In this paper, we propose a framework for multiuser mmWave DCT-Spread CP-less OFDM communication system and analyze it comprehensively. Due to excessive cyclic prefix (CP) usage in conventional multicarrier systems, spectral efficiency reduces and increases transmission latency. Our proposed system enhances spectral efficiency and reduces transmission latency. We introduce an image encryption algorithm based on DNA encoding combined with a chaotic map is introduced to enhance physical layer security (PLS). The impact of block diagonalization (BD) channel precoding for multiuser interference (MUI) reduction and designed subcarrier mapping with time-domain Tukey windowing for out-of-band (OOB) power emission reduction are investigated. In addition, the paper studies the applicability of discrete cosine transforms (DCT)-Spreading for peak-to-average power ratio (PAPR) reduction. Simulation results demonstrate that Turbo and Repeat and Accumulate (RA) channel coding and minimum mean square error (MMSE) and Cholesky decomposition (CD)-based zero-forcing (ZF) signal detection schemes improve bit error rate (BER) performance of the proposed system for different users.