Multiple Quadrants Research Articles

Multiple quadrants displacement tracking control of independent metering electro-hydraulic system

Aiming at the oscillation caused by the hydraulic cylinder of independent metering system (IMS) running between multiple working quadrants, a novel multiple quadrants switching displacement tracking control strategy is proposed in this paper. In this control strategy, both the cylinder chamber pressure under resistance and overrunning conditions are controlled by the inlet valve, and the outlet valve is utilized to control the displacement of cylinder. This method allows the hydraulic cylinder to always run in energy-efficient. When the working quadrant changes, the valve’s working modes are unchanged, which avoids oscillation caused by changes of valves working modes in principle. And a reduced-order active disturbance rejective displacement controller and an active disturbance rejective pressure controller are designed to get high-precision tracking of the displacement and pressure. Numerous experimental results show that the proposed method is reasonable and effective, hydraulic cylinder operates smoothly between multiple quadrants, the pressure and displacement controllers have good anti-interference ability and robustness, and the energy consumption can be reduced by more than 23% compared to the traditional constant pressure valve control system.

High-Voltage Power Supply for Four-Quadrant Dielectric Elastomer Actuators.

Dielectric elastomer actuators (DEAs) are emerging as promising candidates for various applications in robotics and optical devices due to their lightweight, miniaturization potential, high energy density, simple structure, and low power consumption. However, their effective actuation always demands sophisticated high-voltage driving circuits that are compact and responsive. DEAs need to be capable of generating intricate high-voltage waveforms or simultaneously controlling multiple quadrants with distinct high-voltage levels. This paper proposes a high-voltage power supply for DEAs, featuring a four-quadrant high-voltage driving circuit. The circuit is capable of independently generating high-voltage signals ranging from 100 V to 6000 V and producing arbitrary waveforms with adjustable frequencies. The independent operation of the quadrants without crosstalk showcases the system's integration and potential for cross-disciplinary applications.

Effects of hemoglobin concentration on retinochoroidal vascular plexuses: an optical coherence tomography angiography study.

To evaluate retinal and choroidal microvascular structures using optical coherence tomography angiography (OCTA) in patients with anemia and polycythemia vera (PV). In this prospective study, 142 patients (142 eyes) were enrolled and divided into 3 groups: the anemia (n = 56), PV (n = 46), and healthy groups (n = 40, controls). For each patient, 6- × 6-mm macular angiography images were taken using an OCTA system (optovue, Inc., Fremont). For each eye analyzed, the software automatically measured vessel density (VD) in the superficial capillary plexus (SCP), deep capillary plexus (DCP; superior, nasal, temporal, and inferior quadrants), choriocapillaris (CC), and foveal avascular zone (FAZ). The OCTA analysis revealed that the VD of the DCP was significantly decreased in the superior and inferior hemispheres of the whole area, multiple quadrants of the perifovea, and CC with a 1-mm2 flow area in the anemia group compared with the PV group (p < 0.017), but the VD of the SCP did not show any significant difference in any quadrant between the two groups (p > 0.017). When compared with the healthy group, the anemia and PV groups showed a significant difference in multiple quadrants of the parafovea and temporal quadrant of the perifovea in the VD of the SCP and CC with a 2-mm2 flow area (p < 0.017). The FAZ and non-flow area did not manifest any significant difference between the groups (p > 0.017). The hemoglobin concentrations in the anemia, PV, and healthy groups were 8.11 ± 1.33, 17.5 ± 1.2, and 15.6 ± 0.73g/dL, respectively, indicating statistically significant differences between the groups (p < 0.001). In this study, quantitative OCTA analysis revealed a higher tendency for retinal and choroidal microvascular morphological changes in patients with anemia and PV. The outcomes of the current investigation can provide new insights into the retinal and choroidal pathophysiologies found in patients with hemoglobin abnormalities.

Robotic hernia repair with the novel HUGO robot system – An initial experience from a tertiary centre

Abstract Background: Hernia repair using robotic platforms has been on the rise in the last decade. The HUGO robotic-assisted surgery (RAS) system, introduced in 2021, is a new addition to the field. In this study, we share our experience with this innovative system for the management of ventral and groin hernias. Patients and Methods: The aim of our study was to evaluate the feasibility and safety of using the HUGO robotic platform for hernia surgeries. We conducted a retrospective analysis of all hernia surgeries performed with the HUGO system over a 1-year study period. The study assessed various aspects, including the technical manoeuvres of the robotic system, duration of surgery, length of hospital stay, post-operative pain levels and 30-day morbidity rates. Results and Conclusions: A total of seven hernia surgeries were performed using the HUGO system, including five ventral hernias and two groin hernias. The average duration of surgery was 128 min, with a docking duration of 22.8 min. Notably, there were no intraoperative or post-operative adverse events reported during these procedures. The HUGO system features an open console that provides a panoramic view of the operating room. In addition, the individual arm carts can be easily manoeuvred around the operating table, facilitating improved access to multiple quadrants during surgery. In our case series, Robotic hernia repair using the HUGO system has demonstrated feasibility, with post-operative outcomes comparable to traditional approaches. This innovative system serves as an additional tool in the armamentarium of hernia surgery and shows potential for improving surgical outcomes. However, further investigation through large-scale prospective studies is necessary to comprehensively evaluate its efficacy and benefits.

Robotic single-port multiquadrant surgery to treat renal tumors and benign abdominal conditions.

Multiquadrant procedures are technically more demanding than sequential operations. The new single port (SP) system allows to work in every abdominal quadrant maintaining an adequate triangulation without the need for changes in the port positioning. In February 2020, two patients underwent a robotic SP partial nephrectomy for malignancy combined with a cholecystectomy and a left inguinal hernia repair respectively. Both procedures were successfully completed with one robotic docking and without the need for conversion. The operative time was 213 minutes for the right partial nephrectomy (126 min) with cholecystectomy (18 min), and 257 minutes for the left partial nephrectomy (161 min) with inguinal hernia repair (35 min). Estimated blood loss was 200 (150-250) mL, while the total warm ischemia time was 15 minutes for the right partial nephrectomy and 53 minutes for the left partial nephrectomy. There were no intraoperative complications or perioperative transfusions. The postoperative course was uneventful, and the postoperative hospital stay was 1 and 2 days. Both resections had free margins and the median tumor size was 2.5 (1.5-3.5) cm. Histopathology analysis revealed chronic cholecystitis and renal cell carcinomas with free margins and a median tumor size of 2.5 (1.5-3.5) cm. After a mean follow-up of 24 months, no surgical-related complications or recurrence were detected. The robotic SP approach facilitates the completion of combined surgical procedures in multiple abdominal quadrants through a single 25mm incision.

Data science technology course: The design, assessment and computing environment perspectives.

This article discusses the key elements of the Data Science Technology course offered to postgraduate students enrolled in the Master of Data Science program. This course complements the existing curriculum by providing the skills to handle the Big Data platform and tools, in addition to data science activities. We tackle the discussion about this course based on three main requirements, which are related to the need to exploit the key skills from two dimensions, namely, Data Science and Big Data, and the need for a cluster-based computing platform and its accessibility. We address these requirements by presenting the course design and its assessments, the configuration of the computing platform, and the strategy to enable flexible accessibility. In terms of course design, the offered course contributes to several innovative elements and has covered multiple key areas of the data science body of knowledge and multiple quadrants of the job and skills matrix. In the case of the computing platform, a stable deployment of a Hadoop cluster with flexible accessibility, triggered by the pandemic situation, has been established. Furthermore, through our experience with the implementation of the cluster, it has shown the ability of the cluster to handle computing problems with a larger dataset than the one used for the semesters within the scope of the study. We also provide some reflections and highlight future improvements.

The epidemiological and clinicopathological characteristics of multifocal/multicentric breast cancer in the Egyptian Delta and its impact on management strategies.

Multifocal (MFBC)/multicentric (MCBC) breast cancer is being more recognized due to the improved imaging modalities and the greater orientation with this form of breast cancer, however, optimal surgical treatment, still poses a challenge. The standard surgical treatment is mastectomy, however, breast-conserving surgeries (BCS) may be appropriate in certain situations. A total of 464 cases of MF/MCBC out of 4798 cases of breast cancer were retrospectively analyzed from the database of the Oncology Center, Mansoura University (OCMU), between January 2008 and December 2019. Radiologic involvement of multiple quadrants was reported in 27.9% by ultrasonography, 19% by mammography, and 59.1% by magnetic resonance imaging. BCS was performed in 32 cases (6.9%) while 432 cases underwent a mastectomy. Postoperative pathology revealed infiltration of other quadrants grossly in 23.5%, and under the microscope in 63.6% of the examined cases. Mean disease-free and overall survival were 95.5 and 164.6 months, respectively. When compared with MFBC, MCBC showed higher pathologic tumor size (p <0.001), higher stages (p <0.001), higher recurrence rates (p =0.006), and lower DFS (P =0.009) but with similar OS (P =0.8). Mastectomy is still the primary treatment option for MCBC with higher recurrence rates compared with MFBC. However, BCS for properly selected MFBC is considered oncologically safe, following the same rules of breast conservation for unifocal disease.

A compact design for an electric driven hydraulic gear machine capable of multiple quadrant operation

This paper presents an innovative design of an integrated electro-hydraulic (EH) flow generation unit able to operate in multiple quadrants. The proposed unit is composed of a hydraulic machine which can operate in either pumping or motoring mode, and an electric machine, which can operate as electric motor or generator. The adopted morphological integration of the two unit fulfills the goals of maximizing compactness, power to weight ratio, energy efficiency and quietness. The design results from a numerical optimization procedure that includes detailed simulation of both the electric machine and the hydraulic machine, using simulation tools previously developed by the authors, but combined for the first time in this work. After describing the optimization procedure, the paper focuses on the design integration aspects of the novel unit. A 9 kW prototype of the integrated unit was also fabricated and tested to verify its performance. Tests results show a measured overall energy efficiency up to 69%, demonstrating the potentials of the proposed concept, despite some limitations present in the first prototypes which could be addressed in future design refinements.

Dual-Layer Rotation: A Versatile Therapeutic Mammoplasty Technique

BackgroundMultifocal or complex breast lesions are a challenge for breast-conserving surgery, particularly surgery in small breasts or those located in the upper inner quadrant. The dual-layer rotation technique exploits the idea of manipulating the skin and glandular tissue in separate layers to fill the resection cavity via vertical mammoplasty if skin excision is not required, except in the central area.MethodsThe authors performed a retrospective review of consecutive breast cancer patients who underwent DLR mammoplasty between 2017 and 2019 at a single institution. Clinical data, reoperations, surgical complications, delays in adjuvant treatments, and the need for late revisional surgery were evaluated. Aesthetic outcomes were evaluated objectively and subjectively from photographs.ResultsThe study included 46 breasts of 40 patients. Tumors were located in the UIQ (30%, 14/46) or in multiple quadrants (22%, 10/46). One third (33%, 13/40) of the patients had a small breast cup size (A–B). Negative margins were primarily achieved in 45 of the 46 breasts. Major complications occurred in three patients, who needed reoperation, and adjuvant therapy was delayed for one of these patients. Late refinement surgery was needed for two patients. The objective and subjective aesthetic outcomes were good or excellent regardless of the tumor position.ConclusionAs a novel oncoplastic approach, DLR mammoplasty offers a one-step procedure to treat selected breast cancer patients with challenging resection defects due to different breast sizes or lesion locations. The technique preserves the breast’s natural appearance.

Mixed B- and T-lymphocyte Vitreous Infiltrate in Multiple Sclerosis Associated Uveitis

ABSTRACT A 23-year-old man, under treatment for relapsing remitting multiple sclerosis, presented with sudden drop in vision in the left eye for the past 1 week. We noted optic atrophy with sclerosed vessels in multiple quadrants in both eyes, moderate vitreous haze, and active retinal vasculitis in left eye. The patient received therapeutic pars plana vitrectomy in the left eye, and the vitreous sample was analyzed for immunophenotypes by flow cytometry (T-cells) and immunohistochemistry (B-cells). 65.1% of total vitreous cells were CD3+ T-cells. These included 42.4% CD4+, and 20.6% CD8+ T-cells. Immunohistochemistry detected CD20+ B-cells (not quantifiable). Our analysis demonstrated a mixed B- and T-lymphocyte vitreous infiltrate in multiple sclerosis-associated uveitis.

Teeth Eruption Disorders: A Critical Review.

Dental eruption refers to the vertical displacement of a tooth from its initial non-functional towards its functional position. Tooth eruption disorders may be expressed in various clinical conditions, which may be grouped as “primary retention” and “secondary retention”. The purpose of this article is to review the literature and the clinical parameters of the various conditions related to tooth eruption disorders. Materials and Methods: The search strategy of this critical review included keywords in combination with MeSH terms in Medline, Scopus, and Cochrane Library until February 2022 and only in English. Results: “Primary Failure of Eruption” (PFE) occurs during the eruption process and includes clinical characteristics of both primary and secondary retention, which make diagnosis difficult. PFE is distinguished by Types I and II. In Type I, the defect in the eruption process occurs in all the relative teeth at the same time, whilst in Type II, the clinical expressions vary in multiple quadrants of the mouth, and the second molars erupt more. The variability of the PFE’s clinical spectrum seems to be connected to a genetic origin. The differential diagnosis among single ankylosis, secondary retention, and PFE is based on the occlusal relationship between the upper and the lower teeth distally, most commonly the first molar, which has not yet fully erupted. The treatment approach depends on many factors and combines surgical and orthodontic techniques.

Traumatic Perforation of Tympanic Membrane

Introduction: Traumatic perforation of tympanic membrane (TM) is caused by increase in air pressure due to slapping, road traffic accident, blast injury, syringing, trauma by ear buds, etc., The incidence has been increased in recent times due to increased domestic violence and road traffic accidents. Hence, there is a need for early identification, evaluation, and management to reduce the morbidity. Objectives: The objective of the study was to describe etiologies of traumatic perforation of TM, to assess the findings of pure tone audiometry (PTA) among patients with traumatic perforation of TM, and to determine the outcome. Materials and Methods: This study was done between November 2017 and May 2019 in the department of ENT at Bangalore Medical College and Research Institute on 88 patients with traumatic perforation of TM who were subjected to otoscopic examination, tuning fork tests, and PTA. Patients were followed up on weekly basis. Results: Out of 88 patients, 33 patients (37.5%) were in the age group of 21–30 years. Fifty-four were males (61.36%) and 34 were females (38.63%). Slapping is the most common mode of injury with 50 (56.8%) patients. Left ear 55 (62.5%) was more commonly involved than right ear 33 (37.5%). Small perforation 55 (62.5%) was more common followed by medium-sized perforation 25 (28.4%) and large perforations were the least 8 (9.1%). Multiple quadrants were involved in 33 patients (37.5%). Posteroinferior quadrant was most commonly involved. Deafness (75%) was the most common symptom involving 66 patients. Average time taken for spontaneous healing was 37 days. Mean hearing improvement compared between hearing loss at the time of trauma and after 3 months was 13.18 ± 7.05 dB, which is statistically significant (P = 0.0001). Conclusion: Traumatic perforation of TM spontaneously healed in 80 participants (90.90%), whereas eight participants (9.09%) underwent surgery, i.e., tympanoplasty.

Does The Quadrant of Location Change The Prognosis of A Breast Lump? A Cytomorphological Study

Introduction: Tumour location within the breast varies with the highest frequency in the upper outer quadrant (UOQ) and lowest frequency in the lower inner quadrant (LIQ). Whether tumour location is prognostic is unclear. To determine whether tumour location is prognostic, associations between tumour site and clinicopathological characteristics were evaluated. Materials and Methods: All patients enrolled in the Clinical Breast Care Project whose tumour site—UOQ, upper inner quadrant (UIQ), central, LIQ, lower outer quadrant (LOQ)—was determined by a single, dedicated breast pathologist were included in this study. Patients with multicentric disease (n = 73) or tumours spanning multiple quadrants were excluded from further analysis. Clinicopathological characteristics were analysed using chi-square tests for univariate analysis with multivariate analysis performed using principal components analysis (PCA) and multiple logistic regression. Significance was defined as P &lt; 0.05. Results: Of the patients with defined tumour location, 30 had bilateral disease. Tumour location in the UOQ (51.5%) was significantly higher than in the UIQ (15.6%), LOQ (14.2%), central (10.6%), or LIQ (8.1%). Tumours in the central quadrant were significantly more likely to have higher tumour stage (P = 0.003) and size (P &lt; 0.001), metastatic lymph nodes (P &lt; 0.001), and mortality (P = 0.011). After multivariate analysis, only tumour size and lymph node status remained significantly associated with survival. Conclusions: Evaluation of tumour location as a prognostic factor revealed that although tumours in the central region are associated with less favourable outcome, these associations are not independent of location but rather driven by larger tumour size. Tumours in the central region are more difficult to detect mammographically, resulting in larger tumour size at diagnosis and thus less favorable prognosis. Together, these data demonstrate that tumour location is not an independent prognostic factor.

Cytomorphological Study of Breast Lesions in Correlation with Quadrant Location to Assess Prognosis

Abstract: Introduction: Tumour location within the breast varies with the highest frequency in the upper outer quadrant (UOQ) and lowest frequency in the lower inner quadrant (LIQ). Whether tumour location is prognostic is unclear. To determine whether tumour location is prognostic, associations between tumour site and clinicopathological characteristics were evaluated. Materials and Methods: All patients enrolled in the Clinical Breast Care Project whose tumour site—UOQ, upper inner quadrant (UIQ), central, LIQ, lower outer quadrant (LOQ)—was determined by a single, dedicated breast pathologist were included in this study. Patients with multicentric disease (n = 73) or tumours spanning multiple quadrants were excluded from further analysis. Clinicopathological characteristics were analysed using chi-square tests for univariate analysis with multivariate analysis performed using principal components analysis (PCA) and multiple logistic regression. Significance was defined as P &lt; 0.05. Results: Of the patients with defined tumour location, 30 had bilateral disease. Tumour location in the UOQ (51.5%) was significantly higher than in the UIQ (15.6%), LOQ (14.2%), central (10.6%), or LIQ (8.1%). Tumours in the central quadrant were significantly more likely to have higher tumour stage (P = 0.003) and size (P &lt; 0.001), metastatic lymph nodes (P &lt; 0.001), and mortality (P = 0.011). After multivariate analysis, only tumour size and lymph node status remained significantly associated with survival. Conclusions: Evaluation of tumour location as a prognostic factor revealed that although tumours in the central region are associated with less favourable outcome, these associations are not independent of location but rather driven by larger tumour size. Tumours in the central region are more difficult to detect mammographically, resulting in larger tumour size at diagnosis and thus less favourable prognosis. Together, these data demonstrate that tumour location is not an independent prognostic factor.

Progression from preplus to plus disease in the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) Study: incidence, timing, and predictors

To determine the incidence of and timing and predictors for progression from pre-plus to plus disease, based on evaluation of images. Two trained readers independently evaluated posterior pole images of infants from 13 North American centers for pre-plus/plus disease, stage, and zone of retinopathy of prematurity (ROP). Discrepancies between readers were adjudicated. To be eligible for analysis, eyes had to have at least two imaging sessions, the earlier one with pre-plus disease. Of 681 eyes of 444 infants with pre-plus first detected at mean postmenstrual age (PMA) of 35.5±2.1weeks, 54 (7.9%) progressed to plus disease at a mean PMA of 37.6±2.4weeks with the mean interval for progression of 2.7weeks (range, 0.4-8.9weeks). Progression rate was higher for eyes with larger number of quadrants of pre-plus (44% for eyes with four quadrants vs 4% with one quadrant [P<0.0001]), earlier PMA with pre-plus (18% for 32weeks' PMA vs 3% for PMA of >37weeks [P=0.02]), higher ROP stage (12% for stage 3, 2.5% for no ROP [P<0.0001]), lower ROP zone (24% for zone I, 6% for zone II or no ROP [P<0.0001]) at the time of first pre-plus detection. Based on image evaluation, 8% of eyes progressed from pre-plus to plus disease at a mean interval of 3weeks. Pre-plus in multiple quadrants, higher stages of ROP, and lower zones of ROP were associated with higher risk of progression. Image evaluation for pre-plus may help in the identification of high-risk eyes for developing plus disease.

Success of dental implant osseointegration in a florid cemento-osseous dysplasia: A case report with 8-year follow-up.

Florid cemento-osseous dysplasia (FCOD) is a rare benign fibro-osseous lesion which affects multiple quadrants and predominantly the mandible. This case report presents a successful implant placement with 8-year of follow-up in a 44-yearold woman asking for a fixed restoration in mandibular right posterior edentulous area. Radiographic images showed lobular, irregularly shaped radiopacities and radiolucencies almost symmetrically observed in the premolar-molar area of the right and left regions of the mandible. The findings of Xray images were attributable to FCOD. Minimally invasive two-stage surgery with strict infection control was followed to place two implants in lower right posterior region. The implants demonstrated clinically rigid fixation and restored successfully after 6 months. A direct functional connection between dysplastic bone and the implant load bearing surface was evidenced by the lack of symptoms, and the lack of soft tissues inflammation or peri-implant bone loss up to 8 years follow-up.

FLORID CEMENTO-OSSEOUS DYSPLASIA: SYMPTOMATIC CASE REPORT

Florid cemento-osseous dysplasia is a benign fibro-osseous lesion that involves multiple quadrants of the jaws in which normal bone is replaced by fibrous tissue followed by calcification with osseous tissue. We report a case of a 51-year-old woman with melanoderma presenting painful symptoms and swelling of stony consistency in the left mandibular buccal side. Cone beam computed tomographic images showed multiple well-defined sclerotic masses with radiolucent border in anterior and posterior regions of the mandible. Bone scintigraphy showed an increase of uptake of the mandible. The patient was submitted to surgery, and the lesion and the second inferior left premolar were removed. Histopathologic examination showed spicules of bone and cementum-like material in some areas interspersed throughout a moderately cellular fibrous connective tissue stroma; it also revealed coalescent masses of bony trabeculae and hemorrhagic points. The diagnosis was florid cemento-osseous dysplasia. The patient is asymptomatic and under follow-up for 6 months.

Florid osseous dysplasia complicated by secondary periapical infection

Florid osseous dysplasia (FOD) is a benign fibro-osseous lesion that involves multiple quadrants of the jaws and is histopathologically characterized by the replacement of normal bone tissue by fibrous connective tissue which may contain a variable amount of bone and/or cementum like tissue. The lesion is usually asymptomatic and is mostly diagnosed with a chance finding on radiographic examination, and no treatment is necessary. However, a secondary infection may occur and cause complications in an existing FOD. We present a case of florid osseous dysplasia which was complicated by secondary infection from the adjacent tooth.

Conjunctival pigmented lesion: Clinicopathological analysis of 85 cases in Korean population

To evaluate histopathological characteristics of conjunctival pigmented lesions and analyze clinical features related to histologic classification in Asian population, we analyzed medical records, anterior segment photographs, and histological specimen of 85 eyes who had undergone biopsy for pigmented conjunctival lesions at Seoul National University Hospital between 1999 and 2018. Compound nevus was the most common type of conjunctival pigmented lesions (67.1%), followed by conjunctival melanocytic intraepithelial neoplasia (primary acquired melanosis)(11.8%), subepithelial nevus (8.2%), and malignant melanoma (MM)(7.1%). Patients with compound nevus were younger than those with non-compound nevus (22.1 ± 17.0 vs 39.9 ± 18.8 years, p < 0.001), while patients with MM were older than those without melanoma (55.7 ± 18.2 vs 25.8 ± 18.0 years, p = 0.001). The lesion in compound nevus tended to be more frequently located on the temporal conjunctiva than that in the non-compound nevus group (54.4% vs 32.1%, p = 0.053), and feeder vessels were associated with most of compound nevus (98.2% vs 78.6% of non-compound nevus, p = 0.005). The lesion in MM was larger, involved multiple quadrants, and had extrabulbar location than lesions without melanoma (p < 0.001, p < 0.001, and p = 0.002, respectively). Together, the results would help clinicians to distinguish benign conjunctival pigmentations from malignant counterparts in clinical practice without biopsy.

SAT-LB041 Insulin and IGF-2 Equally Regulate Placental Triglyceride Content

Background: Obesity affects 25% of pregnant women and is associated with a higher risk of neonatal complications, such as macrosomia and increased adiposity. In addition to transporting maternal nutrients to the fetus, the placenta receives maternal hormone signals and synthesizes paracrine hormones which influence nutrient flux to the fetus. Obese women were shown to have higher placental lipid content compared to lean women, but the regulation of placental lipid metabolism is unknown. We hypothesized that insulin regulates lipid metabolism in the placenta by activating IR-B, which is the insulin receptor (IR) isoform characterized as having metabolic activity. Methods: Healthy, lean women (n=7) of mean age 34.4 ± 1.4 years and BMI 21.5 ± 0.5 kg/m2 consented for placental collection at elective c-section. Full thickness placental samples from multiple quadrants were obtained. Villous explants were cultured for 24 hours. After 4-hour starvation, explants were treated for 48 hours with insulin 100nM, IGF-1 100nM, IGF-2 100nM, or vehicle. Lipids were extracted from homogenized explants using a chloroform-methanol separation protocol. Triglyceride (TG) content was quantified by colorimetric spectrophotometer and normalized to explant weight. Data were analyzed by one-way ANOVA with a Tukey’s multiple comparisons test. Results: In placenta explants from lean women, insulin induced a 2.5-fold increase in triglyceride content, relative to vehicle (19.8 ± 3 vs 7.3 ± 1.5 mcg/mg, p= 0.002). Similarly, IGF-2 promoted a 3.4-fold increase compared to vehicle-treated placental tissue (24.9 ± 3.3 mcg/mg, p= 0.0002). In contrast, IGF-1 did not significantly alter TG levels (12.7 ± 2.9 vs 10.2 ± 2.6 mcg/mg, p= NS). Conclusions: We show that placental triglyceride content is equally regulated by maternal insulin and placenta-synthesized IGF-2. Since IGF-2 has a high affinity for IR-A and minimal affinity for IR-B, these data indicate that IR-A likely plays a key role in placental lipid metabolism. These findings are novel since IR-A activity is generally characterized as mitogenic, rather than metabolic. Notably, IGF-1, which activates IGF-1R, does not play a role in placental lipid metabolism in vitro. Hyperinsulinemia due to maternal obesity may alter placental triglyceride storage and thus promote neonatal adiposity through greater availability, independent of circulating maternal triglyceride levels. Unless otherwise noted, all abstracts presented at ENDO are embargoed until the date and time of presentation. For oral presentations, the abstracts are embargoed until the session begins. s presented at a news conference are embargoed until the date and time of the news conference. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.