Motoric Tasks Research Articles

Digital and plasma biomarkers for an early diagnosis of Mild Cognitive Impairment and prodromal Alzheimer’s disease

AbstractBackgroundThe application of blood‐based biomarkers for the identification of Alzheimer’s disease (AD) and the development of novel digital technologies as cognitive screening tests are critical to moving toward a reliable, more accessible early diagnosis. Our aim was to evaluate the diagnostic performance of a machine learning‐based cognitive assessment known as Altoida’s digital neuro‐signature (DNS) in patients with non‐degenerative mild cognitive impairment (ndMCI) and MCI due to AD (prodromal AD) and its association with CSF and plasma biomarkers.MethodAltoida’s MCI‐DNS is a 10‐minute cognitive test battery evaluating activities of daily living via motoric and augmented reality tasks. The test consists of placing and finding virtual objects in a real environment and its final score is obtained by weighting multi‐modal digital data features, such as hands’ micro‐movements, speed, reaction times, or navigation trajectories. We included 81 participants, classified according to their clinical status and CSF AD biomarker profile as: cognitively unimpaired controls, CTR (n = 10; age = 68.5±5.9; MMSE = 29.4±1.1), ndMCI (n = 25; age = 67.6±7.2; MMSE = 26.9±1.9) and prodromal AD (n = 46; age = 70.8±4.9; MMSE = 24.3±3.3). We further investigated a subsample of participants classified according to their plasma pTau181 levels as measured by SiMoA [cutoff = 1.37 pg/mL (Sarto et al., 2022)]: pTau181 negative (n = 27; age = 68.5±5.9; MMSE = 26.9±2.7) or pTau181 positive (n = 30; age = 70.3±5.5; MMSE = 24.1±3.7).ResultSignificant differences were found in MCI‐DNS scores between CTR group and ndMCI (F = 23.5; p<0.001) and prodromal AD (F = 114.4; p<0.001) groups. Also, ndMCI showed higher MCI‐DNS scores than the prodromal AD group (F = 4.53; p<0.05, Fig. 1). ROC curves showed an excellent diagnostic accuracy of the MCI‐DNS in the discrimination between CTR vs. ndMCI (AUC = 0.879) and CTR vs. prodromal AD (AUC = 0.975) (Fig. 1). Further analyses showed differences in MCI‐DNS scores between CSF Aβ42 negative and CSF Aβ42 positive (F = 18.9; p<0.001; Fig. 2), as well as between plasma pTau181 negative and plasma pTau181 positive (F = 6.16; p<0.01; Fig. 2). Finally, MCI DNS scores significantly correlated with CSF Aβ42, CSF Aβ42/pTau ratio, CSF neurofilament‐light chain (NfL) and plasma pTau181 concentrations (Fig. 3).ConclusionAltoida’s MCI‐DNS test allows excellent discrimination between CTR and patients with MCI. MCI‐DNS scores significantly correlate with CSF AD core biomarkers, biomarkers of neurodegeneration and blood‐based biomarkers (i.e., plasma pTau181).

Language-Specific Dual-Task Effects After Stroke: A Systematic Review.

The dual-task paradigm has been frequently used to examine stroke-related deficits because it samples behavioral performance under conditions of distraction similar to functioning in real-life environments. This original systematic review synthesizes studies that examined dual-task effects involving spoken language production in adults affected by stroke, including transient ischemic attack (TIA) and poststroke aphasia. Five databases were searched (inception to March 2022) for eligible peer-reviewed articles. The 21 included studies reported a total of 561 stroke participants. Thirteen studies focused on single word production, for example, word fluency, and eight on discourse production, for example, storytelling. Most studies included participants who had suffered a major stroke. Six studies focused on aphasia, whereas no study focused on TIA. A meta-analysis was not appropriate because of the heterogeneity of outcome measures. Some single word production studies found dual-task language effects whereas others did not. This finding was compounded by the lack of appropriate control participants. Most single word and discourse studies utilized motoric tasks in the dual-task condition. Our certainty (or confidence) assessment was based on a methodological appraisal of each study and information about reliability/fidelity. As 10 of the 21 studies included appropriate control groups and limited reliability/fidelity information, the certainty of the findings may be described as weak. Language-specific dual-task costs were identified in single word studies, especially those that focused on aphasia as well as half of the nonaphasia studies. Unlike single word studies, nearly all studies of discourse showed dual-task decrements on at least some variables. https://doi.org/10.23641/asha.23605311.

Wild orangutans can simultaneously use two independent vocal sound sources similarly to songbirds and human beatboxers.

Speech is among the most complex motoric tasks humans ever perform. Songbirds match this achievement during song production through the precise and simultaneous motor control of two sound sources in the syrinx. Integrated and intricate motor control has made songbirds comparative models par excellence for the evolution of speech, however, phylogenetic distance with humans prevents an improved understanding of the precursors that, within the human lineage, drove the emergence of advanced vocal motor control and speech. Here, we report two types of biphonic call combination in wild orangutans that articulatorily resemble human beatboxing and that result from the simultaneous exercise of two vocal sound sources: one unvoiced source achieved through articulatory maneuvering of the lips, tongue, and jaw as typically used for consonant-like call production, plus one voiced source achieved through laryngeal action and voice activation as typically used for vowel-like call production. Orangutan biphonic call combinations showcase unappreciated levels of, and distinct neuromotor channels for, vocal motor control in a wild great ape, providing a direct vocal motor analogy with birdsong based on the precise and simultaneous co-control of two sound sources. Findings suggest that speech and human vocal fluency likely built upon complex call combination, coordination and coarticulation capacities that involved vowel-like and consonant-like calls in an ancestral hominid.

Inhibition skills in children with developmental coordination disorder

ABSTRACT Background Inhibition (Response Inhibition – RI and Interference Control – IC) have been inconsistently examined in Developmental Coordination Disorder (DCD) with response modalities often not considered. Aims To examine RI and IC in children with DCD. Method Twenty-five children 6-10 years with DCD, plus 25 matched typically developing peers completed motor and verbal RI and IC tasks. Results Children with DCD made significantly more errors in the motor and verbal RI tasks, had slower movement time and RT in the motor IC task, and longer completion time in the verbal IC task. Conclusions Children with DCD have RI and IC difficulties in motor and verbal responses.

MORPHOLOGICAL CHARACTERISTICS ASTHE PREDICTORS OF SITUATIONAL SUCCESSFUL IN THE WATER POLO

At the sample of 39 water polo players, aged 12 years (± 6 months), the research was conducted todetermine the impact of morphological characteristics on the situational performance in the waterpolo. In this paper, a set of 12 anthropometric measures as a predictor set of variables was applied,while the criterion variables were situational motor tests; swimming speed at 25 meters with andwithout a ball, vertical jump from the water and side swimming 8 times 2.5 meters. On the basis of theobtained results it was concluded that the morphological characteristics significantly influenced theperformance of situational motoric tasks in water polo, depending on the test from 39% to as much as71%. The most significant applied variables from the morphological space of water polo players werevariables; the volume of the thorax, the height of the body, the width of the hand and the foot with apositive effect, while the weight of the body and the subcutaneous fatty tissue were aggravating factorsfor the performance of situational motoric tasks for the 12-year-old water polo players.

Studying Gaze Behavior to Compare Three Different Hazard Perception Tasks.

The aim of the current study was to compare the traditional, verbal, and motoric tasks regarding their contributions to hazard perception measurement. Traditional hazard perception tasks require the participants to respond to filmed traffic conflicts in an imprecise way, such as by pressing a button. More sophisticated tasks include either verbal specification or motoric localization of the perceived hazards. The present study investigated the participants' gaze behavior when they were provided with an identical set of traffic animations but were instructed to perform one of three types of hazard perception tasks. In an eye tracking study, 69 drivers were shown animated traffic scenarios and instructed to perform the traditional (press button), verbal, or speeded motoric localization hazard perception task. Eye tracking revealed whether and when the participant had fixated a certain hazard cue. The participants in the traditional task group were slower to fixate emerging hazards, but quicker to respond to them than the participants of the verbal and the motoric groups. As a specific benefit, the verbal task differentiated between different types of failures. Additional verbal or speeded motoric localization tasks seem to have increased the participants' alertness when watching the animations. The verbal task provides valuable additional information regarding the participants' performance. To approximate real-life hazard perception ability, it is recommended that researchers and practitioners use a combination of different hazard perception tasks for assessment and training.

Motoric self-regulation by sled dogs and pet dogs and the acute effect of carbohydrate source in sled dogs.

Inhibitory control is a term used to envelop a collection of processes that allow an organism to refrain from engaging in an inappropriate prepotent or responsive behavior. Studies have examined the propensity of inhibitory control by nonhuman animals, from the cognitively complex processes involved in self-control to potentially less cognitively taxing processes such as motoric self-regulation. Focusing on canines, research has suggested that the domestication process as well as experiences during ontogeny contribute to inhibitory control. Diet may also play an important role in an individual's ability to self-regulate. This study examined this possibility by investigating motoric self-regulation in sled dogs, using three well-established tasks (i.e., A-not-B Bucket, Cylinder, and A-not-B Barrier tasks), performed after consumption of one of three dietary treatments with different glycemic index values. We also compared the performance of sled dogs during these tasks with results previously obtained from pet dogs. Overall, the results show many similarities in the performance of sled dogs and pet dogs on the motoric self-regulation tasks, with the notable exception that sled dogs may have a stronger spatial perseveration during the A-not-B Bucket task. Previous research findings reporting a lack of correlation among these tasks are also supported. Finally, during the early postprandial phase (period after consumption), dietary treatments with different glycemic index values did not influence self-regulatory performance for sled dogs.

Individual performance across motoric self-regulation tasks are not correlated for pet dogs.

Inhibitory control, the ability to restrain a prepotent but ineffective response in a given context, is thought to be indicative of a species' cognitive abilities. This ability ranges from "basic" motoric self-regulation to more complex abilities such as self-control. During the current study, we investigated the motoric self-regulatory abilities of 30 pet dogs using four well-established cognitive tasks - the A-not-B Bucket task, the Cylinder task, the Detour task, and the A-not-B Barrier task - administered in a consistent context. One main goal of the study was to determine whether the individual-level performance would correlate across tasks, supporting that these tasks measure similar components of motoric self-regulation. Dogs in our study were quite successful during tasks requiring them to detour around transparent barriers (i.e., the Cylinder and Detour tasks), but were less successful with tasks requiring the production of a new response (i.e., A-not-B Bucket and A-not-B Barrier tasks). However, individual dog performance did not correlate across tasks, suggesting these well-established tasks likely measure different inhibitory control abilities, or are strongly influenced by differential task demands. Our results also suggest other aspects such as perseveration or properties of the apparatus may need to be carefully examined in order to better understand canine motoric self-regulation or inhibitory control more generally.

FORCE-VELOCITY RELATIONSHIP OF LEG EXTENSORS OBTAINED FROM THREE DIFFERENT TYPES OF LOAD

The first aim of this study was to evaluate the shape of force-velocity (F-V) relationships in case of gravitational (W), inertial (I) and combined (W+I) type of load assessed from squat jump (SJ) performed on a modified Smith machine. The second aim was to determine whether there were differences between the same parameters (maximal force, F0; maximal velocity, V0; maximal power, P0) obtained from linear F-V relationship among three different loads. The third aim was to evaluate the concurrent validity of the parameters F0 obtained from different types of load in SJ, with maximum isometric force in squat (Fiso), as well as one repetition maximum in squat (1RM). Fifteen male participants were tested in SJ with three different types of load, squat for obtaining 1RM and isometric squat for obtaining the Fiso. The observed F-V relationships were exceptionally strong and approximately linear (median r ≥ 0.98) independently of used load. The differences between same parameters of different types of load were determined in parameters F0 and V0, while there were no differences between P0. Regarding third aim, concurrent validity for F0 showed to be moderate to high and significant in all 3 types of load (r ≥ 0.56), except between F0 and Fiso in W type of load, where it was non-significant (r ≥ 0.47). The significance of the study reflects in better understanding of the mechanisms of the functioning of muscle system in case of different types of load. Future studies should investigate the impact of different types of load to kinetic and kinematic parameters in case of different motoric tasks and muscle groups.

Utilization of Drivetime – Performing Non-Driving Related Tasks While Driving Highly Automated

To utilize drivetime by engaging in non-driving related (secondary) tasks while driving highly automated is very likely to occur as soon as Level 3 (see NHTSA, 2013) automated vehicles enter the market. For this reason, it has to be investigated in advance whether different tasks are impeding drivers’ capabilities of regaining control in take-over situations and thereby compromising safety. For this purpose, studies regarding take-over in highly automated vehicles were reviewed and an experiment in a high fidelity driving simulator involving 24 participants was conducted, comparing four different types of non-driving related tasks. Results show differences in the dependent variables, dependent on criticality and complexity of the situation. Compared to drivers with visual and motoric tasks, take-over performance of drivers with a cognitive task was superior in well-practiced and noncomplex situations. Although the take-over situations of this study were well practiced and complexity and time criticality of the take-over situations were rather low, drivers reacted faster in manual mode than under the presence of the automated system. Furthermore, the participants reported engaging in those tasks as being rather dangerous and impeding their take-over performance and capability of reaction.

Selected Cognitive And Emotional Resources Of Untrained Youth And Young Wrestlers

Abstract Introduction. Wrestling is a sport that requires proper physical and mental preparation. The authors present selected psychological resources, emotional intelligence and creative attitude, as factors influencing the broadly defined mastery, both in the area of sport and out of it. These variables guarantee better adaptation to changing conditions and they are also connected with the effectiveness of handling different situations and optimal problem solving. The aim of the study was to diagnose emotional intelligence and creative attitude among young female and male wrestlers. Material and methods. The study included 20 females from the regional team of cadets and juniors and 19 male wrestlers from the sports school. The control group consisted of two deliberately selected groups of untrained students - 20 girls and 19 boys. KANH and INTE questionnaires were used in the study. Results. In the three groups under investigation medium levels of emotional intelligence and creative vs. reproductive attitude were observed. It was only female wrestlers who manifested low levels of emotional intelligence which, similar to the levels of nonconformity, heuristic thinking and creative attitude, were lower than in female students from the control group. The female wrestlers demonstrated higher levels of conformity and reproductive attitude. Female students demonstrated higher levels of emotional intelligence and conformity than male students. No differences between male and female wrestlers were observed. Conclusions. The findings show that it is necessary to conduct longitudinal research on athletes and untrained individuals. Bearing in mind that learning a motoric task depends, inter alia, on intellectual and emotional factors, the authors also recommend another course of research, i.e. the verification of how these variables are related to the effectiveness of learning motoric tasks. The authors' own research results as well as further (planned) investigations will make it possible to profile various educational effects and deliberately strengthen the potential of young wrestlers.

Music in the exercise domain: a review and synthesis (Part I)

Since a 1997 review by Karageorghis and Terry, which highlighted the state of knowledge and methodological weaknesses, the number of studies investigating musical reactivity in relation to exercise has swelled considerably. In this two-part review paper, the development of conceptual approaches and mechanisms underlying the effects of music are explicated (Part I), followed by a critical review and synthesis of empirical work (spread over Parts I and II). Pre-task music has been shown to optimise arousal, facilitate task-relevant imagery and improve performance in simple motoric tasks. During repetitive, endurance-type activities, self-selected, motivational and stimulative music has been shown to enhance affect, reduce ratings of perceived exertion, improve energy efficiency and lead to increased work output. There is evidence to suggest that carefully selected music can promote ergogenic and psychological benefits during high-intensity exercise, although it appears to be ineffective in reducing perceptions of exertion beyond the anaerobic threshold. The effects of music appear to be at their most potent when it is used to accompany self-paced exercise or in externally valid conditions. When selected according to its motivational qualities, the positive impact of music on both psychological state and performance is magnified. Guidelines are provided for future research and exercise practitioners.

Music in the exercise domain: a review and synthesis (Part II)

Since a 1997 review by Karageorghis and Terry, which highlighted the state of knowledge and methodological weaknesses, the number of studies investigating musical reactivity in relation to exercise has swelled considerably. In this two-part review paper, the development of conceptual approaches and mechanisms underlying the effects of music are explicated (Part I), followed by a critical review and synthesis of empirical work (spread over Parts I and II). Pre-task music has been shown to optimise arousal, facilitate task-relevant imagery and improve performance in simple motoric tasks. During repetitive, endurance-type activities, self-selected, motivational and stimulative music has been shown to enhance affect, reduce ratings of perceived exertion, improve energy efficiency and lead to increased work output. There is evidence to suggest that carefully selected music can promote ergogenic and psychological benefits during high-intensity exercise, although it appears to be ineffective in reducing perceptions of exertion beyond the anaerobic threshold. The effects of music appear to be at their most potent when it is used to accompany self-paced exercise or in externally valid conditions. When selected according to its motivational qualities, the positive impact of music on both psychological state and performance is magnified. Guidelines are provided for future research and exercise practitioners.

Mapping perception to action in piano practice: a longitudinal DC-EEG study

BackgroundPerforming music requires fast auditory and motor processing. Regarding professional musicians, recent brain imaging studies have demonstrated that auditory stimulation produces a co-activation of motor areas, whereas silent tapping of musical phrases evokes a co-activation in auditory regions. Whether this is obtained via a specific cerebral relay station is unclear. Furthermore, the time course of plasticity has not yet been addressed.ResultsChanges in cortical activation patterns (DC-EEG potentials) induced by short (20 minute) and long term (5 week) piano learning were investigated during auditory and motoric tasks. Two beginner groups were trained. The 'map' group was allowed to learn the standard piano key-to-pitch map. For the 'no-map' group, random assignment of keys to tones prevented such a map. Auditory-sensorimotor EEG co-activity occurred within only 20 minutes. The effect was enhanced after 5-week training, contributing elements of both perception and action to the mental representation of the instrument. The 'map' group demonstrated significant additional activity of right anterior regions.ConclusionWe conclude that musical training triggers instant plasticity in the cortex, and that right-hemispheric anterior areas provide an audio-motor interface for the mental representation of the keyboard.

Perception-action dissociations of a walkable Müller-Lyer configuration.

These studies examined the role of spatial encoding in inducing perception-action dissociations in visual illusions. Participants were shown a large-scale Müller-Lyer configuration with hoops as its tails. In Experiment 1, participants either made verbal estimates of the extent of the Müller-Lyer shaft (verbal task) or walked the extent without vision, in an offset path (blind-walking task). For both tasks, participants stood a small distance away from the configuration, to elicit object-relative encoding of the shaft with respect to its hoops. A similar illusion bias was found in the verbal and motoric tasks. In Experiment 2, participants stood at one endpoint of the shaft in order to elicit egocentric encoding of extent. Verbal judgments continued to exhibit the illusion bias, whereas blind-walking judgments did not. These findings underscore the importance of egocentric encoding in motor tasks for producing perception-action dissociations.

Tapping, talking and the thalamus: Possible influence of the intralaminar nuclei on basal ganglia function

A patient with a discrete lesion of the left, intralaminar thalamic, nuclei exhibited a paradoxical finding with regard to finger-tapping. Normal subjects typically reduce their tapping rate when performing simultaneous verbal activity. Tapping was impaired in our patient's contralesional hand on baseline trials; however, performing the controlled oral word association (COWA) task, while finger-tapping, normalized her deficit. Subsequent experiments showed that motoric tasks rather than cognitive aspects of the COWA task were critical in potentiating finger-tapping performance. A SPECT study performed at rest revealed focal perfusion asymmetries in motor and premotor cortices. Because the caudal intralaminar nuclei project heavily to the striatum, striatal deafferentiation may account for these asymmetries. These observations provide some insight into the influences of the caudal intralaminar thalamic nuclei on basal ganglia function and the basal ganglia's influence on motor gating.

Persisting “Writer's Cramp” as a result of compensation of a temporary palsy due to a hereditary neuropathy with liability to pressure palsies

A 49-year-old man reported several periods of acute paresis of different nerves after exposure to pressure. All palsies showed a good recovery over a period of days to months. The suspected diagnosis of a hereditary neuropathy with liability to pressure palsies was confirmed by the histology of a suralis nerve biopsy, which showed a distinct tomaculous swelling of the myelin. Nine years ago he noticed an acute, distally pronounced palsy of the right arm. A brachial plexus lesion was diagnosed. His profession required written work, thereby forcing him to compensate this weakness by increasing the coactivation of the elbow and upper arm. This coactivation persisted even after complete recovery from the plexus palsy. Thus, the patient showed the typical feature of classical writer's cramp, with broad coactivation of the arm muscles, which has continued to the present. At the same time, however, the patient was able to perform other motoric tasks well, such as painting. After several practice sessions with a special program that makes use of preserved motor abilities to reestablish writing, the patient was again able to write with a normal kinematic profile as documented by the recorded handwriting. This suggests that the "writer's cramp" of our patient is one form of task-related dystonia that may be related more to the perserveration of a misleading motor strategy than to a general inability of the motor system to control the movement properly.

Functional MR Mapping of Activated Cortical Areas

Magnetic resonance imaging (MRI) has recently been demonstrated to be sensitive to changes in neuronal activity of cortical areas. We report our initial experiences with functional MR brain mapping at high spatial resolution using a conventional whole-body MR system. A total of 10 visual and motor cortex activation studies were carried out on 8 healthy volunteers. In each examination, a time course series of 15 strongly T2*-weighted FLASH images was measured from three adjacent slices. The image analysis revealed a subtle but highly significant signal increase in cortical layers of gray matter in primary and associative visual as well as sensorimotoric cortex regions during periods of excessive brain activity provoked by photic stimuli or motoric tasks, respectively. To correlate brain structure and brain function, the computed MR brain activation maps were directly superimposed on T1-weighted anatomic spin-echo images. With this advance into the area of functional neuroimaging, MRI is moving into an established domain of positron emission tomography (PET). We, therefore, discuss the advantages and limitations of the MR method in comparison to PET as far as this can be done at present.

Children at risk for schizophrenia: the Jerusalem Infant Development Study. II. Neurobehavioral deficits at school age.

The development of school-age children born to parents with serious mental disorders was assessed on a variety of perceptual-cognitive and motoric tasks. These same children have been followed up from birth as part of the Jerusalem Infant Development Study. Children with schizophrenic parents, when compared with children with healthy parents or parents having other psychiatric disorders, were more likely to show neurobehavioral dysfunctioning in perceptual-cognitive and motoric areas. Forty-four percent of the offspring of schizophrenics (11 of 25 subjects) showed such dysfunctioning. Male subjects were overrepresented in this poorly functioning group. A stable subgroup (40%) of the offspring of schizophrenics (six of 15 subjects) showed dysfunctioning during infancy and school age. None of the offspring of nonschizophrenic parents showed dysfunctioning during both age periods. While most of the poorly functioning children with schizophrenic parents showed perceptual-cognitive and motoric signs, only perceptual-cognitive signs were strongly linked to parental diagnosis and infant dysfunctioning. Motoric signs, but not cognitive signs, were related to pregnancy and birth complications. These findings provide further support to the schizotaxia hypothesis that some neurointegrative deficits may reflect vulnerability to schizophrenia and that these deficits are clearly apparent at school age, long before the onset of illness. However, these signs are not exclusive to schizophrenic illness, although they occur with a greater prevalence in this group. Definitive statements about the validity of early neurobehavioral signs as indicators of genetic vulnerability await further longitudinal follow-up into the age of risk for actual schizophrenic breakdown or when a diagnosis of schizotypal personality disorder may be made.

Visual space perception and visually directed action.

The results of two types of experiments are reported. In 1 type, Ss matched depth intervals on the ground plane that appeared equal to frontal intervals at the same distance. The depth intervals had to be made considerably larger than the frontal intervals to appear equal in length, with this physical inequality of equal-appearing intervals increasing with egocentric distance of the intervals (4 m-12 m). In the other type of experiment, Ss viewed targets lying on the ground plane and then, with eyes closed, attempted either to walk directly to their locations or to point continuously toward them while walking along paths that passed off to the side. Performance was quite accurate in both motoric tasks, indicating that the distortion in the mapping from physical to visual space evident in the visual matching task does not manifest itself in the visually open-loop motoric tasks.