ABSTRACT Objective This study aims to investigate the efficacy of different types of physiotherapy approaches in individuals with cervical myofascial painful temporomandibular disorders (TMDs). Methods Seventy-five participants with myofascial pain of jaw muscles and cervical myofascial pain were randomized into three groups: exercise group (E), low-level laser therapy group (LLLT), and manual pressure release group (MPR). All patients were assessed before treatment and after 12 sessions of treatment. Results Significant improvement was seen in all groups’ pressure pain threshold (PPT) values (p < 0.01). Some masticatory and neck muscles’ PPT changes in MRP and LLLT groups were significantly higher than the exercise group (p < 0.05). Conclusion Exercise therapy is an effective approach for treatment of TMDs. Additionally, LLLT combined with exercise and MPR combined with exercise have better effects than only exercise therapy. Multimodal treatment approaches should include exercise to achieve better results in clinical practice.