingling, tooth discomfort, and intolerance. According to the oral health report, over forty percent of children and adolescents have undergone orthodontic treatment. The efficacy of orthodontic treatment involving braces can be compromised by the diverse levels of discomfort and suffering experienced by patients, leading to suboptimal treatment outcomes and reduced patient adherence. Nanotechnology has entered all areas of science and technology. This review provides an overview of nanoscience, its application in orthodontics, the underlying processes of orthodontic pain, effective treatment options, and a summary of recent research in Nano-dentistry. The uses of this technology in healthcare span a wide range, including enhanced diagnostics, biosensors, and targeted drug delivery. The reason for this is that nanomaterials possess distinct qualities that depend on their size, which can greatly enhance human well-being and contribute to better health when effectively utilized. The field of dentistry has also experienced significant advancements, particularly in the past decade, especially in the utilization of nanomaterials and technology. Over time, there has been an increase in the availability of dental nanomaterials, and a diverse array of these materials have been extensively studied for both commercial and therapeutic purposes.

Fe3 O4 -Incorporated Metal-Organic Framework for Chemo/Ferroptosis Synergistic Anti-Tumor via the Enhanced Chemodynamic Therapy.

Metal-organic framework (MOF)-based drug delivery nanomaterials for cancer therapy have attracted increasing attention in recent years. Here, an enhanced chemodynamic anti-tumor therapy strategy by promoting the Fenton reaction by using core-shell zeolitic imidazolate framework-8 (ZIF-8)@Fe3 O4 as a therapeutic platform is proposed. Carboxymethyl cellulose (CMC) is used as a stabilizer of Fe3 O4 , which is then decorated on the surface of ZIF-8 via the electrostatic interaction and serves as an efficient Fenton reaction trigger. Meanwhile, the pH-responsive ZIF-8 scaffold acts as a container to encapsulate the chemotherapeutic drug doxorubicin (DOX). The obtained DOX-ZIF-8@Fe3 O4 /CMC (DZFC) nanoparticles concomitantly accelerate DOX release and generate more hydroxyl radicals by targeting the lysosomes in cancer cells. In vitro and in vivo studies verify that the DZFC nanoparticles trigger glutathione peroxidase 4 (GPX4)-dependent ferroptosis via the activation of the c-Jun N-terminal kinases (JNK) signaling pathway, following to achieve the chemo/ferroptosis synergistic anti-tumor efficacy. No marked toxic effects are detected during DZFC treatment in a tumor-bearing mouse model. This composite nanoparticle remarkably suppresses the tumor growth with minimized systemic toxicity, opening new horizons for the next generation of theragnostic nanomedicines.

Application of Inorganic Nanomaterials for Drug Delivery in Lung Cancer

Lung cancer has been one of the most common cancers in the world for more than 100 years and has taken many people's lives. Many people suffer from lung cancer due to smoking, second-hand smoke, and serious air pollution or pollutant gathering environment. It is necessary to find a good medical solution. Compared with traditional chemotherapy and immunotherapy, targeted therapy has more advantages in the impact on patients and the efficiency of treatment. How to develop targeted therapeutic drugs has become a topic, and nanoscale targeted drugs have become the most appropriate choice. Among them, there are many inorganics suitable for nano-targeted drugs and nano-drug carriers, such as metals, metal oxides, and non-metals. By blocking the genetic material in lung cancer cells, it can avoid the division and differentiation of lung cancer cells, so as to achieve the purpose of treating lung cancer. This review will focus on the above three kinds of nano-targeted drugs, and discuss their therapeutic principles, drug delivery, activation mode, and biotoxicity.

Nanomaterials for Targeted Drug Delivery through Skin to Treat Various Diseases: Recent Trends and Future Perspective

There is an increased trend of drug delivery via skin due to its convenience and affordability. To accomplish this task in a better way and more successfully, nanotechnology has opened the door to transport drugs for the treatment of acute diseases in unique ways. For partially solvable drugs especially, designing new drug transportation systems is always challenging. However, it has been fixed by utilizing nanomaterials as effective carriers for drugs. These carriers allow the controlled and continuous drug release at the specific spotted site and have been successfully manipulated for the creation of innovative drug-delivery systems. These innovative systems are applied to overcome the challenge of reduced water solubility that may improve the drug accessibility, sustained release, and high metabolic stability. The prime emphasis of this review is particularly on the universal routes of drug administration through the skin, limitations of conventional drug delivery systems (DDS), and types and properties of nanomaterials (NMs) used. Recent advancements in NMs such as carbon-based NMs, inorganic-/metal-based NMs, polymeric NMs, and hybrid NMs for drug delivery and their mode of action have been summarized. This review further discusses existing constraints and difficulties that impede the integration of nanomaterials from research to practice, as well as recommendations for more efficient use of nanomaterials in a number of diseases.

Nanomaterials in drug delivery—Promises and limitations

The unprecedented upsurge of human suffering, whose canvas seems to broaden by the emergence of incurable diseases as a result of evolution of novel strains of microbes is further compounded by the development of antimicrobial resistance, growing urbanization and lifestyle. Nanomaterials are of nano size-ranging from 10–100 nm, and nowadays, they are finding immense applications in drug delivery owing to their advantages over the conventional drug delivery systems. This review article aims to discuss various types of nanomaterials including polymeric nanoparticles (polymersomes, dendrimers, polymer micelles, nanospheres, and nanogels), inorganic nanoparticles (SiNPs, quantum dots, MXenes, FeONPs, and AuNPs) and lipid-based nanomaterials (liposome, lipid nanoparticles, emulsions, and niosomes) in drug delivery applications. Besides this, the manuscript also discusses their limitations, suitability, theranostics, and safety concerns in drug delivery. From the discussion about their applications and limitations in drug delivery, it can be conclusively stated that because of their versatility, the nanomaterials are promising contenders in the field of nanomedicine and their utility in healthcare has convincingly endorsed the fact that however ‘nano’ the dimensions of nanomaterials are, they have colossal relevance.

Recent Advances in Kaolinite Nanoclay as Drug Carrier for Bioapplications: A Review.

Advanced functional two-dimensional (2D) nanomaterials offer unique advantages in drug delivery systems for disease treatment. Kaolinite (Kaol), a nanoclay mineral, is a natural 2D nanomaterial because of its layered silicate structure with nanoscale layer spacing. Recently, Kaolnanoclay is used as a carrier for controlled drug release and improved drug dissolution owing to its advantageous properties such as surface charge, strong biocompatibility, and naturally layered structure, making it an essential development direction for nanoclay-based drug carriers. This review outlines the main physicochemical characteristics of Kaol and the modification methods used for its application in biomedicine. The safety and biocompatibility of Kaol are addressed, and details of the application of Kaol as a drug delivery nanomaterial in antibacterial, anti-inflammatory, and anticancer treatment are discussed. Furthermore, the challenges and prospects of Kaol-based drug delivery nanomaterials in biomedicine are discussed. This review recommends directions for the further development of Kaol nanocarriers by improving their physicochemical properties and expanding the bioapplication range of Kaol.

Effects of Puerarin-Loaded Tetrahedral Framework Nucleic Acids on Osteonecrosis of the Femoral Head.

Osteonecrosis of the femoral head (ONFH) is recognized as a common refractory orthopedic disease that causes severe pain and poor quality of life in patients. Puerarin (Pue), a natural isoflavone glycoside, can promote osteogenesis and inhibit apoptosis of bone mesenchymal stem cells (BMSCs), demonstrating its great potential in the treatment of osteonecrosis. However, its low aqueous solubility, fast degradation in vivo, and inadequate bioavailability, limit its clinical application and therapeutic efficacy. Tetrahedral framework nucleic acids (tFNAs) are promising novel DNA nanomaterials in drug delivery. In this study, tFNAs as Pue carriers is used and synthesized a tFNA/Pue complex (TPC) that exhibited better stability, biocompatibility, and tissue utilization than free Pue. A dexamethasone (DEX)-treated BMSC model in vitro and a methylprednisolone (MPS)-induced ONFH model in vivo is also established, to explore the regulatory effects of TPC on osteogenesis and apoptosis of BMSCs. This findings showed that TPC can restore osteogenesis dysfunction and attenuated BMSC apoptosis induced by high-dose glucocorticoids (GCs) through the hedgehog and Akt/Bcl-2 pathways, contributing to the prevention of GC-induced ONFH in rats. Thus, TPC is a promising drug for the treatment of ONFH and other osteogenesis-related diseases.

Super‐stable homogeneous embolic agents advance the treatment of hepatocellular carcinoma

Super‐stable homogeneous embolic agents advance the treatment of hepatocellular carcinoma

Functional L-Arginine Derivative as an Efficient Vector for Intracellular Protein Delivery for Potential Cancer Therapy.

The utilization of cytosolic protein delivery is a promising approach for treating various diseases by replacing dysfunctional proteins. Despite the development of various nanoparticle-based intracellular protein delivery methods, the complicated chemical synthesis of the vector, loading efficiency and endosomal escape efficiency of proteins remain a great challenge. Recently, 9-fluorenylmethyloxycarbonyl (Fmoc)-modified amino acid derivatives have been used to self-assemble into supramolecular nanomaterials for drug delivery. However, the instability of the Fmoc group in aqueous medium restricts its application. To address this issue, the Fmoc ligand neighboring arginine was substituted for dibenzocyclooctyne (DBCO) with a similar structure to Fmoc to obtain stable DBCO-functionalized L-arginine derivative (DR). Azide-modified triethylamine (crosslinker C) was combined with DR to construct self-assembled DRC via a click chemical reaction for delivering various proteins, such as BSA and saporin (SA), into the cytosol of cells. The hyaluronic-acid-coated DRC/SA was able to not only shield the cationic toxicity, but also enhance the intracellular delivery efficiency of proteins by targeting CD44 overexpression on the cell membrane. The DRC/SA/HA exhibited higher growth inhibition efficiency and lower IC50 compared to DRC/SA toward various cancer cell lines. In conclusion, DBCO-functionalized L-arginine derivative represents an excellent potential vector for protein-based cancer therapy.

Nano-mediated strategy for targeting and treatment of non-small cell lung cancer (NSCLC).

Lung cancer is the most common type of cancer, with over 2.1 million cases diagnosed annually worldwide. It has a high incidence and mortality rate, leading to extensive research into various treatment options, including the use of nanomaterial-based carriers for drug delivery. With regard to cancer treatment, the distinct biological and physico-chemical features of nano-structures have acquired considerable impetus as drug delivery system (DDS) for delivering medication combinations or combining diagnostics and targeted therapy. This review focuses on the use of nanomedicine-based drug delivery systems in the treatment of lung cancer, including the use of lipid, polymer, and carbon-based nanomaterials for traditional therapies such as chemotherapy, radiotherapy, and phototherapy. The review also discusses the potential of stimuli-responsive nanomaterials for drug delivery in lung cancer, and the limitations and opportunities for improving the design of nano-based materials for the treatment of non-small cell lung cancer (NSCLC).

Application of nanomaterials for drug delivery

One of the most important trends in recent years has been the use of nanomaterials for drug delivery. Drug treatment and application have been considerably aided by drug delivery techniques. The relentless search of cutting-edge delivery systems and methods is essential to the quick development of the medication therapy profession. The development of nanomedicines, or drug-delivery particles of 1-100 nm in size manufactured from medications and excipients, is the result of the fusion of nanotechnology and pharmacy. The primary drug delivery techniques currently in use, the nanomaterials that can be used, and the actual applications of nano-delivery are briefly discussed in this research. The topic of this research is increasing the likelihood and precision of multi-armed bandit attacks. The purpose of this research is to improve understanding of the nanodrug delivery framework. The prevailing trends in the area of drug delivery is further analyzed, where several researches have demonstrated that nanomaterials are one of the good options for drug delivery. The reported research shows several applications of drug delivery in different research areas to demonstrate that nano-delivery holds good promise for use and development. In addition, this research helps one to understand, review and enhance the basic application and development framework of nanodrug delivery

Biomedical materials benefit health

Biomedical engineering is acclaimed as the most effective technological advancement—the stepping- stone toward better human health. An in-depth look into biomedical engineering reveals that emerging materials are recognized as the turbocharger for its progress and the source of innovation. For example, the application of advanced nanomaterials in drug delivery, bioimaging, gene therapy, and so on are pioneering new ways to diagnose and treat cancer and other diseases; tissue repair and organ regeneration are no longer dreams, but attainable miracles because of 3D bioprinted scaffold materials; flexible electronic materials and brain-computer interface chips remove barriers in human-computer interaction, enabling scientists to better interpret the mysteries of life. In addition, functional materials construct diverse diagnosis and treatment equipment, such as microfluidics and major medical devices. Evolving from the deep integration of materials science and biomedical engineering, this popular and innovative research field will enormously benefit people's life and health. Upholding the philosophy of “BME Materials Benefit Health,” BMEMat was launched under the auspices of Shandong University and Wiley. With a commitment to building the most valuable international platform to share knowledge and information, BMEMat covers all research advances related to functional materials for biomedical applications. The article types include Original Articles, Review Articles, Editorials, Short Communications, and Letters to the Editor (author guidelines are available at https://onlinelibrary.wiley.com/page/journal/27517446/homepage/author-guidelines). BMEMat adopts an open-access publishing model and will expand the coverage of Wiley's current materials science journals into biomedical engineering. BMEMat creates an active community by attracting interdisciplinary research in biomedical engineering and materials science. Our professional editorial board comprises the most experienced scientists in the BME field. The Editor-in-Chief, Prof. Hong Liu from State Key Laboratory of Crystal Materials, Shandong University, is the winner of National Outstanding Youth Fund and is among the world's highly-cited scientists. We have nine Associate Editors on board to assist the Editor-in-Chief to expediate the peer review process: Prof. Xiaogang Liu from the National University of Singapore (Singapore), Prof. Wenbo Bu from Fudan University (China), Prof. Chuanbin Mao from University of Oklahoma (USA), Prof. Fan Yi from Shandong University (China), Prof. Andreu Cabot from Catalonia Institute for Energy Research (Spain), Prof. Xiaohu Gao from University of Washington, Seattle (USA), Prof. Angus Johnston from Monash University (Australia), Prof. Xingjie Liang from University of Chinese Academy of Sciences (China), and Prof. Xuebin Yang from University of Leeds (UK). The elite editorial team with their diversity of insights and expertise will provide efficient peer review services and post-acceptance processes to our authors and reviewers, and present our readers with the most important, in-depth, and frontier basic and applied research achievements. We sincerely look forward to welcoming you—as a reader, author, reviewer or commenter—to engage with our journal. We believe that BMEMat will become one of the leading international publishing platforms in the interdisciplinary area of material science, biochemistry, biology, biomedical engineering, and medicine, by providing information on the most important advances in this field to a broader group of researchers and engineers from both academia and industry. The authors declare no conflicts of interest.

Advances in Nanomaterials for Drug Delivery

In recent years, nanomedicine has provided several high-performance tools for overcoming biomedical challenges, resulting in numerous patents [...].

Nanomaterials for Drug Delivery and Cancer Therapy

In recent decades, the interest in nanomaterials has grown rapidly for their applications in many research fields, including drug delivery and cancer therapy [...].

Lignin-Based Nanomaterials as Drug Delivery Vehicles: A Review

Over the past decade, lignin-based nanomaterials have astonishingly gained tremendous popularity among researchers worldwide for utilization in various high-value added fields. However, the copiousness of published articles suggests that lignin-based nanomaterials are currently being given the most priority as drug delivery vehicles or drug carriers. A large number of reports have been published during the past decade reporting successful application of lignin nanoparticles as drug carrier, not only for drugs administered in human but also for drugs used in plants such as pesticides, fungicides, etc. In this review, all of these reports have been discussed in an elaborate fashion so as to present all the available information pertaining to the application of lignin-based nanomaterials in drug delivery in a comprehensive manner.

Plasmonic nanoprobes on single AuNTs for evaluating and monitoring the dynamic release of 2D drug carriers.

The use of nanomaterials in drug delivery has gained significant attention in recent years. In this project, we developed a novel localized surface plasmon resonance (LSPR) nanoprobe on single gold triangular nanoplates (AuNTs) for dynamic monitoring of the drug carrier release process. Graphene, as the drug carrier, could be immobilized on the AuNT surface through the π-π* stacking effect. Upon loading or releasing the model drug (doxorubicin, DOX), subtle changes in the local microenvironment's dielectric constant around the AuNTs induced notable red-shifts or blue-shifts in the LSPR scattering spectra of single AuNTs. Furthermore, the spectral shifts led to a continuous enhancement in the red channel of the dark field microscopy (DFM) images during the drug release process in vitro, demonstrating that the drug release system is not susceptible to potential confounding factors. These release kinetics results under different conditions could be well-fitted using the Higuchi desorption model, further proving that this nanoprobe could be employed for evaluating the controlled release ability of 2D nanocarriers. These findings are expected to inspire new ideas and technologies in the preparation of more effective drug carriers, making a significant contribution to the development of drug delivery nanosystems and nanomedicine.

In situ stimulus-responsive self-assembled nanomaterials for drug delivery and disease treatment.

The individual motifs that respond to specific stimuli for the self-assembly of nanomaterials play important roles. In situ constructed nanomaterials are formed spontaneously without human intervention and have promising applications in bioscience. However, due to the complex physiological environment of the human body, designing stimulus-responsive self-assembled nanomaterials in vivo is a challenging problem for researchers. In this article, we discuss the self-assembly principles of various nanomaterials in response to the tissue microenvironment, cell membrane, and intracellular stimuli. We propose the applications and advantages of in situ self-assembly in drug delivery and disease diagnosis and treatment, with a focus on in situ self-assembly at the lesion site, especially in cancer. Additionally, we introduce the significance of introducing exogenous stimulation to construct self-assembly in vivo. Based on this foundation, we put forward the prospects and possible challenges in the field of in situ self-assembly. This review uncovers the relationship between the structure and properties of in situ self-assembled nanomaterials and provides new ideas for innovative drug molecular design and development to solve the problems in the targeted delivery and precision medicine.