BackgroundFacial symmetry enhances attractiveness, with various therapies available to improve it. However, trends in facial asymmetry remain unclear. This study evaluates differences between specific facial regions using 3D scanning to guide clinical treatment. MethodThe 3dMD face™ system (3dMD Ltd, USA) scanned 88 subjects' faces. Geomagic Wrap 2021 analyzed the left and right sides. Differences in eyebrow peaks, eyebrow tails, eye ends, and mouth corners were evaluated. ResultsMore subjects showed a drooping right side of the face in eyebrow peaks, eyebrow tails, eye ends, mouth corners, tubercula mentale, and mandibular margin positions. A higher proportion had deeper left nasolabial folds and marionette lines, while more had deeper right tear ducts and lateral chin depressions. More subjects exhibited a prominent right forehead and parotid masseter region, with a prominent left temporal and cheek region. Conclusion3D scanning effectively assesses facial asymmetry in clinical practice. Research indicates significant differences in asymmetry between facial regions. Evaluating these differences pre-treatment can guide the selection of therapeutic methods, improving facial asymmetry treatment. Level of Evidence3 (Diagnostic)