Multi-signatures (MS) are a special type of public-key signature (PKS) in which multiple signers participate cooperatively to generate a signature for a single message. Recently, applications that use an MS scheme to strengthen the security of blockchain wallets or to strengthen the security of blockchain consensus protocols are attracting a lot of attention. In this paper, we propose an efficient two-round MS scheme based on Okamoto signatures rather than Schnorr signatures. To this end, we first propose a new PKS scheme by modifying the Okamoto signature scheme and prove the unforgeability of our PKS scheme under the discrete logarithm assumption in the algebraic group model (AGM) and the non-programmable random oracle model (ROM). Next, we propose a two-round MS scheme based on the new PKS scheme and prove the unforgeability of our MS scheme under the discrete logarithm assumption in the AGM and the non-programmable ROM. Our MS scheme is the first one to prove security among two-round MS based on Okamoto signatures.