Coordinated Multi-Point (CoMP) is an effective way to improve user performance in next-generation wireless cellular networks, such as 3GPP LTE-Advanced(LTE-A). The base station cooperation can reduce interference, and increase the signal to interference and noise ratio (SINR) of cell-edge users and improve the system capacity. However, the base station cooperation also adds additional power consumption for signal processing and sharing information through back-haul links between cooperative base stations. As such, CoMP may potentially consume more energy. This paper studies such energy consumption issue in CoMP, presents a semi-dynamic CoMP cluster division algorithm based on energy efficiency (SCCD-EE) that can effectively adapt to users' real-time interference, and employs the idea of Maximal Independent Set (MIS) to solve the problem of cluster overlapping. To verify the feasibility of the proposed algorithm, this paper performs comprehensive evaluations in terms of energy efficiency and system capacity. The simulation results show that the proposed semi-dynamic cluster division algorithm can not only improve the system capacity and the quality of service (QoS) of cell-edge users, but also achieve higher network energy efficiency compared with static cluster methods and Non-CoMP approaches. Copyright © 2016 John Wiley & Sons, Ltd.