Based on the nature that nonlocal operation will change the fixed quantum statistical speed limited by the local operation, we study the performance of Ising-type nonlocal operation in multipartite entanglement detection and classification. We first present the formula of quantum statistical speed for general quantum state under the two-body nonlocal operation, and then investigate several important and experimentally relevant states, including N-qubit W state, Twin-Fock state, Q state and N-qubit GHZ state. The results show that the optimal nonlocal operation can be used to address some intractable problems encountered under the local operation, such as the classification of N-qubit W state and entanglement detection of Q state at the edges. Meanwhile, some defects are presented and discussed. Interestingly, the N-qubit GHZ state is found to be stable when it is probed by weaker nonlocal operation (γ≤N−1) and it maybe helpful to the experimental research. Our work provides an alternative route to investigate entanglement detection and classification, especially for the novel and complex quantum system.