To implement full-wave simulation of electromagnetic wave impinging invisible cloaks, an efficient multidomain pseudospectral time-domain algorithm is developed in this study. The proposed method solves the same forms of Maxwell's equations in both the regular and cloaking areas, and then applies different methods to update the electric and magnetic field components, respectively. The new method requires less grid points per wavelength, meanwhile, the multidomain strategy relieves the complicated treatment of electric and magnetic field components based on Yee grids within finite-difference time-domain methods, and shows advantage of dealing with internal inhomogeneities within the cloaking materials. The results validated feasibility and efficiency of the proposed method in left-hand materials.