Based on the lessons from the Fukushima accident, new strategies to mitigate the spread of accidents in nuclear power plants have been established that consider portable equipment. The diverse and flexible coping strategies (FLEX) and multi-barrier accident coping strategy (MACST) based on the utilization of portable equipment are being adopted in case of an extended loss of all AC power and loss of ultimate heat sink. In this context, the establishment of specific strategies for utilizing portable equipment has emerged as an important issue. This study proposes a multi-unit probabilistic safety assessment (MUPSA)-based evaluation framework consisting of several steps to quantitatively assess the reduction in risk from the use of portable equipment at a multi-unit site, which can provide a basis for establishing optimal portable equipment strategies. According to the framework, after first defining the scope of the evaluation, risk-significant types of portable equipment are selected and the scenarios are analyzed. Risk reduction is then evaluated using modified MUPSA models according to the deployment of the portable equipment. A case study was conducted for an internal loss of off-site power (LOOP) and seismic LOOP focusing on how to evaluate the effectiveness of portable equipment through the developed framework.