The study was conducted to investigate the prevalence of S. Weltevreden and S. Typhimurium in pigs and husbandry environment in Vinh Long province. The method of Salmonella isolation was followed TCVN 10780-1:2017 (ISO 6579-1:2017). In a total of 1,394 examined samples (288 samples of pig manure, 369 environmental and 737 wild animal samples), 146 samples were positive with Salmonella. The prevalence of Salmonella isolated in pigs, environments, and wild animals was not significant difference. Among Salmonella isolates, S. Weltevreden and S. Typhimurium accounted for 15.07% and 13.01%, respectively. In this study, S. Weltevreden was not present in lizard samples; S. Typhimurium was not present in wastewater and feed samples. S. Weltevreden and S. Typhimurium isolates were highly sensitive to 14/14 antibiotics surveyed (78.95%-100%). S. Weltevreden was resistant to 9/14 antibiotics, and S. Typhimurium was resistant to 6/14 antibiotics. Besides, Salmonella isolates also showed multidrug resistant to 2-6 kinds of antibiotics in 8 multi resistant types, in which, there multi-resistance types (Cu+Of, Cl+Bt, Sm+Te) were the most common types (9.76%).