Multiple Gaps Research Articles

Mapping patient pathways for NCDs from a policy perspective: a novel multinational initiative

Abstract Background Chronic diseases like CVD and DM pose global health challenges. Understanding patient pathways is vital for effective disease management and reducing morbidity and mortality. However, until now, comprehensive multinational mapping of patient pathways from a policy or regulatory perspective in the context of chronic disease has not been undertaken. Previous investigations into patient pathways mainly focused on the perspective of individual patients, assembling trajectories of those patients, but did not delve into how these pathways were designed. Methods Patient pathways for CVD and DM will be mapped across 11 countries: Belgium, Finland, France, Hungary, Iceland, Italy, Latvia, Poland, Romania, Slovenia, and Spain. Using a survey tool, detailed descriptions and diagrams of healthcare pathways will be collected, stratified by Kaiser Permanente health pyramid strata. Stakeholder interviews on policy and practice level will refine mappings and identify gaps in the policies. Results Preliminary findings reveal diverse healthcare trajectories and identified multiple gaps in disease management across countries. For many countries, a complete well-developed patient pathway was not found; instead, the pathways were rather fragmented and lacking for some strata of the health pyramid. These insights underscore the need for tailored interventions and enhanced care coordination to optimize continuity of care and patient outcomes. Conclusions Comprehensive patient pathway mapping offers a strategic framework to address gaps in chronic disease management. Our study emphasizes the importance of collaborative efforts in developing context-specific interventions and strengthening healthcare systems to improve public health outcomes. Key messages • Comprehensive patient pathway mapping reveals numerous gaps in global chronic disease management, prompting the need for enhanced strategies. • Collaborative efforts are key to addressing gaps in chronic disease care.

Novel isolates expand the physiological diversity of Prochlorococcus and illuminate its macroevolution.

Prochlorococcus is a diverse picocyanobacterial genus and the most abundant phototroph on Earth. Its photosynthetic diversity divides it into high-light (HL)- or low-light (LL)-adapted groups representing broad phylogenetic grades-each composed of several monophyletic clades. Here, we physiologically characterize four new Prochlorococcus strains isolated from below the deep chlorophyll maximum in the North Pacific Ocean. We combine these physiological properties with genomic analyses to explore the evolution of photosynthetic antennae and discuss potential macroevolutionary implications. The isolates belong to deeply branching low-light-adapted clades that have no other cultivated representatives and display some unusual characteristics. For example, despite its otherwise low-light-adapted physiological characteristics, strain MIT1223 has low chl b2 content similar to high-light-adapted strains. Isolate genomes revealed that each strain contains a unique arsenal of pigment biosynthesis and binding alleles that have been horizontally acquired, contributing to the observed physiological diversity. Comparative genomic analysis of all picocyanobacteria reveals that Pcb, the major pigment carrying protein in Prochlorococcus, greatly increased in copy number and diversity per genome along a branch that coincides with the loss of facultative particle attachment. Collectively, these observations support a recently developed macroevolutionary model, in which niche-constructing radiations allowed ancestral lineages of picocyanobacteria to transition from a particle-attached to planktonic lifestyle and broadly colonize the euphotic zone.IMPORTANCEThe marine cyanobacterium, Prochlorococcus, is among the Earth's most abundant organisms, and much of its genetic and physiological diversity remains uncharacterized. Although field studies help reveal the scope of diversity, cultured isolates allow us to link genomic potential to physiological processes, illuminate eco-evolutionary feedbacks, and test theories arising from comparative genomics of wild cells. Here, we report the isolation and characterization of novel low-light (LL)-adapted Prochlorococcus strains that fill in multiple evolutionary gaps. These new strains are the first cultivated representatives of the LLVII and LLVIII paraphyletic grades of Prochlorococcus, which are broadly distributed in the lower regions of the ocean euphotic zone. Each of these grades is a unique, highly diverse section of the Prochlorococcus tree that separates distinct ecological groups: the LLVII grade branches between monophyletic clades that have facultatively particle-associated and constitutively planktonic lifestyles, whereas the LLVIII grade lies along the branch that leads to all high-light (HL)-adapted clades. Characterizing strains and genomes from these grades yields insights into the large-scale evolution of Prochlorococcus. The new LLVII and LLVIII strains are adapted to growth at very low irradiance levels and possess unique light-harvesting gene signatures and pigmentation. The LLVII strains represent the most basal Prochlorococcus group with a major expansion in photosynthetic antenna genes. Furthermore, a strain from the LLVIII grade challenges the paradigm that all LL-adapted Prochlorococcus exhibit high ratios of chl b:a2. These findings provide insights into the photophysiological evolution of Prochlorococcus and redefine what it means to be a low- vs high-light-adapted Prochlorococcus cell.

Superconducting density of states and vortex lattice of LaRu2P2 observed by scanning tunneling spectroscopy

We provide the superconducting density of states of the pnictide superconductor LaRu2P2(Tc= 4.1 K), measured using millikelvin scanning tunneling microscopy. From the tunneling conductance, we extract a density of states which shows the opening of a s-wave single superconducting gap. The temperature dependence of the gap also follows BCS theory. Under magnetic fields, vortices present Caroli de Gennes Matricon states, although these are strongly broadened by defect scattering. From the vortex core size we obtain a superconducting coherence length ofξ = 50 nm, compatible with the value extracted from macroscopicHc2measurements. We discuss the comparison between s-wave LaRu2P2and pnictide unconventional multiple gap and strongly correlated Fe based superconductors.

Photocatalytic performance of pristine NiO and Ni6MnO8 nanopowders in degradation of Rose Bengal dye.

Effective tuning of bandgap of transition metal oxides is a promising approach in improving their photocatalytic activity towards organic pollutant removal from water. The present paper describes synthesis of nickel oxide and Ni6MnO8 nanopowders by simple hydrothermal technique. During the synthesis of nickel oxide by hydrothermal process, addition of Mn source resulted in the formation of Ni6MnO8. X-ray diffraction analysis has confirmed the formation of nickel oxide and Ni6MnO8 both having cubic structures. The average crystallite size decreases from 20 to 12nm on increasing Mn source concentration during the synthesis of nickel oxide. Rectangular, hexagonal, and triangular faceted structures are revealed from the scanning electron microscopic images. HRTEM also indicated formation of cubical shaped structure with average sizes of 32 and 21nm for pristine NiO and Ni6MnO8 nanopowders. In the case of Ni6MnO8 nanopowder, inter-connected cubes are seen. Modification in Ni6MnO8 nanopowder is found to display multiple optical band gaps at 1.21, 1.82, and 2.65eV. The formation of Ni6MnO8 phase was further confirmed by XPS studies due to the presence of + 4 oxidation state of Mn. The photocatalytic properties of synthesized nickel oxide and Ni6MnO8 nanopowders are measured by using Rose Bengal dye under UV illumination. Enhancement in the photocatalytic activity is noticed in the case of Ni6MnO8 nanopowder as compared to nickel oxide nanopowder. Nearly 90% dye degradation is observed on utilizing Ni6MnO8 nanopowder.

A Study on the Effect of Urban Form on the Street Interface Rhythm Based on Multisource Data and Waveform Classification

Good-quality urban street space is crucial for improving walkability. Frequency and amplitude are the main spatial characteristics of the street interface rhythm, known as a “virtual–real” relation. Exploring the mechanism influencing the urban street interface rhythm can help grasp the movement trend. In this study, the correlation between frequency and urban form is explored through a Pearson correlation analysis with multisource data, and the factors influencing the urban street interface rhythm are presented. The results indicate that frequency has a moderate negative correlation with the block scale and a moderate positive correlation with the number of pedestrian access entrances (PAE-n); the PAE-n also has a strong negative correlation with the block scale. Some spatial characteristics of outstanding streets from different countries are analyzed and discussed based on waveform classification. The regularities of interface rhythm that exist within multiple streets are found: multiple gaps on the street interface exist, acting as a “beat”, which regularly integrates or separates the street interface rhythm. The frequency and amplitude of the “beat” significantly affect streets’ walkability, and the amplitude is generally low and uniform, with good visual accessibility in all directions. A “Small Block and Dense Grid” becomes a key factor in improving walkability. Basic knowledge of the street interface rhythm in urban walking space research is supplemented by this study. Furthermore, theoretical guidance and parametric evidence are provided to improve walkability and promote the continuation of the traditional context.

High beta diversity of gaps contributes to plot-level tree diversity in a tropical forest.

Canopy gaps are widely recognized as being crucial for maintaining the diversity of forest tree communities. But empirical studies have found mixed results because the differences in diversity between individual gaps and non-gaps are often small and statistically undetectable. One overlooked factor, however, is how small individual gap versus non-gap differences may accumulate across sites and potentially have a large effect on forest diversity at the plot scale. Our study investigated sapling richness, density, and composition in 124 treefall gaps, and 200 non-gap sites in the 50-ha tropical forest plot at Barro Colorado Island (BCI), Panama. Additionally, we analyzed species accumulation curves to understand how species richness increases with increasing stem numbers. We observed that sapling richness and density were only slightly higher in gaps 7 years after formation and statistically indistinguishable from non-gaps after 12 years. However, species accumulation curves across multiple gaps were substantially higher than those across non-gaps. Species composition showed small differences between individual gaps and non-gaps but differed significantly between collections of gaps and non-gaps. Specifically, 55 species specialized in 7-year-old gaps compared with 24 in non-gaps; of these, 23 gap-specialized species and zero non-gap species were pioneers. Our results indicate that tree species richness is higher in gaps because of both higher stem density and the presence of gap-specialized species. Our study has finally provided compelling evidence to support the idea that gaps enhance the overall diversity of tropical forest tree communities.

Composite metastructure with tunable ultra-wide low-frequency three-dimensional band gaps for vibration and noise control

Low-frequency vibration and noise control present enduring engineering challenges that garner extensive research attention. Despite numerous active and passive control solutions, achieving multiple ultra-wide attenuation regions remains elusive. Addressing vibration and noise control across a multidirectional broad low-frequency spectrum, three-dimensional metastructures have emerged as innovative solutions. This study introduces a novel three-dimensional composite metastructure featuring multiple ultra-wide three-dimensional complete band gaps. The research emphasizes the design strategy of elastic ligaments to achieve multiple ultra-wide attenuation regions spanning from 0.7 to 40 kHz. The band structures are elucidated through modal analysis and further substantiated by an analytical model based on a spring-mass chain with an additional resonator. The underlying physical mechanism for the formation of multiple ultra-wide band gaps is revealed through novel vibration modes from finite element analyses. Furthermore, we demonstrate that the distribution and the relative width of the ultra-wide band gaps can be tuned by modifying the geometric parameters of the metastructure. Utilizing additive manufacturing, prototypes are fabricated, and low-amplitude vibration tests are conducted to evaluate real-time vibration attenuation properties. Consistency is observed among theoretical, numerical, and experimental results. The proposed structure shows significant potential for high-performance meta-devices aimed at controlling noise and vibration across an extremely wide low-frequency spectrum.

Green knowledge management: a bibliometric analysis, research trends and future directions

Purpose Green knowledge management (GKM) has become a critical factor for modern organizations, offering a multifaceted approach to enhancing business operations while promoting environmental sustainability. The purpose of this paper is to review the literature and explore how GKM helps companies reduce their ecological footprint by digitalizing processes and minimizing physical storage needs, thus aligning with growing expectations for corporate environmental responsibility. The necessity for conducting a GKM review is underscored by the increasing recognition of sustainability, environmental performance and as a critical component of organizational corporate success in the contemporary business landscape. Design/methodology/approach This study conducted a bibliometric analysis of 994 papers related to GKM from 2005 until August 2024. Findings Over the 20 years of research on GKM, this bibliometric analysis drew the interlinked relationships between main theme of KM in the context of sustainable practices, processes, social and related theories. This study identifies green innovation, digital transformation, green and lean supply chains, leadership and technology tools. Future research can explore themes such as green and lean processes, barriers and enablers, role of leadership and ambidexterity in green supply chain integration using different theoretical lenses. Research limitations/implications Although the findings of this study are important to GKM research, there are a number of limitations to this investigation. The research database used exclusively was the Web of Science and Scopus, which contained the indexed papers. Future investigations may draw from various databases, such as EBSCO and Google Scholar. Additionally, the use of topic modelling and other artificial intelligence frameworks could enhance research analysis. Subsequently, research papers may expand their scope to encompass conference papers, books and book chapters, in addition to articles. Practical implications This review gives a holistic understanding of GKM practices across various sectors which not only enhances organizational performance but also contributes to broader environmental goals. This study offers an understanding on GKM on holistic approach that combines total quality management (TQM), absorptive capacity and collaborative frameworks to foster innovation and sustainability. Originality/value It is evident from the review that research in GKM is evolving gaining momentum. This review provides a comprehensive understanding of the GKM literature, from its earliest forms of basic concepts aligned with the sustainability and progressing more into the concepts of GKM adoption for green innovation by highlighting multiple theories, factors and gaps in the studies.

Two-dimensional viscous study of coupled nonlinear fluid resonances in two narrow gaps

The wave-induced hydrodynamics of coupled nonlinear piston-mode fluid resonances within two narrow gaps between three barges are numerically investigated using a two-dimensional viscous wave flume. This study aims to explore the time-dependent nonlinear interactions between fluid oscillations in the two gaps. The coupled synchronous dynamic behaviors of fluid oscillations during the transient evolution stage are first examined in terms of amplitude and frequency modulation. It is shown that phase dynamics, including phase slipping, trapping, and locking, play significant roles in establishing the coupled synchronous dynamic evolutions of fluid oscillations in the two gaps. The quasi-steady state of the amplitude- and phase-frequency responses of fluid oscillations within the gaps, along with the reflection and transmission waves in front of and behind the three-barge system, are further analyzed. This analysis clarifies the significance of viscous damping energy dissipation and radiation damping energy transfer involved in gap resonance problems. This clarification also explains the performance of fully nonlinear potential flow solvers in predicting fluid resonances in the two narrow gaps. Finally, the nonlinear dynamic features of fluid oscillations are examined. The effects of incident wave nonlinearity, i.e., wave steepness, on resonant frequencies, response amplitudes, energy dissipation, and reflection and transmission coefficients are investigated. Harmonic analysis via Fourier transformation reveals the contributions of first-, second-, and third-order harmonics to the overall response amplitudes. The physical insights gained from this study provide a deeper understanding of the coupled nonlinear dynamics of piston-mode fluid resonances in multiple narrow gaps.

Assessment of clinician agreement with and knowledge of evidence-based obesity treatment in the primary care setting.

Effective, evidence-based obesity treatment is needed, which often involves use of anti-obesity medications (AOMs). Data on the breadth and quality of guideline-directed obesity treatment implementation in primary care remain limited. This study aimed to assess primary care clinicians' agreement with and knowledge of guideline-directed obesity treatment, as well as to assess the health status of persons with obesity and their use of AOMs. This multimethod study included a prospective survey of primary care clinicians, utilizing a questionnaire that measured agreement on a 5-point Likert scale and knowledge via multiple choice questions. A retrospective analysis was also performed of patient data collected between 30 June 2016 and 30 June 2020 from primary care clinics in the Midwest. Data were analyzed from 27 clinician survey responders, finding agreement toward all measured areas, however less strong for chronic AOM use and resource allocation. The survey identified multiple gaps in knowledge. Researchers assessed 5656 baseline encounters and 2941 corresponding follow-up encounters. Analysis revealed ≥50% of the total patients experienced persistently uncontrolled obesity (mean body mass index of ≥40kg/m2) and weight-related complications. Low rates (≤10%) of AOM use in clinically eligible patients were shown, with phentermine monotherapy being the most commonly used. Clinicians agree with guideline-directed obesity treatment. Persons with obesity who are poorly controlled identify an opportunity for patient care improvement.

Unveiling the charge density wave mechanism in vanadium-based Bi-layered kagome metals

The charge density wave (CDW), as a hallmark of vanadium-based kagome superconductor AV3Sb5 (A = K, Rb, Cs), has attracted intensive attention. However, the fundamental controversy regarding the underlying mechanism of CDW therein persists. Recently, the vanadium-based bi-layered kagome metal ScV6Sn6, reported to exhibit a long-range charge order below 94 K, has emerged as a promising candidate to further clarify this core issue. Here, employing micro-focusing angle-resolved photoemission spectroscopy (μ-ARPES) and first-principles calculations, we systematically studied the unique CDW order in vanadium-based bi-layered kagome metals by comparing ScV6Sn6 with its isostructural counterpart YV6Sn6, which lacks a CDW ground state. Combining ARPES data and the corresponding joint density of states (DOS), we suggest that the VHS nesting mechanism might be invalid in these materials. Besides, in ScV6Sn6, we identified multiple hybridization energy gaps resulting from CDW-induced band folding, along with an anomalous band dispersion, implying a potential electron-phonon coupling-driven mechanism underlying the formation of the CDW order. Our finding not only comprehensively maps the electronic structure of V-based bi-layer kagome metals but also provides constructive experimental evidence for the unique origin of CDW in this system.

A review of commercial captive breeding of parrots as a supply-side intervention to address unsustainable trade.

The volume and scale of commercial captive breeding of parrots have grown dramatically in recent decades. Although it has been proposed, and is often assumed, that captive breeding can reduce pressure on wild populations, there has been little scrutiny of the scale, viability, or impacts of captive breeding to prevent overexploitation among parrots, compared with similar approaches in other threatened taxa, such as pangolins or tigers. We reviewed the primary and gray literature to quantitatively and qualitatively evaluate evidence concerning 5 criteria, established a priori, for commercial captive breeding of parrots as an effective supply-side intervention. We focused on a sample of 16 threatened parrot species that are heavily traded or for which unsustainable trade has been a factor in the decline of wild populations, representing a range of taxonomic groups, life histories, and native regions. We identified multiple major gaps in knowledge of the extent to which these criteria are met, including a lack of quantitative data on breeding productivity under current commercial breeding practices, the scale and scope of commercial breeding practices in growing parrot markets, particularly in the Middle East and Asia, and the lack of financial viability of captive breeding under effective regulation to prevent laundering or use of wild-sourced specimens as breeding stock. The capacity for captive breeding to displace demand for wild-sourced parrots varied between species, and complex interactions between trade in different species and contexts sometimes made consequences of commercial production difficult to predict. Decision makers and regulatory authorities should approach commercial captive breeding of parrots with caution and take into account knowledge gaps and cross-linkages between trade in different species to avoid unanticipated consequences from stimulating and facilitating unsustainable trade in wild-sourced parrots.

Caring for Persons with Alzheimer's Disease during a Pandemic

The population experiencing Alzheimer's disease (AD) and their caregivers have been tremendously impacted by the global COVID-19 pandemic. Outpatient services became less accessible during the pandemic lockdown which caused increased caregiver burden more than usual. Further examination discovered that caregivers were unable to properly take care of themselves because of the need to provide around-the-clock care to loved ones, who pre-pandemic were able to receive supplemental caregiving services. The purpose of this integrative review was to provide a synthesis of information regarding caregiver experiences, during a time of limited resources, such as with the COVID-19 global pandemic. A comprehensive search of the literature databases Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Medline was completed yielding qualitative and mixed-methods studies. The literature search yielded 14 articles which met the criteria. Three themes emerged during this review. They include: Deprivation of self-care and social connectedness, Fragmented care and resources, and Improved policy development. Multiple gaps in caregiver needs have been identified throughout the literature. Outpatient services, home health aides, and respite care remain necessary elements of care for those with AD and for the relief of the caregiver. Forward planning should include government policies to support caregiving of those with AD, especially in the light of service restrictions or unavailable services.

How do software practitioners perceive human-centric defects?

Context:Human-centric software design and development prioritises the way users prefer to complete their jobs, rather than expecting users to adapt to the software. Software users can have different genders, ages, cultures, languages, disabilities, socioeconomic statuses, and educational backgrounds, among many other differences. Due to the inherently varied nature of these differences and their impact on software usage, preferences and issues of users can vary, resulting in user-specific defects that we term as ‘human-centric defects’ (HCDs). Objective:This research aims to understand the perception and current management practices of such HCDs by software practitioners, identify key challenges in reporting, understanding and fixing them, and provide recommendations to improve HCDs management in software engineering. Methods:We conducted a survey and interviews with software engineering practitioners to gauge their knowledge and experience on HCDs and the defect tracking process. Results:We analysed fifty (50) survey- and ten (10) interview-responses from SE practitioners and identified that there are multiple gaps in the current management of HCDs in software engineering practice. There is a lack of awareness regarding human-centric aspects, causing them to be lost or under-appreciated during software development. Our results revealed that handling HCDs could be improved by following a better feedback process with end-users, a more descriptive taxonomy, and suitable automation. Conclusion:HCDs, given their diverse end-user base, present a major challenge to software practitioners. In the software engineering domain, research on HCDs has been limited and requires effort from research and practice communities to create awareness and support for human-centric aspects.

Topology of SmB6 revisited by means of topological quantum chemistry

The mixed-valence compound SmB6 with partially filled samarium 4f flat bands hybridizing with 5d conduction bands is a paramount example of a correlated topological heavy-fermion system. In this study, we revisit the topology of SmB6 within the formalism of topological quantum chemistry and symmetry-based indicators. Based on this approach, we reach a detailed classification of the material's topology, and we reformulate the origin of topology in terms of band representations. We corroborate these aspects by constructing a minimal TB model that is consistent with all the symmetries of the system and is able to reproduce the topology of the material. We finally unveil the previously overlooked formation of multiple topological gaps, and we discuss its implications for experiments. Published by the American Physical Society 2024

Liver diseases and hepatocellular carcinoma in the Asia-Pacific region: burden, trends, challenges and future directions.

Globally, nearly half of deaths from cirrhosis and chronic liver diseases (CLD) and three-quarters of deaths from hepatocellular carcinoma (HCC) occur in the Asia-Pacific region. Chronic hepatitis B is responsible for the vast majority of liver-related deaths in the region. Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common form of CLD, affecting an estimated 30% of the adult population. Compared with people of European descent, people from the Asia-Pacific region carry more genetic variants associated with MASLD and its progression. Alcohol is a fast-growing cause of CLD and HCC in Asia as a result of the rising per-capita consumption of alcohol. Drug-induced liver injury is under-recognized and probably has a high prevalence in this region. The epidemiological and outcome data of acute-on-chronic liver failure are heterogeneous, and non-unified definitions across regions contribute to this heterogeneity. CLDs are severely underdiagnosed, and effective treatments and vaccinations are underutilized. In this Review, we highlight trends in the burden of CLD and HCC in the Asia-Pacific region and discuss the rapidly changing aetiologies of liver disease. We examine the multiple gaps in the care cascade and propose mitigating strategies and future directions.

Study on vibration bandgap characteristics of a cantilever beam type local resonance unit

This article proposes a novel phononic crystal configuration consisting of a through-hole cantilever beam and a mass block, and conducts numerical analysis and experimental verification on the bandgap characteristics of a two-dimensional periodic array plate containing this configuration. The results indicate that there are multiple bending wave band gaps in the proposed structure, and the formation of the bandgap is due to the coupling between elastic waves in the matrix and the resonance characteristics of the local resonant structure. The width of the bandgap is related to the coupling strength. Further research has also found that the proportion of effective mass of the mode is a criterion for determining whether the mode generates a bandgap. At the same time, the regulation of band gaps by the cell constants and geometric parameters of local resonance units was studied. Based on the above research, by improving the original local resonance structure, more abundant bandgap features were obtained, providing a feasible approach for the design of broadband bandgaps. Finally, the vibration transmission rate of the finite period structural plate was obtained through simulation calculations and experiments, and its attenuation frequency band was basically consistent with the bandgap range, indicating that the structure has good low-frequency vibration reduction performance, which has broad engineering application prospects in the field of vibration and noise reduction.

Photocatalysis-promoted tumor ferroptosis enabled by MOF-derived black TiO2

Ferroptosis has emerged as a novel approach to suppress tumor growth through the iron-dependent accumulation of lipid peroxides, providing new opportunities for cancer therapy. However, the effectiveness of ferroptosis is impeded by the substantial neutralization of reactive oxygen species (ROS), generated through the Fenton reaction, by the high level of glutathione in cancer cells. Here we report a titanium metal–organic frameworks (MOFs)-derived method to create black TiO2 nanoparticles with excellent photocatalytic performance. The nanoparticle has a narrow bandgap of 1.02 eV, multiple discrete gap states, and a high density of oxygen vacancies (46.2 %), facilitating ROS generation under 1064-nm light irradiation. When coated with a tannic acid/Fe3+ layer, the resulting nanocomposite possesses the ability to deplete glutathione concentration, preventing the newly generated ROS from being neutralized and promoting ferroptotic cancer cell death. Complemented by photothermal and chemodynamic effects, in vivo experiments demonstrate a high tumor inhibition rate of 89.8 %. The utilization of MOF-derived nanomaterials represents a universal strategy, offering a solution for ferroptosis-based therapy in solid tumors and contributing to the development of smart, optically active materials with diverse applications in biological contexts.

Employment outcomes of refugee women and men: multiple gender gaps and the importance of high-skill jobs

ABSTRACT Refugee women face significant challenges when seeking employment in Western host countries. To advance gender-sensitive perspectives within migration and refugee research, this study examines differences in employment outcomes between refugee women and men. Specifically, this study provides a nuanced picture of six indicators of employment outcomes, including pay, fixed-term versus permanent employment contract, overqualification, career prospects, an at-home feeling in the workplace and the ability to talk to colleagues about personal problems. The study also shows that individuals’ occupational status plays a role in gender disparities. Our findings, based on a recent survey of refugees working in Austria, reveal several gender gaps, with an especially significant gap regarding fixed-term employment contracts. Refugee women, who are more likely to be disadvantaged in employment outcomes, benefit disproportionately from working in high-skill jobs. The findings underscore the complex nature of gendered patterns in labour market integration of refugees and imply specific policies addressing gender inequality in this setting.

Comprehensive geospatial mapping and monitoring of an eastern coalfield in India

Geospatial mapping and monitoring are crucial for designing slopes in opencast mining, as failure can result in significant economic and life loss. To overcome these issues, the present investigation evaluated the Digital Elevation Model (DEM) generated using high resolution Cartosat-1 satellite imagery. Simultaneously, mapping of shaded relief map, aspect map and slope maps was done for the monitoring of Shatabdi opencast coal mine of Jharia region, an eastern coalfield region of India. Shaded relief map was categorized in to low, moderate and high categories and maximum area was covered by moderate to high shades. The constructed aspect map encompasses the range between 0 and 360 degrees of direction, with categorization and representation through distinct colors. The slope map was classified into various categories based on degrees of slope, including very gentle, gentle, moderate, moderately steep, steep, and very steep slopes. The maps were ground validated using Differential Global Positioning System (DGPS) collected data points by field visit in the region. For opencast mines to operate safely and profitably, slope stability in different stages of mining must be mapped and monitored. The study synthesizes data from diverse sources, highlighting the role of geospatial technology in addressing multiple research gaps within the mining industries prior to leveraging Cartosat-1 satellite data. Slope mapping and monitoring of coalfield regions are crucial to reducing construction costs, mitigation of natural hazard risks like flooding and landslides, and effective conservation of natural resources such as soils, vegetation, and water systems. The present study benefits policymakers, environmental planners and government in formulating policies to ensure safety, reliability, and enhance the economic growth of workers and the country.