With the rapid development of biomanufacturing technology in the medical and pharmaceutical fields, the demand for high-precision and high-quality molds has surged. When Computer numerical control (CNC) machining biomanufacturing molds, the optimization of process parameters becomes the key to improve efficiency and quality. The purpose of this study is to explore the optimization strategy of CNC machining process parameters to achieve the best surface quality, dimensional accuracy and machining efficiency. Through literature review, the spindle speed, feed speed and cutting depth are selected as the key parameters, and the multi-objective optimization model is constructed by response surface method, which is solved by genetic algorithm. The experiment shows that the process parameters of CNC system in mold manufacturing are cutting speed 100 (m/min), feed rate 0.2 (mm/rev) and cutting depth 0.5 (mm), which will effectively reduce the manufacturing cost, and effectively control the alarm times within 35 times in different processing equipment, greatly reduce the risk. The optimization strategy can significantly improve the surface quality and productivity of the mold and reduce the cost. The comparative analysis verifies the effectiveness of the method, which provides new theoretical and technical support for CNC machining in the field of biomanufacturing.
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