Multiple Repercussions Research Articles

The Unseen Effects: Assessing Zia's Socio-Economic Policies in Pakistan

Most of Pakistani society is segregated by ethnicity and driven by sectarian warfare. The problem harms society economically, politically, and socially. Pakistan is plagued by religious extremism. The issue has become the toughest. Pakistani Islam was deeply ingrained, but power politics, radical militarization, and political use of Islam fostered its militant expression. Zia-ul-Haq radicalized Pakistani society to build his dictatorial dictatorship. This study investigates the multiple repercussions of Zia ul Haq's socio-economic and political developments in Pakistan, focusing on Islamization. Nizam-i-Mustafa, Shariah legislation, and the Federal Shariah Court's role in reconciling Pakistan's diverse populace are examined in the study. The paper explores how these measures affect women, ethnic groups, and the judiciary. Zia's economic initiatives, including interest-free banking, Zakat, and Ushr Ordinance, are examined for Islamicity and economic impact. The study also explores political effects, highlighting public discontent in sectarian violence-affected areas. It also investigates how extremism claims have affected Pakistan's global standing. The study illuminates how religion and politics affected Pakistan's socio-political climate during Zia ul Haq.

Impact of dysexecutive syndrome in quality of life in Alzheimer disease: What we know now and where we are headed.

Alzheimer's disease (AD) is a common form of dementia that leads to multiple repercussions in the patient's life. This condition's clinical characteristics include loss of memory, temporal and spatial disorientation, language or executive dysfunction, and subsequent decline of social function. Dysexecutive syndrome (DS), the second most frequent neuropsychological dysfunction in AD, affects multiple brain areas and causes cognitive, behavioral, and emotional difficulties. We aimed to analyze the association between DS and AD and elucidate possible lack of evidence that may urge further research on this theme. Especially when dealing with such a disabling disease, where new findings can directly imply a better prognosis.

Resumen ejecutivo – Diagnóstico, tratamiento y profilaxis de la infección por virus de la Gripe – Documento de Consenso de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC), la Sociedad Española de Infectología Pediátrica (SEIP), la Asociación Española de Vacunología (AEV), la Sociedad Española de Medicina de Familia y Comunitaria (SEMFYC) y la Sociedad Española de Medicina Preventiva,

The influenza virus has accompanied humans since time immemorial, in the form of annual epidemics and occasional pandemics. It is a respiratory infection with multiple repercussions on people's lives at an individual and social level, as well as representing a significant burden on the health system. This Consensus Document arises from the collaboration of various Spanish scientific societies involved in influenza virus infection. The conclusions drawn are based on the highest quality evidence available in the scientific literature and, failing that, on the opinion of the experts convened. The Consensus Document addresses the clinical, microbiological, therapeutic, and preventive aspects (with respect to the prevention of transmission and in relation to vaccination) of influenza, for both adult and pediatric populations. This Consensus Document aims to help facilitate the clinical, microbiological, and preventive approach to influenza virus infection and, consequently, to reduce its important consequences on the morbidity and mortality of the population.

Executive summary. Diagnosis, treatment and prophylaxis of influenza virus infection. Consensus statement of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Pediatric Infectious Diseases (SEIP), the Spanish Association of Vaccinology (AEV), the Spanish Society of Family and Community Medicine (SEMFYC) and the Spanish Society of Preventive Medicine, Public Health and Health Management (SEMPSPGS)

The influenza virus has accompanied humans since time immemorial, in the form of annual epidemics and occasional pandemics. It is a respiratory infection with multiple repercussions on people’s lives at an individual and social level, as well as representing a significant burden on the health system. This Consensus Document arises from the collaboration of various Spanish scientific societies involved in influenza virus infection. The conclusions drawn are based on the highest quality evidence available in the scientific literature and, failing that, on the opinion of the experts convened. The Consensus Document addresses the clinical, microbiological, therapeutic, and preventive aspects (with respect to the prevention of transmission and in relation to vaccination) of influenza, for both adult and pediatric populations. This Consensus Document aims to help facilitate the clinical, microbiological, and preventive approach to influenza virus infection and, consequently, to reduce its important consequences on the morbidity and mortality of the population.

Resolvins' Obesity-Driven Deficiency: The Implications for Maternal-Fetal Health.

Since pregnancy is already characterized by mild but significant inflammatory activity in physiological conditions, when complicated by obesity the probability of a persistent inflammatory state increases, with consequent multiple repercussions that add up to the complications associated with acute inflammation. In this context, the role of resolvins, specialized pro-resolving mediators (SPMs), deriving from omega-3 essential fatty acids, may be crucial. Indeed, differential production in numerous high-risk conditions associated with both childbirth and neonatal health, the correlation between maternal omega-3 intake and resolvin concentrations in maternal blood and at the placental level, and the high values found in breast milk in the first month of breastfeeding, are some of the most important hallmarks of these autacoids. In addition, a growing body of scientific evidence supports the lack of SPMs, at the level of immune-metabolic tissues, in the case of obesity. Furthermore, the obesity-related lack of SPMs seems to be decisive in the context of the current outbreak of COVID-19, as it appears to be one of the causes associated with the higher incidence of complications and negative outcomes of SARS-CoV-2 infection. The usefulness of metabolomics in this field appears clear, given that through the metabolome it is possible to observe the numerous and complex interactions between the mother, the placenta and the fetus in order to identify specific biomarkers useful in the prediction, diagnosis and monitoring of the various obstetric conditions. However, further investigations are needed in order to evaluate the possible use of some resolvins as biomarkers of maternal–fetal outcomes but also to establish adequate integration values in pregnant women with omega-3 fatty acids or with more active derivatives that guarantee optimal SPM production under risky conditions.

5/6 nephrectomy affects enteric glial cells and promotes impaired antioxidant defense in the colonic neuromuscular layer

AimsChronic kidney disease (CKD) produces multiple repercussions in the gastrointestinal tract (GIT), such as alterations in motility, gut microbiota, intestinal permeability, and increased oxidative stress. However, despite enteric glial cells (EGC) having important neural and immune features in GIT physiology, their function in CKD remains unknown. The present study investigates colonic glial markers, inflammation, and antioxidant parameters in a CKD model. Main methodsA 5/6 nephrectomized rat model was used to induce CKD in rats and Sham-operated animals as a control to suppress. Biochemical measures in plasma and neuromuscular layer such as glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity were carried out. Kidney histopathology was evaluated. Colon morphology analysis and glial fibrillary acid protein (GFAP), connexin-43 (Cx43), nuclear factor-kappa B (NF-κB) p65, and GPx protein expression were performed. Key findingsThe CKD group exhibited dilated tubules and tubulointerstitial fibrosis in the reminiscent kidney (p = 0.0002). CKD rats showed higher SOD activity (p = 0.004) in plasma, with no differences in neuromuscular layer (p = 0.9833). However, GPx activity was decreased in the CKD group in plasma (p = 0.013) and neuromuscular layer (p = 0.0338). Morphological analysis revealed alterations in colonic morphometry with inflammatory foci in the submucosal layer and neuromuscular layer straightness in CKD rats (p = 0.0291). In addition, GFAP, Cx43, NF-κBp65 protein expression were increased, and GPx decreased in the neuromuscular layer of the CKD group (p < 0.05). SignificanceCKD animals present alterations in colonic cytoarchitecture and decreased layer thickness. Moreover, CKD affects the enteric glial network of the neuromuscular layer, associated with decreased antioxidant activity and inflammation.

Risk of Drop-Out from Follow-Up Evaluations for Celiac Disease: Is It Similar for All Patients?

Background: Celiac disease (CD) follow-up is a relatively underevaluated topic. However, correct adherence to follow-up procedures is central to the early recognition of complicated CD and other conditions typically associated with CD. Establishing whether patients at increased risk of complications follow clinicians’ recommendations has multiple repercussions. Methods: We retrospectively analyzed the records of patients consecutively diagnosed with CD in our outpatient clinic between January 2004 and October 2017 to investigate the factors associated with drop-out from follow-up procedures. Results: Among the 578 patients analyzed, 40 (6.9%) dropped out during the first six months and 272 (50.6%) during the observation period. The median time to drop-out was 7.4 years (95% confidence interval: 6.8–8.0). No factors were associated with early drop-out. Instead, age at diagnosis >40 years (40–59 years, p < 0.001; ≥60 years, p = 0.048) and classical clinical presentation (p = 0.016) were significantly associated with a lower risk of later drop-out. Conclusions: Patients at increased risk of complicated CD are more compliant with follow-up procedures than patients at lower risk, despite being prescribed the same controls. These results indirectly support the hypothesis of tailored follow-up strategies, differentiated according to the risk of complications.

A Review of Essential Microelements in the Immune System

The immune system is the set of cells and organs that intervene in the body's defense against certain antigens, foreign to the body. This set includes both elements with rapid action and thus belonging to non-specific immunity, and also, elements that provide a slower response, but, with high specificity against each antigen. Nonspecific immunity sums up both cellular and humoral elements, which react quickly on foreign substances and microorganisms. On the other hand, adaptive immunity is based on the existence of lymphocytes, which develop a response, albeit slower, with a high specificity through antibodies secreted by B lymphocytes. Zinc deficiency is the second most widespread micronutrient deficiency. This compound is indispensable for the human body because it is a cofactor for many enzymes including alkaline phosphatase, dismutase superoxide, metalloproteinases. Moreover, zinc is included in the structure of growth and transcription factors and it participates in the cell communication within the immune system. Selenium is an essential trace element, being involved in many biological processes. It is part of a structural component of the amino acid selenocysteine, one of 25 selenoproteins, which are involved in the body's immune defense. Raising the awareness of iron deficiency, recent studies emphasize that it is the most common mineral deficiency worldwide. As it is already well known, iron is particularly important in the transport of oxygen, but its essential roles are not only limited to that. Besides, it is a constituent part of some metalloproteins and a cofactor for many other enzymes. Moreover, iron takes part of ATP synthesis. Therefore, the lack of iron has multiple repercussions on the whole organism, including the immune system.

Deepfake Phenomenon: An Advanced Form of Fake News and Its Implications on Reliable Journalism

In the era of distinctly new media-marked social reality, the process of dissemination of disinformation is becoming an increasingly common phenomenon. As one of the technological innovations that stands out in this field is the deepfake phenomenon – a hyper-realistic digital falsification of video and audio formats. Since it is based on the most sophisticated technology, supported by achievements in the field of artificial intelligence, deepfake unequivocally represents a kind of turning point in the context of production and distribution of fake audio-visual content. To poly perspective point to the multiple repercussions of this phenomenon, the paper provides a deeper insight into the very definition and the specific factors that contribute to the acceptance of deepfake, with special emphasis on its implications on reliable journalism and its social function. The text articulates the role of deepfake in the process of creating and receiving media content, as well as the problem of the emergence of erosion of public trust within a hyperreal media environment.

E-tailers adaptation during early stages of “social distancing causing crises”: an exploratory study

PurposeThis paper studies the impact of social distancing causing crises (SDCC) such as pandemics in its early stages on e-tailers demand and supply side operations and provides a conceptual framework for adaptation.Design/methodology/approachA grounded theory-based approach has been used, wherein journal papers and news articles are the key data sources. Standard qualitative methodology, including open, axial and selective coding has been followed.FindingsThe study provides second order themes derived from first-order categories, the theoretical dimensions and their interrelationships on how e-tailers need to adapt to variations in online buying behaviour, manage manpower shortage and daily necessities inventory shortage, during SDCC. Panic buying emerges as a key disrupting factor as it has multiple repercussions on demand and supply side operations of e-tailers.Research limitations/implicationsExploratory qualitative research such as this is helpful in early development of a research stream and paves the way for future quantitative studies.Practical implicationsThis study makes a valuable contribution on e-tailers adaptation to SDCC with significant managerial implications. There are social, economic and policy implications too. For academicians, this study provides a conceptual framework and serves as a springboard for future research.Originality/valueThe study is unique as perhaps it is one of the first to study e-tailers adaptation to SDCC. It contributes to a body of the literature which is currently scarce but expected to grow exponentially in the coming years.

COVID-19 Perceived Impact and Psychological Variables as Predictors of Unhealthy Food and Alcohol Consumption Trajectories: The Role of Gender and Living with Children as Moderators.

The present study examines the trajectories of unhealthy food and alcohol consumption over time and considers whether perceived impact of COVID-19 and psychological variables are predictors of these trajectories. We ascertained whether these predictors are different in women vs. men and between women living with vs. without children. Data were collected through online surveys administered to 1038 participants from two universities (staff and students) in Chile, across five waves (July to October 2020). Participants provided information about their past-week unhealthy food and alcohol consumption and mental health. Using latent growth curve modeling analysis, we found that higher perceived health and interpersonal COVID-19 impact, younger age and lower depression symptoms were associated with more rapid increases over time in unhealthy food consumption. On the other hand, higher perceived COVID-19 economic impact and older age were associated with more rapid diachronic decreases in alcohol consumption. Gender and living with or without children, for women only, were moderators of these trajectories. This longitudinal study provides strong evidence identifying the multiple repercussions of COVID-19 and mental health factors on unhealthy food and alcohol consumption. These findings highlight the need for interventions aimed at minimizing the impact of the pandemic on unhealthy food and alcohol consumption over time.

Bisphenol A and its effects on the systemic organs of children.

For the past two decades, growing research has been pointing to multiple repercussions of bisphenol A (BPA) exposure to human health. BPA is a synthetic oestrogen which primarily targets the endocrine system; however, the compound also disturbs other systemic organ functions, in which the magnitude of impacts in those other systems is as comparable to those in the endocrine system. To date, the discoveries on the association between BPA and health outcomes mainly came from animal and in vitro studies, with limited human studies which emphasised on children's health. In this comprehensive review, we summarised studies on human, in vivo and in vitro models to understand the consequences of pre-, post- and perinatal BPA exposure on the perinatal, children and adult health, encompassing cardiovascular, neurodevelopmental, endocrine and reproductive effects.Conclusion: Evidence from in vitro and animal studies may provide further support and better understanding on the correlation between environmental BPA exposure and its detrimental effects in humans and child development, despite the difficulties to draw direct causal relations of BPA effects on the pathophysiology of the diseases/syndromes in children, due to differences in body system complexity between children and adults, as well as between animal and in vitro models and humans. What is known: • Very limited reviews are available on how BPA adversely affects children's health. • Previous papers mainly covered two systems in children. What is new: • Comprehensive review on the detrimental effects of BPA on children health outcomes, including expectations on adult health outcomes following perinatal BPA exposure, as well as covering a small part of BPA alternatives. • Essentially, BPA exposure during pregnancy has huge impacts on the foetus in which it may cause changes in foetal epigenetic programming, resulting in disease onsets during childhood as well as adulthood.

POS-785 DIABETES AFTER RENAL TRANSPLANTATION: STUDY OF RISK FACTORS

Post-transplant diabetes is a dreaded complication of immunosuppressive treatment. Its prevalence can vary up to 25% depending on the study, and it has multiple repercussions on graft morbidity and mortality. The objective of this study is to identify the risk factors for the onset of diabetes after kidney transplantation.

Towards global dominance of invasive alien plants in freshwater ecosystems: the dawn of the Exocene?

The global and seemingly unstoppable spread of invasive alien plants emerges as one of the main topics of current science. This is due to the multiple repercussions of invasive plants on biodiversity and ecosystem functioning, plus huge consequences on human existence. In freshwaters, lots of invaders are extremely competitive by virtue of their idiosyncratic reproductive and adaptive strategies. As “inland islands”, freshwaters seem particularly prone to changes when invaded, such as reorganisation of food webs and biotic interactions. Together, these events are self-reinforcing, implying hardly reversible hysteric phenomena. The intention of this paper is to point out: invasion pathways, driving factors, invasion mechanisms, and noticeable effects mediated by plant invaders in freshwaters through an extensive knowledge review. The growing evidence suggests the dawn of a new epochal phase: a globally alien-dominated “bio-historical horizon”, tentatively called “Exocene”, where invaders play predominant roles that drive freshwaters functioning and successional unexpected stages. In the context of invasion science, Exocene reinforces the need for an ecosystem-based perspective to properly understand the implications of plant invaders in freshwaters. Seven challenging issues emerge to be addressed to better outline the global paths of biodiversity and functioning between biomes when faced with biological invasion.

Human–animal relationship influences husbandry practices, animal welfare and productivity in pig farming

The nature of the relationship between humans and farm animals has multiple repercussions on the animals and the farmers and varies with farmers attitudes towards their animals. In particular, this relationship influences animal welfare and human working conditions. The present study, part of a larger research project investigating human–animal relationship (HAR) in pig farming and ways to improve it, had two objectives: 1) to investigate the HAR in a diversity of pig farming situations and to evaluate the possible correlation between farmer attitudes, pigs' reactions to humans, husbandry practices, animal health, welfare and productivity and 2) to find a way to rapidly assign a farmer to a profile, in order to better adapt course content during training sessions on HAR. The study focused on 52 farrow-to-finish farms and consisted of a semi-structured interview with the farmer, observations of the farmer in contact with his/her livestock, two human approach tests conducted on sows and growers and productivity data. Finally, a questionnaire was left at the farm to be filled out by all stockpersons on the farm. Interviews, analyzed using a thematic analysis followed by multiple correspondence analysis and ascendant hierarchical clustering, showed that some farmers develop husbandry practices to improve their HARs and identified three farmer profiles that have been named in relation to the place of the HAR in their profession: Profile 1 farmers for whom HAR is secondary in their work with their pigs, Profile 2 for whom the HAR is useful in their work with their pigs and Profile 3 for whom HAR is central in their work with their pigs. Logistic regression models of the relationships between behavioral tests and productivity data showed that confident sows produce and wean more piglets than fearful sows and that sows of Profile 3 farmers trust more humans than those of Profile 1 or 2 farmers. Farmers' responses to the questionnaire did not predict their profile assignment. Our results confirm the main role of the farmer's attitude towards animals on their farming practices, animal welfare and productivity. The farmers who have more confident pigs and better productivity are those for whom the farm animal is central to their profession, express the most pleasure in working with them and convey empathy for them.

Validación del cuestionario de atribuciones para la detección de coincidencias en trabajos académicos

El plagio como tópico de investigación en el contexto universitario no ha cesado de ser una preocupación constante debido a sus múltiples repercusiones. El presente estudio describe el proceso seguido en la validación del Cuestionario de atribuciones para la detección de coincidencias en trabajos académicos (CUDECO), cuya finalidad es evaluar la relevancia que tiene citar correctamente y detectar las causas que llevan a cometer plagio. A partir de una muestra de 2,331 estudiantes, se realiza un análisis de la fiabilidad como consistencia interna y un análisis factorial exploratorio (AFE) del instrumento. El análisis de la fiabilidad lleva a proponer un reajuste en el cuestionario inicialmente diseñado y el estudio factorial sugiere una estructura configurada por cinco factores: concepto de plagio y sus tipos (parcial y total), causas que motivan la comisión del mismo tanto internas (propias del sujeto) como externas (ajenas al sujeto) y las actitudes del grupo de iguales hacia el plagio, hallazgos en la línea de investigaciones previas.

The Untapped Potential of Transsystemic Thinking

This paper looks to the past, present and future of the unique pedagogical program that defines McGill’s Faculty of Law. Dubbed the Transsystemic Program, this method of teaching and thinking about law is characterized by an integrated approach to law, where courses blend the teaching of multiple legal traditions and systems, and introduce a hybridity of legal orders into the classroom. The retreat from the focus on the law of a given jurisdiction has had multiple repercussions which are examined in this paper. The thesis proposed in the paper is that this method of thinking about law is increasingly important for three major reasons: 1) the ability it inculcates in jurists to help them deal with novel problems, with which traditional methods of legal development, such as caselaw, are currently wrestling; 2) the agility and creativity it develops in jurists, which can help them implement the novel ways they are currently being called upon to solve legal problems (namely through collaborative solutions crafted by the parties as opposed to adjudicative solutions imposed by the court system); and 3) its increased relevance given the development of a novel trend inviting the cross-fertilization of ideas in contemporary judicial methodology.

Grooming Istanbul

Abstract Based on research in Istanbul in 2013–14, the article describes a changing urban geography of beauty, which has multiple repercussions on women’s spatialized notions of femininity, intimate bodily grooming, and aesthetics. Beauty salons in two neighborhoods typically placed on different ends of both the social and the Islamist-secularist axes highlight the similarities and differences of intimate concerns and encounters. Urban beauty salons are where publicly debated ideals of femininity and sexuality are visibly manufactured, and those involved have to negotiate new styles of bodily appearance and forms of intimate relations. Beauty salon customers and workers create strategies to deal with (bodily) intimacy and test the moral, social, and religious boundaries of what is attractive, respectable, or permissible. Defying common assumptions, upwardly mobile pious women display a willingness to establish intimate relationships and negotiate the boundaries of moral permissiveness and bodily well-being.

Discourse objectivization, social variation and style of Spanish second-person singular tú

Abstract This investigation aims to uncover the variation of the Spanish second-person singular subject pronoun tú ‘you.sg’ when it displaces its content away from the particular circumstances of the speaker and changes its deictic meaning to a resource for the objectivization of the utterance. The multiple repercussions of the formal variation (expression and omission) of this subject on internal and external levels of meaning will be explored. Essential to understanding this case of variation is the consideration of prominent features of the communicative situation, as well as the social identities and roles assumed by the speakers within it (including professional affiliation, transactional vs. interpersonal communicative stance and gender). The results of the analysis allow us to sketch basic interactional and discursive tendencies governing objectivizing uses of the second-person singular tú along the oral-written continuum

Leveraging public health nurses for disaster risk communication in Fukushima City: a qualitative analysis of nurses' written records of parenting counseling and peer discussions.

BackgroundLocal public health nurses (PHNs) have been recognized as the main health service providers in communities in Japan. The Fukushima nuclear disaster in 2011 has, however, created a major challenge for them in responding to mothers’ concerns. This was in part due to difficulties in assessing, understanding and communicating health risks on low-dose radiation exposure. In order to guide the development of risk communication plans, this study sought to investigate mothers’ primary concerns and possible solutions perceived by a core healthcare profession like the PHNs.MethodsA total of 150 records from parenting counseling sessions conducted between PHNs and mothers who have attended mandatory 18-month health checkups for their children at the Fukushima City Health and Welfare Center in 2010, 2011 (year of disaster) and 2012 were examined. Discussion notes of three peer discussions among PHNs organized in response to the nuclear disaster in 2012 and 2013 were also analyzed. All transcribed data were first subjected to text mining to list the words according to their frequencies and inter-relationships. The Steps Coding and Theorization method was then undertaken as a framework for qualitative analysis.ResultsPHNs noted mothers to have considerable needs for information on radiation risks as they impact on decisions related to relocations, concerns for child safety, and experiences with interpersonal conflicts within the family owing to differing risk perceptions. PHNs identified themselves as the information channels in the community, recommended the building of their risk communication capacities to support residents in making well-informed decisions, and advocated for self-measurement of radiation levels to increase residents’ sense of control. PHNs also suggested a more standardized form of information dissemination and an expansion of community-based counseling services.ConclusionsInadequate risk communication on radiation in the Fukushima nuclear incident has resulted in multiple repercussions for mothers in the community. Empowerment of local residents to assume more active roles in the understanding of their environment, increasing PHNs’ capacity in communication, and an expansion of health services such as counseling will together better address risk communication challenges in post-disaster recovery efforts.