Ovarian Mucinous Cystadenoma Research Articles

Giant ovarian mucinous cystadenoma complicating term pregnancy: A rare case report

Introduction: Adnexal masses in pregnancy are identified at a rate of 2 to 20 in 1000, which mostly are benign simple cysts. Although the majority of adnexal masses will resolve spontaneously by the beginning of the second trimester, some cases are persistent forms which can result in complications for both mother and fetus. Presentation of case: A 31-year-old pregnant woman was diagnosed with a left ovarian mucinous cystadenoma. The ovarian cyst was first detected in the 8th week of pregnancy, measured 5×5 cm and reached 40×30 cm at 38 weeks of gestation. The patient underwent an elective cesarean delivery along with left salpingo-oophorectomy at term. An alive female baby of 3000 grams was delivered with good APGAR scores at the first and fifth minutes. Histologic examination confirmed the diagnosis of a benign mucinous cystadenoma. Dicussion: The option of surgical intervention versus conservative management should be tailored to the patient’s physical symptoms, characteristics of tumor, and gestational age. An elective cesarean section along with salpingo-oophorectomy can be adopted for a giant ovarian cyst complicating term pregnancy. There is a risk of recurrence after a removal of ovarian mucinous cystadenoma. Conclusion: Ovarian cysts coexisting with pregnancy should be followed up properly by routine ultrasound and regular antenatal care. The decision to postpone surgical management of a complex mass until the time of delivery must balance the risks and benefits for mother and fetus. After surgery, the patient needs to be provided an appropriate follow-up care to manage postoperative recurrence.

MRI Evaluation and Characterization of Ovarian Lesions Based on Ovarian-Adnexal Reporting and Data System MRI.

Background Managing ovarian lesions requires differentiating between benign and malignant cases. The development of a multiparametric MRI approach combining anatomical and functional criteria has led to the creation of the Ovarian-Adnexal Reporting and Data System (O-RADS) MRI scoring system, which enhances diagnostic accuracy. Objectives To study ovarian lesions and their characteristics, along with their risk stratification based on MRI O-RADS. Methods A prospective study used the O-RADS MRI criteria to categorize ovarian lesions. Clinical findings and MRI results were compared with histopathological outcomes to assess diagnostic accuracy. Results We identifiedabdominal pain as the most prevalent clinical finding among our cases (64, 91.43%), followed by a lump in the abdomen (33, 47.5%), dysmenorrhea (33, 47.5%), bleeding per vaginal (15, 21.43%), and weight loss (11, 15.71%). A total of 80 ovarian lesions were examined and characterized on the basis of the O-RADSMRI risk stratification system.Among the 80 ovarian lesions, 54 were histopathologically confirmed ovarian lesions (39 (72.22%) were benign, and 15 (27.77%) were malignant). The most common benign lesions were ovarian serous cystadenoma (28.20%) and ovarian mucinous cystadenoma (20.51%), while the most common malignant lesions were serous carcinoma (33.33%) and mucinous carcinoma (20%). Using the O-RADS MRI scoring system, we categorized six lesions (7.5%) as O-RADS 1 (all benign), 34 lesions (42.50%) as O-RADS 2 (32 benign and 2 malignant), 24 lesions (30%) as O-RADS 3 (23 benign and 1 malignant), seven lesions (8.75%) as O-RADS 4 (four benign and three malignant), and nine lesions (11.25%) as O-RADS 5 (all malignant). Our findings revealed significant differences in the size of lesions, the presence of thick septa, high T2-weighted signal intensity within solid tissue, and patterns of solid component enhancement and wall irregularity between malignant and benign lesions. The MRI cut-off score of ≥4 for malignancy demonstrated a sensitivity of 94.59%, a specificity of 97.5%, an accuracy of 97.62%, a positive predictive value of 94.5%, and a negative predictive value of 97.5%. The positive likelihood ratio was 32.7, while the negative likelihood ratio was 0.025. These results affirm the high diagnostic accuracy of the O-RADS MRI scoring system in distinguishing benign from malignant ovarian lesions. Conclusion The O-RADS MRI score is a highly accurate tool for differentiating between benign and malignant ovarian lesions. Its application can significantly enhance the management and treatment outcomes for patients with adnexal masses. The study confirms the scoring system's high sensitivity, specificity, and overall diagnostic accuracy.

Mucinous cystadenoma of both ovaries and appendix: a case report

Epithelial neoplasm of ovaries is common and almost 40% of them are benign. Cystadenoma of ovary is the commonest epithelial neoplasm. They can be serous or mucinous. They arise from the surface epithelium of ovary, some of them may have germ cell origin. They are multilocular. 80% of ovarian mucinous cyst are benign cystadenoma. They are unilateral in 95% of cases. In this case presentation, it was bilateral and appendix was also showing mucinous cystic degeneration. The mucinous cystadenoma of the appendix is the most common mucinous cyst of the appendix, but the definite diagnosis is made at the time of surgical intervention only. The confirmation is reached by histopathology examination of specimen. This interesting case report is that of a giant bilateral ovarian mucinous cystadenoma of ovary along with the cystic degeneration of appendix. This is a rare case presentation scenario where bilateral giant cyst is found along with same pathology in appendix.

Abstract 2449: Case report: DETECT-A participants with pre-malignant conditions

Abstract Background: Blood based tests for multi-cancer early detection (MCED) are being developed to facilitate the earlier detection of various cancer types. The Detecting cancers Earlier Through Elective mutation-based blood Collection and Testing (DETECT-A) study evaluated the CancerSEEK MCED test, an early version of the Exact Sciences MCED test in development, in 9,911 women, age 65-75, without previous history of cancer (Lennon et al., Science 2020). The degree to which MCED testing will facilitate detection of precancerous conditions or incidental findings is unclear. Here we focus on DETECT-A participants who had pre-cancerous conditions diagnosed during a diagnostic work-up for a positive CancerSEEK MCED test. Methods: In a post-hoc analysis, we report on the detection of precancerous conditions consequent to CancerSEEK MCED testing and follow-up. Electronic health records were reviewed for diagnostic procedures performed, details of premalignant and cancer diagnoses, and vital status. Results: In three individuals, mutations in PIK3CA, TP53, or KRAS genes led to a positive CancerSEEK MCED test result. The prescribed imaging protocol using 2-deoxy-2[fluorine-18] fluoro-D-glucose positron emission tomography-computed tomography (18-FDG PET-CT), revealed a 10.3 × 9.8 × 7.8(cm) ovarian mucinous cystadenoma, a 0.8 cm appendiceal mucinous neoplasm, and 3 colonic polyps displaying high-grade dysplasia. All three participants were diagnosed with clinically significant pre-cancerous lesions, subsequently underwent surgical treatment, and remain alive and cancer-free as of February 2023 (Table 1). Conclusion: The diagnostic evaluation of a positive MCED test may occasionally reveal clinically significant pre-cancerous conditions amenable to interventions. The frequency of such findings and their clinical impact warrants further study. Citation Format: Omair A. Choudhry, Angana Kharge, Seema P. Rego, Paul Z. Elias, Adam H. Buchanan, Anne Marie Lennon, Nickolas Papadopoulos, Frank Diehl, Tomasz M. Beer. Case report: DETECT-A participants with pre-malignant conditions [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2449.

Cistoadenoma mucinoso gigante de ovario

Although ovarian mucinous cystadenoma has a benign growth, it can grow to be very large. We present the case of a 70-year-old patient who came to the clinic for recurrent and diffuse abdominal pain. On physical examination, a large mass was palpated that occupied the entire abdominal cavity, up to the xiphoid appendix, rounded, retentive, with defined edges, non- painful, non-movable. Presence of edema in lower limbs. During the surgical act, a myomatous uterus and a giant left ovarian cyst measuring approximately 40 x3 0 cm and weighing 13.6 kg were identified. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. The biopsy confirmed the diagnosis of benign ovarian mucinous cystadenoma and uterine leiomyomatosis. The postoperative period progressed favorably. The incidence of giant ovarian cystadenoma is relatively unknown due to the lack of a standardized concept and currently available advanced imaging modalities. Keywords: Ovary, Ovarian cysts, Mucinous cystadenoma, Ovarian neoplasms.

Massive ovarian mucinous cystadenoma with torsion: A surgical wonder

Mucinous cystadenomas are some of the commonly encountered ovarian tumors, having huge size which causes pain, pressure, distension, genito urinary symptoms etc. Eventually, these tumors are prone to life threatening complications, like hemorrhage or torsion. These cases may remain asymptomatic for a long period of time. For further diagnosis of symptomatic patients clinical examinations and radiological investigations can be used and help the surgeon in deciding management. We hereby report a case involving a very large mucinous cystadenoma, measuring 25 × 24 centimeter with torsion. The data presented here contains details post admission of this patient in casualty to discharge of the patient, such as (a) clinical history (b) physical examination, (c) laboratory reports, (d) radiological investigations, (e) surgical evaluation, (f) histo pathology reports. These Mucinous cystadenomas constitute a comparatively smaller percentage of cases that can present with pain in abdomen due to an ovarian cause. Here, a huge mucinous ovarian cystadenoma had been found pressing on the abdominal contents leading to a variety of symptoms. The aim is to establish the value of detailed diagnosis and timely surgical treatment of these ovarian tumors as well as to signify the potential fatal outcomes.

A giant ovarian mucinous cystadenoma in a postmenopausal woman: A rare case report

We report a rare case of a giant ovarian mucinous cystadenoma in a 58-year-old menopausal woman, from Kongolo town, Tanganyika Province, Congo, who had been suffering from progressive abdominal distension and shortness of breath for 16 months. Abdominal-pelvic ultrasound finding was consistent with an ovarian tumor, and bilateral oophorectomy and total hysterectomy were performed. The ovarian mass removed was white and contained a viscous fluid. It weighed 7 kg and was oval in shape with a length of 57 cm on the long axis and 48 cm on the short axis. Histopathological analysis of sections from the removed mass and samples of aspirated cyst fluid confirmed the diagnosis of mucinous cystadenoma of the right ovary. Postoperatively, the patient remained in the hospital for 10 days, was discharged in good condition, and was required to visit our outpatient clinic every 6 months. At her past visit, 1 year after discharge, the patient was in good condition and no mass was detected on abdominal-pelvic ultrasound.

Successful delivery after in vitro fertilization-embryo transfer in a woman with metachronous primary cancer of ovary and endometrium: a case report

BackgroundThe appearance of malignancies at various times in the same individual, excluding metastases of the initial primary cancer, is termed multiple primary cancers. Double primary gynecological cancers cause inevitable damage to female reproductive function, and the preservation of fertility in such patients remains a challenging issue as relatively few cases have been reported. This case report provides management options for dual primary ovarian and endometrial cancers, including the choice of ovulation induction protocols, considerations during pregnancy and parturition, with the aim of providing assistance to clinicians.Case presentationWe report a case of a 39-year-old woman with primary infertility and a medical history of right-sided ovarian mucinous borderline tumor with intraepithelial carcinoma, left-sided ovarian mucinous cystadenoma and endometrial cancer, who successfully conceived with in vitro fertilization-embryo transfer (IVF-ET) after three different ovulation induction protocols. During her pregnancy, she was complicated by central placenta praevia with placental implantation and eventually delivered a healthy female infant by caesarean section at 33 gestational weeks.ConclusionsFor patients with double primary gynecological cancers who have an intense desire for fertility, the most appropriate oncological treatment should be applied according to the patient’s individual situation, and fertility preservation should be performed promptly. Ovulation induction protocol should be individualized and deliberate, with the aim of ensuring that the patient’s hormone levels do not precipitate a recurrence of the primary disease during induction of ovulation and maximizing fertility outcomes. In addition, the risk of postpartum hemorrhage due to placental factors cannot be neglected in such patients.

Challenges associated with delayed diagnosis of a giant ovarian mucinous cystadenoma in low resourced settings: a case report

Challenges associated with delayed diagnosis of a giant ovarian mucinous cystadenoma in low resourced settings: a case report

Challenges Associated with Delayed Diagnosis of a Giant Ovarian Mucinous Cystadenoma in Low Resourced Settings: A Case Report

Challenges Associated with Delayed Diagnosis of a Giant Ovarian Mucinous Cystadenoma in Low Resourced Settings: A Case Report

Ovarian mucinous cystadenoma recurred 2 years after laparoscopic surgery: A Case Report

Objective: Recurrence of ovarian mucinous cystadenomas is very rare. This report describes a case of ovarian mucous cystadenoma in a women that recurred 2 years after surgery.
 Case presentation: A 22-year-old patient, with a sizable ovarian tumor underwent laparoscopic-assisted cystectomy. On histopathology, the tumor was diagnosed to be an ovarian mucinous cystadenoma. The mucinous cystadenoma recurred 2 years after surgery and subsequently laparoscopic right adnexectomy was performed.
 Discussion: It has been reported that intraoperative cyst rupture and cystectomy instead of adnexectomy are risk factors for mucinous cystadenoma recurrence. Close follow-up is required for post-cystectomy patients because of the possibility of recurrence.
 Conclusion: The risk of recurrence and the preservation of fertility should be carefully considered when deciding on treatment in young patients with a mucinous cystadenoma. The follow-up is required for post-cystectomy patients because of the possibility of recurrence.

A Case of Huge Mucinous Cystadenoma

Introduction: Ovarian mucinous cystadenoma is a benign tumour that arises from the surface epithelium of ovary. Aim/Objectives: To report the occurrence of a huge benign ovarian tumour. Case Report: A 24-year-old female presented to the OPD with complaints of pain lower abdomen, loss of appetite, and abdominal distension since 4 months. Her USG and CT scan reports showed it to be case of mucinous cystadenoma. She underwent laparotomy with left-sided cystectomy. Her Histopathological report showed borderline mucinous tumour. Peritoneal washing showed negative for atypical cells. Discussion: Giant tumours are now a rare presentation due to their early diagnosis due to routine check-ups on ultrasound

Postmenopausal woman with 24 kgs ovarian mucinous cystadenoma: a rare case report

A case of a 53-year-old postmenopausal woman presenting a giant ovarian cystic mucinous tumor weighing 24 kg is reported here. When she was seen first at our outpatient clinic, she had gross abdominal distension since 2 years, and she complained of unbearable aggressive pain. Her computed tomography (CT) scan was done which came suggestive of ovarian serous cystadenoma of large massive size 35 x 40 x 32 cm with moderate ascites. On exploratory laparotomy, a giant, totally cystic, vascularized and smooth mass attached to the right ovary was encountered. On the postoperative tenth day, she was discharged without any problem. Histopathology report of the right ovarian cystic mass came suggestive of multiloculated cyst with capsule intact with Borderline Mucinous tumor of right ovary weighing 24 kg. This is both one of the largest known examples in the literature and the largest ovarian cyst ever seen at our institution.

Chistadenom mucinos gigant recidivat – caz clinic

Giant ovarian mucinous cystadenoma is a benign tumor in most cases and usually appears in adult or middle-aged women. The mucinous cystadenoma is a noncancerous type of ovarian tumor. The ovarian mucinous cystadenoma is the second most frequent benign ovarian tumor and re­pre­sents approximately 15% of all ovarian tumors. This pa­per presents the clinical case of a 35-year-old patient ad­mit­ted to our hospital, in the gynecology department, with a history of repetitive menometrorrhagia, for about six months, diffuse abdominal pain, radiating in the lum­bar region and the lower limbs, fatiguability, asthenia, dys­pa­reu­nia and the voluminal growth of the abdomen in the previous two months. The physical examination, the gyne­co­lo­gi­cal examination, the laboratory tests focused on ova­rian tumor markers (CA125, HE4, ROMA score) and the echo­gra­phic examination revealed the existence of a giant ova­rian tumoral growth on the only remaining ovary, the left ovary. A particularity of this clinical case is the fact that, five years before, the patient had undergone another surgery for a giant ovarian cyst on the right ovary (mucinous cyst­ade­no­ma), when both a cystectomy and a right adnexectomy had been performed. In our case, we paid special attention to the values of the ovarian tumor markers, since our goal was to surgically intervene for the excision of the intact cyst, but also to keep the left ovary (a reason why we also asked for an extemporaneous examination), taking into account the mis­sing right ovary and the age of the patient, who was only 35 years old.

Трехмерная эхография в оценке морфофункционального состояния эндометрия у пациенток после односторонней аднексэктомии

Objective. To study the morphological and functional characteristics of the endometrium in patients of reproductive age before and after unilateral adnexectomy using a three-dimensional (3D) ultrasound imaging. Patients and methods. A total of 113 patients after unilateral adnexectomy were examined. The mean age of patients was 32.85 ± 4.01 years. Two patient groups were identified: group 1 (n = 51) consisted of patients with mature teratomas; group 2 (n = 62) included patients who underwent surgery for epithelial ovarian tumors (endometrioid (30; 48.4%), serous (21; 33.9%), and mucinous (11; 17.7%) cystadenomas). The 3D ultrasound examination of pelvic organs was performed in the middle luteal phase of the menstrual cycle before surgery and at 6, 12 months after it. The endometrial thickness, volume, and ultrasound pattern were studied, as well as volumetric vascularity indices: vascularization index (VI), flow index (FI), and the vascularizationflow index (VFI). Based on the ESHRE consensus (2022), the ovarian reserve was assessed. Results. The improvement of endometrial perfusion was noted at 12 months after surgery. In patients with ovarian teratomas, compensatory restoration of morphological and functional properties of the ovary and endometrium was recorded. The opposite pattern was observed in the group of patients with epithelial tumors. Thus, patients operated on for ovarian endometriomas had an extremely thin endometrium (3.5 ± 0.1 mm), whose values were 1.5 times lower compared to those of patients with serous and mucinous cystadenomas; the glandular layer volume was expectedly low (1.1 ± 0.9 cm3). Conclusion. The minimum effective restoration period for the collateral ovary after unilateral adnexectomy is at least 6 months. The qualitative and quantitative parameters of 3D Doppler velocimetry can be used as predictors of the endometrial morphological and functional state in patients of reproductive age. Key words: 3D ultrasound, mature teratomas, cystadenomas, endometrium, endometrioid cysts, VOCAL

Comparison of immunohistochemical characteristics of endometriomas with non-endometriotic benign ovarian cysts.

The aim of the study was to investigate the existence of neuroendocrine cells and to compare the density of those in normal ovarian tissue, endometriotic and non-endometriotic benign ovarian cysts. Twenty patients with the diagnosis of endometrioma and 30 control subjects consisting of ovarian serous cystadenoma (n=10), ovarian mucinous cystadenoma (n=10) and normal ovarian tissue (n=10) were included. The tissues were prepared and assessed according to staining density by using the H-score method. Tissues with mucinous cystadenoma were significantly more stained with PAS and VanGieson, when compared to women with endometrioma. Macrophage deposition was higher in cyst samples with endometrioma and in normal ovarian tissue when compared to serous cystadenoma and mucinous cystadenoma. Normal ovarian tissue was significantly more stained with PGP9.5, NSE and SYN when compared to endometrioma and non-endometriotic benign ovarian cyst. PGP9.5 staining was higher in normal ovarian tissue when compared with endometriotic lesions (p<.001). Endometrioma samples were significantly more stained with p53 when compared to non-endometriotic cysts and normal ovarian tissue. c-Kit staining was mild and not statistically significant among all groups. During endometrioma transformation, expression intensity of neuroendocrine markers decreases compared to normal ovarian tissue and other benign ovarian cysts.

Mucinous Cystadenoma of Ovary with Vague Symptoms: A Case Report.

case report; ovarian cysts; symptoms.

Eighteen-Year-Old Nulliparous Woman with Massive Mucinous Cystadenoma in Pregnancy: Case Report

Background: Ovarian mucinous cystadenoma is rare in adolescents. We report the diagnosis and management of a massive ovarian mucinous cystadenoma in a pregnant adolescent. Case Presentation: An 18-year-old G1PO was referred by a midwife to the Komfo Anokye Teaching Hospital on account of excessive abdominal distension at 25 weeks’ gestation and an ultrasound scan finding of a large non-septate cystic adnexal mass. She, however,reported to the hospital 6 weeks later with a complaint of worsening abdominal distension and discomfort. A transabdominal ultrasound scan revealed single intrauterine gestation and a large non-septate cystic adnexal lesion measuring more than 19 cm in its widest plane. She had a conservative in-patients management followed by emergency caesarean delivery, exploratory laparotomy and unilateral salpingo-ophorectomy at 33 weeks 1 day. The outcome of the delivery was a 1.8 kg female infant with Apgar score of 4 and 6 at 1 and 5 minutes respectively. A 6.8 kg cystic ovarian mass measuring about 40 cm at its widest diameter was removed.Conclusion: Although pregnancy-associated adnexal masses are not uncommon, significant socio-economic challenges may render the diagnosis and treatment of extremely large pelvic masses in pregnant adolescents difficult. The decision to optimize maternal and fetal outcomes is essential in managing rare conditions in marginalized obstetric populations.

Lymphangiomatosis of spleen, fallopian tube and abdominal wall associated with mucinous cystadenoma of the right ovary

Lymphangiomas are benign tumors that results from congenital malformation of lymphatic vessels. They are generally found in the neck and axilla. When they involve multiple locations, they present as lymphangiomatosis syndrome. Generalized lymphangiomatosis associated with mucinous cystadenoma of the ovary is a very rare condition. This study describes a 13-year-old girl with lymphangiomatosis of spleen, right fallopian tube and abdominal wall associated with mucinous cystadenoma of the right ovary. Contrast-enhanced abdominopelvic computed tomography scan and magnetic resonance image showed a multiple cystic splenic mass and huge abdominopelvic cystic mass. Splenectomy, excision of right ovary and fallopian tube mass, and excision of abdominal wall mass were performed without any complications. • Lymphangiomas are benign tumors that results from congenital malformation of the lymphatic vessels. • The treatment of choice for large or symptomatic splenic lymphangiomas is complete surgical resection. • Although splenic lymphangiomas are very rare, they should be considered in the differential diagnosis of splenic tumors.

Tumori în pandemie: chistadenom mucinos de ovar gigant.

Tumors in the pandemic era: giant ovarian mucinous cystadenoma. Mucinous cystadenoma is a benign tumor of the ovary originating from the surface epithelium of the ovary, characterized by mucin production. They represent 10-15% of ovarian tumors. The borderline variety represents 10% of mucinous cystadenomas. They can reach very large sizes. We present the case of a patient, aged 65, hospitalized at the end of pandemics with a giant abdominal cystic tumor (diameter 40 cm) with compression disorders. He had a subtotal hysterectomy for uterine fibroids at the age of 25. Laboratory tests are within normal limits except CA19-9 = 398 IU / ml. Abdomino-pelvic ultrasound shows a mid-abdominal liquid formation, inhomogeneous with septa inside that exceeds 30 cm. CT with the contrast substance highlights a multiloculated formation, developed from the left ovary to with iodophilic septa, with mass effect on anatomical elements, with overall dimensions of approx. 230/300/350 mm. With the suspicion of a giant left ovarian cyst suspected of being malignant, a median xipho-umbilical laparotomy was performed and a giant cystic tumor of the left ovary weighing 13 kg, reaching the supramesocolic floor without adhesions, with an ovarian pedicle one cm thick, was removed. Anexectomy was performed on the right side without complications. The postoperative evolution was simple. Histopathological examination determined the diagnosis of borderline mucinous cystadenoma. The epidemiology, clinical signs and imaging diagnosis and surgical treatment of these rare tumors with favorable evolution are discussed.