This study presents a comprehensive study on the potential and efficacy of decomposition-based multi-objective symbiotic organism search (MOSOS/D) algorithm for truss structure optimization. The investigation is carried out on five benchmark truss structures, e.g., 37-bar, 60-bar, 72-bar, 120-bar, and 200-bar truss problems. The optimization performance of MOSOS/D is compared with other established algorithms, such as Multi-Objective Evolutionary Algorithm Based on Decomposition, Non-Dominated Sorting Genetic Algorithm-II, Multi-Objective Equilibrium Optimizer, Multi-Objective Marine Predator Algorithm, Decomposition-Based Multi-Objective Heat Transfer Search, Multi-Objective Passing Vehicle Search, Multi-Objective Evolutionary Algorithm Based on Decomposition Differential Evaluation, Multi-Objective Symbiotic Organisms Search, and Multi-Objective Multi-Verse Optimizer considering several metrics, including Generational Distance, Spacing, Spread, Inverted Generational Distance, Hypervolume and Runtime. The findings demonstrate MOSOS/D’s competitiveness in providing non-dominated solutions with less space between them. It also achieves a good balance between convergence and coverage and, thus, delivers diverse solutions with less computational complexity. However, the efficiency of the MOSOS/D algorithm varies depending on the complexity of the considered truss structure, with some algorithms occasionally outperforming it in one or two aspects for specific benchmarks. This study provides valuable insights to engineers and designers aiming to achieve optimal truss structure design.