Multiple Stimuli-responsiveness Research Articles

Lantern-Shaped Structure Induced by Racemic Ligands in Red-Light-Emitting Metal Halide with Near 100 % Quantum Yield and Multiple-Stimulus Response.

Organic-inorganic metal halides (OIMHs) have become a research hotspot in recent years due to their excellent luminescent properties and tunable emission wavelengths. However, the development of efficient red-light-emitting OIMHs remains a significant challenge. This work reports three Mn-based OIMHs derived from 1-methyl-1,2,3,4-tetrahydroisoquinoline hydrobromide: racemic one (Rac-TBM) and chiral ones (R-TBM and S-TBM). As a result of the synergism of chiral organic ligands inducing a unique lantern-shaped hybrid structure containing both tetrahedra and octahedra, Rac-TBM exhibits red-light emission with near-unity luminescence quantum yield. In comparison, the chiral counterparts R/S-TBM display strong green emission and circularly polarized luminescence (CPL) with a glum value up to ±2.5×10-2. Interestingly, a mixture of R- and S-TBM can transform into Rac-TBM, successfully achieving a sensitive and reversible switch between red light of octahedra and green light of tetrahedra under external stimuli. The outstanding luminescent properties allow Rac-TBM to be utilized not only for X-ray radioluminescence with a detection limit down to 46.29 nGys-1, but also for advanced information encryption systems to achieve leak-proof decryption.

Polymorphic Supramolecular Therapeutic Platforms with Precise Dye/Drug Ratio to Perform Synergistic Chemo-Photo Anti-Tumor Therapy and Long-Term Immune Protection.

Malignant tumor has become one of the hellish killers threatening the health of people around the world, its diagnosis and treatment has become the concerns of public. However, the optimal therapeutic dose, undesired side-effect, and long-term immune activation werekey and bottleneck problems in tumor treatment. Herein, different batches of supramolecular therapeutic platforms, including vesicles, spherical nanoparticles, and cylindrical nanorods, with precise ratios of dye to drug (1:2) and multiple stimulus responsiveness wereconstructed by host-guest complexation between cyanine-camptothecin conjugates (IR780-CPT2) and β-cyclodextrin (β-CD) pendent hydrophilic copolymers. The reduction responsiveness, near-infrared photothermal conversion and singlet oxygen (1O2) generation performances endowed these platforms excellent cancer cells killing effect in both of in vitro cellular experiments and in vivo mice models. More importantly, without affecting the weight of mice, the maturation of dendritic cells, proliferation of T cells, up-regulation of high mobility group protein B1, and reduction of immunosuppressive regulatory T cells weredetected after employing a synergistic chemo-photo therapy, demonstrating the body's immune effect was successfully activated. Thus, during the treatment of primary tumor, the distal tumor was also inhibited. Webelieve this work could provide a distinctive way to fabricate supramolecular theranostic platforms with different morphologies and improve antitumor and antimetastasis capabilities.

Being Smarter, Azobenzene-Containing Biomaterial Showing Triple Stimuli-Responsive Phase Change Property to Light, Humidity and Force at Room Temperature.

Multiple stimuli-responsiveness is an attractive property that is studied in physical chemistry and materials chemistry. While, multiple stimuli-responsive phase change in an isothermal way is rarely addressed for functional materials at room temperature. In this study, one azobenzene-containing surfactant AZO is designed for the fabrication of triple stimuli-responsive phase change biomaterial (Alg-AZO) through the electrostatic complexation with natural alginate. Thanks to the photoisomerization ability, molecular flexibility and hydrophilicity of AZO, together with the tailoring effect of alginate on AZO, Alg-AZO could perform reversible isothermal phase transition between liquid crystalline and isotropic liquid states under the stimuli of either light or humidity at room temperature. Furthermore, the humidity-induced isotropic state can also fast transit to ordered state under shear force, owing to the π-π interactions between planar trans-AZO in Alg-AZO material. With good biocompatibility, self-healing property and in vivo wound healing promoting capacity that is promoted by light, humidity and force, Alg-AZO would be suitable for working as a new smart biomaterial in biological and biomedical areas. This work provides a designing strategy for gaining multiple stimuli-responsive smart materials based on biomacromolecules, and also opening a new opportunity for gaining self-healing biomaterials capable of working in various conditions.

Fabrication of multi-responsive dynamic poly(ethylene glycol)-iron oxide nanoparticle nanocomposite hydrogels through interfacial boronate-catechol crosslinking

Poly(ethylene glycol) (PEG)-based nanocomposite (NC) hydrogel with multiple advantageous properties such as high mechanical strength and stimuli-responsiveness have been demonstrated as promising materials across various fields. Here, an innovative type of PEG-based NC hydrogels is fabricated using phenylboronic acid-polyethyleneimine (PBA-PEI)-functionalized iron oxide nanoparticles (PP-IOPs) to crosslink the dopamine-modified 4arm-PEG (DA-4APEG) through boronate-catechol crosslinking. DA-4APEG/PP-IOP NC hydrogels exhibit tunable microstructures (i.e., pore size) and properties (i.e., rheological, mechanical, and swelling behaviors) by changing the number of PP-IOPs in the hydrogel network. With the dynamic crosslinks and magnetic nanoparticles in the network, DA-4APEG/PP-IOP NC hydrogels are self-healable and also responsive to various stimuli, including temperature, pH, glucose, dopamine, hydrogen peroxide, magnetic field, and near-infrared light. Therefore, a versatile PEG-based hydrogel platform has been developed, featuring customizable properties, multiple stimuli-responsiveness, and dynamic characteristics, making it suitable for advanced applications.

Multiple Stimulus Response Material Based on Sr-tcbpe MOF for Mechanochromism, Visualization Labeling, and Etching Toward TNP.

The abuse and excessive discharge of organic pollutants such as nitroaromatic compounds (NACs) have become a hot topic of concern for all humanity and society, and the development of fast, effective, and targeted technical means for detecting NACs also faces many challenges. Here, we reported a strontium-based metal-organic framework (MOF) {[Sr2(tcbpe)(H2O)4]}n (Sr-tcbpe), in which tcbpe represents deprotonated 4',4‴,4″‴,4‴‴-(ethene-1,1,2,2-tetrayl)tetrakis(([1,1'biphenyl]-4-carboxylic acid)). In Sr-tcbpe, Sr-O polyhedron and deprotonated tcbpe4- ligand have a staggered connection to form a self-assembled three-dimensional network structure. In addition, it is found that Sr-tcbpe undergoes no luminescent color change when grinding under solvent protection, while mechanochromic fluorescence behavior is observed when grinding directly, leading to luminescent color changes from cyan to green (Sr-tcbpe-G). Additionally, Sr-tcbpe and Sr-tcbpe-G could selectively detect PNP, DNP, and TNP, and Sr-tcbpe achieves visual fluorescence sensing detection toward TNP at a limit of detection as low as 2.25 μM. Moreover, during the detection process, unexpectedly, TNP exhibits a selective etching effect on Sr-tcbpe, which could drill nano holes with different sizes on the surface area of MOF materials to a certain extent, achieving the conversion of chemical energy to mechanical energy. In addition, the successful preparation of a portable sensor Sr-tcbpe@gypsum block provides a platform for the perfect combination of mechanochromic fluorescence behavior and visualization detection toward TNP. It lays the foundation for the practical application of MOF materials in daily life.

Temperature-Switching Flexible Strain Sensors Based on Vanadium Dioxide for Intelligent Packaging Applications.

Flexible sensors are promising for intelligent packaging and artificial intelligence, but the required multistimulus response is still a challenge in external environments. A candidate material for such multistimulus response is VO2 due to its unique semiconducting properties. Herein, W-doped VO2(M) with a tunable phase transition temperature was prepared by the hydrothermal method, and then, VO2(M)-based flexible sensors were fabricated employing a direct-write strategy, where conductive inks with VO2(M) powders were patterned onto various substrates. These sensors achieve dual responses to temperature and strain and exhibit high stability (over 2000 stretch-release cycles) to accurately monitor various statuses (opening and closing, temperature changes, etc.) of intelligent packaging. The spatial pressure distribution of different objects was discerned by the prepared VO2(M)/poly(dimethylsiloxane) (PDMS) sponge flexible pressure sensor arrays, and the information was successfully edited using the Morse code. The sensing signals from the intelligent packaging were collected and remotely transmitted to intelligent terminals via a wireless local-area network to achieve real-time monitoring of the packaged contents. Therefore, in this work, we not only designed new flexible sensors with multiple stimulus responses but also demonstrated the potential applications of W-doped VO2(M)-based flexible sensors in intelligent packaging.

A smart L‐alanine modified Cd‐NDI metal‐organic framework crystalline material: Photochromic properties and photocatalytic degradation dye applications

1, 4, 5, 8‐naphthalene diimide (NDI)‐based MOFs, due to their tunable structures and properties, have shown promising applications in photochromism, photocatalysis, electrocatalysis, photothermal therapy, etc. Herein, using an L‐alanine modified NDI ligand, i.e. N, N′‐bis(L‐alanine)naphthalenediimide (AlaNDI), a novel Cd‐NDI Cd (AlaNDI)(H2O)]·DMF·H2O (complex 1) was constructed under solvothermal conditions, which has an obvious different structure with the previously reported ones. Structural analysis shows that the packing structure of complex 1 consists of two adjacent Cd atoms sharing two AlaNDI ligands, forming a dimetallic building block [Cd2O8]. Each building block connects a total of four AlaNDI ligands, where two Cd atoms are bridged by two ligands. The building blocks are interconnected by ligands to form a two‐dimensional layered structure. Based on the features of the NDI skeleton, it was found that complex 1 possesses multiple stimulus responses involving sensitivity to light: a reversible photochromism property and good photocatalytic degradation activity against various dyes, especially against cationic dyes crystal violet (CV), methyl violet (MV), and Janus green B (JGB). In addition, the stimulus‐response mechanism was investigated by control experiments. It is revealed that the photocatalytic active species may be related to h+ and •OH.

Healable and multi driving mode soft actuator enabled by disulfide-bonded liquid crystal elastomers

Due to the great potential in many applications, multi-responsive soft actuators as a kind of smart materials have attracted great interest from the scientific community. Liquid crystal elastomers (LCEs) are gradually becoming their preferred candidate matrix because of their unique mesogenic anisotropy and polymer elasticity. Here, we designed and synthesized a new disulfide-bonded aromatic molecule (named DSAC), which was used to endow the LCE matrix with a self-healing effect to extend the service life. The large conjugate structure greatly reduces the bond energy of the disulfide bond, thus allowing self-healing to occur at a lower temperature. Furthermore, the LCE matrix was coated with a novel type of functional layer with photothermal and conductive properties to make it be driven by multi-modes. Based on the above, we have prepared a healable and dual-driving mode soft actuator enabled by disulfide-bonded liquid crystal elastomers with multiple stimulus–response properties, which shows great potential in flexible electronics, artificial muscles and soft robots.

Multistimuli-responsive tetraphenylethene molecular switches displaying acid-sensing, photochromism, and metal ion detection properties

Aggregation-induced emission (AIE) smart materials with multiple stimulus responses have a wide range of applications. Here, a series of tetraphenylethylene (TPE) derivatives, TPEN1S3, TPEN2S2, TPEN3S1 were synthesized. The sensitivity of molecules to pH, UV light, and metal ions could be effectively tuned by modulating the ratio of amino to sulfonic acid groups. These TPE derivatives exhibited yellow emissions in aggregated state due to the AIE characteristics. Acidification conversion of the NH2 groups to NH3+ for three molecules induced the suppression of intramolecular charge transfer (ICT), which resulted in a 72–102 nm blue shift in the fluorescence emission. Solid powders of these compounds exhibited reversible protonation-deprotonation process induced by HCl/NH3·H2O vapor. TPEN1S3, TPEN2S2 and TPEN3S1 in solution could be photoactivated and emit blue fluorescence (ca. 482 nm, 475 nm, and 480 nm). Photocyclo-dehydrogenation reactions of compounds were triggered by the UV irradiation and the maximum cyclization ratios could reach 12%, 66%, and 50%, respectively. Protonation of NH2 group significantly enhanced the rate of the photocyclo-dehydrogenation reaction. Furthermore, the solid powders of protonated compounds displayed pronounced reversible photochromic properties due to the generation of cyclization intermediate. In addition, TPEN1S3, TPEN2S2, and TPEN3S1 exhibited responsiveness to a diverse range of metal ions. Specifically, the TPEN2S2 molecule functioned as a photo sensor for Li + ions with a blue shift in fluorescence emission. The limit of detection (LOD) value was 0.679 μM. These multiple stimuli-responsive AIE molecules hold significant potential for use in advanced photo-controlled patterning, encryption applications, and the detection of metal ions.

Anti-freezing and moisturizing PAA/PEDOT: PSS ionogels with multiple stimulus responses for flexible wearable electronics

Hydrogel is a promising material for wearable electronics due to its good mechanical properties, electrical conductivity and body adaptability. However, subzero freezing and water loss under high temperature or prolonged placement are great challenges for hydrogels. Here, polyacrylic acid / poly (3,4-ethylenedioxythiophene): poly (styrene sulfonate) (PAA/PEDOT: PSS) ionogels were designed by entangling PAA and PEDOT: PSS chains with each other in a binary solvent system of water and ionic liquid (IL) and chemical cross-linking by N, N’-methylene bisacrylamide (MBA). It has excellent mechanical properties (8.3 kPa, > 500 %), skin-adapted Young's modulus (<10 kPa), high conductivity (8.06 S·m−1), and strong adhesion (13.3 kPa). Ionogel has a sensitive response as a sensor (GF = 2.08, 0–200 %; GF = 3.64, 200–400 %; GF = 4.58, 400–510 %). Especially, the freeze-resistance and long-term moisturizing properties make ionogels exhibit long-lasting and robust utility. As a scalable application platform, we demonstrate the potential applications of this novel ionogel as a body-conformable electronic product in a series of conceptual demonstrations, including full range of human motion response, human–machine interaction (HMI), temperature signal detection and TENG device assembly.

Multi-responsive novel phosphamide organogels dominated by a natural diterpene rigid backbone

Functional supramolecular organogels with unique properties and morphology can be obtained by designing gelators’s chemical structure. Rosin, an important natural renewable diterpene resource, consists of a rigid ring skeleton and chiral structure similar to triterpenoids and has excellent self-assembly ability in solution. In this paper, four novel rosin-based derivatives were proposed and synthesized in one step by introducing phosphamide groups by using natural rosin as raw material. They could form eleven types of monoamide and diamide organogels in specific solvents. The minimum gelatinization concentration is 50–180 mg/mL. In particular, by adjusting the number and type of phosphamide groups and rigid structures, the morphology and other properties of the gel could be modulated. Two-dimension lamellar and three-dimensional fiber network organogels were obtained and the hydrogen bond and π–π stack were proved to be the most important driving forces for the gelation. What is particularly important is that the gels exhibited multiple stimulus responsiveness, such as temperature, acid-base and anions. Thus, the four dehydroabietylamine phosphamide gelators synthesized by the one-step method provide new ways of designing novel gel-based soft materials for intelligent response, ion detection, etc.

Tailoring raloxifene into single-component molecular crystals possessing multilevel stimuli-responsive room-temperature phosphorescence

Simultaneously achieving room-temperature phosphorescence (RTP) and multiple-stimuli responsiveness in a single-component system is of significance but remains challenging. Crystallization has been recognized to be a workable strategy to fulfill the above task. However, how the molecular packing mode affects the intersystem crossing and RTP lifetime concurrently remains unclear so far. Herein, four economic small-molecular compounds, analogues of the famous drug raloxifene (RALO), are facilely synthesized and further explored as neat single-component and stimuli-responsive RTP emitters via crystallization engineering. Thanks to their simple structures and high ease to crystallize, these raloxifene analogues function as models to clarify the important role of molecular packing in the RTP and stimuli-responsiveness properties. Thorough combination of the single-crystal structure analysis and theoretical calculations clearly manifests that the tight antiparallel molecular packing mode is the key point to their RTP behaviors. Interestingly, harnessing the controllable and reversible phase transitions of the two polymorphs of RALO-OAc driven by mechanical force, solvent vapor, and heat, a single-component multilevel stimuli-responsive platform with tunable emission color is established and further exploited for optical information encryption. This work would shed light on the rational design of multi-stimuli responsive RTP systems based on single-component organics.

Self-Healing Hydrogel Bioelectronics.

Hydrogels have emerged as powerful building blocks to develop various soft bioelectronics because of their tissue-like mechanical properties, superior bio-compatibility, the ability to conduct both electrons and ions, and multiple stimuli-responsiveness. However, hydrogels are vulnerable to mechanical damage, which limits their usage in developing durable hydrogel-based bioelectronics. Self-healing hydrogels aim to endow bioelectronics with the property of repairing specific functions after mechanical failure, thus improving their durability, reliability, and longevity. This review discusses recent advances in self-healing hydrogels, from the self-healing mechanisms, material chemistry, and strategies for multiple properties improvement of hydrogel materials, to the design, fabrication, and applications of various hydrogel-based bioelectronics, including wearable physical and biochemical sensors, supercapacitors, flexible display devices, triboelectric nanogenerators (TENGs), implantable bioelectronics, etc. Furthermore, the persisting challenges hampering the development of self-healing hydrogel bioelectronics and their prospects are proposed. This review is expected to expedite the research and applications of self-healing hydrogels for various self-healing bioelectronics.

Preparation and application of the thermo-/pH−/ ion-sensitive semi-IPN hydrogel based on chitosan

Chitosan based hydrogels with multiple stimulus responses have broad application prospects in many fields. Considering the advantages of semi interpenetrating network (IPN) technology and the special temperature and ion responsiveness of polymers containing zwitterionic groups, a semi-IPN hydrogel was prepared through in situ free radical polymerization of N,N-dimethyl acrylamide and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide with polyethylene glycol dimethacrylate as a crosslinker and carboxymethyl chitosan as filler. The gel mass fraction and swelling ratio were measured, and the preparation conditions were optimized. The result indicated that the hydrogel possessed a unique thermo-/pH−/ ion-sensitive behavior. The swelling ratio increased with the increase of temperature and ion concentration, and showed a decreasing trend with the increase in pH. In addition, the hydrogel was stable when the stimuli changed. Adsorption behavior of the hydrogel to Eosin Y (EY) was systematically investigated. The adsorption process can be described well by the pseudo-second-order kinetic model and Langmuir isotherm model, indicating that it was a chemical adsorption. The experiments indicated that the hydrogel exhibited good antifouling and reusability features. Therefore, the semi-IPN hydrogel with antifouling properties and thermo-/pH−/ion-sensitivity can be easily manufactured is expected to find applications in water treatment fields.

A Smart Single-Fluorophore Polymer: Self-Assembly Shapechromic Multicolor Fluorescence and Erasable Ink.

A novel smart fluorescent polymer polyethyleneimine-grafted pyrene (PGP) is developed by incorporating four stimuli-triggers at molecular level. The triggers are amphiphilicity, supramolecular host-guest sites, pyrene fluorescence indicator, and reversible chelation sites. PGP exhibits smart deformation and shape-dependent fluorescence in response to external stimuli. It can deform into three typical shapes with a characteristic fluorescence color, namely, spherical core-shell micelles of cyan-green fluorescence, standard rectangular nanosheets of yellow fluorescence, and irregular branches of deep-blue fluorescence. A quasi-reversible deformation between the first two shapes can be dynamically manipulated. Moreover, driven by reversible coordination and the resulting intramolecular photoinduced electron transfer, PGP can be used as an aqueous fluorescence ink with erasable and recoverable properties. The fluorescent patterns printed by PGP ink on paper can be rapidly erased and recovered by simple spraying a sequence of Cu2+ and ethylene diamine tetraacetic acid aqueous solutions. This erase/recover transformation can be repeated multiple times on the same paper. The multiple stimulus responsiveness of PGP makes it have potential applications in nanorobots, sensing, information encryption, and anticounterfeiting.

Bio-inspired dual-responsive photonic crystal with smart responsive hydrogel for pH and temperature detection

Responsive photonic crystals (PCs) with bio-inspired microstructures and tailorable functionalities are of critical importance for their potential applications in diverse fields such as biological detection, sensing, decoration, anti-counterfeiting, etc. However, limited by preparation technologies and design theories, it is still a challenge to accurately and uniformly deposit smart responsive materials on natural PC structures and achieve dual stimulus response. Herein, a simple and rapid in situ polymerization method is presented for preparing dual-responsive PCs with ultra-precise micro-/nanoscale hierarchical structures. Exposure of the reaction site by deacetylation of Morpho butterfly wings allows in situ polymerisation of poly (N-isopropylacrylamide-co-acrylic acid) (P(NIPAAM-co-AAc)) on the surface of the natural photonic structure. The obtained P(NIPAAM-co-AAc) photonic crystals (P(NIPAAM-co-AAc)-PCs) exhibited a dual response to pH and temperature reversibility. In addition, the synergistic effect of the structures and materials on the optical response of the natural PCs is revealed. This work allows the combination of natural hierarchical PC structures with smart hydrogel to achieve an optical response to pH and temperature, thus opening up the channels for responsive PC to multiple stimulus responses.

A smart low-molecular-mass naphthalene-pyrazoline gelator: Gelation behavior and selective fluorescent detection Cu2+

A smart low-molecular-mass organic gelator based on naphthalene-pyrazoline has been designed and synthesized. The gelator G can form a thermo reversible stable gel in tert-butanol, cyclohexane, cyclohexanol, and DMSO through self-assembly, it emits blue and yellow-green fluorescence under ultraviolet radiation. Notably, it has multiple stimulus responses of light, heat, shock and ion. In addition, it could act as an efficient fluorescent probe for the selective sensing of Cu2+ in the solution containing water. The detection limit of Cu2+ in THF deionized aqueous solution (V:V = 9:1) is 5.65 × 10−8 M. The complex ratio of G to Cu2+ is 1:1. In addition, the G has good biocompatibility in living cells.

Multiple-stimuli response composite hydrogels with high mechanical property and triple shape memory effect

Shape memory hydrogels are widely used in soft robots and other fields. However, it is difficult to realize multiple-shape memory hydrogels with high strength and simple driving modes. The mechanical properties of a hydrogel were improved in this study through the creation of a double network hydrogel using a combination of gelatin and PAAm. Additionally, hydrogen bonding was introduced into the structure of the hydrogel through the incorporation of acryl 11-aminodecanoic acid (A11AUA). The helical structure of gelatin and the semi-crystalline segment of A11AUA provide enabling the hydrogels to realize a triple shape memory effect at different temperatures. In addition, we found that the hydrogel could also complete shape memory behavior in the FeCl3 solution due to the carboxyl group in A11AUA. And we prepared composite hydrogel to realize remote infrared driving by introducing nano Fe3O4. We believe that this triple-shape memory hydrogel with high mechanical property and multiple stimulus responses can expand the application of hydrogel in soft robots, sensors, and other fields.

Preparation and characterization of thermal/NIR/magnetically actuated hydrogel based on asymmetric structure

In recent years, hydrogel actuators have been widely used in various types of intelligent devices due to their unique stimulus responsiveness (such as temperature, near-infrared (NIR) light, and pH). Herein, a thermal/NIR/magnetically actuated hydrogel based on asymmetric structure was constructed. Iron oxide nanoparticles (Fe3O4 NPs) were loaded onto graphene oxide (GO) to firstly prepare magnetic GO (mGO) with high photothermal conversion ability and magnetic property. Then they were introduced into the PNIPAM hydrogel with the assistance of magnetic field in the polymerization process to obtain the gradient distribution of mGO in the hydrogel. The prepared mGO/PNIPAM hydrogel exhibited fast bending behaviors in different stimulus environments as well as good reversible cycling performance. Thus, the mGO/PNIPAM hydrogel actuator was successfully used as intelligent devices such as NIR switch for controlling circuit, temperature and NIR light-actuated petals, magnetic-actuated starfish, and triple-actuated bionic octopus. This work provides a new strategy for the construction and preparation of multiple stimuli-responsiveness hydrogel actuators.

Ultralong organic room-temperature phosphorescence, multiple stimulus responsiveness and high-level anti-counterfeiting based on multifunctional carbazolyl imidazolopyridine

Ultralong organic room-temperature phosphorescence materials induced by host−guest doping and the underlying mechanism have become the current research focus. Furthermore, high-level anti-counterfeiting and information encryption require multifunctional luminescent materials. Here, CzIP and L-CzIP with push−pull electronic system are successfully constructed by imidazopyridine units and commercial/self-made carbazole. The comparison experiment results indicate that trace isomer doping not only shows slight influence on crystal stacking and molecular space conformation but also significantly changes fluorescence and phosphorescence spectra and phosphorescence lifetime by boosting intersystem spin–orbit coupling. Non-radiative relaxation of CzIP and L-CzIP can be effectively inhibited by polymethyl methacrylate (PMMA) doping but not for crystallize. PMMA doping further confirms intrinsic phosphorescent characteristic of L-CzIP, whose room-temperature phosphorescence lifetime (84.83 ms) is close to that of CzIP (100.14 ms). Concentration-dependent fluorescent and phosphorescent emission and dynamic phosphorescent emission are also observed for CzIP in PMMA film. More importantly, a new aminopyridine/CzIP-doped system gives room-temperature phosphorescence lifetimes of 657.56 ms and afterglow lifetimes of 4 s. Notably, CzIP also shows high-contrast mechanochromism, selective response and differentiation to HCl, CF3COOH, and CH3COOH, and excellent detection capability to picric acid in aqueous medium and solid state. Finally, various anti-counterfeiting and encryption patterns are successfully constructed based on multifunction of CzIP. This work not only provides a multifunctional luminous material but also more importantly provides a theoretical basis and experimental guidance for designing novel ultralong organic room-temperature phosphorescence materials and achieving high-level anti-counterfeiting and encryption.