Multiband RF Pulses Research Articles

An MR fingerprinting approach for quantitative inhomogeneous magnetization transfer imaging.

Magnetization transfer (MT) and inhomogeneous MT (ihMT) contrasts are used in MRI to provide information about macromolecular tissue content. In particular, MT is sensitive to macromolecules, and ihMT appears to be specific to myelinated tissue. This study proposes a technique to characterize MT and ihMT properties from a single acquisition, producing both semiquantitative contrast ratios and quantitative parameter maps. Building on previous work that uses multiband RF pulses to efficiently generate ihMT contrast, we propose a cyclic steady-state approach that cycles between multiband and single-band pulses to boost the achieved contrast. Resultant time-variable signals are reminiscent of an MR fingerprinting acquisition, except that the signal fluctuations are entirely mediated by MT effects. A dictionary-based low-rank inversion method is used to reconstruct the resulting images and to produce both semiquantitative MT ratio and ihMT ratio maps, as well as quantitative parameter estimates corresponding to an ihMT tissue model. Phantom and in vivo brain data acquired at 1.5 Tesla demonstrate the expected contrast trends, with ihMT ratio maps showing contrast more specific to white matter, as has been reported by others. Quantitative estimation of semisolid fraction and dipolar T1 was also possible and yielded measurements consistent with literature values in the brain. By cycling between multiband and single-band pulses, an entirely MT-mediated fingerprinting method was demonstrated. This proof-of-concept approach can be used to generate semiquantitative maps and quantitatively estimate some macromolecular-specific tissue parameters.

Iterative correction of RF envelope distortion with GRATER-measured waveforms.

To develop and evaluate a method for RF envelope correction without extra hardware or synchronization. Transmitted RF waveforms are measured through a simple pulse sequence called the gradient reversal approach to evaluate RF (GRATER). The measured RF waveforms are used to compute predistorted RF waveforms. This process is repeated until a stopping criterion is met, for example, based on pulse performance or a maximum number of iterations. Excitation profiles and simultaneous multi-slice (SMS) image quality are compared before and after RF predistortion. The proposed method improved the accuracy of multiband RF pulses, reducing normalized root mean squared error (NRMSE) by >12-fold, and reducing spurious side-lobe excitation by >6-fold. The reduction in unwanted side-lobe signal is demonstrated using SMS bSSFP imaging at 3T in phantoms and in the heart. Iterative GRATER-based predistortion is a practical, hardware-free way to boost performance of short duration, low flip angle RF pulses, such as those used in SMS bSSFP imaging. Because of its efficiency, this technique could be included as part of an initial scan setup or for use with subsequent scans.

Simultaneous multislice cardiac magnetic resonance fingerprinting using low rank reconstruction.

This study introduces a technique for simultaneous multislice (SMS) cardiac magnetic resonance fingerprinting (cMRF), which improves the slice coverage when quantifying myocardial T1, T2 , and M0 . The single-slice cMRF pulse sequence was modified to use multiband (MB) RF pulses for SMS imaging. Different RF phase schedules were used to excite each slice, similar to POMP or CAIPIRINHA, which imparts tissues with a distinguishable and slice-specific magnetization evolution over time. Because of the high net acceleration factor (R=48 in plane combined with the slice acceleration), images were first reconstructed with a low rank technique before matching data to a dictionary of signal timecourses generated by a Bloch equation simulation. The proposed method was tested in simulations with a numerical relaxation phantom. Phantom and in vivo cardiac scans of 10 healthy volunteers were also performed at 3T. With single-slice acquisitions, the mean relaxation times obtained using the low rank cMRF reconstruction agree with reference values. The low rank method improves the precision in T1 and T2 for both single-slice and SMS cMRF, and it enables the acquisition of maps with fewer artifacts when using SMS cMRF at higher MB factors. With this technique, in vivo cardiac maps were acquired from three slices simultaneously during a breathhold lasting 16 heartbeats. SMS cMRF improves the efficiency and slice coverage of myocardial T1 and T2 mapping compared with both single-slice cMRF and conventional cardiac mapping sequences. Thus, this technique is a first step toward whole-heart simultaneous T1 and T2 quantification with cMRF.

Multiband RF pulse design for realistic gradient performance.

PurposeSimultaneous multi‐slice techniques are reliant on multiband RF pulses, for which conventional design strategies result in long pulse durations, lengthening echo‐times so lowering SNR for spin‐echo imaging, and lengthening repetition times for gradient echo sequences. Pulse durations can be reduced with advanced RF pulse design methods that use time‐variable selection gradients. However, the ability of gradient systems to reproduce fast switching pulses is often limited and can lead to image artifacts when ignored. We propose a time‐efficient pulse design method that inherently produces gradient waveforms with lower temporal bandwidth.MethodsEfficient multiband RF pulses with time‐variable gradients were designed using time‐optimal VERSE. Using VERSE directly on multiband pulses leads to gradient waveforms with high temporal bandwidth, whereas VERSE applied first to singleband RF pulses and then modulated to make them multiband, significantly reduces this. The relative performance of these approaches was compared using simulation and experimental measurements.ResultsApplying VERSE before multiband modulation was successful at removing out‐of‐band slice distortion. This effectively removes the need for high frequency modulation in the gradient waveform while preserving the benefit of time‐efficiency inherited from VERSE.ConclusionWe propose a time‐efficient RF pulse design that produces gradient pulses with lower temporal bandwidth, reducing image artifacts associated with finite temporal bandwidth of gradient systems.

Fast quantitative MRI using controlled saturation magnetization transfer.

PurposeThis study demonstrates magnetization transfer (MT) effects directly affect relaxometry measurements and develops a framework that allows single‐pool models to be valid in 2‐pool MT systems.MethodsA theoretical framework is developed in which a 2‐pool MT system effectively behaves as a single‐pool if the RMS RF magnetic field (B1rms{\ ext{B}}_{1}^{{{\ ext{rms}}}}) is kept fixed across all measurements. A practical method for achieving controlled saturation magnetization transfer (CSMT) using multiband RF pulses is proposed. Numerical, Phantom, and in vivo validations were performed directly comparing steady state (SS) estimation approaches that under correct single‐pool assumptions would be expected to vary in precision but not accuracy.ResultsNumerical simulations predict single‐pool estimates obtained from MT model generated data are not consistent for different SS estimation methods, and a systematic underestimation of T2 is expected. Neither effect occurs under the proposed CSMT approach. Both phantom and in vivo experiments corroborate the numerical predictions. Experimental data highlights that even when using the same relaxometry method, different estimates are obtained depending on which combination of flip angles (FAs) and TRs are used if the CSMT approach is not used. Using CSMT, stable measurements of both T1 and T2 are obtained. The measured T1 (T1CSMT)) depends on B1rms{\ ext{B}}_{1}^{{{\ ext{rms}}}}, which is therefore an important parameter to specify.ConclusionThis work demonstrates that conventional single pool relaxometry, which is highly efficient for human studies, results in unreliable parameter estimates in biological tissues because of MT effects. The proposed CSMT framework is shown to allow single‐pool assumptions to be valid, enabling reliable and efficient quantitative imaging to be performed.

Multiband RF pulses with improved performance via convex optimization

Selective RF pulses are commonly designed with the desired profile as a low pass filter frequency response. However, for many MRI and NMR applications, the spectrum is sparse with signals existing at a few discrete resonant frequencies. By specifying a multiband profile and releasing the constraint on “don’t-care” regions, the RF pulse performance can be improved to enable a shorter duration, sharper transition, or lower peak B1 amplitude. In this project, a framework for designing multiband RF pulses with improved performance was developed based on the Shinnar–Le Roux (SLR) algorithm and convex optimization. It can create several types of RF pulses with multiband magnitude profiles, arbitrary phase profiles and generalized flip angles. The advantage of this framework with a convex optimization approach is the flexible trade-off of different pulse characteristics. Designs for specialized selective RF pulses for balanced SSFP hyperpolarized (HP) 13C MRI, a dualband saturation RF pulse for 1H MR spectroscopy, and a pre-saturation pulse for HP 13C study were developed and tested.

SU-F-303-06: Effect of Multiband RF Pulse Duration On Cine MRI Tracking Accuracy for MRI-GRT

Purpose: Exception gating and dynamic MLC tracking on MRI-gRT systems require segmentation of high temporal resolution images. Multi-band excitation is an emerging MRI acceleration technique that simultaneously excites a short comb of 2D slices, thereby increasing effective temporal resolution. However, the design of multiband RF pulses imposes tradeoffs between slice profiles and the temporal duration of the pulse. The goal of this study was to determine whether slice profiles of shorter duration multiband RF pulses affect organ tracking accuracy for MRI-gRT. Methods: Three-band Shinnar-Le Roux (SLR) RF pulses were designed with slice bandwidths of 1.5kHz and durations ranging from 750 to 3000 µs. The pulses were implemented into a golden angle radial pulse sequence of our own design. Time series of dynamic 2D sagittal cine images of an MRI-compatible dynamic phantom (Model 008M, CIRS) with 2.5 cm superior/inferior target motion were acquired at 3T using each of the RF pulse durations. Images were reconstructed offline in Matlab. The target was contoured on the last image of the time series and tracked through the time series using normalized cross-correlation with a Powell optimizer and B-spline interpolator. Peak-to-peak (P2P) centroid displacements along the superior/inferior dimension were estimated and compared against the phantom motion trajectory. Results: Transition band sizes of the multiband RF slice profiles ranged from 2.1 to 4.6 mm for intended 5 mm slices. P2P centroid displacements ranged from 2.3 to 2.6 cm, demonstrating good agreement with the 2.5 cm phantom displacement, and indicating that slice profile has minimal effect on tracking ability. Conclusion: Slice profile does not affect tracking ability, permitting the use of shorter duration RF pulses to increase temporal resolution during MRI-gRT. Future work will investigate the advantages of multiband excitation for 2D/3D image registration and will combine multiband excitation with in-plane acceleration to further improve temporal resolution. Elekta Instruments, AB

A low power radiofrequency pulse for simultaneous multislice excitation and refocusing.

Simultaneous multislice (SMS) acquisition enables increased temporal efficiency of MRI. Nonetheless, MultiBand (MB) radiofrequency (RF) pulses used for SMS can cause large energy deposition. Power independent of number of slices (PINS) pulses reduce RF power at cost of reduced bandwidth and increased off-resonance dependency. This work improves PINS design to further reduce energy deposition, off-resonance dependency and peak power. Modifying the shape of MB RF-pulses allows for mixing with PINS excitation, creating a new pulse type with reduced energy deposition and SMS excitation characteristics. Bloch Simulations were used to evaluate excitation and off-resonance behavior of this "MultiPINS" pulse. In this work, MultiPINS was used for whole-brain MB = 3 acquisition of high angular and spatial resolution diffusion MRI at 7 Tesla in 3 min. By using MultiPINS, energy transmission and peak power for SMS imaging can be significantly reduced compared with PINS and MB pulses. For MB = 3 acquisition in this work, MultiPINS reduces energy transmission by up to ∼50% compared with PINS pulses. The energy reduction was traded off to shorten the MultiPINS pulse, yielding higher signal at off-resonances for spin-echo acquisitions. MB and PINS pulses can be combined to enable low energy and peak power SMS acquisition.

Simultaneous acquisition of image and navigator slices using CAIPIRINHA for 4D MRI

Respiratory organ motion is still the major challenge of various image-guided treatments in the abdomen. Dynamic organ motion tracking, necessary for the treatment control, can be performed with volumetric time-resolved MRI that sequentially acquires one image and one navigator slice. Here, a novel imaging method is proposed for truly simultaneous high temporal resolution acquisition. A standard balanced steady state free precession sequence was modified to simultaneously acquire two superimposed slices with different phase cycles, namely an image and a navigator slice. Instead of multiband RF pulses, two separate RF pulses were used for the excitation. Images were reconstructed using offline CAIPIRINHA reconstruction. Phantom and in vivo measurements of healthy volunteers were performed and evaluated. Phantom and in vivo measurements showed good image quality with high signal-to-noise ratio (SNR) and no reconstruction issues. We present a novel imaging method for truly simultaneous acquisition of image and navigator slices for four-dimensional (4D) MRI of organ motion. In this method, the time lag between the sequential acquisitions is eliminated, leading to an improved accuracy of organ motion models, while CAIPIRINHA reconstruction results in an improved SNR compared with an existing 4D MRI approach.

High-order multiband encoding in the heart.

Spatial encoding with multiband selective excitation (e.g., Hadamard encoding) has been restricted to a small number of slices because the RF pulse becomes unacceptably long when more than about eight slices are encoded. In this work, techniques to shorten multiband RF pulses, and thus allow larger numbers of slices, are investigated. A method for applying the techniques while retaining the capability of adaptive slice thickness is outlined. A tradeoff between slice thickness and pulse duration is shown. Simulations and experiments with the shortened pulses confirmed that motion-induced excitation profile blurring and phase accrual were reduced. The connection between gradient hardware limitations, slice thickness, and flow sensitivity is shown. Excitation profiles for encoding 32 contiguous slices of 1-mm thickness were measured experimentally, and the artifact resulting from errors in timing of RF pulse relative to gradient was investigated. A multiband technique for imaging 32 contiguous 2-mm slices, with adaptive slice thickness, was developed and demonstrated for coronary artery imaging in healthy subjects. With the ability to image high numbers of contiguous slices, using relatively short (1-2 ms) RF pulses, multiband encoding has been advanced further toward practical application.

Method for improved multiband excitation profiles using the Shinnar–Le Roux transform

A method to design multiband RF pulses for magnetic resonance imaging is described. The method is based on the Shinnar–Le Roux transform and involves a phase correction that provides control over the phase of the excited bands. The theory behind the method and this phase correction is outlined. The method is demonstrated with the design of RF pulses for Hadamard encoding and Haar wavelet encoding. Experimentally measured excitation profiles and images for RF pulses designed with the new method are compared to those designed by the conventional method. The conventional method is shown to result in distortion of the excitation profile when the bands are closely spaced. A 78% reduction in this distortion is attributed to the new method. This translates into a 52% reduction of out-of-slice signal in Haar wavelet encoding. Magn Reson Med 42:577–584, 1999. © 1999 Wiley-Liss, Inc.

Method for improved multiband excitation profiles using the Shinnar-Le Roux transform.

A method to design multiband RF pulses for magnetic resonance imaging is described. The method is based on the Shinnar-Le Roux transform and involves a phase correction that provides control over the phase of the excited bands. The theory behind the method and this phase correction is outlined. The method is demonstrated with the design of RF pulses for Hadamard encoding and Haar wavelet encoding. Experimentally measured excitation profiles and images for RF pulses designed with the new method are compared to those designed by the conventional method. The conventional method is shown to result in distortion of the excitation profile when the bands are closely spaced. A 78% reduction in this distortion is attributed to the new method. This translates into a 52% reduction of out-of-slice signal in Haar wavelet encoding. Magn Reson Med 42:577-584, 1999.