Multiple Switching Research Articles

A New Concept of Reconfigurable Antenna Structure Based on an Array of RF-MEMS Switches

A geometrical reconfigurable structure based on RF Micro-electro-mechanical switches (RF-MEMS) is proposed in this work. The structure is composed of an array of gold metallic patches interconnected together utilizing RF-MEMS switches in order to change its geometry and, consequently, the scattering parameters. In particular, the reconfigurability is achieved by activating multiple RF-MEMS switches, which enables the change in electrical length and, consequently, the resonance frequency of the structure. As a proof of concept, an experimental antenna prototype composed of an array of 7×7 elements interconnected by a set of RF-MEMS switches has been designed, fabricated numerically, and experimentally assessed. The structure can be set as an antenna or as other basic radio frequency components. The obtained experimental results are in good agreement with the simulations, with an error of less than 5% for the considered radiating structures. The quite promising results demonstrate the potential and flexibility of the proposed structure.

Forget-me-not phylogenomics: Improving the resolution and taxonomy of a rapid island and mountain radiation in Aotearoa New Zealand (Myosotis; Boraginaceae)

Island and mountain systems represent natural laboratories for studies of species radiations, but they often present several challenges for phylogenetic inference and species delimitation. The southern hemisphere forget-me-nots (Myosotis, Boraginaceae) comprise a geologically recent radiation centred in Aotearoa New Zealand, a mountainous archipelago, with about 50 species that are morphologically and ecologically divergent but lack genetic variation sufficient to resolve phylogenetic relationships and species boundaries using standard DNA Sanger sequencing markers, AFLPs, or microsatellites. Many of these Myosotis species are geographically restricted in alpine areas, uncommon or threatened, have polyploid and dysploid genomes, and are of high taxonomic and conservation priority. Here we present phylogenomic analyses using target-capture of Angiosperms353 baits, and genome skimming of whole plastomes and nrDNA, to improve resolution of the radiation, explore biogeographic and morphological patterns within it, and address specific taxonomic questions for each species. Our comprehensive sampling includes over 300 individuals representing nearly all species from New Zealand and Australia, which is ∼ 2–3 × more taxon sampling and ∼ 80–120 × more molecular data than previously published for Myosotis. Exploration of different data filtering, curation and analyses (coalescent vs. concatenation) improved the resolution of the Angiosperms353 tree, which despite short backbone branches with low support values, showed taxonomic and geographic patterns, including multiple switches between ebracteate and bracteate inflorescences and multiple expansions within New Zealand from Te Waipounamu South Island to Te Ika-a-Māui North Island, Rakiura Stewart Island, subantarctic islands, and Australia. Some of these patterns were also seen in the genome skimming datasets, and comparison of the three datasets was useful for improving our understanding of the taxonomy and resolution of this radiation. Although this phylogenomic study does not fully overcome all of the challenges regarding species delimitation of this rapid island and mountain species radiation, it nevertheless makes an important contribution to an integrative taxonomic revision of the southern hemisphere species of Myosotis.

An online open circuit faults diagnosis method for converter using the lightweight two-channel deep network

Online diagnostic technology is crucial for ensuring the reliable operation of power converters in industrial applications. However, quickly diagnosing the faults of a power converter using intelligent algorithms is challenging due to the redundancy and noise of the sensor measurement signal. Hence, this paper proposes a lightweight two-channel deep network (LTCDN) to overcome it and achieve rapid fault diagnosis. It consists of a quadratic mean preprocessing layer (QMPL), a two-channel convolutional layer (TCCL), and a bidirectional gated recurrent unit (BGRU). The QMPL is designed to achieve denoising and lightening of output currents. Then, the TCCL is proposed to extract edge features and internal key information for improving diagnostic accuracy. Finally, the BGRU classifier completes the online fault diagnosis with a fast detection speed and high precision. It is evaluated through experiments with real-time open circuit faults for multiple switches of a four-level active neutral point clamped (4L-ANPC) converter, demonstrating superior performance with a false diagnosis rate of less than 1% and a diagnosis time of under 8ms. The method combines a novel data preprocessing layer with an efficient neural network to provide an effective fault detection method for a 4L-ANPC converter, which not only has high accuracy but also has significant computational efficiency. Its scalability for more complex multilevel converters is also verified.

Preferences for Starting Daily, On-Demand, and Long-Acting Injectable HIV Preexposure Prophylaxis Among Men Who Have Sex With Men in the United States (2021-2022): Nationwide Online Cross-Sectional Study.

Long-acting (LA) injectable preexposureprophylaxis (PrEP) and on-demand PrEP may improve overall PrEP uptake among men who have sex with men (MSM), but little is understood about the PrEP option preferences of MSM in practical scenarios where they may choose between various PrEP options. This study aims to examine the preferences for starting various PrEP options among a US nationwide online convenience sample of MSM from September 2021 to February 2022. Participants reporting no prior HIV diagnosis were provided brief descriptions of each PrEP option and were asked, "If [PrEP option] were available from your local doctor and you could access it for free, would you go to your doctor in the next month to start [PrEP option]?" Those who said "yes" to multiple options were asked to rank them in order of preference. MSM currently taking daily oral (DO) PrEP were asked whether they would switch to on-demand or LA PrEP options. Log binomial models were created to examine the association between willingness to start or switch to on-demand and LA PrEP with various sociodemographic and behavioral factors. In the analytic sample (N=7760), among the participants who did not use any PrEP in the past 12 months (n=5108, 66%), 54% (n=2445) reported willingness to start at least 1 PrEP option and 41% (n=1845) of participants showed interest in starting multiple PrEP options. Overall, the highest willingness was reported for on-demand PrEP (n=2235, 44%), followed by DO PrEP (n=2174, 43%) and LA PrEP (n=1482, 29%). LA PrEP was ranked first among those interested in multiple options. Characteristics associated with ranking LA PrEP as a first option to start PrEP versus DO or on-demand PrEP were region of residence (residing in the West vs Northeast), report of sexually transmitted infection diagnosis in the past year, report of illicit drug use other than marijuana in the past year, and prior awareness of LA PrEP. Among current DO PrEP users (n=2379, 31%), 58% (n=1386) were willing to switch to on-demand or LA PrEP, and LA PrEP was ranked first among participants who were open to switching to both options. Willingness to switch to LA PrEP was higher among those who used illicit drugs other than marijuana in the past year, who heard of LA PrEP prior to the survey, and those who took 15 or less doses of oral PrEP in the last 30 days. LA PrEP was the highest-ranked option among most MSM who were willing to try multiple options or switch from DO PrEP. These findings highlight that LA PrEP might fill coverage gaps among MSM who use illicit drugs, have had a recent sexually transmitted infection diagnosis, and have less than optimal DO PrEP adherence.

Switch monitoring algorithm for 220 kV terminal substation startup process based on multi time scale graph model

The switch monitoring in the startup process of 220 kV terminal substation is a dynamic and changeable process, which has obvious characteristics of diversified scales in time, so as to solve the problem of switch monitoring under multivariable and multi-scale interference. The switch monitoring framework for the startup process of 220KV terminal substation is built. The process layer uses the graphic configuration software and combines the internal and external models of the substation to build the objective function for the generation of the substation graphic model. The particle swarm optimization algorithm is used to solve it to generate the optimal substation graphic model. Through the online monitoring device, the signals such as sensors, normally open and normally closed contacts are collected in real time, and the status of the switchgear is obtained through processing, the reduced half trapezoidal cloud model multivariable multi-scale sample entropy similarity tolerance criterion is used for softening treatment, and the multivariable multi-scale cloud sample entropy is determined to achieve the extraction of multiple time scale switch fault feature vectors, which are used as the input of the SE-DSCNN fault diagnosis model. Combined with the substation diagram, the switch fault identification during the startup process of the substation is realized, and the fault switch position is located. The experimental results show that the algorithm can accurately generate the substation model, which includes all the equipment in the substation, accurately describes the connection relationship and operation status of the equipment, and has high accuracy, integrity and aesthetics; The algorithm can effectively extract and analyze the MMCES entropy characteristics of different types of switch faults; The algorithm can realize the switch monitoring during the startup of substation C, and determine the fault switch and fault location.

An approach for real-time implementation of cyber security in power system network

Abstract In this era of Web World-3, usage of the Internet of Things (IoT) in power system networks has attained scalable altitude. By using this technology, data can be transferred and monitored from the far end. Further, the suggested corrective actions are also executed. However, recently, many cyber-attacks have been observed on the power system in which activities such as injection of false data, unwanted switching operations, formation of sub-system layers, and false indication of failure of cyber-physical components (CpC) are experienced. In the worst case, it leads to invite cascade tripping of the power system. Utmost care is taken for the selection of CpC for the power system. However, it is observed that the cyber attackers mostly take entry into the network using the CpC of the power system. Cyber attackers perform false switching operations and false data injection. This article suggests a cyber security concept to minimize the false switching operations and false data injection in the power system network. A hardware model is prepared and the working scheme is implemented using IoT technology. The hardware result suggests that the un-authentic attempt/cyber-attack has been identified and the alarm is generated. It also does not permit the un-authentic person to access the real-time data. A wide range of applicability of the suggested scheme has been verified by hardware results. In addition to this, the power factor correction algorithm also works satisfactorily in the hardware along with the cyber security constraints. In order to prove wide range of applicability of the suggested scheme, additional features such as controlling of multiple switching devices and interlock between CB and earthing switch has been successfully implemented in developed hardware.

Rich dynamics of a hepatitis C virus infection model with logistic proliferation and time delays

AbstractIn this paper, we study a dynamic model of hepatitis C virus (HCV) infection with density‐dependent proliferation of uninfected and infected hepatocytes and two time delays, which is derived from a three‐dimensional model by the quasi‐steady‐state approximation. The model can exhibit forward bifurcation or backward bifurcation, and an explicit control threshold parameter is obtained for the case of backward bifurcation. It is shown that if the proliferation rate of infected hepatocytes is greater than the proliferation rate of uninfected hepatocytes by a certain amount, it becomes more difficult for the virus to be removed. The model has rich dynamical properties: (i) In some parameter regions, bistability can occur; (ii) both time delays (virus‐to‐cell delay) and (cell‐to‐cell delay) can lead to Hopf bifurcations; (iii) same length of time delays and can lead to at most one stability switch, but different time delays can lead to multiple stability switches. Several sufficient conditions for the global stability of the disease‐free equilibrium and the endemic equilibrium are obtained for both forward and backward bifurcation scenarios. In particular, several sharp results on global stability are obtained. Theoretical and numerical results portray the complexity of viral evolutionary dynamics in chronic HCV‐infected patients.

Should I stay or should I go again: Multiple switching between fee-for-service Medicare and Medicare advantage among older beneficiaries.

To evaluate whether having previously disenrolled from Medicare Advantage (MA) is associated with lower hazards of future MA enrollment. Secondary data from Medicare. We examined beneficiaries with baseline FFS enrollment from 2017-2019 using a 20% sample of Medicare claims. Cox proportional hazard models were used to examine the association of prior MA enrollment (in the three years prior to baseline FFS enrollment) with MA re-enrollment, and whether this association is modified by Alzheimer's Disease and Related Dementias (ADRD), prior nursing home use, chronic illness, dual eligible status, and availability of MA plans and quality. Not applicable. Overall, 3.3% of beneficiaries switched to MA annually. Of those with prior MA enrollment, MA switching percentages were 9.0%, 4.6%, and 6.8% for those whose most recent MA enrollments were 1, 2, and 3 years prior to their baseline FFS year. Comparatively, the switching percentages was 3.2% for those with no prior MA enrollment. The hazards of switching to MA were 2.73 (p < 0.001), 1.29 (p < 0.001), and 1.97 (p < 0.001) times greater than remaining in FFS for beneficiaries whose most recent MA enrollments were one, two, and three years prior to their baseline FFS year. Hazards of switching were generally similar between those with and without ADRD, stratified by recency in prior MA experience, except those with dual eligibility. Among those with ADRD, switching hazards were greatest for 3 years prior MA enrollees in counties with the fewest available (HR: 3.84, p < 0.001) and lowest-rated plans (HR: 4.02, p < 0.001). Recency of switching from MA to FFS was the strongest predictor of a FFS-to-MA switch, identifying a population of beneficiaries who multiply switch regardless of health status or MA access. Future health policy considerations should more closely examine the vulnerabilities and long-term outcomes of this population.

Performance Analysis of a Reconfigurable Fault‐Tolerant Converter for Renewable Energy–Based Standalone System

ABSTRACTThis paper proposes a reconfigurable fault‐tolerant multiport converter for a renewable energy–based standalone system. The operation of the proposed converter for various single and multiple switch faults is discussed and verified with the help of a laboratory prototype. Experimental findings showcase the converter's ability to seamlessly connect renewable sources with a DC bus and an energy storage device, ensuring a consistent, regulated power supply despite single or multiple switch faults. Furthermore, a thorough examination of performance metrics including stress, loss, cost, sensitivity, and reliability affirms the effectiveness and resilience of the proposed approach. Comparative analysis solidifies the notion of the converter's superiority, emphasizing its fault tolerance, efficiency, and reliability when contrasted with alternative solutions.

Clinicians' use of Health Information Exchange technologies for medication reconciliation in the U.S. Department of Veterans Affairs: a qualitative analysis.

Medication reconciliation is essential for optimizing medication use. In part to promote effective medication reconciliation, the Department of Veterans Affairs (VA) invested substantial resources in health information exchange (HIE) technologies. The objectives of this qualitative study were to characterize VA clinicians' use of HIE tools for medication reconciliation in their clinical practice and to identify facilitators and barriers. We recruited inpatient and outpatient prescribers (physicians, nurse practitioners, physician assistants) and pharmacists at four geographically distinct VA medical centers for observations and interviews. Participants were observed as they interacted with HIE or medication reconciliation tools during routine work. Participants were interviewed about clinical decision-making pertaining to medication reconciliation and use of HIE tools, and about barriers and facilitators to use of the tools. Qualitative data were analyzed via inductive and deductive approaches using a priori codes. A total of 63 clinicians participated. Over half (58%) were female, and the mean duration of VA clinical experience was 7 (range 0-32) years. Underlying motivators for clinicians seeking data external to their VA medical center were having new patients, current patients receiving care from an external institution, and clinicians' concerns about possible medication discrepancies among institutions. Facilitators for using HIE software were clinicians' familiarity with the HIE software, clinicians' belief that medication information would be available within HIE, and their confidence in the ability to find HIE medication-related data of interest quickly. Six overarching barriers to HIE software use for medication coordination included visual clutter and information overload within the HIE display; challenges with HIE interface navigation; lack of integration between HIE and other electronic health record interfaces, necessitating multiple logins and application switching; concerns with the dependability of HIE medication information; unfamiliarity with HIE tools; and a lack of HIE data from non-VA facilities. This study is believed to be the first to qualitatively characterize clinicians' HIE use with respect to medication reconciliation. Results inform recommendations to optimize HIE use for medication management activities. We expect that healthcare organizations and software vendors will be able to apply the findings to develop more effective and usable HIE information displays.

Dynamics of a non-local intraspecific competition predator–prey model with memory effect

In the paper, we investigate a diffusive predator–prey model with nonlocal intraspecific prey competition and spatial memory under Neumann boundary conditions. Through stability and bifurcation analysis, we find that the memory-based diffusion coefficient and the spatiotemporal diffusive delay have important effects on the dynamics of the model. By using the spatiotemporal diffusive delay as a bifurcation parameter, the critical values are determined for the stability of the positive constant steady state and the associated Hopf bifurcation. We find that the system may admit no stability switch, one stability switch and multiple stability switches.

Late Paleozoic tectonic switching and metallogenic evolution of the southern Yili arc terrane, NW China

Recognition of tectonic switching is of great significance for understanding the formation and evolution of ancient accretionary orogenic belts and can provide insights into metallogenic evolution. The western Tianshan orogenic belt, which lies within the southern Central Asian Orogenic Belt (CAOB), experienced a prolonged tectono-magmatic evolution during the late Paleozoic in response to evolution of the Paleo-Asian Ocean. The aim of this contribution is to constrain the subduction process and timing of tectonic switching from subduction to collision in southern parts of the western Tianshan. To address this, we present the results of an integrated investigation of whole-rock major and trace element and Sr-Nd-Hf isotope data, together with zircon U-Pb ages for late Paleozoic volcanic rocks from the southern Yili arc terrane of the southern western Tianshan. Based on the temporal-spatial distribution of different compositions of volcanic rocks, three distinct episodes of magmatism have been recognized, including: 1) ∼ 380 – ∼340 Ma, this episode of magmatism has high Ce/Y ratios of basalts and Ho/Yb ratios of felsic rocks, and show large variations in εHf(t) (−9.6 to + 15.6) and εNd(t) (−5.2 to + 5.4) values, which is interpreted to be originated from a mantle source with variable input of slab-derived components incorporated in a trench advance setting; 2) ∼ 340 – ∼320 Ma, this episode of magmatism shows low Ce/Y ratios of basalts and Ho/Yb ratios of felsic rocks, and relatively higher εHf(t) (−3.8 to + 14.6) and εNd(t) (−1.5 to + 5) values, reflecting crust-mantle interactions and likely formation in a back-arc basin environment; 3) ∼ 320 – ∼300 Ma, this episode of magmatism has Ce/Y ratios of basalts and Ho/Yb ratios of felsic rocks, and mostly positive εHf(t) (−1.1 to + 14.5) and εNd(t) (+1.6 to + 8.4) values, suggesting continent–continent collision between the northern Tarim Craton and the southern limb of the Kazakhstan composite continent (i.e., Yili and Chinese Central Tianshan Block). Consistently, the two tectonic switching events (ca. 340 Ma and ca. 320 Ma) were temporally associated with skarn Zn-Pb and orogenic Au mineralization in southern Yili arc terrane, respectively. This study presents an example of multiple tectonic switching and metallogenic evolution in hot accretionary orogens.

Real-world evidence of avatrombopag for the treatment of immune thrombocytopenia intolerant or ineffective to eltrombopag/hetrombopag.

Due to the limited real-world research on the application of avatrombopag (AVA) for immune thrombocytopenia (ITP) in China, we evaluated the effectiveness and safety of AVA in clinical practice. We included 121 adult ITP patients treated with AVA across three medical centres. Based on the reasons for choosing AVA, these patients were divided into eltrombopag (ELT)/hetrombopag (HET) intolerance group (IG), and ELT/HET unresponsive group (UG). Compared with UG, more patients in IG had a history of liver disease and received fewer treatments before AVA. Amongst all patients, 83% had platelet response (≥30 × 109/L) after AVA and 62% achieved complete response (≥100 × 109/L, CR). Sixty-two percent in IG and 56% in UG were able to discontinue more than one concomitant ITP medication. A total of 17 patients underwent multiple switches of thrombopoietin receptor agonists (TPO-RAs), resulting in an 88% platelet response rate. Sixty-three patients discontinued AVA, 27% were due to unaffordability. AVA was well tolerated in most patients. In the ITP population, AVA proved effective and safe, particularly in patients intolerant or unresponsive to ELT/HET. Patients benefited from TPO-RAs switches, particularly those undergoing multiple switches. However, many patients struggled with the long-term financial burden of AVA.

A Wireless‐Driven Electric Responsive Long‐Lived Room Temperature Phosphorescent Switching Device

AbstractLong‐lived room temperature phosphorescent (RTP) materials have prospective applications, but endowing long‐lived RTP materials with on‐off regulation property is challenging. Here, the first electric responsive long‐lived RTP switching device under photoexcitation with a wireless power transmission (WPT) system is demonstrated. It exhibits long persistent phosphorescence (180.1 ms for the film and 180.8 ms for the device) and excellent reversibility (&gt;1000 cycles). Due to the effective dual‐state Förster resonance energy transfer (FRET) process from the triplet and singlet states of the chromophore donor to the singlet state of the dye acceptor, the devices exhibit switching characteristics. The appearance of the dye's absorption can be modulated by electro‐acid based on proton‐coupled electron transfer (PCET) mechanism, resulting in the device being electrically controlled. In addition, by integrating WPT coils outside the device, it can be driven wirelessly, thereby overcoming the reliance on electrical stimulation methods on the power supply. Finally, due to the multiple switching characteristics (color, fluorescence, phosphorescence) of this device, it is successfully applied in anti‐counterfeiting and information encryption.

Expanded gene and taxon sampling of diplomonads shows multiple switches to parasitic and free-living lifestyle

BackgroundDiplomonads are anaerobic flagellates classified within Metamonada. They contain both host-associated commensals and parasites that reside in the intestinal tracts of animals, including humans (e.g., Giardia intestinalis), as well as free-living representatives that inhabit freshwater and marine anoxic sediments (e.g., Hexamita inflata). The evolutionary trajectories within this group are particularly unusual as the free-living taxa appear to be nested within a clade of host-associated species, suggesting a reversal from host-dependence to a secondarily free-living lifestyle. This is thought to be an exceedingly rare event as parasites often lose genes for metabolic pathways that are essential to a free-living life strategy, as they become increasingly reliant on their host for nutrients and metabolites. To revert to a free-living lifestyle would require the reconstruction of numerous metabolic pathways. All previous studies of diplomonad evolution suffered from either low taxon sampling, low gene sampling, or both, especially among free-living diplomonads, which has weakened the phylogenetic resolution and hindered evolutionary insights into this fascinating transition.ResultsWe sequenced transcriptomes from 1 host-associated and 13 free-living diplomonad isolates; expanding the genome scale data sampling for diplomonads by roughly threefold. Phylogenomic analyses clearly show that free-living diplomonads form several branches nested within endobiotic species. Moreover, the phylogenetic distribution of genes related to an endobiotic lifestyle suggest their acquisition at the root of diplomonads, while traces of these genes have been identified in free-living diplomonads as well. Based on these results, we propose an evolutionary scenario of ancestral and derived lifestyle transitions across diplomonads.ConclusionsFree-living taxa form several clades nested within endobiotic taxa in our phylogenomic analyses, implying multiple transitions between free-living and endobiotic lifestyles. The evolutionary history of numerous virulence factors corroborates the inference of an endobiotic ancestry of diplomonads, suggesting that there have been several reversals to a free-living lifestyle. Regaining host independence may have been facilitated by a subset of laterally transferred genes. We conclude that the extant diversity of diplomonads has evolved from a non-specialized endobiont, with some taxa becoming highly specialized parasites, others becoming free-living, and some becoming capable of both free-living and endobiotic lifestyles.

Corvisyringophilus, a New Genus in the Family Syringophilidae (Acariformes: Prostigmata) and Its Phylogenetic Position among Primitive Genera.

Syringophilidae is one of the most species-rich families in the superfamily Cheyletoidea, comprising approximately 420 species across 62 genera and two subfamilies. In this paper, we propose a new genus, Corvisyringophilus, and a new species, C. krummi gen. n. et sp. n., found in the wing covert quills of the Common Raven, Corvus corax Linnaeus, in Iceland. Corvisyringophilus is placed among the primitive genera of syringophilid mites, which possess the full complement of idiosomal and leg setae. Phylogenetic analysis based on morphological characters suggests that this genus forms a sister clade to Blaszakia Skoracki & Sikora, 2008, and Charadriphilus Bochkov & Mironov, 1998, which inhabit birds of the orders Musophagiformes and Charadriiformes, respectively. The study proposes that the current distribution patterns of quill mites, based on their morphological characteristics, may result from multiple host switching followed by co-speciation events, highlighting the complex evolutionary dynamics within this family.

Geography and ecology structure diversification in Ziziphus Mill. (Rhamnaceae)

Understanding the processes responsible for creating and preserving biodiversity within tropical ecosystems is essential for gaining deeper insights into the history, dynamics, and resilience of these environments. We investigated the biogeography and evolution of Ziziphus Mill. (Rhamnaceae), a genus of c.50 species found in all major tropical biomes and across Africa, Asia and Australasia to evaluate how ecology and geography structures its diversification, and their associations with functional traits. We used consistency and retention indices, as well as the delta statistic to test for phylogenetic signal in ecology, geography and functional traits. We constructed a time-calibrated phylogeny using BEAST, followed by the reconstruction of biome and geographical affinities in BioGeoBEARS, and ancestral functional trait evolution using phytools and ape. At a global scale, geography structures Ziziphus’ diversification more than ecology, as evidenced by higher phylogenetic signal in retention indices and the delta statistic. Multiple ecological switches among biomes are associated with dispersal events, which structure Ziziphus’ diversification at smaller scales. Biogeographic estimation suggests that Ziziphus evolved out of closed biomes in Asia during the Oligocene. Long distance dispersal from Asia to Africa resulted in the occupation of two novel biomes, the expanding tropical grassy biome and the desertic biome. Geographic transitions across continents that retain the same biome are fewer but are demonstrated by a dispersal from the closed biome in Asia to the same ecological setting in Australia. In keeping with the younger age of the savanna biome and the Pliocene radiation of geoxylic species, the youngest species in Ziziphus are mostly found in open biomes, and the youngest habit is geoxylic. Leaf hair appears to confer advantages across biomes whilst being a synapomorphy for open and desertic clades. One of two evolutions back into closed biomes is associated with the development of the liana habit. We inferred the most complete phylogeny for Ziziphus to date. Ziziphus originated in closed biomes in Asia in the Oligocene. At a global scale, geography structures diversification more than ecology (biome preference) in Ziziphus. Biome shifts are frequently associated with long distance dispersal events. Shifts in growth form are frequently associated with biome shifts.

Investigating When Patients With Multiple Sclerosis Should Switch From a Low- or Moderate-Efficacy Therapy to a High-Efficacy Treatment.

Investigating When Patients With Multiple Sclerosis Should Switch From a Low- or Moderate-Efficacy Therapy to a High-Efficacy Treatment.

Ultra-low-energy operation of electromagnetic bi-stable actuator under restricted energy supply

During the periodic drug administration for chronic diseases, unexpected battery depletion can be significantly problematic for the patients. While body heat harvesting utilizing the wearable thermoelectric generator (WTEG) shows the significant potential in continuous drug delivery systems (DDSs) by providing ceaseless power source, the power and the voltage output might not be sufficient to drive micropump actuators in such drug delivery systems. The continuous actuating current also imposes an additional challenge in developing efficient and compact voltage boosting circuits. In this paper, we propose an ultra-low-energy operating method of the WTEG-powered electromagnetic micropump system. In combination with our electromagnetic bi-stable actuator (EBA) where the energy demand is discretized, we present (1) the dedicated high-efficient charge pumps (CPs) (2) and the actuating pulse control method to prevent redundant energy waste. The proposed 10-stage charge pump is designed to reduce the conversion loss by utilizing multiple flying-capacitor switching structure, and the 2-stage series–parallel charge pump (SPCP) is fabricated with flexible thin-film super-capacitors (TFSCs) to realize the high boosting performance within compact and wearable features. Applying the proposed control method with the 10-stage CP in our WTEG-powered micropump system, we significantly reduce the charging time per actuation by 88.8% compared to the commercial boosting circuit. Also, the 2-stage SPCP achieves 84.0% reduction in the charging time while utilizing flexible and wearable features, showing a significant potential for self-powered wearable healthcare applications.

Multiple Chirality Switching of a Dye‐Grafted Helical Polymer Film Driven by Acid &amp; Base

AbstractA stimuli‐responsive multiple chirality switching material, which can regulate opposed chiral absorption characteristics, has great application value in the fields of optical modulation, information storage and encryption, etc. However, due to the rareness of effective functional systems and the complexity of material structures, developing this type of material remains an insurmountable challenge. Herein, a smart polymer film with multiple chirality inversion properties was fabricated efficiently based on a newly‐designed acid &amp; base‐sensitive dye‐grafted helical polymer. Benefited from the cooperative effects of various weak interactions (hydrogen bonds, electrostatic interaction, etc.) under the aggregated state, this polymer film exhibited a promising acid &amp; base‐driven multiple chirality inversion property containing record switchable chiral states (up to five while the solution showed three‐state switching) and good reversibility. The creative exploration of such a multiple chirality switching material can not only promote the application progress of current chiroptical regulation technology, but also provide a significant guidance for the design and synthesis of future smart chiroptical switching materials and devices.