This paper describes the effectiveness of Memory Math, a multimedia software program developed to teach students with learning and cognitive disabilities to effectively use a peg- and keyword mnemonic strategy to learn basic multiplication facts. According to the math Standards (National Council of Teachers of Mathematics, 2000), accuracy with basic facts is a critical element in the development of new skills and achievement in higher levels of math. One avenue for improving accuracy on basic skills is computer-assisted instruction (CAI). CAI offers an alternative to the teacher-intensive coaching often required to facilitate self-directed performance on basic skills. This paper demonstrates that CAI provides an effective mechanism for teaching students a mnemonic memory strategy to increase their independent performance and accuracy on tasks of basic multiplication.