The 2nd International Conference on Particle Physics and Astrophysics (ICPPA-2016) was held in Moscow, Russia, from October 10 to 14, 2016. The conference is organized by the National Research Nuclear University “MEPhI”. The aim of the Conference is to promote contacts between scientists and to develop new ideas in fundamental research. We bring together experts and young scientists working on experimental and theoretical aspects of nuclear, particle and astroparticle physics and cosmology.The conference covers a wide range of topics such as accelerator physics, (astro) particle physics, cosmic rays, cosmology and methods of experimental physics: detectors and instruments. These directions are unified by development of the Standard Model which is evidently not complete. There are deviations from the Standard Model: neutrino oscillations, the dark matter existence. Together with strong interactions they are main subjects of the Conference.New results from leading high energy physics collaborations are discussed. Main LHC experiments (ATLAS, CMS, ALICE) presented their results and detector upgrade prospects on the conference. Various aspects of Standard Model testing and search for new phenomena are main subjects of the conference. Among them: flavor physics at B factories, precision multi-boson production measurements, dark matter searches.Electroweak interaction was discussed in the talks given by participants of neutrino physics experiments (Borexino, Neutrino-4, SOX, T2K and others). Enigmatic properties of neutrinos such as their tiny masses, oscillations between different neutrino types, cannot be explained in frame of the modern theory and require new approaches. Properties of neutrinos influenced the formation of the large-scale structure of the Universe and may be neutrinos are partially responsible for the excess of matter over anti-matter. Also our current challenge is the nature of the Dark matter. Many opportunities arise with the development of neutrino detection technologies comprising: measurements of neutrinos from the Sun, measurements of geo-neutrino from the deep interior of the Earth, detecting neutrino fluxes from supernovae and different astrophysical sources. They were the subject of discussion which have been held at the conference. Neutrino physics experiments make huge demands to technologies like ultra-high precision measurements, huge detector size, excellent reliability and ultra-low radioactive background.AcknowledgmentsWe are thankful to Anotonova M M, Buzhan P Zh, Gurov Yu B, Vdovkina S S, Zherebtsova E S, Esipova E A, Kovylyaeva A A, Kozlov E S, Koshelenko D D, Matveev N A, Mayorov A G, Nigmatkulov G A, Novikov A S, Svadkovsky I V, Smirnov Yu S, Voronov S A and Yurin K O for the assistance in organizing the conference and heavy work on proceedings.Conference organizers would like to express their gratitude to the TFT company (supply and maintenance of CAEN equipment, delivery of equipment and components for scientific research) for their support.