Intake Of Multivitamin Supplements Research Articles

Assessing the risk of prenatal depressive symptoms in Chinese women: an integrated evaluation of serum metabolome, multivitamin supplement intake, and clinical blood indicators.

Prenatal depressive symptoms (PDS) is a serious public health problem. This study aimed to develop an integrated panel and nomogram to assess at-risk populations by examining the association of PDS with the serum metabolome, multivitamin supplement intake, and clinical blood indicators. This study comprised 221 pregnant women, categorized into PDS and non-PDS groups based on the Edinburgh postnatal depression scale. The participants were divided into training and test sets according to their enrollment time. We conducted logistic regression analysis to identify risk factors, and employed liquid chromatography/high resolution mass spectrometry-based serum metabolome analysis to identify metabolic biomarkers. Multiple factor analysis was used to combine risk factors, clinical blood indicators and key metabolites, and then a nomogram was developed to estimate the probability of PDS. We identified 36 important differential serum metabolites as PDS biomarkers, mainly involved in amino acid metabolism and lipid metabolism. Multivitamin intake works as a protective factor for PDS. The nomogram model, including multivitamin intake, HDL-C and three key metabolites (histidine, estrone and valylasparagine), exhibited an AUC of 0.855 in the training set and 0.774 in the test set, and the calibration curves showed good agreement, indicating that the model had good stability. Our approach integrates multiple models to identify metabolic biomarkers for PDS, ensuring their robustness. Furthermore, the inclusion of dietary factors and clinical blood indicators allows for a comprehensive characterization of each participant. The analysis culminated in an intuitive nomogram based on multimodal data, displaying potential performance in initial PDS risk assessment.

Vitamin D Status in Term Newborns and Their Mothers

The aim of this study is: 1) To evaluate vitamin D serum levels of fullterm newborns and its association with the maternal levels; 2) To evaluate the diet and the intake of multivitamin supplements of women; 3) To analyze seasonal dependence in serum levels of mother-baby pairs. The prospective study was carried out between July 2018 and February 2020 at the University Hospital of Obstetrics and Gynecology “Maichin dom”, Sofia. The study included 45 full-term newborns and their mothers. Data collected included maternal health, nutrition, vitamin intake, and anthropometric data of the newborns. The laboratory tests performed: maternal serum 25(OH)D levels taken in the third trimester of pregnancy and umbilical cord levels of 25(OH)D. The results show that the mean birth weight was 3234.22 ± 370.29 g and the mean gestational age was 38.13±0.89 weeks. A 25(OH)D sufficiency was found in 58% of mothers and 67% of newborns. A strong positive correlation between maternal and neonatal 25(OH)D concentrations (p = 0.007) was found. A relationship between maternal diet, vitamin supplementation and serum vitamin D levels was observed. The level of 25(OH)D in the umbilical cord in winter is lower than in summer (p = 0.002). Due to the essential role of vitamin D for the normal development of the fetus and the infant, a testing for serum levels of vitamin D during pregnancy is recommended.

A Prospective Study on the Relationship between Iron Supplement Intake, Hemoglobin Concentration, and Risk of Parkinsonism.

The findings regarding whether the greater iron level or intake is a risk factor to Parkinson's disease (PD) or parkinsonism was not clear. The purpose of this study is to establish a consistent association between iron supplementation and parkinsonism risk, we conducted a large-scale prospective cohort study using comprehensive longitudinal data from the UK Biobank. The longitudinal cohort data of 385,898 participants (including 911 cases) who were middle to old aged British adults and joined the UK Biobank study from 2006 to 2010 and were followed up until 2018 was analyzed. The associations between iron supplement intake, hemoglobin levels and all cause subsequent parkinsonism risk after corrections of potential confounders (sex, age, household income, education length, employment status, deprivation level, body mass index, physical activity level, household numbers, smoking and drinking levels, health status, blood pressure) were investigated. Analyses revealed that (a) iron supplementation was significantly associated with higher parkinsonism risk, (b) greater hemoglobin was weakly and insignificantly associated with lower parkinsonism risk, and (c) multivitamin or vitamin C supplement intake was not significantly associated with parkinsonism risk. Regardless of whether the subjects were classified as anemic, normal, or polycythemic or in the hemoglobin level quintile, there was no nonlinear association between hemoglobin and parkinsonism risk. Parkinsonism risk did not differ between participants reporting supplementary iron intake with or without vitamin C or multivitamin supplement intake. Furthermore, polygenic risk score of PD negatively correlated with hemoglobin level, while it did not associate with intake of iron supplement or multivitamin or vitamin C supplement intake. The results suggest excessive iron intake may increase parkinsonism risk. Interventional studies are warranted to examine whether iron intake restriction is beneficial for individuals without clinical iron deficiency.

The need and safety of vitamin supplementation in adults with obesity within 9 months post sleeve gastrectomy (SG): assessment based on intake

The aim of the study was to assess the need and safety of vitamin supplementation in adults with obesity post bariatric surgery (SG), based on intake assessment. Patients with obesity class III, and with obesity class II with comorbidities were followed up at 3, 6 and 9 months post bariatric surgery. Based on a 4-day food record questionnaire, the intake of vitamins and calories was assessed and an interview regarding the consumption of supplements was conducted. The study showed a deficiency in the dietary intake of vitamin D, folate (B9) and vitamin B1 (in 93–100% of respondents), vitamins E and C (in 53–67% of respondents), vitamins A, PP and vitamins B2 and B6 (in 10 to 23% of respondents) and vitamin B12 (only 1 woman). The intake of multivitamin supplements was implemented by 72% of respondents, independently, all patients were taking a vitamin D supplement. Vitamin deficiencies were only reported in a small percentage of patients (3–17%), who did not take supplements throughout the observation period. Supplementation with vitamins D, E, C, B1 and folic acid (B9), used regularly, supplemented the nutritional deficiencies of patients. The intake of vitamin A, B2, PP, and B6 with supplements did not significantly affect the overall intake. Supplementation with vitamin B12 turned out to be unjustified to the nutritional recommendations. The dietary and/or supplemental intake of vitamins did not exceed the tolerable upper intake level (UL). The results of the study confirm the need to implement vitamin supplementation for bariatric patients and its safety.

Study on the correlation between homocysteine-related dietary patterns and gestational diabetes mellitus:a reduced-rank regression analysis study

BackgroundThis study aimed to evaluate the association between homocysteine-related dietary patterns and gestational diabetes mellitus.MethodsA total of 488 pregnant women at 24–28 weeks of gestation between January 2019 and December 2020 were included. Demographic characteristics, dietary intake, and multivitamin supplement intake information were collected using a food frequency questionnaire (FFQ); fasting venous blood samples were collected for serum index detection. Serum homocysteine (Hcy), folic acid, and B12 were selected as response variables, and hyperhomocysteinemia (hHcy)-related dietary patterns were extracted using the reduced rank regression.. The relationship between the score of hHcy-related dietary patterns and GDM was analyzed using a multivariate logistic regression model.ResultsThree hHcy-related dietary patterns were extracted. Only mode 2 had a positive and significant relationship with the risk of developing GDM. After adjusting for confounding factors, the risk of GDM was significantly increased in the highest quartile array compared with the lowest quartile of the pattern (OR = 2.96, 95% Confidence Interval: 0.939–9.356, P = 0.004). There was no significant correlation between dietary pattern 1 and GDM risk (P > 0.05).ConclusionsHomocysteine-related dietary patterns were positively associated with gestational diabetes mellitus. Adjusting dietary patterns may contribute to the intervention and prevention of GDM.

Association between Homocysteine-Related Dietary Patterns and Gestational Diabetes Mellitus: A Study Using the Reduced Rank Regression Method

Background: This study aimed to evaluate the association between homocysteine-related dietary patterns and gestational diabetes mellitus. Methods: A total of 488 pregnant women at 24-28 weeks of gestation between January 2019 and December 2020 were included. Demographic characteristics, dietary intake, and multivitamin supplement intake information were collected using a Food Frequency Questionnaire (FFQ); fasting venous blood samples were collected for serum index detection. Serum homocysteine (Hcy), folic acid, and B12 were selected as response variables, and hyperhomocysteinemia (hHcy)-related dietary patterns were extracted using the descending rank regression method. The relationship between the score of hHcy-related dietary patterns and GDM was analyzed using a multivariate logistic regression model. Results: Three hHcy-related dietary patterns were extracted: (Mode 1) more meat, cattle meat intake, green leafy vegetables, dark vegetables and soy, and less consumption of shrimp; (Mode 2) livestock meat, eggs and more grains, green leafy vegetables, bacteria, algae, dairy, and less nuts intake; and (Mode 3) livestock meat intake, and less soy intake. Because the explanatory variation of mode 3 was relatively small, it was not retained. Only mode 2 had a positive and significant relationship with the risk of developing GDM. After adjusting for confounding factors, the risk of GDM was significantly increased in the highest quartile array (OR=2.96, 95% Confidence Interval: 0.939-9.356, P=0.004). There was no significant correlation between dietary pattern 1 and GDM risk (P >0.05). Conclusion: Homocysteine-related dietary patterns were positively associated with gestational diabetes mellitus.

Birth outcomes across the spectrum of maternal age: dissecting aging effect versus confounding by social and medical determinants

BackgroundGiven the trend of increasing maternal age and associated adverse reproductive outcomes in the US, this study aimed to assess whether this association is due to an independent aging or confounded by sociodemographic, biomedical, or behavioral determinants in a predominantly Black US population.MethodsData was from 8509 women enrolled in the Boston Birth Cohort. Adverse reproductive outcomes included spontaneous preterm delivery, cesarean delivery, and low birth weight. Covariates included sociodemographic (parity, race/ethnicity, education, marital status, income, receipt of public assistance, nativity); biomedical (obesity, hypertensive disorders, diabetes mellitus); and behavioral (consistent intake of multivitamin supplements, support from father of baby, support from family, major stress in pregnancy, cigarette smoking, alcohol intake). Analysis included Lowess and marginal probability plots, crude and adjusted sequential logistic regression models to examine age-outcome associations and to what degree the association can be explained by the above covariables.ResultOverall, the study sample had high levels of spontaneous preterm birth (18%), cesarean delivery (33%) and low birth weight (26%). Unadjusted models showed no significant difference odds of spontaneous preterm birth by maternal age but higher odds of cesarean section (aOR: 1.77, 95% CI: 1.60, 1.95) and low birth weight (aOR: 1.15, 95% CI: 1.04, 1.28) among women 30 years or older. Adjustment for sociodemographic factors, biomedical conditions and behavioral factors revealed higher odds of spontaneous preterm birth: (aOR: 1.30, 95% CI: 1.14, 1.49), cesarean section deliveries (aOR: 1.68, 95% CI: 1.51, 1.87) and low birth weight (aOR: 1.36, 95% CI: 1.21, 1.53). Across all ages, optimal BMI status and consistent multivitamin supplement intake were protective of spontaneous preterm birth and low birth weight.ConclusionIn this high-risk minority population, we demonstrated that the association between increasing maternal age and adverse pregnancy outcomes was due to an independent aging effect and the presence of confounding by sociodemographic, biomedical, and behavioral factors. Some modifiable risk factors to counteract aging effect, include optimizing BMI and consistent intake of multivitamin supplement. A fundamental change in how care is provided to women, particularly low income Black women, is needed with emphasis on the protective role of optimal nutritional status.Trial registrationClinicalTrials.gov Identifier: NCT03228875

Association between Homocysteine-Related Dietary Patterns and Gestational Diabetes Mellitus: A Study Using the Reduced Rank Regression Method

Background: This study aimed to evaluate the association between homocysteine-related dietary patterns and gestational diabetes mellitus. Methods: A total of 488 pregnant women at 24-28 weeks of gestation between January 2019 and December 2020 were included. Demographic characteristics, dietary intake, and multivitamin supplement intake information were collected using a food frequency questionnaire (FFQ); fasting venous blood samples were collected for serum index detection. Serum homocysteine (Hcy), folic acid, and B12 were selected as response variables, and hyperhomocysteinemia (hHcy)- related dietary patterns were extracted using the descending rank regression method. The relationship between the score of hHcy-related dietary patterns and GDM was analyzed using a multivariate logistic regression model. Results: Three hHcy-related dietary patterns were extracted: (mode 1) more meat, cattle meat intake, green leafy vegetables, dark vegetables and soy, and less consumption of shrimp. (mode 2) livestock meat, eggs and more grains, green leafy vegetables, bacteria, algae, dairy, and less nuts intake; and (model 3) livestock meat intake, and less soy intake. Because the explanatory variation of mode 3 was relatively small, it was not retained. Only mode 2 had a positive and significant relationship with the risk of developing GDM. After adjusting for confounding factors, the risk of GDM was significantly increased in the highest quartile array (OR=2.96, 95% Confidence Interval: 0.939-9.356, P=0.004). There was no significant correlation between dietary pattern 1 and GDM risk (P >0.05).

Maternal postpartum plasma folate status and preterm birth in a high-risk US population.

While maternal folate deficiency has been linked to poor pregnancy outcomes such as neural tube defects, anaemia and low birth weight, the relationship between folate and preterm birth (PTB) in the context of the US post-folic acid fortification era is inconclusive. We sought to explore the relationship between maternal folate status and PTB and its subtypes, i.e. spontaneous and medically indicated PTB. Observational study. Boston Birth Cohort, a predominantly urban, low-income, race/ethnic minority population at a high risk for PTB.ParticipantsMother-infant dyads (n 7675) enrolled in the Boston Birth Cohort. A sub-sample (n 2313) of these dyads had maternal plasma folate samples collected 24-72 h after delivery. Unadjusted and adjusted logistic regressions revealed an inverse relationship between the frequency of multivitamin supplement intake and PTB. Compared with less frequent use, multivitamin supplement intake 3-5 times/week (adjusted OR (aOR) = 0·78; 95 % CI 0·64, 0·96) or >5 times/week (aOR = 0·77; 95 % CI 0·64, 0·93) throughout pregnancy was associated with reduced risk of PTB. Consistently, higher plasma folate levels (highest v. lowest quartile) were associated with lower risk of PTB (aOR = 0·74; 95 % CI 0·56, 0·97). The above associations were similar among spontaneous and medically indicated PTB. If confirmed by future studies, our findings raise the possibility that optimizing maternal folate levels across pregnancy may help to reduce the risk of PTB among the most vulnerable US population in the post-folic acid fortification era.

Maternal plasma folate, vitamin B12 levels and multivitamin supplementation during pregnancy and risk of Autism Spectrum Disorder in the Boston Birth Cohort

BackgroundThe role of preconception/prenatal nutrition in the development of Autism Spectrum Disorder (ASD) is under-studied. Maternal adequate folate intake is important in protecting against neural tube defects in offspring, but uncertainty remains on its role in ASD. ObjectiveTo understand the relationship between maternal multivitamin supplementation during pregnancy and maternal plasma biomarkers of folate and vitamin B12 measured 24–72 hours after delivery and risk of later Autism Spectrum Disorder in children. MethodsData are from the Boston Birth Cohort, an ongoing longitudinal prospective birth cohort study that recruited low-income urban, primarily minority mother-offspring pairs (n=1,391) at the Boston Medical Center and followed them from birth through childhood between 1998–2013. Based on electronic medical records, children were diagnosed as having ASD (n=107) or categorized as ‘typical’ (n=1284). Prenatal multivitamin supplement intake data and maternal blood samples were collected 24–72 ho...

Intake of multivitamin supplements and incident asthma in Norwegian adults: the HUNT study.

Although intake of multivitamin supplements is becoming increasingly popular, the relationship between intake of multivitamin supplements and incident asthma remains unclear. Prospective studies in adults with long-term follow-up are especially scarce. Our objective was to investigate the association between intake of multivitamin supplements and asthma development in Norwegian adults.We followed 16 952 adult subjects from the second survey of the Nord-Trøndelag Health Study (1995–1997) up to 2006–2008, who, at baseline, were free of asthma and provided information on their intake of multivitamin supplements and cod liver oil. Regular intake of multivitamin supplements or cod liver oil was defined as daily intake for ≥3 months during the year prior to baseline. Incident asthma was defined as reported new-onset asthma after the 11-year follow-up.Intake of multivitamin supplements only was associated with an increased odds ratio for incident asthma (OR 1.55, 95% CI 1.12–2.13) after adjustment for a number of common confounding factors (model I). Similar odds ratios were found for intake of cod liver oil only and for intake of both supplements (1.59 and 1.73, respectively).Regular intake of multivitamin supplements was associated with an increased odds ratio for incident asthma in Norwegian adults.

Red blood cell folate concentrations in term newborns: recent findings in the Slovak Republic

Folate plays one of the most important functions for nucleotide biosynthesis and cellular methylation reactions in cells. Folate-mediated one-carbon metabolism is essential for metabolic processes in the human body. During periods of rapid cell growth, such as perinatal period, increased amounts of folate are required. The determination of red blood cell (RBC) folate concentration levels is the most accurate indicator of long-term folate level status in the body. This prospective study determined RBC folate concentration levels on the first day of life from umbilical cord blood samples in the whole group of full-term newborns (n = 150), who were hospitalized at the Department of Neonatology at the University Hospital in Bratislava. Immunochemical analysis for the determination of folate levels in erythrocytes was performed (Roche Diagnostics, Germany). Mothers were asked to select different types of food and use folic acid or other multivitamin supplements containing also folic acid. Our results of RBC folate ranged from 625 to 1748 ng/mL (5th–95th percentile). The median was 935 ng/mL and deficiency was not observed in any sample. RBC folate concentration levels in newborns due to mother’s intake of multivitamin supplements were significantly increased (p = 0.02). No differences were observed in the levels of RBC folate concentration when mothers used only folic acid. The RBC folate concentration tended to change based on many factors on both the mother’s and the newborn’s sides. Our results showed different results of RBC folate when focused on neonatal period and maternal intake of vitamins during pregnancy.

Socioeconomic, health, and dietary determinants of multivitamin supplements use in Belgium

This study aimed at investigating the use of multivitamin supplements in relationship to dietary pattern, socio-economic conditions and some health indicators. A cross-sectional design was used. Mailed questionnaires were sent to 5,000 Belgian military men. Use of multivitamins, frequency and food consumption were recorded during the past year, together with health (BMI, smoking, physical activity) and socioeconomic indicators (education, income). Dietary patterns were determined using the Mediterranean Diet Score (MDS). Use of multivitamin supplements was associated with healthy lifestyle characteristics, such as a higher physical activity level and non smoking. Moreover, it was found that on average more participants with a Flemish cultural background (19.8%) used supplements compared with participants with a French cultural background (9.3%). The MDS was related to multivitamin supplement use, with 34.9% of users having the highest score range. The socioeconomic indicators 'education' and 'income' were not related to vitamin supplement use. A low BMI, healthy diet, regular physical activity, non-smoking status and cultural background were associated with a higher intake of multivitamin supplements.

Seasonal Vitamin D Intake In Quebec Preschoolers

As a number of seasonal factors affect cutaneous synthesis of vitamin D, especially in young children, our objective was to verify if winter and summer vitamin D intakes in Quebec preschoolers reach the adequate intake of 5 microg/day. A three-month retrospective food frequency questionnaire and a 24-hour food recall were used with parents of 98 children (mean age 56 months) in summer and of 72 of these children (mean age 65 months) in winter. To ensure completeness of data, vitamin D content of foods not covered in the Canadian Nutrient File was taken from other sources. According to the food frequency questionnaire, total vitamin D intakes were 9.7 +/- 4.3 microg/day in summer and 11.6 +/- 4.8 microg/day in winter. Only 10% of children in summer and 7% in winter had an intake below 5 microg/day. The 24-hour food recall vitamin D intake estimate was lower (summer 7.0 +/- 3.8 microg/day, winter 7.2 +/- 4.2 microg/day). This difference could be partly due to a discrepancy in the estimation of multivitamin supplement intake. However, according to both estimates, vitamin D intakes appeared generally adequate in this sample of Quebec preschoolers.

Calcium, Vitamin D, Dairy Foods, and the Occurrence of Colorectal Adenomas among Men and Women in Two Prospective Studies

A high intake of calcium, vitamin D, or specific dairy products is thought to reduce the incidence of colorectal cancer. The association of these nutrients and foods with the occurrence of colorectal adenomas, precursors of cancer, was studied in two large US cohort studies. Cases were patients with a diagnosis of adenomatous polyps of the left colon or rectum (331 men, 1986-1990; 350 women, 1980-1988), and controls were persons with endoscopic findings negative for adenoma (9,159 men and 8,585 women). After adjustment for age, total energy, family history of colorectal cancer, body mass index, alcohol consumption, folate, intake of saturated fat and fiber, indications for endoscopy, and previous endoscopy, total calcium intake was not associated with the risk for adenoma (relative risk (RR), highest vs. lowest quintile of intake: men, 1.13, 95% confidence interval (CI) 0.76-1.66; women, 1.17, 95% CI 0.81-1.69). Total vitamin D intake was unrelated to the risk for adenoma in men (RR = 1.29, 95% CI 0.87-1.93). An inverse nonsignificant association was observed in women in the 1980-1988 analyses (RR = 0.68, 95% CI 0.41-1.13, trend p = 0.09), mainly attributable to the intake of multivitamin supplements, but an analysis of 4-year data (1984-1988) using a more detailed dietary assessment showed no association with vitamin D (RR = 1.04, 95% CI 0.65-1.67). Milk consumption and intake of total fermented dairy products were not related to adenoma risk. In conclusion, the occurrence of colorectal adenoma was neither related to calcium intake nor to milk consumption, whereas vitamin D from supplements but not diet was slightly, but not significantly, inversely associated with risk among women only.