Amid concerns about freshwater scarcity, the agricultural sector faces challenges in water conservation and optimizing crop yields, highlighting the limitations of traditional irrigation scheduling methods. To overcome these challenges, this paper introduces a unified, learning-based predictive irrigation scheduler that integrates machine learning and Model Predictive Control (MPC), while also incorporating multi-agent principles. The proposed framework incorporates a three-stage management zone delineation process, utilizing k-means clustering and hydraulic parameters estimates for optimized agro-hydrological modeling. Long Short-Term Memory (LSTM) networks are employed for accurate and computationally efficient root zone soil moisture modeling. The scheduler, formulated as a mixed-integer MPC with zone control, utilizes the identified LSTM networks to maximize root water uptake while minimizing overall water consumption and fixed irrigation costs. Additionally, the learning-based scheduler adopts a multi-agent MPC paradigm, where decentralized hybrid actor–critic agents and the concept of a limiting irrigation management zone are employed to enhance computational efficiency. Evaluating the performance on a 26.4-hectare field in Lethbridge for the 2015 and 2022 growing seasons demonstrates the superiority of the proposed scheduler over the widely-used triggered scheduling approach in terms of Irrigation Water Use Efficiency (IWUE) and total prescribed irrigation. Notably, the proposed approach achieves water savings between 7 to 23%, coupled with IWUE increases ranging from 10 to 35%.