Multiple Pulmonary Artery Aneurysms Research Articles

Behçet’s disease detecting by hemoptysis and recurrent epididymo-orchitis: A case report from Syria

Behçet’s disease is a chronic systemic inflammatory vasculitis of unknown etiology. It is characterized by recurrent episodes of oral aphthous ulcers, genital ulcers, skin lesions, ocular lesions, and other manifestations. This disease affects many organs and systems, showing a wide range of clinical features. Although pulmonary artery involvement is not common in Behçet’s disease, its presence carries a substantial risk of mortality. This report provides a detailed history of a 25-year-old male who was admitted with productive cough, hemoptysis, dyspnea on minimal exertion, fever, and chest pain. He had recurrent orchitis and epididymitis for 7 years, as well as oral and genital ulcers and severe headache. Clinical examination revealed decreased breath sounds at the right middle lung. Thoracic computed tomography angiography confirmed multiple pulmonary artery aneurysms bilaterally. The patient was diagnosed with Behçet’s disease, and immunosuppression therapy was initiated. During follow-up, the patient did not report any complications. This case report underscores the significance for clinicians to consider Behçet’s disease as a differential diagnosis in patients presenting with hemoptysis and a history of orchitis and epididymitis, given that Behçet’s disease rarely causes pulmonary artery aneurysms.

COMPLETE REMISSION OF MULTIPLE SEVERE AND REFRACTORY PULMONARY ANEURYSMS IN BEHCETS DISEASE AFTER TREATMENT WITH INFLIXIMAB

Introduction: Behcets disease is a multisystem disorder that can affect multiple organs.Vascular complications are common in Behçets disease.Arterial complications can include pulmonary artery aneurysms. These have a high risk of rupture and can be life threatening. Observation: This report details a case of Behçets Disease in a 52-year-old patient of North African descent. The diagnosis was made after the patient experienced massive hemoptysis caused by multiple pulmonary artery aneurysms. The initial treatment prescribed for the aneurysm involved immunosuppressive medication, including cyclophosphamide and corticosteroids. During a 6-month follow-up period, the patient showed an unfavorable progression. Treatment with infliximab was attempted and resulted in a successful response to this treatment. Conclusion: This is a new observation that reinforces the superiority of infliximab in severe and refractory Behcets disease.

Multiple pulmonary artery aneurysms in miliary tuberculosis

Pulmonary artery aneurysms are rare life threatening complications of tuberculosis (TB). Clinical symptoms range from being silent to fatal hemoptysis. Computed tomography angiography is diagnostic and shows the vascular nature of the lesions and their origin from the pulmonary arteries. The typically described Rasmussen’s aneurysm arises in cavitary TB due to inflammation induced damage to the tunica of the pulmonary artery. However, aneurysms may also rarely occur in non-cavitary TB. In this report, we describe a case of multiple aneurysms of the pulmonary artery in a case of non-cavitary miliary TB.

P5‐109: A fatal case of multiple mycotic pulmonary artery aneurysms due to Aspergillus terreus in a post COVID‐19 patient

P5‐109: A fatal case of multiple mycotic pulmonary artery aneurysms due to <i>Aspergillus terreus</i> in a post COVID‐19 patient

Multiple bilateral pulmonary arterial aneurysms with massive thrombosis in inferior vena cava and hepatic vein.

The authors declare that there are no conflict of interests.

Hughes-Stovin: A rare entity and challenging therapeutic management

Hughes Stovin is a rare disorder first described in 1959. It's usually diagnosed along Behcet disease (BD), with a High mortality rate that results from the ruptured pulmonary aneurysm. To investigate the course and spectrum of Hughes Stovin syndrome in BD and to assess the clinical and imaging features, treatment, and outcomes. A 38 year-old male, with a family history of AngioBehçet disease (brother who passed away) presented to the hospital with Hemoptysis in the context of a 1 year neglected history of genital/oral aphtae and pseudofolliculitis. CT angiography showed multiple pulmonary arterial aneurysms ( Fig. 1 ), pulmonary embolism along a right brachiocephalic vein thrombosis. A diagnosis of Hughes Stovin syndrome (HSS) associated with Behcet disease was made. Treatment was initiated with methylprednisolone IV 1 g daily for three days then discharged from hospital with prescription of Colchicine. Six months later, the patient had recurrence of his hemoptysis with a CT revealing an alveolar hemorrhage. Corticosteroid and immunosuppressant were the mainstay of therapy but the patient wasn’t compliant to treatment. 1 year later, without any follow-up meanwhile, the patient experienced chest pain and hemodynamic instability, CT revealed an increase in aneurysmal size and intraalveolar hemorrhage. The patient was immediately stabilized and an embolization of the right lower pulmonary artery was performed along immunosuppressants and corticoids. Few months later, the patient had a similar hospitalization that led to the embolization of right upper pulmonary artery with success. He is now still being monitored. HSS is a rare disease affecting mostly male patients between 12 and 40 years of age. Co-morbid conditions like Behçet disease and Hughes Stovin make medical management complicated and very challenging, as the history of this disease is unpredictable.

HUGHES STOVIN SYNDROME: A RARE FORM OF BEHCET’S DISEASE PRESENTING AS RECURRENT INTRACARDIAC THROMBI

Hughes Stovin syndrome (HSS) is very rare, believed to be a cardiovascular variant of Behcet's disease, characterized by an association of multiple pulmonary artery aneurysms and peripheral venous thrombosis. Intracardiac thrombi is a rare presentation, found in 6 patients among the 38 case reports

Hughes-Stovin syndrome-a rare entity with combination of venous thrombosis and multiple pulmonary arterial aneurysms.

Hughes-Stovin syndrome-a rare entity with combination of venous thrombosis and multiple pulmonary arterial aneurysms.

Bilateral multiple pulmonary artery aneurysms associated with cavitary pulmonary tuberculosis: a case report

BackgroundPulmonary artery aneurysms constitute <1% of aneurysms occurring in the thoracic cavity. Congenital cardiac defects are responsible for the majority (>50%) of cases, however, pulmonary artery aneurysm is a rare sequelae of pulmonary tuberculosis reported in about 5% of patients with chronic cavitary tuberculosis on autopsy. The natural history of this potentially fatal condition remains poorly understood and guidelines for optimal management are controversial.Case presentationA 24-year-old man, a nursing student of African descent, was referred to us from an up-country regional hospital with a 4-week history of recurrent episodes of breathlessness, awareness of heartbeats and coughing blood 3 weeks after completing a 6-month course of anti-tuberculosis drugs. A physical examination revealed conjuctival and palmar pallor but there were no stigmata of connective tissue disorders, systemic vasculitides or congenital heart disease. An examination of the cardiovascular system revealed accentuated second heart sound (S2) with early diastolic (grade 1/6) and holosystolic (grade 2/6) murmurs at the pulmonic and tricuspid areas respectively. Blood tests showed iron deficiency anemia, prolonged bleeding time, and mild hyponatremia. A chest radiograph revealed bilateral ovoid-shaped perihilar opacities while a computed tomography scan showed bilateral multiple pulmonary artery pseudoaneurysms with surrounding hematoma together with adjacent cystic changes, consolidations, and tree-in-bud appearance. Our patient refused to undergo surgery and died of aneurismal rupture after 9 days of hospitalization.ConclusionsThe presence of intractable hemoptysis among patients with tuberculosis even after completion of anti-tuberculosis course should raise an index of suspicion for pulmonary artery aneurysm. Furthermore, despite of its rarity, early recognition and timely surgical intervention of pulmonary artery aneurysm is crucial to reducing morbidity and preventing the attributed mortality.

Hughes-Stovin syndrome: a case report

Hughes–Stovin syndrome (HSS) is a very rare clinical entity, which is characterized by peripheral venous thrombosis and multiple pulmonary and/or bronchial artery aneurysms and is associated with a high mortality. Although the exact etiology of HSS is still not known, possible causes include infection and angiodysplasia. Because of its histopathological and clinical similarities with Behcet's disease (BD), it is also considered as a variant of BD. HSS usually present with cough, dyspnea, fever, chest pain, and hemoptysis, which can be massive and often fatal. We report a case of a 24-year-old man who presented with thrombosis of inferior vena cava (IVC) with recurrent hemoptysis. There were evidences of pulmonary artery aneurysm and thrombosis of IVC and lower extremity veins on contrast-enhanced computed tomography (CECT) scan of the thorax and color Doppler study, respectively. There were no orogenital ulcerations or uveitis consistent with BD. Pulmonary transcatheter embolization was planned but the patient died following massive hemoptysis probably because of rupture of the aneurysm.

Combined pulmonary vasodilator therapy and endovascular intervention for Hughes–Stovin syndrome

Hughes–Stovin syndrome (HSS), a rare syndrome considered by some a form of Behçet's disease, is characterized by multiple pulmonary and/or bronchial artery aneurysms and thrombophlebitis [1,2]. It affects mainly young men, especially from Mediterranean countries and the Near East [2]. Acute manifestations include low-grade fever, weight loss, thrombophlebitis and hemoptysis [2]. The presence of pulmonary arterial aneurysms (PAA) carries a poor prognosis. Massive hemoptysis is the main cause of death.

Síndrome Hughes-Stovin: Caso clínico

We report a 25 year old mole admitted to a critical care unit for fever, lung opacities and acute respiratory failure. A chest angio-CAT sean showed multiple pulmonary artery aneurysms. A deep venous thrombosis of both lower limbs was also documented. A Hughes-Stovin syndrome was postulated. An inferior vena cava filter was placed. The patient received antimicrobial therapy subsiding fever and respiratory failure. Subsequently, he was treated with intravenous and oral steroids and one dose of cyclophosphamide. The patient was discharged in good conditions fifteen days after admission.

Multiple pulmonary arterial aneurysms in a young male patient with incomplete Behçet′s syndrome

Multiple pulmonary arterial aneurysms in a young male patient with incomplete Behçet′s syndrome

Anévrisme pulmonaire complètement résolu après un traitement médical au cours de la maladie de Behçet

Pulmonary artery aneurysm in Behcet disease compromises seriously the diagnosis since its fatal rupture is still the major cause of death in this disease. Pulmonary artery aneurysm requires urgent management and several treatments have been proposed, including steroids, immunosuppressive drugs, embolisation and surgery. Herein, we report a patient with Behçet's disease in whom multiple pulmonary artery aneurysms were completely resolved after a combined treatment with corticosteroids and azathioprine. Pulmonary artery aneurysms in Behçet's disease are reported to indicate poor prognosis and high mortality. Computed tomographic scans of the chest and angiography are the most common diagnostic procedures used in the diagnosis or evaluation of pulmonary artery aneurysm. Immunosuppression is the main therapy for the treatment of a vasculitis.

Use of an amplatzer vascular plug in embolization of a pulmonary artery aneurysm in a case of hughes-stovin syndrome: a case report

IntroductionHughes-Stovin syndrome is a rare condition characterized by peripheral deep venous thrombosis accompanied by single or multiple pulmonary arterial aneurysms. The limited number of cases has precluded controlled studies of the management of pulmonary artery aneurysms, which usually cause massive hemoptysis leading to death. This is the first report of a new endovascular treatment of a single large pulmonary arterial aneurysm.Case presentationAn 18-year-old Caucasian man was referred to our department with recurrent severe hemoptysis. His medical history included Hughes-Stovin syndrome diagnosed during a recent hospital admission. The patient was initially treated with corticosteroids. Because of his recurrent hemoptysis, we decided to embolize a 3.5 cm pulmonary arterial aneurysm using an Amplatzer Vascular Plug. The procedure was not complicated, and the patient's post-intervention course was uneventful. The patient has remained free from any complications of the embolization 36 months after the procedure.ConclusionPercutaneous embolization of a single large pulmonary artery aneurysm with an Amplatzer Vascular Plug in a patient with Hughes-Stovin syndrome is a less invasive procedure that represents the best multidisciplinary approach in treating these patients.

A case of Behcet's disease with pulmonary artery aneurysm and thrombosis

A 22 year old patient with dyspnea, cough, chest pain, fatigue, mild fever and swelling of the lower extremities was hospitalized. Physical examination revealed bilateral decrease in respiratory sounds and end-inspiratory fine rales at the left posterobasal area. Circumferences of both legs were increased. During hospitalization period, oral aphthous and scrotal ulceration were appeared. Bilateral multiple peripheral and central pulmonary artery aneurysms at middle zones were found with dynamic computerized tomography of thorax and magnetic resonance angiography of the lungs. Patient was diagnosed as Behcet's disease with lung involvement. Magnetic resonance angiography performed at the sixth month of the treatment revealed a significant regression in aneurysmatic changes, whereas a right ventricular thrombosis had been developed.

Hughes-Stovin syndrome: A rare cause of hemoptysis

Multiple pulmonary artery aneurysms are seen along with venous thrombosis in Hughes-Stovin syndrome, which many investigators believe is an incomplete form of Behcet's disease. We present a case of hemoptysis with multiple pulmonary artery aneurysms, femoral vein thrombosis, and oral ulcers with emphasis on its CT features.

Detection of Cardiovascular System Involvement in Behçet's Disease Using Fluorodeoxyglucose Positron Emission Tomography

Behçet's disease (BD) theoretically affects all sizes and types of vessels; however, there have been few reports describing the clinical efficacy of using (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in patients with BD. Eight patients who were registered at the BD Specialty Clinic of Severance Hospital between 2004 and 2008 underwent FDG-PET scans to evaluate the cardiovascular presentations associated with BD. Medical records and FDG-PET images of the patients were retrospectively reviewed to determine the clinical significance of the cardiovascular findings. The median quantitative FDG uptake index was 1.46 (range, 0.58-2.61). FDG uptake was detected in multiple pseudoaneurysms, aortitis and arteritis associated with aortic regurgitation, and aneurysmatic dilation of the sinus of Valsalva, atherosclerotic change of the proximal ascending aorta associated with aortic regurgitation, and multiple pulmonary artery aneurysms. The quantitative FDG uptake intensity was significantly associated with the ESR level. FDG-PET scans may have clinical value as a workup study for patients with BD who have cardiovascular presentations.

A Case of Isolated Peripheral Pulmonary Artery Branch Stenosis Associated with Multiple Pulmonary Artery Aneurysms

Selective right pulmonary arteriography and 3-dimensional computed tomography revealed multiple severe stenoses of the peripheral pulmonary artery associated with poststenotic aneurysms in a 65-year-old woman. She was referred to the hospital for evaluation of dry cough, gradually increasing dyspnea and multiple nodular shadows on a chest radiograph. Echocardiography and cardiac catheterization showed severe pulmonary hypertension, though other structural heart diseases or well-characterized congenital syndromes were ruled out. She was diagnosed as isolated peripheral pulmonary artery branch stenosis. Recent advances in CT technology enable a less-invasive assessment of pulmonary artery, and can be useful in the management of pulmonary arterial hypertension.

Síndrome de Hughes-Stovin

Hughes-Stovin syndrome is a rare disorder of unknown etiology characterized by the association of multiple pulmonary artery aneurysms and deep venous thrombosis. Some authors consider this entity an incomplete form of Behcet's disease due to the similarities between the radiologic and anatomopathological findings of pulmonary involvement. The authors report a case of Hughes-Stovin syndrome whose first venous thrombotic event preceded the development of pulmonary aneurysms by five years.