Abstract: Numerous herbal-based Ayurvedic and Chinese medications contain a variety of phytochemicals that may have a neuroprotective impact and help treat a variety of neurodegenerative diseases. The natural medicinal drug has long been used to treat neural signs and symptoms. There has been an enormous public and clinical interest in the use of Phytoconstituents for neuroprotection or the prevention of neurodegenerative illnesses. Various compounds, isolated from exclusive natural sources with multiple objectives seem as a capacity and promising class of therapeutics for the remedy of illnesses associated with neuro-related issues. It is vitally important to identify and create novel therapeutic strategies. The possibility for safe, naturally occurring secondary metabolites with neuroprotective characteristics is present in plants and other natural products. This review intends to take a closer look at some specific elements of natural phytoactives that are thought to be significant for the treatment of neuro-related illnesses.