Potential Applications Of Nanomaterials Research Articles

An Overview of Nanotechnology in Dental Medicine

The dentistry industry has been modernized by nanotechnology, as this emerging field has opened up new doors for dental treatment, restoration, and tissue regeneration. The potential applications of nanomaterials in dentistry are reviewed in this paper, ranging from advanced restorative materials to targeted drug delivery systems. Due to their unique characteristics (e.g., high surface area-to-volume ratios and tunable physicochemical properties), nanomaterials allow for the precise control of material behavior at the nanoscale. The ability of nanostructured materials to promote tissue regeneration offers the prospect of developing new approaches in bone and periodontal regeneration. Therefore, this review thoroughly analyzes nanomaterials’ characteristics and biomedical applications, highlighting how they can aid in overcoming challenges in dental care and create possibilities for more individualized and less-invasive dental treatments.

Material Trends and Clinical Costings in Systematically Identified CDER‐Approved Nanomedicines

AbstractResearch into mechanisms and potential applications of nanomaterials in medicine has expanded steadily in recent decades, with increasing translational focus. Development costs, including for clinical trials, are often cited as factors limiting the translational viability of novel nanomedicines, especially compared to small new molecular entities (NMEs) and therapeutic biologics. Yet, to date, there has been no systematic investigation into the clinical programs or costs of translating and commercializing nanomedicines, nor a comparison to NMEs and therapeutic biologics, to support these claims. Here, nanomedicines approved by the United States Food and Drug Administration's Center for Drug Evaluation and Research (CDER) from 2011 to 2023 are systematically identified and categorized. Nanomedicines were identified as formulations where submicron particle size contributes to product function. Like biologics and NMEs, nanomedicines are most frequently approved for oncological indications. Notably, all anti‐cancer nanomedicines are indicated to treat orphan diseases, which is representative of the potential for nanomedicines to occupy pharmaceutical niches in treating diseases affecting smaller patient cohorts. The median estimated cost of pivotal trials for nanomedicines is 47% that of biologics and NMEs approved in the same timeframe. The findings indicate higher manufacturing costs in nanomedicine development may be mitigated by savings elsewhere, increasing translational viability.

Nanostructures for the Prevention, Diagnosis, and Treatment of COVID‐19: A Review

AbstractViral infections are a significant cause of death globally, resulting in substantial ethical, social, and economic costs. In recent years, the world has experienced the worst epidemic of the current millennium, caused by the Coronavirus 2019, a severe acute respiratory syndrome. This infection can cause severe complications in various organs, such as the stomach, heart, liver, kidney, and brain. Antimicrobial drugs or vaccines can be a practical approach to combating these pathogens. However, there are drug‐resistant or emerging infections that do not have effective drugs or vaccines. Therefore, it is necessary to explore new approaches for early diagnosis, prevention, and effective therapies. So, nanomaterials are widely considered due to their unique properties. This review employs a practical approach to elucidate the role of nanostructures against COVID‐19. Also, the effects and benefits of various types of nanostructures are discussed that have been used to diagnose, prevent, and treat COVID‐19 in recent years. Furthermore, by evaluating different nanostructures, the utilization of biocompatible nanoparticles consisting of selenium and chitosan derivatives is suggested as a promising candidate for industrial use in the fight against COVID‐19. Ultimately, this study can offer insight into the potential applications of nanomaterials in combating emerging microbial infections.

Applications of quartz crystal microbalance with dissipation in nanomedicine (QCM-D): a personal experience

Due to their unique physical and chemical properties, the potential application of nanomaterials in medicine is partic¬ularly attractive. Despite the many advantages that nanomaterials can offer as diagnostic and therapeutic tools, their transition from the bench to clinical practice is extremely challenging. One of the many barriers that nanomedicines may encounter is their toxicological effect. In fact, the development of novel nanomaterials / nanoparticles must pro¬ceed always in tandem with the assessment of any potential toxicological effects associated to them. Once nano¬materials reach the systemic circulation, they interact with endothelial cells, plasma proteins, and other blood compo¬nents. There is no doubt that the study of nanomaterials-blood interactions is crucial to warrant the biocompatibility of nanomaterials developed for human use.

Unveiling key mechanisms: Transcriptomic meta-analysis of diverse nanomaterial applications addressing biotic and abiotic stresses in Arabidopsis Thaliana

The potential applications of nanomaterials in agriculture for alleviating diverse biotic and abiotic stresses have garnered significant attention. The reported mechanisms encompass promoting plant growth and development, alleviating oxidative stress, inducing defense responses, modulating plant-microbe interactions, and more. However, individual studies may not fully uncover the common pathways or distinguish the effects of different nanostructures. We examined Arabidopsis thaliana transcriptomes exposed to biotic, abiotic, and metal or carbon-based nanomaterials, utilizing 24 microarray chipsets and 17 RNA-seq sets. The results showed that: 1) from the perspective of different nanostructures, all metal nanomaterials relieved biotic/abiotic stresses via boosting metal homeostasis, particularly zinc and iron. Carbon nanomaterials induce hormone-related immune responses in the presence of both biotic and abiotic stressors. 2) Considering the distinct features of various nanostructures, metal nanomaterials displayed unique characteristics in seed priming for combating abiotic stresses. In contrast, carbon nanomaterials exhibited attractive features in alleviating water deprivation and acting as signaling amplifiers during biotic stress. 3) For shared pathway analysis, response to hypoxia emerges as the predominant and widely shared regulatory mechanism governing diverse stress responses, including those induced by nanomaterials. By deciphering shared and specific pathways and responses, this research opens new avenues for precision nano-agriculture, offering innovative strategies to optimize plant resilience, improve stress management, and advance sustainable crop production practices.

A Comprehensive Review on Potential Application of Nanomaterials in the Field of Agricultural Engineering

A Comprehensive Review on Potential Application of Nanomaterials in the Field of Agricultural Engineering

Study of the properties of Multi-walled carbon nanotubes/ Carbon Quantum Dots Nanocomposites

In recent years, there has been a growing interest in the synthesis and characterization of nanomaterials for various applications. Carbon nanotubes (CNTs) and quantum dots (QDs) are among the promising nanomaterials due to their unique properties. This study aims to synthesize and characterize multi-walled CNTs and QDs using the hydrothermal method. MWCNTs were synthesized at a temperature of 200°C using Ferrocene and Sulfur as precursors, while QDs were prepared at a temperature of 160°C using Polyethylene glycol (PEG). To fabricate the nanocomposite films, MWCNTs and QDs were mixed at different weight ratios (3:1, 2:2, and 1:3) through ultrasonic dispersion. The resulting mixture was then used to form films on glass surfaces. Characterization of the composites was carried out using a series of analyses including Fourier-transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), and electrical conductivity measurements. From the FESEM measurements, spherical particles of various sizes were observed, with a wide size distribution of less than 10nm. XRD analysis revealed d-spacing values of 0.34nm, 0.39nm, and 0.46nm for all the mentioned weight ratios. Additionally, the diameter of the particles ranged from 32.48nm to 31.96nm, with a length of approximately 1µm. The electrical conductivity of the films was also measured, and the obtained results indicated activation energies of 0.155eV, 0.14eV, and 0.25eV for the respective weight ratios. The resulting nanocomposite films exhibited unique properties as characterized by various techniques. These findings contribute to the understanding and potential applications of nanomaterials in diverse

Nanomaterials in Animal Husbandry: Research and Prospects.

Anti-inflammatory, antiviral, and anti-cancer treatments are potential applications of nanomaterials in biology. To explore the latest discoveries in nanotechnology, we reviewed the published literature, focusing on co-assembled nanoparticles for anti-inflammatory and anti-tumor properties, and their applications in animal husbandry. The results show that nanoparticles have significant anti-inflammation and anti-tumor effects, demonstrating broad application prospects in animal breeding. Furthermore, pooled evidence suggests that the mechanism is to have a positive impact on inflammation and tumors through the specific drug loading by indirectly or directly targeting the disease sites. Because the precise regulatory mechanism remains unclear, most studies have focused on regulating particular sites or even specific genes in the nucleus by targeting functional co-assembled nanoparticles. Hence, despite the intriguing scenarios for nanotechnology in farmed animals, most results cannot yet be translated into field applications. Overall, nanomaterials outperformed similar materials in terms of anti-inflammatory and anti-tumor. Nanotechnology also has promising applications in animal husbandry and veterinary care, and its application and development in animal husbandry remain an exciting area of research.

Influence of the block copolypeptide surfactant structure on the size of polypeptide nanoparticles obtained by mini emulsion polymerisation

Polypetide nanoparticles obtained by miniemulsion polymerisation of amino acid N-carboxyanhydrides (NCA) are a novel class of tuneable bio-derived functional nano materials for potential applications in nutraceutics, agriculture, and medicine.

Impact of nanomaterials on the intestinal mucosal barrier and its application in treating intestinal diseases.

The intestinal mucosal barrier (IMB) is one of the important barriers to prevent harmful substances and pathogens from entering the body environment and to maintain intestinal homeostasis. The dysfunction of the IMB is associated with intestinal diseases and disorders. Nanomaterials have been widely used in medicine and as drug carriers due to their large specific surface area, strong adsorbability, and good biocompatibility. In this review, we comprehensively discuss the impact of typical nanomaterials on the IMB and summarize the treatment of intestinal diseases by using nanomaterials. The effects of nanomaterials on the IMB are mainly influenced by factors such as the dosage, size, morphology, and surface functional groups of nanomaterials. There is huge potential and a broad prospect for the application of nanomaterials in regulating the IMB for achieving an optimal therapeutic effect for antibiotics, oral vaccines, drug carriers, and so on.

Magnetized bioconvection flow of Sutterby fluid characterized by the suspension of nanoparticles across a wedge with activation energy

AbstractNanofluids are playing a vital part in advancing practical life. The potential application of nanomaterials in a multitude of scenarios, such oil recovery, the melting of electronic systems in computers, cooling systems, the construction of fluid, cooling spirals, engineering and manufacturing, heat storage devices, and bioengineering. The microorganisms have a vital role to play in numerous applications, such as biological sciences, drugs, and biotechnology, biofuels processing, wastewater treatment, and food production. The current investigation exhibits a numerical model for Sutterby fluid with activation energy, thermal radiation, and bioconvection flowing past a stretching/shrinking wedge. The set of conservative governing partial differential equations (PDEs) is converted into a dimensionless ODEs system by using suitable similarity variables. The obtained new system of the model with dimensionless relative boundary conditions is tackled numerically by manipulating the famous shooting method through bvp4c solver in MATLAB coding. The physical and mathematical findings for profiles of velocity, temperature, concentration, and microbe dispersion owing to various controlling parameter inputs are displayed in tables and graphs. Flow velocity is shown to decrease as the bioconvection Rayleigh number increases. Moreover, the Prandtl number increases, the thermal field of the fluid decreases while it increases for the temperature ratio parameter. Furthermore, it is determined from this situation that the concentration field decreases as the Brownian motion parameter increases. The field of the microorganism decreases as the Peclet number increases.

Potential Applications of Nanomaterials in Wastewater Treatment

Abstract Over the last few decades, nanotechnologies have gained a great deal of attention, and various nanomaterials and techniques have been developed for water remediation. This study deals with the adsorption of Naphthol green B onto the magnetite nanoparticles synthetized by the coprecipitation method at the laboratory temperature. According to the obtained results, the sorption process is obvious only at the acidic condition when the pH of solution decreases to pH level 3. According to nonlinear fit of experimental data, the sorption of the Naphthol green B onto magnetite nanoparticles is assumed as multilayer, while the Freundlich model fits better (96.158 %) than the Langmuir model does (55.941 %).

A Review on Recent Trends in Nanomaterials and Nanocomposites for Environmental Applications

Background: Depletion and contamination of environmental resources such as water, air and soil caused by human activities is an increasingly important challenge faced around the world. The consequences of environmental pollution are felt acutely by all living beings, both on a short and long-term basis, thereby making methods of remediation of environmental pollution an urgent requirement. Objectives: The objective of this review is to dissect the complications caused by environmental degradation, highlight advancements in the field of nanotechnology and to scrutinize its applications in environmental remediation. Furthermore, the review aims to concisely explain the merits and drawbacks of nanotechnology compared to existing methods. Conclusion: The current and potential applications of nanomaterials and nanocomposites in the prevention, control and reduction of air, water and soil pollution and the mechanisms involved have been elucidated, with their various merits and demerits. The applications of nanotechnology in the fields of carbon capture and agriculture have also been discussed in this review.

Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing.

Diabetic wound shows delayed and incomplete healing processes, which in turn exposes patients to an environment with a high risk of infection. This article has summarized current developments of nanoparticles/hydrogels and nanotechnology used for promoting the wound healing process in either diabetic animal models or patients with diabetes mellitus. These nanoparticles/hydrogels promote diabetic wound healing by loading bioactive molecules (such as growth factors, genes, proteins/peptides, stem cells/exosomes, etc.) and non-bioactive substances (metal ions, oxygen, nitric oxide, etc.). Among them, smart hydrogels (a very promising method for loading many types of bioactive components) are currently favored by researchers. In addition, nanoparticles/hydrogels can be combined with some technology (including PTT, LBL self-assembly technique and 3D-printing technology) to treat diabetic wound repair. By reviewing the recent literatures, we also proposed new strategies for improving multifunctional treatment of diabetic wounds in the future.

Biomedical and bioactive engineered nanomaterials for targeted tumor photothermal therapy: A review.

Currently, a lot of efforts have been applied to diagnosis and treat tumors through the fabrication of highly-efficient and multi-functional nanomaterials. Superior to other methods, photothermal therapy (PTT) has been demonstrated as a noninvasive, controllable, and targeted strategy to eliminate tumor cells. The use of functional biomedical and bioactive nanomaterials can enhance the photothermal performances and meanwhile integrate with favorable functions, by taking into account their risk assessments. In this review, novel engineered photothermal nanomaterials, such as noble metal-, carbon-, semiconductor-, and organic molecule-based PTT agents, as well as their targeted biomedical applications were summarized and discussed comprehensively. Particularly, the latest advances of not only the conventional nanomaterials, but also the newly-discovered alternatives, like Au-Ag, graphdiyne, and selenides, were introduced. Besides the benefits, the risks and other implications of novel PTT agents were recorded and evaluated. Moreover, the potential applications of nanomaterials in targeted and multi-functional PTT treatments, which served as foundations and directions for future PTT approaches developments, were stated. Depending on the urgency and boosting demands for tumor treatments, novel engineering advancements of techniques, not limited to PTT and nanomaterials, are prerequisites in the history of medical development.

Dynamic changes of protein corona compositions on the surface of zinc oxide nanoparticle in cell culture media

The potential applications of nanomaterials used in nanomedicine as ingredients in drug delivery systems and in other products continue to expand. When nanomaterials are introduced into physiological environments and driven by energetics, they readily associate proteins forming a protein corona (PC) on their surface. This PC could result in an alteration of the nanomaterial’s surface characteristics, affecting their interaction with cells due to conformational changes in adsorbed protein molecules. However, our current understanding of nanobiological interactions is still very limited. Utilizing a liquid chromatography–mass spectroscopy/mass spectroscopy technology and a Cytoscape plugin (ClueGO) approach, we examined the composition of the PC for a set of zinc oxide nanoparticles (ZnONP) from cell culture media typically and further analyzed the biological interaction of identified proteins, respectively. In total, 36 and 33 common proteins were investigated as being bound to ZnONP at 5 min and 60 min, respectively. These proteins were further analyzed with ClueGO, a Cytoscape plugin, which provided gene ontology and the biological interaction processes of identified proteins. Proteins bound to the surface of nanoparticles that may modify the structure, therefore the function of the adsorbed protein could be consequently affect the complicated biological processes.

Molten-Salt Synthesis of Complex Metal Oxide Nanoparticles.

The development of feasible synthesis methods is critical for the successful exploration of novel properties and potential applications of nanomaterials. Here, we introduce the molten-salt synthesis (MSS) method for making metal oxide nanomaterials. Advantages over other methods include its simplicity, greenness, reliability, scalability, and generalizability. Using pyrochlore lanthanum hafnium oxide (La2Hf2O7) as a representative, we describe the MSS protocol for the successful synthesis of complex metal oxide nanoparticles (NPs). Furthermore, this method has the unique ability to produce NPs with different material features by changing various synthesis parameters such as pH, temperature, duration, and post-annealing. By fine-tuning these parameters, we are able to synthesize highly uniform, non-agglomerated, and highly crystalline NPs. As a specific example, we vary the particle size of the La2Hf2O7NPs by changing the concentration of the ammonium hydroxide solution used in the MSS process, which allows us to further explore the effect of particle size on various properties. It is expected that the MSS method will become a more popular synthesis method for nanomaterials and more widely employed in the nanoscience and nanotechnology community in the upcoming years.

Potential Application of Nanomaterials in Oil and Gas Field Drilling Tools and Fluids Design

Potential Application of Nanomaterials in Oil and Gas Field Drilling Tools and Fluids Design

Potential applications and human biosafety of nanomaterials used in nanomedicine.

With the rapid development of nanotechnology, potential applications of nanomaterials in medicine have been widely researched in recent years. Nanomaterials themselves can be used as image agents or therapeutic drugs, and for drug and gene delivery, biological devices, nanoelectronic biosensors or molecular nanotechnology. As the composition, morphology, chemical properties, implant sites as well as potential applications become more and more complex, human biosafety of nanomaterials for clinical use has become a major concern. If nanoparticles accumulate in the human body or interact with the body molecules or chemical components, health risks may also occur. Accordingly, the unique chemical and physical properties, potential applications in medical fields, as well as human biosafety in clinical trials are reviewed in this study. Finally, this article tries to give some suggestions for future work in nanomedicine research. Copyright © 2017 John Wiley & Sons, Ltd.

Studies on plant cell toxicity of luminescent silica nanoparticles (Cs2[Mo6Br14]@SiO2) and its constitutive components

As part of the risk evaluation before potential applications of nanomaterials, phytotoxicity of newly designed multifunctional silica nanoparticles (CMB@SiO2, average diameter of 47 nm) and their components, i.e., molybdenum octahedral cluster bromide units (CMB, 1 nm) and SiO2 nanoparticles (nSiO2, 29 nm), has been studied using photosynthetic Arabidopsis thaliana cell suspension cultures. CMB clusters presented toxic effects on plant cells, inhibiting cell growth and negatively affecting cell viability and photosynthetic efficiency. Nevertheless, we showed that neither nSiO2 nor CMB@SiO2 have any significant effect on cell growth and viability or photosynthetic efficiency. At least, part of the harmful impact of CMB clusters could be ascribed to their capacity to generate an oxidative stress since lipid peroxidation greatly increased after CMB exposure, which was not the case for nSiO2 or CMB@SiO2 treatments. Exposure of cells to CMB clusters also leads to the induction of several enzymatic antioxidant activities (i.e., superoxide dismutase, guaiacol peroxidase, glutathione peroxidase, glutathione reductase, and glutathione S-transferase activities) compared to control and the other treatments. Finally, using electron microscopy, we showed that Arabidopsis cells internalize CMB clusters and both silica nanoparticles, the latter through, most likely, endocytosis-like pathway as nanoparticles were mainly found incorporated into vesicles.