An analog comb filter is implemented by linking multiple VDCC-based notch filters in a cascading fashion (N in total), eliminating N different pole frequencies. This study focuses on suppressing a fundamental frequency of power-line interference of 50 Hz and its consecutive three odd harmonics at 150 Hz, 250 Hz, and 350 Hz. One significant advantage of this comb filter is the independent control over filters' parameters like quality factor and pole frequency. Additionally, these filters can be electronically tuned by adjusting the transconductance gain of VDCC. The suggested notch filter configuration involves 2 capacitors, 2 resistors, and 1 VDCC element. Extensive simulations were conducted using PSPICE simulator software to validate the effectiveness of these filters. The basic building block, VDCC, is designed and implemented in the simulation using integrated circuits MAX435 and AD844.•Design uses a VDCC-based high Q notch filter as the active building block.•The filter employs fewer active and passive components.•Simulated results using commercially available ICs, MAX435 and AD844, confirm the filter's practical utility.