The arrival of Afro-descendant migrants, mainly from Haiti and the Dominican Republic, has led to the emergence of new discourses on migration, multiculturalism, and mental health in health services in Chile since 2010. In this article, I explore how mental health institutions, experts, and practitioners have taken a cultural turn in working with migrant communities in this new multicultural scenario. Based on a multisited ethnography conducted over 14 months in a neighbourhood of northern Santiago, I focus on the Migrant Program-a primary health care initiativeimplemented since 2013. I argue that health practitioners have tended to redefine cultural approaches in structural terms focusing mainly on class aspects such poverty, social stratification, and socioeconomic inequalities. I affirm that this structural-basedapproachfinds its historical roots in apolitical and ideological context that provided the conditions forthe development ofcommunity psychiatry experiencesduring the 1960s and 1970s, as well as in multicultural and gender policies promoted by the state since the 1990s. This case reveals howhealth institutions and practitioners have recently engagedindebates on migration and intersectionality from a structural approachin Chile.