Multi-study Analysis Research Articles

The influence of dental bleaching on patient's quality of life: A multistudy analysis of aesthetic and psychosocial outcomes

ObjectivesTo assess the Quality of Life (QoL) of participants treated with dental bleaching using different techniques by administering two questionnaires Oral Health Impact Profile (OHIP-14) and Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ), as well as the bleaching efficacy and tooth sensitivity (TS). Materials and MethodsSecondary results for nine randomized clinical trials were included, involving 489 participants who underwent bleaching procedures. The questionnaires were applied at baseline and 30-day post-bleaching. Bleaching efficacy (ΔSGU/ΔEab) and TS were also evaluated (VAS/NRS). The effect of bleaching on aesthetic self-perception was evaluated using the Paired t-test. The Kruskal-Wallis test assessed variations by technique. Also, the correlations between questionnaires and outcomes was evaluated (α = 0.05). ResultsAfter the bleaching treatment, both questionnaire revealed significant differences compared to the baseline, regardless of the factor evaluated (p < 0.05), except for Physical pain in OHIP-14 (p = 0.53). No correlation was found between OHIP-14 and bleaching efficacy (p < 0.008). A significant correlation was found between bleaching efficacy and dental self-confidence, indicating that dental self-confidence increased as the number of SGU (ΔSGU) increased, while social impact (ΔEab) and aesthetic concern (ΔSGU) decreased. Additionally, a significant correlation was observed between TS and OHIP-14 (Physical pain). For PIDAC, both dental self-confidence and psychological impact were correlated with TS in the VAS. ConclusionSubjects who underwent dental bleaching treatment improved their self-perception and dental self-confidence. Dental bleaching, besides enhancing the patient's smile, also improves their self-esteem. Clinical RelevanceDental bleaching, besides improving the patient's smile, also enhances their self-esteem.

The role of emotional intelligence and quality relationships in athletes’ and coaches’ levels of satisfaction: a multi-study analysis

ABSTRACT The purpose of the current research was to examine emotional intelligence (EI) within the context of the coach-athlete relationship. A series of studies were conducted to test (a) the associations between coaches’ and athletes’ EI and facets of performance satisfaction and (b) whether the coach-athlete relationship quality explains the association between individuals’ EI and performance satisfaction. The first two studies included data from British (study 1; n = 254) and Belgium athletes (study 2; n = 256) participating in team sports. The third study employed a sample of 109 British (n = 24) and Belgian (nn = 79) team sport coaches. Data were obtained using a multi-section questionnaire. Path analyses revealed that both athletes’ and coaches’ EI predicted performance satisfaction and that coach-athlete relationship quality explained the association between EI and performance satisfaction. The findings of this study add to the growing literature on EI in sport and highlight the important role of emotional abilities and interpersonal skills.

Assessing melanoma prognosis: the interplay between patient profiles, survival, and BRAF, NRAS, KIT, and TWT mutations in a retrospective multi-study analysis.

The incidence and prevalence of melanoma are increasing globally, presenting a significant public health concern. The main genetic drivers of melanoma include BRAF, NRAS, KIT and triple wild-type (TWT) mutations. Little is known about the effects of these mutations on outcomes in terms of demographics and patient characteristics. We examined differences in melanoma mortality risk and mutation count across mutation type and patient disease profile. We extrapolated primary melanoma patient data from 14 studies via the cBioportal database. Patients were divided into demographic groups and classified according to BRAF, NRAS, KIT and TWT mutation status. Analyses included two-sample Student t -test and two-way analysis of variance tests analysis with Tukey's post hoc test. Survival outcomes were compared via Kaplan-Meier curve and Cox regression. NRAS-mutated patients exhibited decreased overall survival compared to BRAF-mutated patients. Male patients had higher mutation counts across all gene groups than females, with the fewest TWT mutations in comparison to BRAF, NRAS and KIT mutations. Males also exhibited increased mortality risk for NRAS, KIT and TWT mutations compared to BRAF mutations. An unknown primary melanoma was associated with increased mortality risk across all gene groups. NRAS-mutated acral melanoma patients had an increased mortality risk compared to NRAS-mutated cutaneous melanoma patients. Older patients had a higher mortality risk than younger patients. Patients with heavier versus lower weights had lower mortality risk, which was more pronounced for BRAF-mutated patients. These relationships highlight the importance of demographic and pathologic relationships to aid in risk assessment and personalize treatment plans.

A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis

Background: The COVID-19 pandemic has presented numerous challenges to the global healthcare system and emerging evidence suggests a potential link between COVID-19 treatment, specifically steroid therapy, and the development of avascular necrosis (AVN) of the hip. This review aims to provide a comprehensive overview of recent studies and case reports investigating the relationship between COVID-19, corticosteroid therapy, and the development of AVN. Understanding the nuances of AVN in the context of COVID-19 is crucial for healthcare professionals to navigate treatment decisions and mitigate potential complications. Materials and Methods: The Preferred Reporting Items for Systematic Reviews and a Meta-Analysis (PRISMA) were used in the systematic review until 1 September 2023. The full texts of the remaining twenty-three (n = 23) articles were independently reviewed by the authors of this review. Conclusions: The association between steroid therapy for COVID-19 and the development of hip AVN is a noteworthy concern even though no relationship is evident between the duration of treatment, cumulative dosage of medication, maximum daily dosage received, and presence of AVN. Further research with larger cohorts and long-term follow up is needed to better understand the causative relationship and optimal management strategies for hip AVN in the context of COVID-19 and steroid therapy.

A multi-study analysis enables identification of potential microbial features associated with skin aging signs.

Introduction: During adulthood, the skin microbiota can be relatively stable if environmental conditions are also stable, yet physiological changes of the skin with age may affect the skin microbiome and its function. The microbiome is an important factor to consider in aging since it constitutes most of the genes that are expressed on the human body. However, severity of specific aging signs (one of the parameters used to measure "apparent" age) and skin surface quality (e.g., texture, hydration, pH, sebum, etc.) may not be indicative of chronological age. For example, older individuals can have young looking skin (young apparent age) and young individuals can be of older apparent age. Methods: Here we aim to identify microbial taxa of interest associated to skin quality/aging signs using a multi-study analysis of 13 microbiome datasets consisting of 16S rRNA amplicon sequence data and paired skin clinical data from the face. Results: We show that there is a negative relationship between microbiome diversity and transepidermal water loss, and a positive association between microbiome diversity and age. Aligned with a tight link between age and wrinkles, we report a global positive association between microbiome diversity and Crow's feet wrinkles, but with this relationship varying significantly by sub-study. Finally, we identify taxa potentially associated with wrinkles, TEWL and corneometer measures. Discussion: These findings represent a key step towards understanding the implication of the skin microbiota in skin aging signs.

Multifocal contact lens success predictability

PurposeThe current multi-study analysis combined data from three studies to quantify the relationship between the initial reaction to soft multifocal contact lens (MFCL) design types at dispensing and evaluate the predictability of overall vision satisfaction (OVS) and intention to purchase (ITP) after 1 week of wear. MethodThree prospective studies tested MFCLs over 1-week of wear following the same protocol, using a range of potentially predictive ratings at dispensing, and both OVS and ITP at 1-week as an indicator acceptance level. In each study, two of MyDay® multifocal, clariti® 1 day multifocal, Biofinity® multifocal (worn as a daily disposable lens) or 1 DAY ACUVUE® MOIST MULTIFOCAL were dispensed for 1-week of daily wear. OVS was recorded on a 100-point VAS and ITP on a 5-point LIKERT scale. Fourteen possible predictors were entered in the statistical model, and predictability was assessed using Chi-square Automatic Interaction Detector (CHAID) statistical test. ResultsA total of 210 participants (152 female & 58 male; 53.9 ± 6.5 years, range 41–71 years), representing 420 MFCL fits, equally distributed between emergent n = 65, established n = 70 and advanced n = 75 presbyopes, completed the studies. OVS on dispensing was the predictor of both OVS (p < 0.001) and ITP (p < 0.001) at 1-week. For OVS predictability, 70.8 % with OVS at dispensing > 91 points reported good OVS at 1-week and 73.4 % with OVS on dispensing ≤ 80 points reported poor OVS at 1-week. For ITP predictability, 74.6 % with OVS at dispensing > 94 points reported a positive ITP at 1-week and 65.9 % with OVS on dispensing ≤ 63 points reported negative ITP at 1-week. ConclusionOverall vision satisfaction at the time of dispensing MFCLs is a powerful indicator of both OVS and ITP after 1-week of wear. Initial patient subjective assessments provide a clinically useful indicator of the likeliness of success.

Free-living physical activity and executive function: A multi-study analysis of age groups and times of day

BackgroundExecutive Function (EF) is a potential mechanism linking physical activity (PA) and mental health. However, evidence regarding the association between free-living PA and EF is limited with mixed results. Across two studies, we examined associations between accelerometer-assessed moderate-to-vigorous PA (MVPA) and facets of EF in different age groups (Study 1) and at different times of day (Study 2). MethodIn Study 1, we tested the association between MVPA and verbal fluency across seven days in 285 participants (children, adults, older adults). In Study 2, we tested between- and within-person associations between MVPA and working memory (afternoon, evening, next morning) across three 18-day bursts in 64 preadolescents. ResultsStudy 1 showed no association between MVPA and verbal fluency overall, but there was an interaction by age group: a positive association was evident in older adults only. In Study 2, we observed a positive between-person association between MVPA and subsequent afternoon and next morning working memory, but not within-person. In the evening, MVPA was not related to working memory. ConclusionsThe association between free-living PA and EF differs between age groups and times of day. Future research should consider these factors when examining the association and its role for mental health.

Stereotypes and OCD-Symptom Presentations: A Mixed-Methods Evaluation Using Male-Character Vignettes

Stereotypes toward symptom presentations of obsessive compulsive disorder (OCD) are poorly understood. A mixed-methods, multistudy analysis of OCD stigma was conducted. In Study 1 ( N = 60), participants read one of five vignettes (symmetry/just right, contamination, sexual, harm/aggression, scrupulous OCD) before responding to open-ended questions. Inductive content analyses revealed anxiety-relevant stereotypes (e.g., trivialization) for symmetry/just right and contamination and serious mental-illness stereotypes (e.g., dangerous) for harm/aggression and sexual vignettes. In Study 2 ( N = 698), participants read one of seven vignettes (OCD-symptom presentations, generalized anxiety disorder, schizophrenia) before responding to stigma measures. The sexual, harm/aggression, and schizophrenia vignettes were strongly associated with serious mental-illness stigma. The scrupulous vignette was associated with the most anxiety-relevant stigma. Together, these studies detail stereotype endorsement across OCD-symptom presentations. Stigma-reduction interventions should include psychoeducation and address macro-level stereotypes (i.e., stereotypes that exist across symptom presentations) while enhancing opportunities for contact to mitigate stigma.

Exploring young consumers’ intention to pay for shared express packaging: A multi-study analysis

Drawing upon imprinting theory and self-identity concept, this research investigates how young consumers’ waste sorting experience influences their willingness to pay for shared express packaging. Study 1 conducts an experiment in a professional data collection agency in China and reports that waste sorting experience is positively related to willingness to pay for shared express packaging. Study 2 adopts a questionnaire survey to extend the results of Study 1, utilizing 434 participants from the same agency. The results of Study 2 reveal that young consumers’ waste sorting experience is positively related to their willingness to pay for shared express packaging and their pro-environmental attitudes mediate this relationship. In addition, perceived social worth moderates the mediating effect of waste sorting experience on willingness to pay for shared express packaging via pro-environmental attitudes. Implications and future research directions are discussed.

A Multi-Study Synthesis of Facilitators and Barriers to SARS-CoV-2 Testing Enrollment in School Settings.

Understanding the motivators and barriers to testing enrollment from different stakeholder perspectives is essential to increasing participation in school-based testing programs, particularly among underserved populations. This multistudy analysis aimed to identify facilitators and barriers to enrollment in school-based testing for coronavirus disease 2019 (COVID-19). Four independent studies collected and analyzed qualitative data from study participants regarding: (1) motivators, benefits, and/or reasons for enrolling and/or participating in COVID-19 testing in schools; and/or (2) concerns, barriers, and/or negative outcomes related to COVID-19 testing in schools. Study authors conducted a retrospective review of findings from the independent studies to identify themes related to testing motivators and concerns that emerged across the studies. The analysis identified 10 distinct themes regarding the perceived motivators of COVID-19 testing in schools and 15 distinct themes regarding concerns and barriers to COVID-19 testing in schools. Common motivators across multiple studies included convenience of testing in school and the desire to keep self and others safe from COVID-19. Concerns about the implications of receiving a positive test result was a barrier identified by multiple studies. Themes from 4 independent studies revealed insights about the motivations and barriers to enrolling and participating in COVID-19 testing programs in kindergarten through 12th grade school settings. Study findings can be used to improve enrollment and participation in new and existing school-based testing programs to reduce transmission of COVID-19 and other infectious diseases in schools.

Protective factors in borderline personality disorder: A multi-study analysis of conscientiousness, distress tolerance, and self-compassion

BackgroundDespite a growing literature characterizing risk factors associated with the development and maintenance of borderline personality disorder (BPD), substantially less is known about potentially protective factors in BPD. MethodsIn a sample of online (N = 272) participants with likely BPD, major depressive disorder (MDD), or no disorder (ND) and an independent sample of in-person (N = 90) participants diagnosed with BPD, MDD, or ND, we tested the cross-sectional and longitudinal associations among BPD features and three putatively protective personality, cognitive, and affective-behavioral factors: conscientiousness, self-compassion, and distress tolerance. ResultsOnly conscientiousness was significantly lower in BPD than MDD (ds: .67–.73) across both studies and more strongly related to BPD features (rs: −.68 to −.59) than MDD symptoms (rs: −.49 to −.43) in dimensional analyses across both studies. However, in a multiple regression analysis including all three factors in Study 1, only self-compassion predicted decreases in BPD features (β = −.28) and MDD symptoms (β = −.21) over one month. LimitationsStudy 1 participants completed all measures online and exhibited some differential attrition at one month follow-up. Study 2 participants were all diagnosed by one trained assessor and the smaller sample size limited our power to detect effects. ConclusionsLow conscientiousness may be most strongly related to BPD, whereas self-compassion may be a prospective transdiagnostic protective factor.

Batch effect correction methods for NASA GeneLab transcriptomic datasets

Introduction:RNA sequencing (RNA-seq) data from space biology experiments promise to yield invaluable insights into the effects of spaceflight on terrestrial biology. However, sample numbers from each study are low due to limited crew availability, hardware, and space. To increase statistical power, spaceflight RNA-seq datasets from different missions are often aggregated together. However, this can introduce technical variation or “batch effects”, often due to differences in sample handling, sample processing, and sequencing platforms. Several computational methods have been developed to correct for technical batch effects, thereby reducing their impact on true biological signals.Methods:In this study, we combined 7 mouse liver RNA-seq datasets from NASA GeneLab (part of the NASA Open Science Data Repository) to evaluate several common batch effect correction methods (ComBat and ComBat-seq from the sva R package, and Median Polish, Empirical Bayes, and ANOVA from the MBatch R package). Principal component analysis (PCA) was used to identify library preparation method and mission as the primary sources of batch effect among the technical variables in the combined dataset. We next quantitatively evaluated the ability of each of the indicated methods to correct for each identified technical batch variable using the following criteria: BatchQC, PCA, dispersion separability criterion, log fold change correlation, and differential gene expression analysis. Each batch variable/correction method combination was then assessed using a custom scoring approach to identify the optimal correction method for the combined dataset, by geometrically probing the space of all allowable scoring functions to yield an aggregate volume-based scoring measure.Results and Discussion:Using the method described for the combined dataset in this study, the library preparation variable/ComBat correction method pair out ranked the other candidate pairs, suggesting that this combined dataset should be corrected for library preparation using the ComBat correction method prior to downstream analysis. We describe the GeneLab multi-study analysis and visualization portal which will allow users to access the publicly available space biology ‘omics data, select multiple studies to combine for analysis, and examine the presence or absence of batch effects using multiple metrics. If the user chooses to perform batch effect correction, the scoring approach described here can be implemented to identify the optimal correction method to use for their specific combined dataset prior to analysis.

Merits and limitations of latent profile approaches to teachers' achievement goals: A multi-study analysis.

Research on teacher goals has primarily followed a variable-centered approach, although person-centered approaches have inspired achievement goal research in other domains. The multiple goal perspective posits that individuals pursue different combinations of goals-goal profiles-that might be differentially adaptive or maladaptive. We investigate how beneficial goal profiles may be for research on teacher motivation, using data from three study sets (total N = 3,681) from different countries (Israel, Germany) and institution types (schools, universities). We analyzed whether psychologically meaningful, coherent, and generalizable goal profiles could be identified and compared the explanatory power of profiles and individual goals as predictors of teachers' self-efficacy and work-related distress. Results showed six psychologically meaningful and largely generalizable goal profiles. Compared to individual goals, profiles only explained little differences in self-efficacy and work-related distress. Given these findings, we critically evaluate achievement goal profiles as a means to study effects of teacher goals.

Understanding the selection of intelligent engineering B2B platform in China through the fuzzy DANP and TOPSIS techniques: A multi-study analysis

With the Internet’s popularity and the economy’s rapid development, e-commerce has entered a whole new era in China. This study aims to investigate the factors affecting intelligent engineering B2B platforms and develop an indicator system based on the theory of resource complementarity. In addition, this study used a combination of qualitative and quantitative research to calculate the weights. We used the Fuzzy Decision-Making Trial and Evaluation Laboratory and Analytic Network Process (fuzzy DANP) method to determine the weights of the dimensions and indicators. The Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method ranks the well-known intelligent engineering B2B platforms in China. The results show that platform transaction volume, relationship stability and durability, and degree of dependence are key elements affecting the platforms. Finally, it is proposed that media and companies can prioritize two aspects of cooperation performance and relationship quality to improve the operational efficiency of both parties. Platforms should pay more attention to three indicators: relationship stability and durability, closeness, and platform traffic increase, to reasonably allocate resources, grasp the development opportunities, attract users to reside, and improve the economic benefits of the companies.

The steep road to nonviral nanomedicines: Frequent challenges and culprits in designing nanoparticles for gene therapy.

The potential of therapeutically loaded nanoparticles (NPs) has been successfully demonstrated during the last decade, with NP-mediated nonviral gene delivery gathering significant attention as highlighted by the broad clinical acceptance of mRNA-based COVID-19 vaccines. A significant barrier to progress in this emerging area is the wild variability of approaches reported in published literature regarding nanoparticle characterizations. Here, we provide a brief overview of the current status and outline important concerns regarding the need for standardized protocols to evaluate NP uptake, NP transfection efficacy, drug dose determination, and variability of nonviral gene delivery systems. Based on these concerns, we propose wide adherence to multimodal, multiparameter, and multistudy analysis of NP systems. Adoption of these proposed approaches will ensure improved transparency, provide a better basis for interlaboratory comparisons, and will simplify judging the significance of new findings in a broader context, all critical requirements for advancing the field of nonviral gene delivery.

Influence of Grit on Physical Activity, Sitting Time and Dietary Behaviors: A Multi-Study Analysis

Engaging in physical activity (PA), minimizing sitting time and consuming a healthy diet are behaviors associated with health and wellness across the lifespan. The present multi-study analysis examined the relationship between grit and PA, sitting time and dietary behaviors in several populations that included US adults, active-duty military personnel, veterans, college students and performing artists. The four research laboratories administered an internet-based survey between spring and summer of 2020. The common questionnaires on the surveys were the Grit Scale Short Form, International Physical Activity Questionnaire Short Form and the Rapid Eating Assessment for Participants Short Form. Multiple regression analyses were conducted to examine the association between grit, PA, sitting time and dietary behaviors. PA was associated with grit for US adults, civilians and college students but not for performing artists or active-duty military populations. Sitting time was associated with grit for US adults and active-duty military personnel. US adults, college students and performing artists were found to have a positive association between healthy dietary behaviors and grit. Overall, the findings indicate that grit has a positive influence on PA, sitting time and dietary behaviors across the unique populations; however, the relationships indicate some nuanced differences between the populations.

Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis.

Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent. To study the cross-sectional associations of pulmonary function with structural brain variables. Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses. FEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume. In cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.

A multistudy analysis reveals that evoked pain intensity representation is distributed across brain systems.

Information is coded in the brain at multiple anatomical scales: locally, distributed across regions and networks, and globally. For pain, the scale of representation has not been formally tested, and quantitative comparisons of pain representations across regions and networks are lacking. In this multistudy analysis of 376 participants across 11 studies, we compared multivariate predictive models to investigate the spatial scale and location of evoked heat pain intensity representation. We compared models based on (a) a single most pain-predictive region or resting-state network; (b) pain-associated cortical-subcortical systems developed from prior literature ("multisystem models"); and (c) a model spanning the full brain. We estimated model accuracy using leave-one-study-out cross-validation (CV; 7 studies) and subsequently validated in 4 independent holdout studies. All spatial scales conveyed information about pain intensity, but distributed, multisystem models predicted pain 20% more accurately than any individual region or network and were more generalizable to multimodal pain (thermal, visceral, and mechanical) and specific to pain. Full brain models showed no predictive advantage over multisystem models. These findings show that multiple cortical and subcortical systems are needed to decode pain intensity, especially heat pain, and that representation of pain experience may not be circumscribed by any elementary region or canonical network. Finally, the learner generalization methods we employ provide a blueprint for evaluating the spatial scale of information in other domains.

A multistudy analysis of abusive supervision and social network service addiction on employee's job engagement and innovative work behaviour

Almost every organization aspires to gain a competitive advantage through innovation and creativity. In recent years, researchers have become increasingly interested in the factors that foster or inhibit innovative work behaviour (IWB) and employee engagement. In this study, we used the conservation of resources (COR) theory to examine the influence of abusive supervision on employee job engagement and IWB via a mediator, namely, social network service (SNS). We also investigated the moderating effect of organizational support in this study. Our hypothesized model is supported by multisampling field data sets. We conducted two independent studies to carry out this research. Data were collected from information technology (IT) firms in Study 1 and consultancy companies in Study 2. Multisampling field data sets provided support for our hypothesized model. We found that abusive supervision harms employee job engagement and IWB, both directly and indirectly through SNS addiction (Study 1). In Study 2, we used time‐lag data to replicate the findings of Study 1. We also found in Study 2 that organizational support reduced the positive relationship between abusive supervision and SNS addiction. The indirect link between abusive supervision and employee work outcomes is significantly influenced by organizational support. Implications and future research directions are also discussed.

Understanding the Selection of Cross-Border Import E-Commerce Platforms Through the DANP and TOPSIS Techniques: A Multi-Study Analysis

ABSTRACT The platform of cross-border e-commerce has gained momentum in recent years. It is of paramount importance to fathom the factors influencing consumers’ choice of the platform and the relationships among the underlying factors. Departing from the theoretical lens of perceived value and our comprehensive review of the literature, this paper proposes a selection model including four dimensions and twelve criteria of cross-border import e-commerce platform. We propose a multi-study approach, in which the DANP technique is leveraged to extract and analyze the influence of the relationships between dimensions and criteria to determine their weight; then we use the TOPSIS technique to further evaluate three cross-border import e-commerce platforms in China, including Tmall Global, Koala and JD Global, to validate our model. The results show that when consumers choose a cross-border import e-commerce platform, products and experience are the most salient elements, while services and risks are the effective elements, with the greatest impact of risks.