Naive Model Research Articles

Intrusion Detection System in Network Security Using Naive Bayes and Support Vector Machine

An Intrusion Detection System (IDS) is designed to detect suspicious activities or security threats within a network, necessitating continuous advancements in the field. Both implementation techniques and algorithmic research play pivotal roles in enhancing IDS capabilities. This study addresses this need by focusing on the implementation and comparison of two prominent classification models: Naive Bayes and Support Vector Machine (SVM). The study is centered within the domain of Intrusion Detection System (IDS) tailored for network security. In the course of this research, a relevant dataset sourced from Kaggle serves as the foundation for training and testing both classification models. The findings of this study underscore the models' efficacy in intrusion detection. The SVM model, in particular, emerges as a standout performer, showcasing an accuracy rate that approaches 100%, thus exemplifying its potential in real-world scenarios. Meanwhile, the Naive Bayes model delivers commendable accuracy, surpassing 88%. This investigation not only contributes to the advancement of intrusion detection methodologies but also highlights the viability of these classification models for bolstering network security against the ever-evolving threat landscape.

Ovarian–Adnexal Reporting and Data System (O-RADS) MRI Scoring: Diagnostic Accuracy, Interobserver Agreement, and Applicability to Machine Learning

Abstract Objectives To evaluate the interobserver agreement and diagnostic accuracy of ovarian–adnexal reporting and data system magnetic resonance imaging (O-RADS MRI) and applicability to machine learning. Material and methods Dynamic contrast-enhanced pelvic MRI examinations 471 lesions were retrospectively analyzed and assessed by three radiologists according to O-RADS MRI criteria. Radiomic data were extracted from T2, and post-contrast fat-suppressed T1-weighted images. Using these data, an artificial neural network (ANN), support vector machine, random forest, and naive Bayes models were constructed. Results Among all readers, the lowest agreement was found for the O-RADS 4 group (kappa: 0.669 (95% confidence interval [CI] 0.634–0.733)), followed by the O-RADS 5 group (kappa: 0.709 (95% CI 0.678–0.754)). O-RADS 4 predicted a malignancy with an area under the curve (AUC) value of 74.3% (95% CI 0.701–0.782), and O-RADS 5 with an AUC of 95.5% (95% CI 0.932–0.972),(p < 0.001). Among the machine learning models, ANN achieved the highest success, distinguishing O-RADS groups with an AUC of 0.948, a precision of 0.861, and a recall of 0.824. Conclusion The interobserver agreement and diagnostic sensitivity of the O-RADS MRI in assigning O-RADS 4–5 were not perfect, indicating a need for structural improvement. Integrating artificial intelligence into MRI protocols may enhance their performance. Advances in knowledge Machine learning can achieve high accuracy in the correct classification of O-RADS MRI. Malignancy prediction rates were 74% for O-RADS 4 and 95% for O-RADS 5.

Unlocking the future: machine learning models for predicting in-hospital mortality after transcatheter aortic valve replacement: a single-arm meta-analysis

Abstract Background Transcatheter aortic valve replacement (TAVR) continues to be increasingly performed. While machine learning has demonstrated utility in predicting adverse outcomes in various cardiovascular procedures, its effectiveness in predicting in-hospital mortality in TAVR remains uncertain. Purpose We aimed to examine the accuracy of machine learning in predicting in-hospital mortality in TAVR. Methods We searched PubMed and Cochrane databases up to February 2024 for observational studies assessing the diagnostic accuracy of machine learning for predicting in-hospital mortality in TAVR. Extracted data included study characteristics, patient demographics, type of predictive model used, and area under the receiver operating characteristic curves (AUC). Predictive accuracy was assessed by pooling AUC of machine-learning models across studies. AUC values ranging from 0.80 to 0.90, 0.70 to 0.80, 0.60 to 0.70, and 0.50 to 0.60 corresponded to excellent, good, fair, and poor discrimination ability, respectively (1). We used a random effects model to estimate the overall effect size with a 95% confidence interval (CI). Heterogeneity was evaluated with the I2 test.We conducted subgroup analyses based on the type of machine-learning model utilized to assess for any potential differences in predictive accuracy. Results A total of three studies were identified, comprising a study population of 70,714 patients. Across studies, eight machine learning models were utilized, consisting of three artificial neural network models, one logistic regression model, one naive Bayes model, two random forest models, and one support vector machine model. Pooled AUC showed excellent accuracy of machine learning in predicting in-hospital mortality in TAVR (0.92; 95% CI 0.90 - 0.95). Subgroup analyses revealed similar yet excellent accuracy across all types of machine learning models utilized: artificial neural network (0.92; 95% CI 0.86-0.99), logistic regression (0.92; 95% CI 0.89-0.95), naive Bayes (0.90; 95% CI 0.88-0.92), random forest (0.94; 95% CI 0.87-1.00), and support vector machine (0.94; 95% CI 0.91-0.96). Conclusion Our study suggests that utilizing machine learning can accurately predict in-hospital mortality in TAVR. Operators of TAVR procedures may benefit from incorporating machine learning prediction models in their clinical practice. Further exploration of machine learning on outcomes in TAVR is needed to verify our findings.

Enhancing the accuracy and effectiveness of diagnosis of spontaneous bacterial peritonitis in cirrhotic patients: A machine learning approach utilizing clinical and laboratory data

PurposeSpontaneous bacterial peritonitis (SBP) is a bacterial infection of ascitic fluid that develops naturally, without being triggered by any surgical conditions or procedures, and is a common complication of cirrhosis. With a potential mortality rate of 40 ​%, accurate diagnosis and prompt initiation of appropriate antibiotic therapy are crucial for optimizing patient outcomes and preventing life-threatening complications. This study aimed to expand the use of computational models to improve the diagnostic accuracy of SBP in cirrhotic patients by incorporating a broader range of data, including clinical variables and laboratory values. Patients and methodsWe employed 5 machine learning classification methods - Decision Tree, Support Vector Machine, Naive Bayes, K-Nearest Neighbor, and Random Forest, utilizing a variety of demographic, clinical, and laboratory features and biomarkers. ResultsAscitic fluid markers, including white blood cell (WBC) count, lactate dehydrogenase (LDH), total protein, and polymorphonuclear cells (PMN), significantly differentiated between SBP and non-SBP patients. The Random Forest model demonstrated the highest overall accuracy at 86 ​%, while the Naive Bayes model achieved the highest sensitivity at 72 ​%. Utilizing 10 key features instead of the full feature set improved model performance, notably enhancing specificity and accuracy. ConclusionOur analysis highlights the potential of machine learning to enhance the accuracy of SBP diagnosis in cirrhotic patients. Integrating these models into clinical workflows could substantially improve patient outcomes. To achieve this, ongoing multidisciplinary research is crucial. Ensuring model interpretability, continuous monitoring, and rigorous validation will be essential for the successful implementation of real-time clinical decision support systems.

Enhancing SQL Injection Attack Detection Using Naïve Bayes and SMOTE Method on Imbalanced Datasets

SQL injection attack detection is a crucial aspect of cybersecurity, considering the potential damage that such attacks can cause. This study aims to evaluate the effectiveness of the Naive Bayes model in detecting SQL injection attacks on an imbalanced dataset. To address the data imbalance issue, the SMOTE (Synthetic Minority Over-sampling Technique) method was applied. The study consists of two phases: first, training and testing the Naive Bayes model on the original dataset without SMOTE, and second, training and testing on the dataset with SMOTE applied. The results indicate that the Naive Bayes model on the dataset without SMOTE achieved an accuracy of 0.9948, F1 Score of 0.9885, Precision of 0.9906, and Recall of 0.9946. After applying SMOTE, the model's performance improved significantly, with an accuracy of 0.9950, F1 Score of 0.9950, Precision of 0.9950, and Recall of 0.9950. This improvement suggests that SMOTE effectively enhanced class balance in the dataset, improving the model's ability to detect both malicious and safe queries. The study recommends exploring other resampling methods, feature engineering analysis, and testing on more diverse datasets as well as implementation in real-world environments for future research.

A novel Bayesian Pay-As-You-Drive insurance model with risk prediction and causal mapping

The modern vehicle insurance industry is increasingly adopting Pay-As-You-Drive (PAYD) insurance models, aligning premium costs with driving behavior. Our study introduces a Bayesian approach to PAYD insurance, leveraging the strengths of Naive Bayes classifiers and Bayesian Networks to handle uncertainty and integrate prior knowledge in risk assessment. The Naive Bayes model achieved an 87.5% accuracy in predicting risk partitions. With the Bayesian Network providing insights into causal relationships through a Directed Acyclic Graph (DAG), we also address the challenges of traditional actuarial models — low interpretability of intra-factor relationships and thus hard to plan for risk management for both provider and policyholder. Our research contributes to optimizing insurance pricing strategies. Still, the causal mapping also dismisses the meaningfulness of using geographic grouping in insurance pricing (discriminatory or not). It reassures the theoretical advantage of the PAYD model over the traditional model, facilitating access to affordable coverage for policyholders.

Early diagnostic model of pyonephrosis with calculi based on radiomic features combined with clinical variables

ObjectiveThis retrospective aims to develop a comprehensive predictive model based on CT radiomic features and clinical parameters, facilitating early preoperative diagnosis of pyonephrosis.MethodsClinical and radiological data from 311 patients treated for upper urinary tract stones with obstructive pyelohydronephrosis, between January 2018 and May 2023, were retrospectively collected. Univariate and multivariate logistic regression analyses were conducted on clinical data to identify independent risk factors for pyonephrosis. A clinical model was developed using logistic regression. The 3D Slicer software was employed to manually delineate the region of interest (ROI) in the preoperative CT images, corresponding to the area of pyelohydronephrosis, for feature extraction. The optimal radiomic features were selected to construct radiomic models and calculate the radiomic score (Radscore). Subsequently, a combined clinical–radiomic model—the nomogram—was established by integrating the Radscore with independent risk factors.ResultsUnivariate and multivariate logistic regression analyses identified cystatin C, Hounsfield Unit (HU) of pyonephrosis, history of ipsilateral urological surgery, and positive urine culture as independent risk factors for pyonephrosis (P < 0.05). Fourteen optimal radiomic features were selected from CT images to construct four radiomic models, with the Naive Bayes model demonstrating the best predictive performance in both training and validation sets. In the training set, the AUCs for the clinical model, radiomic model, and nomogram were 0.902, 0.939, and 0.991, respectively; in the validation set, they were 0.843, 0.874, and 0.959. Both calibration and decision curves showed good agreement between the predicted probabilities of the nomogram and the actual occurrences.ConclusionThe nomogram, constructed from CT radiomic features and clinical variables, provides an effective non-invasive predictive tool for pyonephrosis, surpassing both clinical and radiomic models.

THE INFLUENCE OF DATA SAMPLING ON SOLVING THE PROBLEM OF PATTERN RECOGNITION FOR DIAGNOSTICS OF INDUSTRIAL EQUIPMENT

With the sophisticated technology that modern industrial organizations are equipped with, state prediction and diagnostics are essential duties. The current research aims to develop a more accurate modified artificial intelligence system for industrial equipment diagnostics in the oil and gas industry. Researching faulty signals and processing methods utilized by equipment in the oil and gas industry, as well as assessing the advantages and disadvantages of different signal extraction strategies, are the first steps in the process. The second is the application of artificial intelligence to decision-making and equipment defect detection. This method widely used by the oil and gas sectors to lower equipment failure rates. The recommended diagnostic system helps organizations reduce the financial risks associated with equipment defects by increasing production dependability, enabling for maintenance planning, predicting probable failures, and expediting equipment repairs. The article is devoted to the study of the data sampling influence on the classifier’s predictive ability in diagnosing of the industrial equipment. Various types of data samples were considered, such as: simple random sample, cluster sample, systematic sample. According to the results of listed data samples were built classifiers based on particle swarm optimization and ensemble models (bagging and voting type). The best results were achieved using the systematic sampled dataset and an ensemble modeling strategy with voting, which combines forecasting based on a neural net, gradient boosted trees and naive Bayes models: accuracy 93.6%; classification error 8%; recall 94.32%; precision 93.87%. The resulting best strategy for diagnosing equipment based on data sampling and an ensemble model was used for implementation in FMEA (Failure Mode and Effects Analysis) technology in order to obtain an improved version, which is adapted for working with big data.

Optimizing the fairness of survival prediction models for racial/ethnic subgroups: A study on predicting post-operative survival in stage IA and IB non-small cell lung cancer.

380 Background: The recent surge of utilizing machine learning (ML) to develop prediction models for clinical decision-making aids is promising. However, these models can demonstrate racial bias due to inequities in real-world training data. In lung cancer, multiple models have been developed to predict prognosis, but none have been optimized to mitigate bias in performance among racial/ethnic subgroups. We developed a ML model to predict five-year survival in Stage 1A-1B non-small cell lung cancer (NSCLC), ensuring fairness on race. Methods: In the National Cancer Database, we identified patients with histopathologically confirmed stage 1A -1B NSCLC who underwent curative intent lobectomy from 2004 – 2017. We split the study cohort into a training and test sets (70%/30%). We trained and compared various ML models to predict 5-year overall survival. Patient demographic, clinical, and disease characteristics were used as input features for the models. To evaluate model fairness, we used the equalized odds ratio (eOR), which compares the true positive and false positive rates across groups; an eOR value of 1 represents equivalent rates across racial groups. We utilized 3 approaches to mitigate model bias and optimize for fairness of the best “naïve” model: grid search, threshold optimizer, and the exponentiated gradient methods. We evaluated model performance before and after bias mitigation using the area under the curve (AUC). Results: 124,298 patients fit our inclusion/exclusion criteria; 87% of patients were White, 8% were Black/African American, 3% Hispanic, and 2% Asian. Eighty percent of patients were diagnosed with stage 1A cancer; 20% had stage 1B cancer. The best naïve ML model, not optimized for fairness on race, had an eOR of 0.25 with an AUC of 0.66 (95% CI 0.65-0.66) overall. This model demonstrated an AUC of 0.65 (0.65-0.66) among white patients, 0.64 (0.62-0.66) among Black patients, 0.64 (0.60-0.68) among Asian patients, and 0.71 (0.68-0.74) among Hispanic patients. The threshold optimizer bias mitigation strategy improved fairness the most while maintaining similar overall performance of AUC 0.65 (0.64-0.66). With this strategy the eOR improved to 0.83 while AUC remained relatively stable across racial subgroups. Conclusions: We developed a ML model to predict 5-year survival in patients undergoing surgery for stage IA-IB NSCLC and employed model bias mitigation strategies that significantly improved model fairness, without diminishing overall performance. These strategies should be considered when developing prediction models for clinical decision making to avoid perpetuating disparities in care due to algorithm bias. Model performance metrics. Equalized Odds Ratio True Positive Rate False Positive Rate AUC Naive model 0.25 0.61 0.30 0.66 Threshold optimizer mitigated model 0.83 0.62 0.32 0.65

Enhancing resistant starch fraction in modified elephant foot yam starch: optimizing preparation conditions and exploring tribological properties

IntroductionElephant foot yam starch is highly susceptible to enzymatic digestion. To address this, heat-moisture treatment (HMT) has been used to modify its digestive properties and functionalities. However, when using modified starch in various food compositions, it is ultimately necessary to cook it in water-rich environments. The present work thus offers a systematic understanding of the heating and cooking procedures for modified starch, with a view to maintaining its structural and digestive properties.MethodsExperimental investigations employing X-ray diffraction, scanning electron microscopy, and enzymatic digestion have been utilized to gain insights into the characteristics of cooked starches. The interactions between amylose and amylopectin in native starch are more susceptible to disruption during cooking, which results in changes in texture and a reduction in resistant starch (RS) retention. Additionally, these preparations have been investigated by tribology to test structure and and friction.Results and discussionThe application of HMT has been observed to induce changes that stabilize the interactions between amylose and amylopectin, thereby ensuring better maintenance of granular integrity and higher RS retention under specific cooking conditions. The findings indicate that following a 2-min cooking period at 100°C, the modified elephant foot yam starch (EFYS) demonstrated enhanced granular stability, which was subsequently compromised after 10 min of cooking. Additionally, when modified elephant foot yam starch (EFYS) was heated at a temperature of 86°C for 2 and 6 min, it demonstrated superior preservation of resistant starch (RS) in comparison to a cooking time of 10 min. Moreover, the HMT starch exhibited the highest RS retention when cooked at 100°C for 2 and 6 min at approximately 39.12% and 20.23%, respectively. However, this retention decreased significantly to 1.08% after 10 min of cooking. Furthermore, the insights from tribology, when combined with the proposed naive models, enhance the understanding of how preparation conditions affect the functionalities of starches, which is crucial for designing food products with desired textural and nutritional qualities, especially in water-rich environments, where maintaining structural integrity and RS content is important.

Novel prediction model of early screening lung adenocarcinoma with pulmonary fibrosis based on haematological index

BackgroundLung cancer (LC), a paramount global life-threatening condition causing significant mortality, is most commonly characterized by its subtype, lung adenocarcinoma (LUAD). Concomitant with LC, pulmonary fibrosis (PF) and interstitial lung disease (ILD) contribute to an intricate landscape of respiratory diseases. Idiopathic pulmonary fibrosis (IPF) in association with LC has been explored. However, other fibrotic interrelations remain underrepresented, especially for LUAD-PF and LUAD-ILD.MethodsWe analysed data with statistical analysis from 7,137 healthy individuals, 7,762 LUAD patients, 7,955 ILD patients, and 2,124 complex PF patients collected over ten years. Furthermore, to identify blood indicators related to lung disease and its complications and compare the relationships between different indicators and lung diseases, we successfully applied the naive Bayes model for a biomarker-based prediction of diagnosis and development into complex PF.ResultsMales predominantly marked their presence in all categories, save for complex PF where females took precedence. Biomarkers, specifically AGR, MLR, NLR, and PLR emerged as pivotal in discerning lung diseases. A machine-learning-driven predictive model underscored the efficacy of these markers in early detection and diagnosis, with NLR exhibiting unparalleled accuracy.ConclusionsOur study elucidates the gender disparities in lung diseases and illuminates the profound potential of serum biomarkers, including AGR, MLR, NLR, and PLR in early lung cancer detection. With NLR as a standout, therefore, this study advances the exploration of indicator changes and predictions in patients with pulmonary disease and fibrosis, thereby improving early diagnosis, treatment, survival rate, and patient prognosis.

Prediction of Heart Disease Risk among Patients in Federal Medical Centre, Abeokuta Using Naïve Bayes

Heart disease is a silent killer, which can cause sudden death of individuals without obvious symptoms. The risk of heart disease is a sign in human beings that must not be neglected. Therefore, this study aimed to predict heart disease among patients in the Federal Medical Hospital Centre (FMC), Abeokuta. Descriptive statistics and data visualization techniques were used to gain insights into the distribution and relationships among the variables. Subsequently, a Naive Bayes classifier model was built using 80% of the data for training and 20% for testing. In addition, a Decision Tree Algorithm (DT) model was used to compare the performance of the Naive Bayes model. The performances of the two models were evaluated using accuracy, sensitivity, ROC-AUC, specificity, precision, and the F1-score. The Naive Bayes model achieved an overall accuracy of 83.61%, precision of 89.29%, recall of 78.12%, F1-Score of 83.33%, ROC-AUC of 90%, sensitivity of 78.12%, and specificity of 89.66. On the other hand, they were compared with the Decision Tree (DT) model which achieved an overall accuracy of 75.41%, precision of 77.42%, recall of 75%, F1-Score of 76.19%, ROC-AUC of 84.54%, sensitivity of 75%, and specificity of 75.86%. Similarly, the confusion matrix for both analyses gave the correct classification of 25 and 22 cases of patients who have heart disease while their wrong classification was 7 and 10 cases of patients who have no heart disease respectively. Furthermore, the importance of features carried out on both showed that the most significant features are the maximum heart rate achieved, fasting blood sugar, resting blood pressure, and chest pain respectively for Naive Bayes and Decision Tree. The findings of the analysis showed that the Naive Bayes model outperformed the Decision Tree in every aspect of the analyses in predicting the risk of heart disease based on the data used and, it suggested that medical health insurance should consider incorporating predictive modelling techniques like Naive Bayes into their risk assessment algorithms, which can be of great use in the medical line.

Exploring the synergy of guided numeric and text analysis in e-commerce: a comprehensive investigation into univariate and multivariate distributions

This research adopts a holistic approach to analyze customer reviews in the e-commerce industry by utilizing a combined approach of numerical and text analysis. Specifically, this study integrates univariate, multivariate, and sentiment analysis to gain comprehensive insights into product preferences and customer satisfaction. The methodology includes a detailed examination of univariate distributions to uncover numerical trends in product ratings and preferences. Multivariate distributions are explored to understand the complex relationships between related variables. Sentiment analysis is performed using the Sentiment Intensity Analyzer to categorize reviews into positive, neutral, and negative sentiments. Additionally, N-gram analysis is applied to both recommended and non-recommended reviews to identify key themes, such as dissatisfaction with product size and satisfaction with fit. Logistic regression and naive Bayes models are employed to classify sentiment, with logistic regression achieving high accuracy on both training (91.3%) and validation data (89.2%). This research highlights the significant role of product recommendations as indicators of positive sentiment, while product ratings reveal the complexity in consumer judgment. The study contributes significantly to understanding the dynamics of customer reviews in the e-commerce industry, providing a solid foundation for smarter decision-making to improve customer experience and product quality.

Process Optimization in a Condiment SME through Improved Lean Six Sigma with a Surface Tension Neural Network

This study offers an innovative solution to address performance issues in the manufacturing process of garlic salt within a condiment-producing SME. A hybrid Lean/Six Sigma model utilizing a Surface Tension Neural Network (STNN) was implemented to control temperature and relative humidity in real-time. The model follows the Define, Measure, Analyze, Improve, Control (DMAIC) methodology to identify root causes and correlate them with waste. By integrating statistical tools, artificial intelligence, and engineering design principles, alternative solutions were evaluated to minimize waste. This document contributes to existing knowledge by demonstrating the integration of an STNN with the Lean/Six Sigma framework in condiment production, an area with limited empirical research. It underscores the benefits of advanced AI technologies in enhancing traditional process optimization methods. The STNN model achieved 97.31% accuracy for temperature classification and 97.37% for humidity, outperforming a Naive Bayes model, which attained 90% accuracy for both. The results showed a 3.15% increase in yield, saving 39.7 kg of waste per batch. Additionally, a 2.13-point improvement at the Six Sigma level was achieved, reducing defects per million opportunities by 551.722. These improvements resulted in significant cost savings, with a reduction in waste-related losses amounting to USD 1585 per batch. The study demonstrates that incorporating artificial intelligence into the Lean/Six Sigma methodology effectively addresses the limitations of traditional statistical methods. Significant improvements in yield and waste reduction highlight the potential of this approach, enhancing operational efficiency and profitability, and fostering sustainable manufacturing practices critical for SMEs’ competitiveness and sustainability in the global market.

Machine Learning to Differentiate Malignant and Non-malignant Pleural Effusion Findings

Introduction: This study developed a method using machine learning techniques to differentiate between malignant and non-malignant pleural effusions, analyzing texture parameters in computed tomography scans Method: The study involved forty-one patients, with their computed tomography examinations classified into three groups: True Positive - patients with both cytopathological analysis and pleural biopsy indicating malignancy; True Negative - patients with negative results in both tests; and False Negative - patients with negative cytopathological analysis but positive pleural biopsy results. Four machine learning methods were applied across three analyses: True Positive versus True Negative, True Positive versus False Negative, and True Negative versus False Negative. The logistic regression model demonstrated notable effectiveness, achieving an Area Under the Curve of 0.84 ± 0.02 in the True Positive versus True Negative analysis and 0.81 ± 0.05 in the True Positive versus False Negative comparison. In the True Negative versus False Negative analysis, the Naive Bayes model achieved an Area Under the Curve of 0.72 ± 0.02. Results: Statistically significant differences were observed in the liquid Lactate Dehydrogenase and protein content between the True Positive and True Negative groups (p-values of 0.0390 and 0.0249, respectively), and in the liquid pH level between the True Positive and False Negative groups (p-value of 0.0254). The use of textural features in combination with machine learning techniques provided a reliable classification for investigating suspected pleural effusion findings. This method represents a potential tool for assisting in clinical diagnosis and decision-making, enhancing the accuracy of pleural effusion assessments Conclusion: In conclusion, our approach not only improves diagnostic accuracy but also offers a faster and non-invasive alternative, significantly benefiting clinical decision-making and patient care.

Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression.

In advanced prostate cancer (PC), in particular after acquisition of resistance to androgen receptor (AR) signaling inhibitors (ARSI), upregulation of AR splice variants compromises endocrine therapy efficiency. Androgen receptor splice variant-7 (ARV7) is clinically the most relevant and has a distinct 3' untranslated region (3'UTR) compared to the AR full-length variant, suggesting a unique post-transcriptional regulation. Here, we set out to evaluate the applicability of the ARV7 3'UTR as a therapy target. A common single nucleotide polymorphism, rs5918762, was found to affect the splicing rate and thus the expression of ARV7 in cellular models and patient specimens. Serine/arginine-rich splicing factor 9 (SRSF9) was found to bind to and increase the inclusion of the cryptic exon 3 of ARV7 during the splicing process in the alternative C allele of rs5918762. The dual specificity protein kinase CLK2 interferes with the activity of SRSF9 by regulating its expression. Inhibition of the Cdc2-like kinase (CLK) family by the small molecules cirtuvivint or lorecivivint results in the decreased expression of ARV7. Both inhibitors show potent anti-proliferative effects in enzalutamide-treated or -naive PC models. Thus, targeting aberrant alternative splicing at the 3'UTR of ARV7 by disturbing the CLK2/SRSF9 axis might be a valuable therapeutic approach in late stage, ARSI-resistant PC.

Population-Based Artificial Intelligence Assessment of Relationship Between the Risk Factors for Diabetic Retinopathy in Indian Population

ABSTRACT Purpose Risk factors (RFs), like ‘body mass index (BMI),’ ‘age,’ and ‘gender’ correlate with Diabetic Retinopathy (DR) diagnosis and have been widely studied. This study examines how these three secondary RFs independently affect the predictive capacity of primary RFs. Methods The dataset consisted of four population-based studies on the prevalence of DR and associated RFs in India between 2001 and 2010. An Autoencoder was employed to categorize RFs as primary or secondary. This study evaluated six primary RFs coupled independently with each secondary RF on five machine-learning models. Results The secondary RF ‘gender’ gave a maximum increase in Area under the curve (AUC) score to predict DR when combined separately with ‘insulin treatment,’ ‘fasting plasma glucose,’ ‘hypertension history,’ and ‘glycosylated hemoglobin’ with a maximum increase in AUC for the Naive Bayes model from 0.573 to 0.646, for the Support Vector Machines (SVM) model from 0.644 to 0.691, for the SVM model from 0.487 to 0.607, and for the Decision Tree model from 0.8 to 0.848, respectively. The secondary RFs ‘age’ and ‘BMI’ gave a maximum increase in AUC score to predict DR when combined separately with ‘diabetes mellitus duration’ and ‘systolic blood pressure,’ with a maximum increase in AUC for the SVM model from 0.389 to 0.621, and for the Decision Tree model from 0.617 to 0.713, respectively. Conclusion The risk factor ‘gender’ was the best secondary RF in predicting DR compared to ‘age’ and ‘BMI,’ increasing the predictive power of four primary RFs.

A Novel Method for Targeted Identification of Essential Proteins by Integrating Chemical Reaction Optimization and Naive Bayes Model.

Targeted identification of essential proteins is of great significance for species identification, drug manufacturing, and disease treatment. It is a challenge to analyze the binding mechanism between essential proteins and improve the identification speed while ensuring the accuracy of the identification. This paper proposes a novel method called EPCRO for identifying essential proteins, which incorporates the chemical reaction optimization (CRO) algorithm and the naive Bayes model to effectively detect essential proteins. In EPCRO, the naive Bayes model is employed to analyze the homogeneity between proteins. In order to improve the identification rate and speed of essential proteins, the protein homogeneity rate is integrated into the CRO algorithm to balance between local and global searches. EPCRO is experimentally compared with 17 existing methods (including, DC, SC, IC, EC, LAC, NC, PeC, WDC, EPD-RW, RWHN, TEGS, CFMM, BSPM, AFSO-EP, CVIM, RWEP, and EPPSO-DC) based on biological datasets. The results show that EPCRO is superior to the above methods in identification accuracy and speed.

Leveraging Deterministic Weather Forecasts for In Situ Probabilistic Temperature Predictions via Deep Learning

Abstract We propose a neural network approach to produce probabilistic weather forecasts from a deterministic numerical weather prediction. Our approach is applied to operational surface temperature outputs from the Global Deterministic Prediction System up to 10-day lead times, targeting METAR observations in Canada and the United States. We show how postprocessing performance is improved by training a single model for multiple lead times. Multiple strategies to condition the network for the lead time are studied, including a supplementary predictor and an embedding. The proposed model is evaluated for accuracy, spread, distribution calibration, and its behavior under extremes. The neural network approach decreases the continuous ranked probability score (CRPS) by 15% and has improved distribution calibration compared to a naive probabilistic model based on past forecast errors. Our approach increases the value of a deterministic forecast by adding information about the uncertainty, without incurring the cost of simulating multiple trajectories. It applies to any gridded forecast including the recent machine learning–based weather prediction models. It requires no information regarding forecast spread and can be trained to generate probabilistic predictions from any deterministic forecast. Significance Statement Weather is difficult to predict a long time in advance because we cannot measure the state of the atmosphere precisely enough. Consequently, it is common practice to run forecasts several times and look at the differences to evaluate how uncertain the prediction is. This process of running ensemble forecasts is expensive and consequently not always feasible. We propose a middle ground where we add uncertainty information to forecasts that were run only once, using artificial intelligence. Our method increases the value of these forecasts by adding information about the uncertainty without incurring the cost of multiple full simulations.

Predicting non-suicidal self-injury among Chinese adolescents: The application of ten algorithms of machine learning

Background and aimsHigh non-suicidal self-injury (NSSI) prevalence among adolescents is a global health issue. However, current prediction models for adolescent NSSI rely on a limited set of algorithms, resulting in biased predictions. Therefore, the aim of this study is to develop multiple machine learning models to enhance prediction accuracy and mitigate biases among Chinese adolescents. MethodsA total of 4487 junior and senior high school students in China were recruited. Multiple algorithms were included, such as logistic regression, decision tree, support vector machine, Naive Bayes, multi-layer perceptron, K-nearest neighbors, and ensemble learning algorithm like random forest, bagging, AdaBoost, and stacking to build predictive models. Data processing techniques, including standardization and the synthetic minority oversampling technique, were employed to optimize the predictive model. The model was trained on 70 % of the data, reserving 30 % for testing. ResultsThe ten prediction models achieved a good performance, with area under the receiver operating characteristic curve (AUC) scores above 0.700 in the test set. The stacking and random forest models achieved AUC scores of 0.904 and 0.898, respectively. The prediction performance of the Naive Bayes model was relatively poor. The top five important variables were resilience, bully, suicidal ideation, internet addiction, and depression. ConclusionsThe ensemble machine learning algorithm showed promising results predicting NSSI among adolescents. Such algorithms should be recommended for future NSSI research to enhance predictive accuracy. Identification of important features in NSSI prediction can help develop screening protocols and lay a foundation for clinical diagnosis and intervention in adolescent populations.