Optimal site selection for the establishment of a municipal waste-water-treatment plant (WWTP) is an amazingly complex task that involves several factors such as regulations, as well as environmental, economic and social considerations. This paper presents the criteria and applied methods (geographic information system (GIS)/fuzzy analytical hierarchy process (AHP)) used in the screening of potential sites for the WWTP of the Bent Saidane rural locality (northern Tunisia). For this reason, nine factors accompanied by three sets of site selection criteria were used. GIS-based multi-criteria analysis techniques based on the standardised fuzzy logic concept and weighted overlay were applied for generation of all maps in the Universal Transverse Mercator coordinate system. Multiscale evaluations based on the weighted linear combination method were also assessed. The study indicated that 0.14 and 0.11% of the total area of the Bent Saidane locality were found to be highly suitable and very highly suitable, respectively. According to these results, the GIS followed by the fuzzy AHP method could pinpoint the optimal sites selected as the most suitable, due to their minimum impact on the environment, as well as on public health, for the construction of a future WWTP in the Bent Saidane rural area.