Multiple Eruptive Dermatofibromas Research Articles

Multiple Eruptive Dermatofibromas in a Patient with Primary Sjögren’s Syndrome

Multiple eruptive dermatofibromas (MEDF) are rare tumors and thought to be associated with the disturbances in the immune system. In our 40-year-old case, 5 nodules have developed in a 4-month period. The patient was diagnosed by a dermatologist to have MEDF, and referred to rheumatology outpatient clinic because of the symptoms such as dry mouth, and polyarthralgia. After clinical and laboratory evaluation, the diagnosis of primary Sjögren’s syndrome (SS) was made. According to the best of our knowledge, this case is the first reported association between MEDF and primary SS. Therefore, when the diagnosis of MEDF is made, SS should also been included in the comprehensive evaluation of associated diseases.

P10: Multiple eruptive dermatofibromas in an immunocompetent patient

P10: Multiple eruptive dermatofibromas in an immunocompetent patient

Multiple Eruptive Dermatofibromas Secondary to Imatinib Mesylate in a Patient with Chronic Myeloid Leukemia.

Multiple Eruptive Dermatofibromas Secondary to Imatinib Mesylate in a Patient with Chronic Myeloid Leukemia.

Multiple Eruptive Dermatofibromas in Patient with Systemic Lupus Erythematosus

Abstract Introduction. Multiple eruptive dermatofibromas are described in association with different immune-mediated conditions like SLE, pemphigus, myasthenia gravis, HIV infection, organ transplantation, acute myeloid leukemia, ulcerative colitis, atopic dermatitis and immunosuppressive therapy. Case Report. A forty-five year-old woman presented at our Department with over 20 dermatofibromas on her trunk and extremities developed spontaneously over the last 3 years, out of which more than 10 lesions developed over the previous year. The patient was diagnosed with systemic lupus erythematosus before the onset of lesions and was treated with different immunomodulatory agents (corticosteroids, methotrexate, antimalarials, azathioprine, belimumab, anti IL-6 antibody). Dermoscopy of different lesions revealed different dermatoscopic patterns without pattern predominance. A biopsy specimen of one lesion confirmed the diagnosis. Conclusion. There are few cases reports describing a possible link between systemic lupus erythematosus and multiple dermatofibromas. The mechanism is still unknown but is believed to be due to the altered immunity in immune-mediated diseases.

Multiple eruptive dermatofibromas

Multiple eruptive dermatofibromas

Multiple eruptive dermatofibromas associated with pregnancy- a case and literature review

Dermatofibromas are common and asymptomatic benign histiocytic tumors. The occurrence in a small number (up to 5 lesions) is frequent. However, the expression "multiple eruptive dermatofibromas" is reserved for the appearance of more than 5 lesions in less than four months. Multiple eruptive dermatofibromas are rare and usually associated with an underlying systemic condition, the most common being autoimmune diseases or HIV infection. Herein we report multiple eruptive dermatofibromas developing in an otherwise healthy pregnant woman. Although the pathogenesis of this condition remains unknown, it is believed to be related to immunological alterations, given the strong association with states of immunosuppression or, in the case of pregnancy, with a state of immunotolerance.

Multiple Eruptive Dermatofibromas in a Patient with HIV infection

Multiple eruptive dermatofibromas is a rare event characterized by the appearance multiple dermatofibromas in few months. It is usually associated with immunodysregulation/immunosuppression. An appropriate work-up of underlying diseases must be done after this diagnosis, including search for HIV infection and lupus erythematosus. We present a case of multiple eruptive dermatofibromas in a female patient with HIV infection, possibly associated with a decrease in the CD4+ T cell count and viral load increase.

Dermatological aspects of the S2k guidelines on Down syndrome in childhood and adolescence.

With an incidence of 1 in 700 births, Down syndrome (DS) is not an uncommon condition. It is associated with various disorders of different organ systems. Serious disorders include cardiac defects and leukemia. With an onset during the newborn period, the latter does not always progress to classic myeloid leukemia (transient myeloproliferative disorder). Skin manifestations in newborns include pustules/vesiculopustules. In individuals with DS, such lesions should not only prompt suspicion for typical neonatal rashes and infections but also for transient myeloproliferative disorder. However, most dermatoses are benign. They essentially comprise disorders of keratinization that present as xerosis, keratosis pilaris, lichenification, and ichthyosis vulgaris. Also typical but not specific is the four-finger palmar crease (simian crease). Patients frequently develop folliculitides, which - due to elastolysis - subsequently progress to anetoderma. The known immune disturbance in DS patients explains the occurrence of autoimmune diseases such as alopecia areata and vitiligo. Typical skin conditions associated with DS include elastosis perforans serpiginosa, syringomas, milia-like calcinosis cutis, and multiple eruptive dermatofibromas.

Multiple Eruptive Dermatofibromas in a Patient With Systemic Lupus Erythematosus Treated With Methylprednisolone.

Multiple Eruptive Dermatofibromas in a Patient With Systemic Lupus Erythematosus Treated With Methylprednisolone.

Multiple eruptive dermatofibromas occuring in a patient under hemodialysis

Multiple eruptive dermatofibromas occuring in a patient under hemodialysis

Multiple eruptive dermatofibromas occuring in a patient under hemodialysis

Multiple eruptive dermatofibromas occuring in a patient under hemodialysis

Multiple eruptive dermatofibromas associated with systemic sclerosis

Multiple eruptive dermatofibromas associated with systemic sclerosis

Multiple Eruptive Dermatofibromas Masquerading as Cutaneous Lymphoma.

A 34-year-old male came with complaints of multiple firms to hard nontender, nonitchy nodules, measuring 2 cm × 2 cm to 1 cm × 1.5 cm, present predominantly over the lower limbs. This condition started 5 years back as a single nodule over the thigh but gradually increased in number and size with time to involve both lower limbs. A differential diagnosis of cutaneous lymphoma and dermatofibroma was considered. He underwent a biopsy and immunohistochemistry for the same which were consistent with hemosiderotic histiocytoma and positive for vimentin. The patient was advised surgical excision for the same. The occurrence of multiple dermatofibromas although rare has been reported in a few case reports; however, the occurrence of multiple dermatofibromas of the hemosiderotic variant has not been documented yet.

Multiple eruptive myxoid dermatofibromas

Abstract Multiple eruptive dermatofibromas are a rare presentation of dermatofibroma and have been associated with altered immunity. A rare case of multiple eruptive myxoid dermatofibromas (MEMDFs), characterized by marked stromal mucin deposition, is reported herein; additionally, an in-depth discussion on the implication of altered immunity is presented. Because MEMDFs can be an initial manifestation of systemic lupus erythematosus, it is necessary for dermatologists to perform a skin biopsy for pathological diagnosis and a comprehensive survey for autoimmunity, infectious diseases, especially human immunodeficiency virus infection, hematologic diseases, and malignancies, or other immunodeficiency conditions when the patient is diagnosed with MEMDFs.

Multiple eruptive dermatofibromas

We report a 34 year-old woman with psoriasis, systemic lupus erythematosus (SLE), and recent anti-TNFa therapy, who presented with multiple, eruptive dermatofibromas (MEDF). Although the pathogenesis of MEDF remains unknown, there is substantial evidence that this phenomenon represents an aberrant immune response. Like the more common presentation of solitary dermatofibromas, these lesions are benign, and no treatment is required. However, MEDF is increasingly recognized as a sign of immune dysregulation and an appropriate work-up should be initiated to identify an underlying cause in patients without a known trigger.

A case of multiple eruptive dermatofibromas in a healthy adult.

Dear Editor: Multiple eruptive dermatofibromas (MEDF) are very rare and usually have been associated with autoimmune diseases, immunosuppressant therapy, hematologic malignancy, and other conditions. Zaccaria et al.1 noted that the incidence of MEDF is higher in patients with underlying diseases than in healthy persons. A 64-year-old man visited our department because of multiple lesions of the skin that had developed rapidly during the previous 3 months. Physical examination revealed firm, brownish, dome-shaped papules (>30) that were 5~10 mm in diameter, with lateral dimpled signs, on the trunk and legs (Fig. 1). He did not have any specific medical or family history. Excision biopsy of a papule on the right thigh showed a relatively well-demarcated dermal nodule composed of tightly interdigitating fascicles of spindle-shaped fibrohistiocytic cells (Fig. 2A, B). Immunohistochemical analysis revealed that many of the tumor cells were positive for factor XIIIa (Fig. 2C) and negative for CD34. Laboratory tests were conducted to rule out connective tissue disease and immunosuppressive state. Complete blood cell count, metabolic and hepatitis panels, erythrocyte sedimentation rate, analysis of T-cell subset, C3/C4, immunoglobulins, and thyroid-stimulating hormone showed normal results. Anti-human immunodeficiency virus antibody, antinuclear antibody, and double-stranded DNA antibody were all negative. Fig. 1 (A) Multiple brownish, dome-shaped nodules that were 5~10 mm in diameter on the trunk and legs. (B) A bean-sized, brownish, firm nodule on the right thigh. Fig. 2 (A) Excision biopsy of 1 papule on the right thigh showed a relatively well- demarcated dermal nodule overlaid by hyperplastic epidermis with basal hyperpigmentation (H&E, ×20). (B) Proliferation of spindle-shaped fibrohistiocytic cells ... One or several dermatofibromas (DF; 15) are extremely rare. In 1970, Baraf and Shapiro2 first described multiple DF. Ammirati et al.3 proposed that MEDF should be defined as the presence of 5~8 DF appearing within a period of 4 months. However, this criterion is arbitrarily chosen, and therefore, it might not be entirely valid for all cases. It is important to note the dynamic changes in some lesions within a short period, in contrast to the static state usually observed in DF4. Indeed, some cases reported as MEDF did not meet the criteria or did not indicate the period of development. In our review of the literature published between 1973 and 2012, 21 of 72 subjects were otherwise healthy, whereas 51 (70%) had an underlying disease. Forty-one cases (80%) among the patients with underlying disease were related to various immunodeficiency states. The etiology of DF is unclear. It was proposed that DF represents an abortive immunoreactive process mediated by dermal dendritic cells, developing as a response to a putative pathogen that the suppressed immune system cannot clear5. Accordingly, the development of MEDF could be considered a manifestation of immunosuppression; however, in our case, no abnormal specific immune defect or a medical history of using immunosuppressive agents could be found. Herein, we report a rare case of MEDF in a healthy adult, along with a literature review.

Multiple eruptive dermatofibromas related to imatinib treatment

Multiple eruptive dermatofibromas related to imatinib treatment

Congenital multiple clustered dermatofibroma and multiple eruptive dermatofibromas - unusual presentations of a common entity

Dermatofibroma is one of the most common entities seen in dermatology clinical practice. Several clinical subtypes have nevertheless been described, all of them of uncommon occurrence. The authors present two rare clinical variants of dermatofibromas: congenital multiple clustered dermatofibroma (the presented case is the 4th congenital case to be reported so far) and multiple eruptive dermatofibromas developing in the setting of a Sjögren's syndrome. Since the uncommon subtypes may not be clinically evident, dermatologists should familiarize themselves with their main features and we advise a high level of clinical suspicion in order to reach the correct diagnosis.

Congenital multiple clustered dermatofibroma and multiple eruptive dermatofibromas: Exceedingly rare presentations of a common entity

Congenital multiple clustered dermatofibroma and multiple eruptive dermatofibromas: Exceedingly rare presentations of a common entity

Dermatofibromes multiples « éruptifs » familiaux

Multiple eruptive dermatofibromas (DF) are rare and frequently associated with immune and neoplastic diseases. There have also been reports of rare familial cases. Herein we report a new such case. A 79-year-old woman and her 37-year-old daughter were seen for disseminated DF over a period of several decades, from adolescence onwards. Neither had any history of diseases or treatments normally associated with multiple DF. History-taking revealed similar lesions in other family members. DF are common benign cutaneous tumours, generally seen on the lower limbs of young or middle-aged women. These lesions occur either in isolation or are relatively few. Multiple or so-called eruptive DF, defined by the presence of more than 15 lesions in a single patient, is rare and is associated in 60% of cases with autoimmune diseases, HIV infection, neoplastic disease or immunosuppressant therapy. Familial forms such as those described herein are extremely rare.