This paper provides a comprehensive study of signal integrity issues in RRAM-based neuromorphic chip crossbar arrays due to interconnect parasitic. First, the parasitic parameters of the crossbar array are calculated by the partial equivalent element circuit (PEEC) method with an efficient unit-cell approach. Numerical experiments show that for a <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$50\times 50$ </tex-math></inline-formula> array scale, this method consumes only 1.5% of the calculation time of the commercial software based 3D model, which translates to a calculation speed up of 72 times. Moreover, the PEEC circuit simulation results match well with those of the 3D model. Then, we investigate the effects of parasitic parameters such as capacitance and inductance, as well as the feature size of the crossbar array on signal integrity. All of them will lead to corresponding changes in parasitic effects, which in turn result in the most common signal integrity issues such as crosstalk, time delay and mutual capacitive coupling induced sneak path problem. Different from other studies, the excitation used in this paper is the neural spike signal generated by the Izhikevich neuron model, which is both rich in dynamic characteristics and high in computational efficiency. Finally, based on the study we propose a simple but effective design scheme for reduction of signal distortion, which can provide valuable design guidance for neuromorphic systems to achieve high performance and high computational accuracy.