Mutual Affinity Research Articles

The natural history of Amblyomma maculatum sensu lato, a vector of Rickettsia parkeri rickettsiosis, in southern Arizona.

Amblyomma maculatum sensu lato (s.l.) is an ixodid tick found in the semi-arid southwestern United States and northern Mexico where it is a parasite of medical and veterinary significance, including as a vector for Rickettsia parkeri, a cause of spotted fever rickettsiosis in the Americas. To describe the comprehensive natural history of this tick, monthly small mammal trapping and avian mist netting sessions were conducted at sites in Cochise County Arizona, within the Madrean Archipelago region where human cases of R. parkeri rickettsiosis and adult stages of A. maculatum s.l. were previously documented. A total of 1949 larvae and nymphs were removed from nine taxonomic groups of rodents and ten species of birds and were used in combination with records for adult stages collected both from vegetation and hunter-harvested animals to model seasonal activity patterns. A univoltine phenology was observed, initiated by the onset of the annual North American monsoon and ceasing during the hot, dry conditions preceding the following monsoon season. Cotton rats (Sigmodon spp.) were significantly more likely to be infested than other rodent taxa and carried the highest tick loads, reflecting a mutual affinity of host and ectoparasite for microhabitats dominated by grass.

Trace element and isotope composition of calcite, apatite, and zircon associated with magmatic sulfide globules

AbstractThe formation of volatile-rich phases in magmatic sulfide systems has been interpreted at least in six different ways. The most popular model attributes their origin to secondary processes, mostly due to the presence of serpentine, chlorite, phlogopite, amphibole, and calcite. While chlorite and serpentine are likely to form as alteration products, the other volatile-rich minerals have the potential to originate in a range of ways, including by primary magmatic processes. Based on mineralogical and petrological studies, it was recently suggested that volatile- and incompatible element-rich halos around sulfide globules may form due to the interaction between three immiscible liquids: silicate, carbonate, and sulfide. This hypothesis was confirmed by experimental data revealing the systematic envelopment of sulfide globules by carbonate melt, indicating their mutual affinity. In this study, we present data on isotopic signatures and trace element distributions of three minerals commonly found in spatial association with sulfides—calcite, apatite, and zircon—to address the question of the source and nature of volatiles and other incompatible elements involved in the formation of the halos. Here we compare our new hypothesis with all the previously proposed explanations to show if they can be consistent with obtained results. Our findings indicate that both mantle and crustal sources play a role in the formation of volatile- and incompatible element-rich halos, strongly correlating with sulfur isotope data previously reported for the sulfide globules in the same intrusions. This correlation confirms the shared origin of sulfides, carbonate and fluids during ore-forming processes, ruling out the secondary origin of volatile-rich phases. The isotope and trace element signatures support the newly proposed hypothesis that volatile- and incompatible element-rich halos could have been formed due to the interaction of immiscible sulfide, carbonate, and silicate melts. The volatile-rich carbonate melt could be sourced from the mantle or it could be added from the crust. Regardless of the origin, carbonate melt and sulfide liquid both immiscible with mafic magma tend to stick to each other resulting in the formation of volatile- and incompatible element-rich halos commonly documented in magmatic sulfide deposits.

From the periphery to the centre: Protestantism and Korean identity in the north-west region

In late 19th-century Korea, Protestantism was perceived as a symbol of western civilization and a messenger for western-style modernity. It was also accepted within the framework of a clash between civilizations, a confrontation of power against power. In such a context, traditional elements were seen as something to be discarded, while western-style modernity, including Protestantism, became the object of aspiration. As is well recognized, the ‘north-west region’ of Korea emerged as the cradle and most vibrant epicentre for the reception of Protestantism, outpacing other regions in terms of both rapid qualitative and quantitative growth within a short time frame. This raises the question: Why did Protestantism receive such an active and passionate welcome in the north-western region? As part of a case study, this article focuses on Pyeongan Province and explores how the encounter between the north-western region and Protestantism reshaped the pre-existing ‘identity’ of north-westerners. In essence, the reason why the people of the north-west region embraced Protestantism more actively compared to other regions was twofold: first, due to their long-standing aspiration to move towards the centre, which had persisted from the past, and, second, because the Protestantism introduced to this region had a mutual affinity with the north-western people. This can be considered as the factor that enabled the rise of north-western people in the early modern period.

Efficient degradation representation learning network for remote sensing image super-resolution

The advancements in convolutional neural networks have led to significant progress in image super-resolution (SR) techniques. Nevertheless, it is crucial to acknowledge that current SR methods operate under the assumption of bicubic downsampling as a degradation factor in low-resolution (LR) images and train models accordingly. However, this approach does not account for the unknown degradation patterns present in real-world scenes. To address this problem, we propose an efficient degradation representation learning network (EDRLN). Specifically, we adopt a contrast learning approach, which enables the model to distinguish and learn various degradation representations in realistic images to obtain critical degradation information. We also introduce streamlined and efficient pixel attention to strengthen the feature extraction capability of the model. In addition, we optimize our model with mutual affine convolution layers instead of ordinary convolution layers to make it more lightweight while minimizing performance loss. Experimental results on remote sensing and benchmark datasets show that our proposed EDRLN exhibits good performance for different degradation scenarios, while the lightweight version minimizes the performance loss as much as possible. The Code will be available at: https://github.com/Leilei11111/EDRLN.

Neural Network Language Models, Mutual Sense Affinity, and Short Text Ranking According to Closeness to a Semantic Standard

Neural Network Language Models, Mutual Sense Affinity, and Short Text Ranking According to Closeness to a Semantic Standard

Comparative Study of Autogenic and Allogenic Chondrocyte Transplants on Polyethersulfone Scaffolds for Cartilage Regeneration.

The aim of this study was to evaluate the chondrogenic potential of chondrocyte transplants cultured in vitro on polyethersulfone (PES) membranes. Forty-eight rabbits (96 knee joints) were used in the project. The synthetic, macro-porous PES membranes were used as scaffolds. Fragments of articular cartilage were harvested from non-weight-bearing areas of the joints of the animals. Chondrocytes were isolated and then cultivated on PES scaffolds for 3 weeks. The animals were divided into four groups. All the lesions in the articular cartilage were full thickness defects. In Group I, autogenic chondrocytes on PES membranes were transplanted into the defect area; in Group II, allogenic chondrocytes on PES membranes were transplanted into the defect area; in Group III, pure PES membranes were transplanted into the defect area; and in Group IV, lesions were left untreated. Half of the animals from each group were terminated after 8 weeks, and the remaining half were terminated 12 weeks postoperatively. The samples underwent macroscopic evaluation using the Brittberg scale and microscopic evaluation using the O'Driscoll scale. The best regeneration was observed in Groups II and I. In Group I, the results were achieved with two surgeries, while in Group II, only one operation was needed. This indicates that allogenic chondrocytes do not require two surgeries, highlighting the importance of further in vivo studies to better understand this advantage. The success of the study and the desired properties of PES scaffolds are attributed mainly to the presence of sulfonic groups in the structure of the material. These groups, similar to chondroitin sulfate, which naturally occurs in hyaline cartilage, likely enable mutual affinity between the scaffold and cells and promote scaffold colonization by the cells.

THE ACTIVITY OF FRENCH LEGATION IN BUCHAREST (1943)

During the Second World War, the Romanian-French diplomatic relations were visibly disrupted due to the war alliances then existing, as well as by the conflict events. However, the long-standing friendship between the two states did not support a definitive break of diplomatic relations. Moreover, amid certain crucial moments at that time, the two states made known their mutual affinity and friendship and they assisted each other diplomatically in defending each other's national interests to the greatest extent. In this study, I would therefore focus on the highlights of the Romanian-French diplomatic collaboration throughout the year of 1943 and describe the main events that characterized the activity of the French legation in Bucharest. To the purpose of analyzing this chapter in the Romanian-French relations, I will foremost refer to documents in the CNSAS archive. These documents, reflecting a large part of the Gaullist Resistance activity inside the French legation in Bucharest, are unique and they aid with the understanding of the nature of the Romanian-French relations of those years.

Visual Object Tracking With Mutual Affinity Aligned to Human Intuition

Visual Object Tracking With Mutual Affinity Aligned to Human Intuition

Stability and Formation of the Li3PS4/Li, Li3PS4/Li2S, and Li2S/Li Interfaces: A Theoretical Study.

Solid electrolytes have shown superior behavior and many advantages over liquid electrolytes, including simplicity in battery design. However, some chemical and structural instability problems arise when solid electrolytes form a direct interface with the negative Li-metal electrode. In particular, it was recognized that the interface between the β-Li3PS4 crystal and lithium anode is quite unstable and tends to promote structural defects that inhibit the correct functioning of the device. As a possible way out of this problem, we propose a material, Li2S, as a passivating coating for the Li/β-Li3PS4 interface. We investigated the mutual affinity between Li/Li2S and Li2S/β-Li3PS4 interfaces by DFT methods and investigated the structural stability through the adhesion energy and mechanical stress. Furthermore, a topological analysis of the electron density identified preferential paths for the migration of Li ions.

Loneliness in the Norwegian adolescent population: prevalence trends and relations to mental and self-rated health

BackgroundLoneliness has become a significant public health problem and should be addressed with more research over a broader period. This study investigates the variations in the prevalence of loneliness among a nationally representative study population of Norwegian adolescents over the last three decades and whether age, gender, self-rated health, and mental distress are associated with these changes.MethodsAdolescents aged 13–19 years completed the structured and validated questionnaires from the three waves of the Young-HUNT Study: 1995–1997, 2006–2008, and 2017–2019. Loneliness was measured with one item asking, ‘Are you lonely?’. Hopkins Symptom Checklist-5 was used to measure mental distress (cut-off ≥ 2). Self-rated health was assessed by a single question ‘How is your health at the moment?’ Measures were provided by self-report. Descriptive analyses were stratified by age, gender, self-rated health, and mental distress. Linear-by-Linear association test across survey years was performed to test time trends of loneliness. Logistic regression was used to analyze the cross-sectional associations of self-rated health and mental distress with loneliness, adjusting for sociodemographic factors in all three waves of Young-HUNT.ResultsLoneliness prevalence doubled from 5.9% in 1995/97 to 10.2% in 2017/19 in the total population sample. The highest loneliness prevalence and an increase from 8.9% in 1995/97 to 16.7% in 2017/19 was observed in girls of 16–19 years. Among mentally distressed adolescents, loneliness increased from 22.3% in 1995/97 to 32.8% in 2006/08 and lowered to 27% in 2017/19. Increasing loneliness prevalence was seen in those with poor self-rated health, i.e., 14.6% in 1995-97 and 26.6% in 2017-19. Mental distress and poor self-rated health were associated with higher odds of loneliness in each wave (p < 0.001).ConclusionThe results highlight the increasing burden of loneliness in the Norwegian adolescent population, especially girls. Those with mental distress and poor self-rated health have a higher risk of experiencing loneliness. Thus, health-promoting upbringing environments for children and adolescents that support mutual affinity, social support, integration, and belongingness in adolescents’ daily arenas are essential.

Dimethyl sulfoxide heavily extends homogeneous regions of the Propionitrile/DMSO/Water mixtures

The ternary mixtures exhibit peculiar solvation properties thanks to simultaneously possessing a few functional groups. The preparation of such systems opens a wide avenue to fine-tune the physicochemical properties of the medium and, therefore, obtain designer solvents to match specific problems in applications. Understanding the mutual affinities of the components and structural features of the mixtures is a key prerequisite to enriching the treasury of available solvents. Water, propionitrile (PN), and dimethyl sulfoxide (DMSO) are three polar liquids. Yet, their polarities are of different degrees that prevent infinite mutual miscibilities. We hereby report that significant contents of DMSO permit one to prepare PN/DMSO/water mixtures with any coveted molar fraction of PN. By using densitometric measurements over wide ranges of compositions and supportive computer simulations, we have identified that xDMSO/xwater ≥ 1 is sufficient for the ternary homogeneous mixture incorporating any contents of PN from 298.15 to 323.15 K. The numerical simulations suggest that the partially amphiphilic nature of DMSO represents a paramount factor to make a successful interface between PN and water workable. The paper, for the first time, discusses binary and ternary complexes in the PN/DMSO/water single-phase mixtures in the context of their relative thermodynamics stabilities. The reported new physical insights boost the progress in the ongoing development of modern on-demand solvents and promise evident practical applications in biomedical fields.

Design, synthesis, and characterization of protein origami based on self-assembly of a brick and staple artificial protein pair

A versatile strategy to create an inducible protein assembly with predefined geometry is demonstrated. The assembly is triggered by a binding protein that staples two identical protein bricks together in a predictable spatial conformation. The brick and staple proteins are designed for mutual directional affinity and engineered by directed evolution from a synthetic modular repeat protein library. As a proof of concept, this article reports on the spontaneous, extremely fast and quantitative self-assembly of two designed alpha-repeat (αRep) brick and staple proteins into macroscopic tubular superhelices at room temperature. Small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM with staining agent and cryoTEM) elucidate the resulting superhelical arrangement that precisely matches the a priori intended 3D assembly. The highly ordered, macroscopic biomolecular construction sustains temperatures as high as 75 °C thanks to the robust αRep building blocks. Since the α-helices of the brick and staple proteins are highly programmable, their design allows encoding the geometry and chemical surfaces of the final supramolecular protein architecture. This work opens routes toward the design and fabrication of multiscale protein origami with arbitrarily programmed shapes and chemical functions.

Opinion Dynamics Systems on Barabási–Albert Networks: Biswas–Chatterjee–Sen Model

A discrete version of opinion dynamics systems, based on the Biswas-Chatterjee-Sen (BChS) model, has been studied on Barabási-Albert networks (BANs). In this model, depending on a pre-defined noise parameter, the mutual affinities can assign either positive or negative values. By employing extensive computer simulations with Monte Carlo algorithms, allied with finite-size scaling hypothesis, second-order phase transitions have been observed. The corresponding critical noise and the usual ratios of the critical exponents have been computed, in the thermodynamic limit, as a function of the average connectivity. The effective dimension of the system, defined through a hyper-scaling relation, is close to one, and it turns out to be connectivity-independent. The results also indicate that the discrete BChS model has a similar behavior on directed Barabási-Albert networks (DBANs), as well as on Erdös-Rènyi random graphs (ERRGs) and directed ERRGs random graphs (DERRGs). However, unlike the model on ERRGs and DERRGs, which has the same critical behavior for the average connectivity going to infinity, the model on BANs is in a different universality class to its DBANs counterpart in the whole range of the studied connectivities.

Cyanidin chloride protects mice from methicillin-resistant Staphylococcus aureus-induced pneumonia by targeting Sortase A

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) has been developing rapidly in recent years. It poses a severe peril to global health care, and the new strategies to against the MRSA is urgently needed. Sortase A (SrtA) regulates the anchoring of many surface proteins. Compounds repress Staphylococcus aureus (S. aureus) cysteine transpeptidase SrtA are considered adequate potent virulence inhibitors. Then, we describe the identification of an effective SrtA inhibitor, cyanidin chloride, a bioflavonoid compound isolated from various plants. It has a reversible inhibitory effect on SrtA activity at an IC50 of 21.91 μg/mL. As a SrtA inhibitor, cyanidin chloride antagonizes SrtA-related virulence phenotypes due to its breadth and specificity, including fibrinogen adhesion, A549 cell invasion, biofilm formation, and surface protein (SpA) anchoring. Subsequently, molecular docking and fluorescence quenching revealed that SrtA and cyanidin chloride had robust mutual affinity. Further mechanistic studies revealed that Arg-197, Gly-167, and Sep-116 were the key-binding sites mediating the interaction between SrtA and cyanidin chloride. Notably, a significant therapeutic effect of cyanidin chloride in vivo was also observed on the mouse pneumonia model induced by MRSA. In conclusion, our study indicates that cyanidin chloride potentially represents a new candidate SrtA inhibitor for S. aureus and potentially be developed as a new antivirulence agent.

Analog Video ve "Pornografi Yılları"

Adult film industry, always leading the way when it comes to new technologies, quickly adopts analog video before it becomes a mainstream audio-visual medium. The mutual affinity provides advantage for both parties: Transforming the industry practices, aesthetics and the content, technology contributes to industry with more profit and answers the demands of the porn regulars. In return, pornography helps the new technology become widespread by providing distribution network, content, motivation and available eager users. Therefore, this paper aims to review the role of pornography and adult film industry in the rise of the video recorders and analyze some examples regarding the video case in Turkey. Although the data collected from 1980s newspapers and magazines as part of the dissertation about video spectatorship in Turkey doesn’t reveal this role first-hand, there is a bond between technology and pornography. Collective video film-viewing in public space, a unique practice in Turkey, however, challenges pornography-privacy relation and the necessity of device ownership.

Solvation shell thermodynamics of extended hydrophobic solutes in mixed solvents.

The ability of various cosolutes and cosolvents to enhance or quench solvent density fluctuations at solute-water interfaces has crucial implications on the conformational equilibrium of macromolecules such as polymers and proteins. Herein, we use an extended hydrophobic solute as a model system to study the effect of urea and methanol on the density fluctuations in the solute's solvation shell and the resulting thermodynamics. On strengthening the solute-water/cosolute repulsive interaction, we observe distinct trends in the mutual affinities between various species in, and the thermodynamic properties of, the solvation shell. These trends strongly follow the respective trends in the preferential adsorption of urea and methanol: solute-water/cosolute repulsion strengthens, urea accumulation decreases, and methanol accumulation increases. Preferential accumulation of urea is found to quench the density fluctuations around the extended solute, leading to a decrease in the compressibility of the solvation shell. In contrast, methanol accumulation enhances the density fluctuations, leading to an increase in the compressibility. The mode of action of urea and methanol seems to be strongly coupled to their hydration behavior. The observations from this simple model is discussed in relation to urea driven swelling and methanol induced collapse of some well-known thermo-responsive polymers.

A novel Phe‐206‐Leu mutation in acetolactate synthase confers resistance to penoxsulam in barnyardgrass (Echinochloa crus‐galli (L.) P. Beauv)

Barnyardgrass (Echinochloa crus-galli (L.) P. Beauv) has evolved resistance to the acetolactate synthase (ALS) inhibitor penoxsulam which is used to control weeds in rice fields in China. The present study is conducted to identify the target-site resistance (TSR) mechanisms conferring resistance in a penoxsulam-resistant population. The ALS sensitivity in vitro of the resistant population was sixfold lower to penoxsulam than that of the sensitive population. ALS sequencing revealed that no known mutation conferring ALS herbicide resistance was detected. However, a novel mutation Phe-206-Leu was identified in the ALS gene. Additionally, ALS gene expression level of the resistant population was lower than that of the sensitive population. Therefore, the penoxsulam resistance was not due to the overexpression of ALS gene. Molecular docking revealed that this mutation may change the interaction of the penoxsulam-ALS binding and weaken its mutual affinity by approximately 10%. Arabidopsis thaliana transformed with mutant ALS had fourfold greater resistance to penoxsulam and varied cross-resistance to other ALS herbicides than those transformed with sensitive ALS. Mutant and sensitive ALS proteins expressed by the baculovirus system exhibited different in vitro penoxsulam sensitivity levels. Mutant ALS had eightfold lower sensitivity to penoxsulam than sensitive ALS. This report provides clear evidence that the ALS mutation at position 206 (Phe-206-Leu) confers penoxsulam resistance in barnyardgrass. Phe-206 was confirmed to be the ninth amino acid residue related to ALS herbicide resistance in weeds. © 2022 Society of Chemical Industry.

Nodulation competitiveness and diversification of symbiosis genes in common beans from the American centers of domestication

Phaseolus vulgaris (common bean), having a proposed Mexican origin within the Americas, comprises three centers of diversification: Mesoamerica, the southern Andes, and the Amotape-Huancabamba Depression in Peru-Ecuador. Rhizobium etli is the predominant rhizobium found symbiotically associated with beans in the Americasalthough closely related Rhizobium phylotypes have also been detected. To investigate if symbiosis between bean varieties and rhizobia evolved affinity, firstly nodulation competitiveness was studied after inoculation with a mixture of sympatric and allopatric rhizobial strains isolated from the respective geographical regions. Rhizobia strains harboring nodC types α and upgamma, which were found predominant in Mexico and Ecuador, were comparable in nodule occupancy at 50% of each in beans from the Mesoamerican and Andean gene pools, but it is one of those two nodC types which clearly predominated in Ecuadorian-Peruvian beans as well as in Andean beans nodC type upgamma predominated the sympatric nodC type δ. The results indicated that those beans from Ecuador-Peru and Andean region, respectively exhibited no affinity for nodulation by the sympatric rhizobial lineages that were found to be predominant in bean nodules formed in those respective areas. Unlike the strains isolated from Ecuador, Rhizobium etli isolated from Mexico as well from the southern Andes was highly competitive for nodulation in beans from Ecuador-Peru, and quite similarly competitive in Mesoamerican and Andean beans. Finally, five gene products associated with symbiosis were examined to analyze variations that could be correlated with nodulation competitiveness. A small GTPase RabA2, transcriptional factors NIN and ASTRAY, and nodulation factor receptors NFR1 and NFR5- indicated high conservation but NIN, NFR1 and NFR5 of beans representative of the Ecuador-Peru genetic pool clustered separated from the Mesoamerican and Andean showing diversification and possible different interaction. These results indicated that both host and bacterial genetics are important for mutual affinity, and that symbiosis is another trait of legumes that could be sensitive to evolutionary influences and local adaptation.

Investigation of aqueous and organic co-solvents roles in fabricating seawater reverse osmosis membrane

The addition of co-solvents in aqueous or organic phases of interfacial polymerization is a feasible strategy to tune the performance of aromatic polyamide (PA) thin-film composite (TFC) membrane for brackish water desalination, however, limited progress has been made in developing co-solvent-tailored seawater reverse osmosis (SWRO) membrane. Herein, SWRO membranes were prepared by adding various types of aqueous and organic co-solvents to reveal their impacts on the formation of the PA crumples. It was found that the aqueous/organic co-solvents affected the solubility parameter distance and interfacial tension between two immiscible phases, facilitating the diamine diffusion rate and resulting in a significant change in PA structure. The PA layer with modulated microstructure and varied surface features such as widened void structure, rougher surface, better wettability, and controlled cross-linking degree can be derived from the high interfacial instability that existed between the co-solvent and initial PA film due to the close mutual affinity. Besides, the additional polyvinyl alcohol coating layer atop the PA membrane successfully further enhanced the membrane selectivity. Overall, the mechanistic insights attained in this study revealed the relationship of diamine diffusion, physicochemical properties of PA layer and membrane separation performance for co-solvent-assisted membrane fabrication to render resultant SWRO membrane with more comparable permselectivity. The optimized TFC-SWRO membranes exhibited pure water permeability of 2.2 and 3.2 L m −2 h −1 bar −1 upon the assistance of aqueous and organic co-solvents, respectively, while maintaining excellent NaCl rejection of approximately 99% under seawater desalination tests. ✓ Aqueous or organic co-solvents were used aiming to flexibly design high-performance SWRO membrane. ✓ The synergistic impacts of solubility parameter and interfacial tension were established to elucidate diamine diffusion behavior. ✓ The relationship of “monomer diffusion - structure property - separation performance” was elaborated. ✓ The formation of a PVA coating layer enhanced the selectivity of co-solvent-assisted SWRO membrane.

Polycrystalline morphology and mechanical strength of nanotube fibers

Correlating mechanical performance with mesoscale structure is fundamental for the design and optimization of light and strong fibers (or any composites), most promising being those from carbon nanotubes. In all forms of nanotube fiber production strategies, due to tubes’ mutual affinity, some degree of bundling into liquid crystal-like domains can be expected, causing heterogeneous load transfer within and outside these domains, and having a direct impact on the fiber strength. By employing large-scale coarse-grained simulations, we demonstrate that the strength s of nanotube fibers with characteristic domain size D scales as s ~ 1/D, while the degree of longitudinal/axial disorder within the domains (akin to a smectic ↔ nematic phase transition) can substantially mitigate this dependence.