Muscle Function In Older Women Research Articles

Acute and chronic effect of resistance training on pelvic floor muscle morphology and function in older women: a clinical trial

We aimed to evaluate the effects of resistance training with and without pelvic floor muscle (PFM) contraction on pelvic floor morphology and muscle function in older women. Seventeen older women without pelvic floor disorders participated in this clinical feasibility trial. The women were divided into three groups: resistance training without PFM contraction (RT); resistance training with simultaneous PFM contraction (RT+PFMC); and control. Maximum voluntary contraction (MVC) and the endurance of PFM contraction were measured by perineometer, and bladder neck angle and Hiatal area by translabial ultrasound. As an acute effect, MVC increased in the RT group (effect size r = −0.51). After 12 weeks, worsening was observed in the duration of contraction in RT (effect size r = −0.55) and RT+PFMC (effect size r = −0.52). Bladder neck angle improved in the RT+PFMC group (effect size r = −0.51). Resistance training acutely improves MVC and chronically worsens the duration of contraction. Resistance training with simultaneous PFM contraction improves the bladder neck angle after 12 weeks.

PERCENT TIME SPENT IN AN IMPAIRED GLUCOSE STATE AND ADVERSE MUSCLE OUTCOMES: THE SWAN STUDY

Abstract Sarcopenia is common among older adults, but associations of sarcopenia and diabetes are mixed. Beyond sarcopenia, relationships between glucose levels and muscle quality and power are understudied. We examined the association of time spent in an impaired glucose state and muscle outcomes. Muscle quality and power were assessed in 2015-2016 in 1,614 women (aged 66 + 2.7 years) without diabetes at baseline. Muscle quality was the average grip strength (measured in three trials using a Jamar dynamometer) per kilogram whole-body skeletal muscle mass (measured using bioelectrical-impedance analysis). Muscle power (Watts/kilogram body weight) was assessed using a 3-cycle timed stair climb: [(body weight (N)*stair height (m))/average ascent time (sec)]/body weight (kg). Fasting blood was collected at 11 visits; glucose ≥100mg/dL was considered impaired, with percent time spent in an impaired glucose state (%IGS) calculated as:(number visits with impaired glucose)/(number visits with glucose)*100 and categorized as ≤24%(n=1,203), 25-49%(n=184), 50-74%(n=136), ≥75%(n=91). Cross-sectional multivariable linear regression models were constructed for muscle outcomes with the independent predictor %IGS, adjusting for age, menopausal status, race/ethnicity, hormone use, and height. Compared to the lowest %IGS, all other groups had significantly lower mean muscle quality (β range: -0.091, -0.110 and -0.135, respectively) with the largest difference vs. highest %IGS (β= -0.135, 95%CI:-0.192,-0.077). Similar results were observed for muscle power (β range: -0.022, -0.024 and -0.020, respectively), though the highest %IGS was not significantly different. Results suggest that a longer time in an impaired glucose state from middle to older age may be associated with lower muscle function in older women.

Association of Muscle Mass, Muscle Strength, and Muscle Function with Gait Ability Assessed Using Inertial Measurement Unit Sensors in Older Women.

Aging-related muscle atrophy is associated with decreased muscle mass (MM), muscle strength (MS), and muscle function (MF) and may cause motor control, balance, and gait pattern impairments. This study determined associations of three speed-based gait variables with loss of MM, MS, and MF in older women. Overall, 432 older women aged ≥65 performed appendicular skeletal muscle, handgrip strength, and five times sit-to-stand test to evaluate MM, MS, and MF. A gait test was performed at three speeds by modifying the preferred walking speed (PWS; slower walking speed (SWS); faster-walking speed (FWS)) on a straight 19 m walkway. Stride length (SL) at PWS was significantly associated with MM. FWS and coefficient of variance (CV) of double support phase (DSP) and DSP at PWS showed significant associations with MS. CV of step time and stride time at SWS, FWS, and single support phase (SSP) at PWS showed significant associations with MF. SL at PWS, DSP at FWS, CV of DSP at PWS, stride time at SWS, and CV of SSP at PWS showed significant associations with composite MM, MS, and MF variables. Our study indicated that gait tasks under continuous and various speed conditions are useful for evaluating MM, MS, and MF.

Dietary omega-3 polyunsaturated fatty acid and alpha-linolenic acid are associated with physical capacity measure but not muscle mass in older women 65–72 years

PurposeThe aim was to investigate the cross-sectional association of dietary omega-3 polyunsaturated fatty acids PUFA (alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)) intake with multiple physical functions, muscle mass and fat mass in older women.MethodStudy subjects were 554 women from the Osteoporosis Risk Factor and Prevention Fracture Prevention Study, with dietary intake assessed with 3-day food record. Body composition was measured by dual-energy X-ray absorptiometry. Physical function measures included walking speed 10 m, chair rises, one leg stance, knee extension, handgrip strength and squat. Short physical performance battery (SPPB) score was defined based on the European working group on sarcopenia criteria.ResultsThe multivariable adjusted models showed statistically significant associations for dietary ALA with higher SPPB (β = 0.118, P = 0.024), knee extension force at baseline (β = 0.075, P = 0.037) and lower fat mass (β = − 0.081, P = 0.034), as well as longer one-leg stance (β = 0.119, P = 0.010), higher walking speed (β = 0.113, P = 0.047), and ability to squat to the ground (β = 0.110, P = 0.027) at baseline. Total dietary omega-3 PUFA was associated with better SPPB (β = 0.108, P = 0.039), one-leg stance (β = 0.102, P = 0.041) and ability to squat (β = 0.110, P = 0.028), and with walking speed (β = 0.110, P = 0.028). However, associations for dietary EPA and DHA with physical function and body composition were not significant.ConclusionDietary omega-3 and ALA, but not EPA and DHA, were positively associated with muscle strength and function in older women. The intake of omega-3 and its subtypes was not associated with muscle mass. Longitudinal studies are needed to show whether omega-3 intake may be important for muscle function in older women.

Dietary nitrate intake is associated with muscle function in older women.

BackgroundIn younger individuals, dietary nitrate supplementation has been shown to improve short‐term vascular and muscle function. The role of higher habitual nitrate intake as part of a typical diet on muscle function in ageing has not been investigated. A cross‐sectional study of relationships between dietary nitrate and measures of muscle function in older community‐dwelling Australian women (n = 1420, ≥70 years) was undertaken.MethodsParticipants completed a semi‐quantitative food frequency questionnaire assessing dietary intake over the previous year. Total nitrate from vegetables and non‐vegetable sources was calculated from a validated instrument that quantified the nitrate content of food recorded within the food frequency questionnaire. Handgrip strength and timed‐up‐and‐go (TUG) were assessed, representing muscle strength and physical function, respectively. Cut‐points for weak grip strength (<22 kg) and slow TUG (>10.2 s) were selected due to their association with adverse outcomes. Linear and logistic regressions were used to examine the relationship between total nitrate intake and muscle function measures.ResultsMean ± standard deviation (SD) total nitrate intake was 79.5 ± 31.2 mg/day, of which 84.5% came from vegetables. Across the unadjusted tertiles of nitrate intake (<64.2 mg/day; 64.2 to <89.0 mg/day; ≥89.0 mg/day), women in the highest tertile had a 4% stronger grip strength and a 5% faster TUG performance compared with the lowest tertile. In multivariable‐adjusted models, each SD higher nitrate intake (31.2 mg/day) was associated with stronger grip strength (per kilogram, β 0.31, P = 0.027) and faster TUG (per second, β −0.27, P = 0.001). The proportion of women with weak grip strength (<22 kg) or slow TUG (>10.2 s) was 61.0% and 36.9%, respectively. Each SD higher nitrate intake (31.2 mg/day) was associated with lower odds for weak grip strength (OR 0.84, 95% CI 0.74–0.95, P = 0.005) and slow TUG (OR 0.86, 95% CI 0.76–0.98, P = 0.021). Compared with women in the lowest tertile of nitrate intake, women in the highest nitrate intake tertile had lower odds for weak grip strength (OR 0.65, 95% CI 0.49–0.87, P trend=0.004) and slow TUG (OR 0.72, 95% CI 0.53–0.97, P trend = 0.044).ConclusionsThis investigation highlights potential benefits of nitrate‐rich diets on muscle strength and physical function in a large cohort of older women. Considering poor muscle strength and physical function is associated with a range of adverse health outcomes such as falling, fractures, cardiovascular disease, and mortality, increasing dietary nitrate, especially though vegetable consumption may be an effective way to limit age‐related declines in muscle function.

Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men

BackgroundMyostatin, its inhibitor follistatin, and growth/differentiation factor 11 (GDF11) have been proposed as factors that could potentially modify biological aging. The study aimed to test whether there is a relationship between these plasma circulating proteins and muscle strength, power and optimal shortening velocity (υopt) of older adults.MethodsThe cross-sectional study included 56 women and 45 men aged 60 years and older. Every participant underwent examination which included anthropometric and bioimpedance analysis measurements, functional and cognitive performance tests, muscle strength of upper and lower extremities, muscle power testing with two different methods and blood analyses.ResultsWomen had higher plasma levels of myostatin and GDF11 than men. Men had higher plasma level of follistatin than women. In women, plasma level of myostatin was negatively correlated with left handgrip strength and υopt. Follistatin was negatively correlated with maximum power output (Pmax), power relative to kg of body mass (Pmax∙kg− 1) (friction-loaded cycle ergometer) and power at 70% of the 1-repetition maximum (1RM) strength value (P70%) of leg press (Keiser pneumatic resistance training equipment), and positively correlated with the Timed Up & Go (TUG) test. GDF11 was negatively correlated with body mass, body mass index, waist circumference, fat mass and the percentage of body fat. In men, there were no significant correlations observed between circulating plasma proteins and muscle function measures.ConclusionsThe circulating plasma myostatin and follistatin are negatively associated with muscle function in older women. There is stronger relationship between these proteins and muscle power than muscle strength. GDF11 has a higher association with the body mass and composition than muscle function in older women.

Increased Quadriceps Muscle Attenuation Correlates With Reduced Cellular And Whole Muscle Function In Older Women

Increased Quadriceps Muscle Attenuation Correlates With Reduced Cellular And Whole Muscle Function In Older Women

Hydrotherapy improves pain and function in older women with knee osteoarthritis: a randomized controlled trial

BackgroundCurrently, there is poor evidence of the effect of hydrotherapy alone on patients with hip or knee osteoarthritis. ObjectivesThe study aimed to assess the impact of hydrotherapy on pain, function, and muscle function in older women with knee osteoarthritis. MethodsA randomized controlled trial was conducted to evaluate the efficacy of hydrotherapy in women with knee osteoarthritis. Seventy-three women aged 65 and older were randomized to hydrotherapy (n=36) or a control group (n=37). The hydrotherapy group received the intervention program in a heated pool (twice per week for six weeks) and an educational protocol while the control group received an educational protocol only. Primary outcomes (before and post-treatment) were pain intensity (0–100) and function (0–100), assessed with the WOMAC questionnaire. Secondary outcomes (before and post-treatment) were knee extensor and knee flexor muscle performance (strength, power, and endurance), assessed by an isokinetic dynamometer. The magnitude of change between the groups for the outcomes was calculated using linear regression models adjusted by baseline outcome values. ResultsThe hydrotherapy group had better outcomes for pain (adjusted mean difference=11 points, 95% CI: 3–18) and function (adjusted mean difference=12 points, 95% CI: 5–18). Patients receiving hydrotherapy had better performance for knee flexor and extensor strength, knee flexor power, and knee extensor endurance. ConclusionOlder women with knee osteoarthritis are likely to have benefits from a course of hydrotherapy exercises.Registry of clinical trials (Trial number RBR-8F57KR) – http://www.ensaiosclinicos.gov.br/rg/RBR-8f57kr/.

Fish oil and exercise improves older women's muscle function.

Combining omega-3 supplements with a resistance exercise training programme can improve muscle function in older women, say researchers from the universities of Glasgow and Aberdeen.

Effects of long-term low-dose dietary creatine supplementation in older women

ObjectiveWe aimed to investigate the effects of a one-year low-dose creatine supplementation trial on bone health, lean mass, and muscle function in older postmenopausal women. MethodsA double-blind, randomized, parallel-group, placebo controlled trial was conducted between November 2011 and November 2013 in Sao Paulo, Brazil. Postmenopausal osteopenic women were randomly allocated (1:1) into creatine (n=56; 1g/d) or placebo group (n=53; dextrose at same dose). At baseline and after one year of intervention, we assessed parameters of bone health, body composition, and muscle function. Blood parameters were also assessed before and after the intervention and adverse events were recorded throughout the trial. Possible differences in dietary intake were assessed by three 24-h dietary recalls. ResultsBone mineral density at lumbar spine, femoral neck, total femur, and whole body did not differ within- or between-groups. No significant changes in body weight, BMI, absolute and relative body fat, and body lean mass were observed. Muscle function, as assessed by timed-up-and-go and timed-stands tests, were not significantly changed within- or between-groups. Safety laboratory parameters remained unaltered. ConclusionA one-year low-dose creatine supplementation (1g/d) was free of adverse effects, but did not affect bone health parameters, lean mass, or muscle function in older women. Further studies with longer follow-up periods and higher doses of creatine supplementation are warranted. (Registered at clinicaltrials.gov as NCT01472393).

Effects of feedback-based balance and core resistance training vs. Pilates training on balance and muscle function in older women: A randomized-controlled trial

BackgroundAging is associated with decline in physical function that could result in the development of physical impairment and disability. Hence, interventions that simultaneously challenge balance ability, trunk (core) and extremity strength of older adults could be particularly effective in preserving and enhancing these physical functions. ObjectiveThe purpose of this study was to compare the effects of feedback-based balance and core resistance training utilizing the a special computer-controlled device (Huber®) with the conventional Pilates training on balance ability, neuromuscular function and body composition of healthy older women. MethodsThirty-four older women (age: 70±4 years) were randomly assigned to a Huber group (n=17) or Pilates group (n=17). Both groups trained for 8 weeks, 3 times a week. Maximal isometric strength of the trunk flexors, extensors, and lateral flexors, leg power, upper-body strength, single- and dual-task static balance, and body composition were measured before and after the intervention programs. ResultsSignificant group×time interactions and main effects of time (p<0.05) were found for body composition, balance ability in standard and dual-task conditions, all trunk muscle strength variables, and leg power in favor of the Huber group. The observed improvements in balance ability under both standard and dual-task conditions in the Huber group were mainly the result of enhanced postural control in medial-lateral direction (p<0.05). ConclusionFeedback-based balance and core resistance training proved to be more effective in improving single- and dual-task balance ability, trunk muscle strength, leg power, and body composition of healthy older women than the traditional Pilates training.