An improved multi-objective design optimization framework is proposed for the efficient design of proprotor blades tailored to specific high-altitude mission requirements. This framework builds upon existing methods by leveraging a reformulated Vortex Particle Method (rVPM) and incorporates three key stages: (1) rapid determination of overall proprotor parameters using a semi-empirical model, (2) optimized blade chord and twist distribution bounds based on minimum energy loss theory, and (3) global optimization with a high-fidelity rVPM-based aerodynamic solver coupled with a multi-objective hybrid optimization algorithm. Applied to a small high-altitude tiltrotor, the framework produced Pareto-optimal proprotor designs with a figure of merit of 0.814 and cruise efficiency of 0.896, exceeding mission targets by over 15%. Key findings indicate that large taper ratios and low twist improve hover performance, while elliptical blade planforms with high twist enhance cruise efficiency, and a tip anhedral further boosts overall performance. This framework streamlines the industrial customization of proprotor blades, significantly reducing the design space for advanced optimization while improving performance in demanding high-altitude environments.