Mucociliary Clearance Time Research Articles

Evaluation of nasal mucociliary clearance in patients with psoriasis.

Psoriasis is an autoimmune pathology characterized by chronic inflammation with known multiorgan involvement. In the literature, there are few studies investigating the effects of psoriasis on upper respiratory tract mucosa. Our aim in our study was to investigate the possible effect of psoriasis disease severity and duration on nasal mucosa. A study group was formed from patients with psoriasis and disease duration, Psoriasis Area Severity Index (PASI) and Nasal Obstruction Symptom Evaluation (NOSE) scores of these patients were recorded. Demographic data were noted in all participants with the participation of control group patients, saccharin test was performed to evaluate the nasal mucosa and nasal mucociliary clearance (NMC) times were measured. Psoriasis patients with pathology that may cause nasal obstruction were excluded from the study. A total of 59 people (30 patients and 29 controls) aged 20-65 years were included in the study. There was no difference in age and gender distribution between the two groups. No statistically significant difference in the NMC time between two groups. In the patients group, a correlation was observed between the NMC time to the NOSE test, but no correlation was observed between the NMC time to the duration of the disease and the PASI score. In our study, no difference was observed in NMC time between the two groups and according to the duration or severity of the disease. In addition, NOSE score of patients was also relatively low. No significant impact of psoriasis on nasal functions was found.

Nasal microbiome and the effect of nasal decolonization with a novel povidone-iodine antiseptic solution: a prospective and randomized clinical trial

The aim of this study was to assess the profile of nasal microbiome and evaluate the effect of a specific nasal decolonization solution on the microbiome. We conducted a randomized, placebo-controlled, and parallel-group clinical study of 50 volunteers aged 18 years and older. The subjects were randomly assigned to receive a nasal antiseptic solution, containing povidone-iodine as the main ingredient, (n = 25) or a control solution (n = 25). Nasal swabs were obtained before application (baseline) and at 3 timepoints after application (5 min, 2 h, 24 h). Nasal swabs were subjected to next generation sequencing analysis and cultured in agar plates. At baseline, there were substantial associations between anaerobic species, Corynebacterium spp., Staphylococcus spp., and Dolosigranulum spp. Then, a high bioburden reduction was observed after the application of povidone-iodine (log10 3.68 ± 0.69 at 5 min; log10 3.57 ± 0.94 at 2 h; log10 1.17 ± 1.40 at 24 h), compared to the control. The top species affected by the treatment were Cutibacterium acnes, Staphylococcus, and Corynebacterium species. None of the subjects experienced any adverse effects, nor increases in mucociliary clearance time. Antiseptic solutions applied to the anterior nares can transiently and markedly reduce the bioburden of the nose. The registration number for this clinical trial is NCT05617729.

Effects of submucoperichondrial application of platelet-rich plasma on nasal mucosal healing after septoplasty

Objective(s)Our aim is to investigate the effects of the submucoperichondrial application of Platelet Rich Plasma (PRP) on nasal mucosal healing after septoplasty surgery. Method(s)This prospective randomized observational study was conducted between July 2019 and February 2021, with 40 patients aged 18–60 years who underwent closed the only septoplasty operation for similar septal deviations. Patient divided into two group; 21 patients were placed in PRP group to which PRP was applied on all mucosal surface and submucoperichondrial area of septum and 19 patients were placed in control group to which saline solution was applied on same regions. Nasal obstruction score, mucociliary clearance time, presence of nasal crusting, and bleeding time were evaluated on 5th, 10th, 15th day after surgery and compared between groups. ResultsIntranasal crusting on day 10 was found to be lower in the PRP group (n:13 68.4 %) than control group (n:7 33.3 %) with a statistically significant difference (p = 0.028). The nasal obstruction score on day 10 and 15 were found to be lower in the PRP group (3,33 ± 2,75, 2,07 ± 2,20) (than the control group (5,44 ± 2,26, 3,37 ± 1,92) with a statistically significant difference (p = 0,003,p = 0,009). The mucociliary clearance rate was found to be higher and the bleeding time was found to be lower in the PRP group, but a statistically significant difference was not observed. ConclusionsApplication of submucoperichondrial PRP could have beneficial effects on nasal mucosal repair, nasal crusting, and congestion after septoplasty surgery.

Is the relationship between SNOT-22 and NOSE and mucociliary clearance time an appropriate assessment method for functional outcomes of septorhinoplasty?

Objectives: The study aimed to evaluate subjective and objective results after septorhinoplasty and to investigate the correlations between NOSE and SNOT-22 scales and saccharin clearance test (SCT) results. Patients and Methods: One hundred patients (37 males, 63 females; mean age: 26.4±8.4 years; range, 18 to 56 years) with nasal septal surgery indication were included in the study between January 2017 and January 2019. A SCT was applied to all cases preoperatively and in the first postoperative month, and SNOT-22 and NOSE questionnaires were filled. Results: No relationship was detected when the relationship between preoperative SCT and NOSE and SNOT-22 scores was evaluated. However, there was a statistically significant correlation between preoperative SNOT-22 scores and postoperative SCT values in 26% of the cases (r=0.260). Similarly, if the preoperative NOSE and SNOT-22 scores of the cases are low, it should be expected that the SCT value measured at the first postoperative month will be low, with a probability of 28% and 26%, respectively. As the preoperative NOSE value of the patients increased, the SNOT-22 value increased by 57.9% and 27.6%, respectively. Similarly, as the postoperative NOSE values increased, the postoperative SNOT-22 values increased by 51.8%. A positive relationship was found in all these bilateral correlations. According to the results obtained, the NOSE and SNOT-22 scores were 93% accurate and 98% acceptable. Conclusion: Although the statistically significant relationship between SCT results in the postoperative period and SNOT-22 and NOSE is a remarkable finding, there is a need for future studies that also evaluate long-term results to make more precise comments on this issue.

Evaluation of Nasal Mucociliary Clearance Time in Patients with Schizophrenia.

Nasal mucociliary clearance time (NMCT) is prolonged in patients with olfactory disorders. It is essential to differentially diagnose conductive and neural olfactory disorders. Here, we used the mucociliary clearance test to investigate a disease associated with neural olfactory disorders, i.e. schizophrenia. Data on age, gender, and duration of disease were collected. The study involved 56 schizophrenia patients and 56 healthy controls. There was no significant difference between the groups regarding age and gender (p = 0.459 and p = 0.768 respectively). Mean NMCT of patients with schizophrenia was 13.82 ± 3.22min and mean NMCT of healthy controls was 10.15 ± 2.94min. There was significant difference between the groups regarding NMCT (p < 0.001). In the patient group, there was a significant positive correlation between duration of disease, age, and NMCT (Pearson r = 0.286, p = 0.032, and Pearson r = 0.522, p < 0.001 respectively). This study has shown a prolonged NMCT in patients with schizophrenia compared to the healthy control group.

An assessment of the effects of adenoid hypertrophy on mucociliary clearance and nasal cytology in children.

The aim of this study was to demonstrate the benefits of the systematic use of nasal cytology and mucociliary clearance in the diagnostic workup of nasal disorders in children with adenoid hypertrophy (AH) to reach a well-defined diagnosis, establish a rational therapeutic approach, avert from complications, and develop the patient's life quality. In this prospective study, a total of 61 pediatric patients (aged 5-12 years) were evaluated. The case group consisted of 31 children with AH symptoms, while the control group comprised 30 children without AH symptoms.Exclusions included previous adenoidectomy/adenotonsillectomy, cardiovascular/neurological diseases, acute/allergic rhinitis, genetic disorders (e.g., Down syndrome), and immunodeficiency. The control group consisted of children without nasal obstruction symptoms and without AH, who admitted for various reasons. Medical history, examinations, fiberoptic nasopharyngoscopy, cephalometric evaluations, AST, and nasal cytology were conducted. At the end of the study, a significant increase in the mucociliary clearance time was observed in the group with AH compared to the control group (p<0.05). Although AH may disrupt MCC, there is no correlation between the size of the hypertrophy and MCC time.When the distribution of cells in the nasal cytology is evaluated, no difference was detected between the AH group and control groups. Nasal mucociliary clearance has been found to be decreased, particularly in the presence of significant AH.

The Effect of Intranasal Steroid on Nasal Mucociliary Clearance in Allergic Rhinitis

Intranasal glucocorticosteroids are the most effective treatment for allergic rhinitis and are recommended as first-line therapy for patients with moderate to severe Allergic Rhinitis, particularly when nasal congestion is the prominent symptom. The use of intranasal corticosteroids showed to affect the mucociliary action by decreasing the prolonged mucociliary clearance time and increasing the mucociliary clearance rate. Keywords: AR- Allergic Rhinitis, INCS- Intranasal corticosteroid, NMC- Nasomucociliary clearance, MCT- Mucociliary Clearance Time, MCR- Mucociliary clearance rate, OAH- Oral antihistamine

Mucociliary Flow Rate in Allergic Rhinitis Patients

The vital part of this mechanism is an adequate quantity of mucus with appropriate rhinological qualities and adequate functioning of cilia which beat in metachronous fashion towards nasopharynx at a frequency of 7-16 Hz at body temperature. Nasal Mucociliary Clearance (NMC) is determined to obtain an in vivo measurement of the effectiveness of the interaction between the cilia and mucus. Any disturbance in the number and movement of cilia and mucus production leads to altered mucociliary clearance as occurs in allergic rhinitis. Aim of this study was to find the mucociliary clearance time and mucociliary clearance rate in group of 100 patients of allergic rhinitis. We found that the MCT is prolonged and MCR is reduced in these patients. Keywords: MCC- Nasociliary clearance, NMC- Nasal Mucociliary Clearance, MCT- Mucociliary clearance time, MCR- Mucociliary clearance rate

Study to Assess the Efficacy of Different Concentration of Nasal Douching on Symptoms and Mucociliary Clearance in Persistent Allergic Rhinitis

Introduction: Allergic rhinitis (AR) is acknowledged as a significant health challenge on a global scale affecting 08 – 39.7% of total population. The management of Allergic rhinitis encompasses patient education on avoidance of allergens as well as the use of pharmacotherapy and allergen- specific immunotherapy. Avoidance of allergen may not be practically applicable always and the pharmacological treatment has side effects on long term use. Hence an alternate treatment modality is required to alleviate the symptom for long duration with less side effects. Materials and Methods: we conducted a randomized double blinded prospective study on 75 patients with allergic rhinitis. They were randomized into 3 groups, 1st group using isotonic saline irrigation, 2nd group using hypertonic nasal irrigation and 3rd group as control. The evaluation was done using SNOT22 score and nasal mucociliary clearance time. Results: Isotonic Saline Nasal Irrigation was found to reduce overall symptoms better than Hypertonic Saline Nasal Irrigation group. Nasal douching also improved Nasal Mucociliary Clearance. Isotonic Saline Nasal Irrigation restored Mucociliary Clearance better than Hypertonic Saline Nasal Irrigation. Compliance to treatment was found to be good for short term. Conclusion: Nasal irrigation along with other medications definitely had better outcome in symptom control in patients with AR. However studies to know the effect of nasal douching in AR for longer duration are needed.

Correlation between the severity of lung involvement and nasal mucociliary clearance time and acute phase biomarkers in patients with COVID-19

Objectives: The aim of this research was to evaluate the correlation between the increased nasal mucociliary clearance time (NMCT) and chest computed tomography severity scores (CT-SS) and acute phase biomarkers in patients diagnosed with coronavirus disease 2019 (COVID-19) pneumonia. Patients and Methods: A total of 116 hospitalized patients were included in the prospective study between November 2021 and June 2022. For the measurement of the NMCT, all patients underwent the saccharin test. The patients were separated into two groups: Group 1, which included 53 patients (28 females, 25 males; mean age: 50.1±13.2 years; range, 19 to 75 years) with an NMCT of 7-13 min, and Group 2, comprising of 63 patients (32 females, 31 males; mean age: 52.3±12.1 years; range, 30 to 82 years) with an NMCT of 14-21 min. The CT-SS was adapted from a previous method including ground-glass opacity, interstitial opacity, and air entrapment and was used to express the severity and rate of involvement of COVID-19 pneumonia. Results: The mean CT-SS was 3.8±1.6 in Group 1 and significantly higher in Group 2 with 6.2±2.0 (p&lt;0.001). In addition, a strong positive correlation was determined between the NMCT and CT-SS (r=0.711). The mean lung lobe involvement was 3.6±1.5 in Group 1 and 4.8±0.5 in Group 2, and the difference was statistically significant (p&lt;0.001). The mean ferritin levels showed a statistically significant difference at 244.6±146.9 mg/L in Group 1 and 436.5±449.1 mg/L in Group 2 (p=0.038). Conclusion: The saccharin clearance test is not routinely used in clinical practice but with the lights of our study’s results increased NMCT results correlates with pneumonia severity scores in CT and it may be useful in the prediction of prognosis of pneumonia in COVID-19 patients.

The effect of autosomal dominant polycystic kidney disease on mucociliary clearance.

Autosomal dominant polycystic kidney disease (ADPKD) is a renal disease with genetic transmisson. Mutations in the PKD1 and PKD2 genes, which encode integral membrane proteins of the cilia of primary renal tubule epithelial cells, are seen in ADPKD. The aim of this study was to evaluate the sinonasal epithelium, which is epithelium with cilia, by measuring the nasal mucociliary clearance time, and to investigate the effect of ADPKD on nasal mucociliary clearance. The study included 34 patients, selected from patients followed up in the Nephrology Clinic, and 34 age and gender-matched control group subjects. The nasal mucociliary clearance time (NMCT) was measured with the saccharin test. The mean age of the study subjects was 47.15 ± 14.16years in the patient group and 47.65 ± 13.85years in the control group. The eGFR rate was determined as mean 72.06 ± 34.26mL/min in the patient group and 99.79 ± 17.22mL/min in the control group (p < 0.001). The NMCT was determined to be statistically significantly longer in the patient group (903.6 ± 487.8s) than in the control group (580 ± 259s) (p = 0.006). The study results showed that the NMCT was statistically significantly longer in patients with ADPKD compared to the control group, but in the linear regression analysis results, no correlation was determined between eGFR and NMCT.

A Comparison of Nasal Mucociliary Clearance Time in COVID-19 and Variant COVID-19 Patients

A Comparison of Nasal Mucociliary Clearance Time in COVID-19 and Variant COVID-19 Patients

Upper Airway Mucociliary Clearance is Impaired in Dyspneic COVID-19 Patients.

Covid-19 is transmitted mainly by respiratory droplets and as the upper airway mucosa is the first innate immune barrier, it is crucial to understand the effects of SARS-CoV-2 on this system. In the current study, we aimed to evaluate the nasal mucociliary clearance in patients with SARS-CoV-2 infection and their symptom development. Observational cross-sectional study. The nasal mucociliary clearance (NMC) time was evaluated by the saccharin test and the results were compared between patients with SARS-CoV-2 infection (group 1) and controls (group 2, asymptomatic patients with a negative polymerase chain reaction test). We also compared the NMC time for each specific symptom suffered by participants in group 1 with the NMC time of the control group as well as with the patients in group 1 who were asymptomatic. There was a significant increase in NMC time in group 1with dyspnea when compared to the control group (p = 0.032) and also when compared to patients who were infected were not dyspneic (p = 0.04). There were no differences in the clearance times when considering other symptoms. COVID-19 patients with dyspnea present with altered nasal mucociliary clearance.

&lt;i&gt;In situ&lt;/i&gt; gels as a modern method of intranasal vaccine delivery

The continuous emergence of new pathogens and the evolution of microbial drug resistance make it absolutely necessary to develop innovative, effective vaccination strategies. Use of nasal vaccination can increase convenience, safety, cause both local and systemic immune reactions. Intranasal administration nevertheless has a number of shortcomings that can be overcome by using the latest achievements of pharmaceutical science. One of the aspects of such solution may be the use of systems for the production of intranasal vaccines in situ polymer compositions that provide a directed sol-gel transition controlled by the physiological conditions of the nasal cavity. At the same time, the gelation of the administered dose in contact with the nasal mucosa involves prolonged exposure of the drug at the injection site, greater mucoadhesion, counteraction to mucociliary clearance, modified and more complete release. A number of both foreign and domestic manufacturers produces polymers such as chitosan, gums, polyoxyethylene and polyoxypropylene block copolymers (poloxamers, proxanols), carbomers. For effective pharmaceutical development of new intranasal IBD delivery systems corresponding to the QbD concept, not only the knowledge of the range of excipients is necessary, but also simple, accessible, and reproducible methods for determining indicators that define the critical parameters of such delivery systems. In accordance with the conducted scientific search, the main indicators of standardization of in situ intranasal systems were identified: temperature and time of gel formation, gel strength, rheological characteristics, mucoadhesion, release, nasal mucociliary clearance time.

Specific local nasal immunotherapy: Single center experience on 324 patients

ObjectiveTo evaluate the efficacy and safety of specific local nasal immunotherapy (LNIT) in patients with allergic rhinitis. Materials and methodsA retrospective single-center study of 324 patients with allergic rhinitis (191 allergic to mites, 133 allergic to Grarninaceae or Parietaria pollen) treated with specific LNIT was carried out. As control group, 158 patients without allergic rhinitis were enrolled. All patients were evaluated before and after 32 weeks of treatment by subjective analysis of their self-reported symptoms and by objective analysis of nasal provocation test, nasal resistance by anterior rhinomanometry, and mucociliary clearance time. ResultsClinical efficacy of LNIT for allergy to mites and pollens was confirmed by the differences in the symptoms score between the active group and the placebo group. The nasal provocation test and the rhinomanometric analysis confirm the result with a difference statistically significant. No differnces in mucociliary clearance time were found. ConclusionsSpecific LNIT is a valide alternative to subcutaneous and sublingual administration. It is effective, safe, well tolerated by the patient, it can be done at home with fewer systemic reactions.

Sino-Nasal Status in Patients with Chronic Obstructive Pulmonary Disease

Background. Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease with serious impact on quality of life (QoL). There are limited studies available supporting coexistence of sino-nasal involvement in COPD. Methods. A prospective study was conducted to evaluate sino-nasal status in patients with COPD (n=100) presenting to the Department of Respiratory Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur from July 2011 to October 2012. COPD was diagnosed based on the Global initiative on Obstructive Lung Disease (GOLD) guidelines. Sino-nasal status was assessed by detailed history, radiograph of the para-nasal sinuses (PNS), nasal endoscopy and mucociliary clearance time. Results. Sino-nasal symptoms were present in 74 patients with COPD; nasal discharge (75.7%) being the most common. Tobacco smokers with COPD had a higher occurrence of sino-nasal symptoms (76.8%). Radiograph of para-nasal sinuses showed that maxillary sinus was most commonly involved. Nasal endoscopy revealed discharge in 63.5% cases. Nasal mucociliary clearance time was delayed (>11 to >40 min) in 98% cases. Nasal mucociliary clearance time was significantly delayed (>20 min) in COPD patients who were tobacco smokers as compared to non-smokers (53.7% versus 16.7%) and also related with increasing severity of COPD. Conclusions. Our observations suggest that sino-nasal involvement and delayed mucociliary clearance are common in patients with COPD, especially in tobacco smokers. Assessment of upper airway involvement in all the patients with COPD can help better therapeutic intervention and improvement in QoL.

Does Maras powder affect the nasal mucociliary clearence?

Many studies have been conducted about the effect of cigarettes and other tobacco products on mucociliary clearance. However, there has been no study of the relationship between mucociliary clearance and Maras powder, which is a smokeless tobacco product. The aim of this study was to evaluate the effect of Maras powder use on mucociliary clearance through comparisons with cigarette smokers and those who used no tobacco products. The study included 75 male volunteers, aged 23-54years. Group 1 (n: 25) comprised subjects who do not use any tobacco products, Group 2 (n: 25) those who smoked cigarettes, and Group 3 (n: 25) those who used Maraş powder. The saccharin test was used to evaluate mucociliary clearance and the time was recorded in seconds. The groups were statistically compared in respect of mean age and mucociliary clearance time (MCCT). The mean MCCT was determined to be 645.8 ± 200 secs for the whole study sample, 497 ± 108 secs for Group 1, 796 ± 200 secs for Group 2, and 644 ± 161 secs for Group 3. The difference between the groups in respect of MCCT was statistically significant (p < 0.001). No statistically significant difference was determined between the groups in respect of mean age (p = 0.730). The study results demonstrated that the nasal mucociliary clearance time was prolonged both by cigarettes and by the use of Maras powder, and that this time was prolonged more by cigarette smoking than the use of Maras powder.

The effect of Ramadan fasting on nasal mucociliary activity and peak nasal inspiratory flow.

In this study, we aimed to investigate the effect of Ramadan fasting (RF) on nasal mucociliary clearance (MCC) and peak nasal inspiratory flow (PNIF). Sixty-two (41 male and 21 female) healthy subjects who stated that they would fast continuously during the month of Ramadan were included in this prospective study. Day 0 (baseline), 1st day (after one day of RF), and 29th (after 29days of RF) nasal mucociliary clearance time (MCT) with saccharine test and PNIF values were determined. Subject weights (SW) were measured on Day 0 and Day 29. The obtained data were analyzed statistically. The mean of SW on day 0 was 78.53 ± 10.95kg, and the mean of SW on Day 29 was 78.69 ± 10.87kg. There was no significant difference in terms of SW (p = 0.251, p > 0.05). A significant difference was found between the MCT and PNIF values measured on different study days (p < 0.05). The MCT values for Day 29 were significantly higher than the values for other days (p < 0.05). There was no significant difference between the MCT values on the first day and the baseline (p = 0.891, p > 0.05). The PNIF values for Day 29 were significantly higher than the values for other days (p < 0.05). The PNIF values on the first day were significantly higher than the baseline (p = 0.008, p < 0.05). The present study showed that RF leads to MCT prolongation and PNIF increase. Ramadan fasting causes deterioration in nasal airway defense and improvement in nasal respiration.

Impact of smoking on nasal mucociliary clearance time in Kano metropolis, Nigeria.

Mucociliary clearance is an important defense mechanism in human upper and lower respiratory airways. Impairment of this process by certain conditions such as cigarette smoking can predispose to chronic infection and neoplasm of the nose and paranasal sinuses. This was a cross-sectional study conducted in Kano metropolis, Nigeria. Eligible adults were enrolled, a saccharine test was conducted, and the nasal mucociliary clearance time was assessed. Analysis of the result was carried out using Statistical Product and Service Solutionsversion 23.0. There were 225 participants categorized into 75 active smokers (33.3%), 74 passive smokers (32.9%), and 76 nonsmokers (33.8%, living in a smoking-free zone). The age range of the participants was between 18 and 50 years, with a mean age of (31.2 ± 5.6) years. All participants were males. There were 139 (61.8%) of Hausa-Fulani ethnic group, 24 (10.7%) Yoruba, 18 (8.0%) Igbo, and 44 (19.5%) other ethnic groups. Findings in this study showed that the average mucociliary clearance time among active smokers was prolonged ([15.25 ± 6.20] min) compared to passive ([11.41 ± 4.25] min) and nonsmokers ([9.17 ± 2.76] min) respectively, with a statistical significance (F = 33.59, P < 0.001). Binary logistic regression revealed that the number of cigarettes smoked per day was an independent predictor of prolonged mucociliary clearance time (P = 0.008, odds ratio = 0.44, 95% confidence interval = 0.24-0.80). Active cigarette smoking is associated with prolonged nasal mucociliary clearance time. The number of cigarette sticks smoked per day was found to be an independent predictor of prolonged mucociliary clearance time.

A comparison of central compartment atopic disease and lateral dominant nasal polyps.

The characteristics and surgical outcomes of central compartment atopic disease (CCAD) vary by region and race. Therefore, we aimed to identify the risk factors, symptom severity, and prognosis of CCAD in the Asian population. This case-control study recruited patients diagnosed with chronic rhinosinusitis with nasal polyps who underwent functional endoscopic sinus surgery (FESS) at a tertiary hospital in Taiwan. Patients were classified into CCAD and lateral-dominant nasal polyp (LDNP) groups based on endoscopic and computed tomography imaging findings. The demographic data, symptom severity scores, and surgical outcomes of the 2 groups were analyzed. Our study included 442 patients (CCAD group: n = 51; LDNP group: n = 391). We found that CCAD was strongly related to both asthma (9.8% vs 3.5%, p = 0.04) and allergic rhinitis symptoms (43.3% vs 26.6%, p = 0.01). Higher eosinophil counts were detected in blood serum (5.8% vs 2.8%, p < 0.01) and histopathologic profiles (57.0 vs 17.3, p < 0.01) among patients with CCAD. Improvements in 22-item Sino-Nasal Outcome Test (SNOT-22) score and mucociliary clearance time (MCT) after surgical intervention revealed that the CCAD group had a better response to FESS (SNOT-22 score: -31.82 vs -22.66, p < 0.01; MCT: -233.06 vs -191.93 seconds, p = 0.03). The revision FESS rate was not different between the 2 groups. Polyps originating from the central compartment were found to be related to asthma and allergic rhinitis in Taiwanese patients. A higher eosinophil count was suggested in both serum and local nasal tissue from patients with CCAD. FESS serves as an effective treatment for symptom relief in patients with CCAD.