BackgroundWeed infestation in cotton has been reported to offer severe competition and cause yield reduction to a large extent. Weeding via cultural practices is time consuming, tedious, and expensive due to long duration of cotton crop and regular monsoon rains during cotton production in India. Chemical weed control has been successfully utilized in cotton in the recent past. However, continuous use of similar herbicides leads to resistance in weeds against herbicides. And when sprayed to the field, herbicides not only suppress weeds but leave undesirable residues in the soil that are hazardous to the environment. Therefore, a study was performed at cotton research area at Chaudhary Charan Singh Haryana Agricultural University, Hisar, Haryana during two consecutive kharif seasons (2020 and 2021) to determine the most suitable and sustainable weed management strategy through the integration of chemical and cultural methods.ResultsMulching with rice straw of 7.5 t ha−1 resulted in significantly higher cotton seed yield (3 189 and 3 084 kg ha−1) and better weed control in comparison to no mulch treatments (2 990 and 2904 kg ha−1) in 2020 and 2021, respectively. Among various weed management levels, the significantly lowest cotton seed yield was recorded in untreated control (1 841 and 1 757 kg·ha−1 during 2020 and 2021, respectively) in comparison to other treatments while all other treatments were statistically at par with each other during both years of crop experimentation.ConclusionMulching with rice straw of 7.5 t·ha−1 along with a pre-emergence application of pendimethalin (active ingredient) at 1.5 kg·ha−1fb (followed by) one hoeings at 45 days after sowing (DAS) and fb glyphosate 2 kg·ha−1 (Shielded spray) at 90 DAS is a viable option for effective control of grassy and broadleaved weeds in Bt cotton in north-west India.