In this paper, we present a novel approach for designing single-/multiple-band bandpass filters (BPFs) using a hybrid metamaterials approach, incorporating substrate integrated waveguide (SIW), spoof surface plasmon polariton (SSPP), and defected surface structures (DSSs) technologies. The substrate-integrated plasmonic waveguide (SIPW) is constructed by embedding a hybrid dual SSPP into a three-layer SIW. The SIPW demonstrates a reduced phase velocity and a lowered lower cutoff frequency, extracted from the slow-wave dispersion relationship. Initially, the SIPW-based single-band metamaterial BPF demonstrates miniaturized size and broadened bandwidth. Furthermore, by loading a pair of complementary electric-inductive capacitive (ELC) resonators consisting of DSSs and adjusting their symmetry properties and geometric parameters, multiple BPFs from 1 to 3 are realized. To validate the proposed designs, three prototypes are fabricated and measured. The results demonstrate good filtering performances of proposed metamaterial BPFs, featuring high reflection loss (S11 < −10.5 dB) and a high level of out-of-band rejection exceeding 25 dB between multiple passbands.