Mother-daughter Pairs Research Articles

Intertwining Influences on Perceptions of Risk, Pain, and Injury in Sport: A Close Study of a Chinese New Immigrant Mother–Daughter Pair

Sociological research on sport risk, pain, and injury primarily focuses on young, Western, high-performance male athletes in organized sport. In contrast, ethnic minority women’s experiences with sporting pain and injury, and risk perceptions are often underrepresented. This paper presents a close study of a Chinese new immigrant mother’s risk rationality and practices as related to her daughter’s sporting experiences in New Zealand. A conceptual framework of “neoliberal ethnic discourses of risk” was used to explore how intertwining factors of ethnicity, gender, and immigrant identity, influenced participants’ preferences for particular sports, and their perception and experiences of risk, pain, and injury. This study invites sports sociologists and organizations to consider how cultural and gendered discourses influenced Chinese new immigrant women’s sporting participation in host countries, such as New Zealand, especially why the group might be less active and more resistant to particular sports and physical activities while strongly favoring others.

The Characteristics and Inheriting Pattern of Skin Aging in Chinese Women: An Intergenerational Study of Mothers and Daughters.

The aging of the skin, which is affected by both external and internal causes, can reflect the external age and the internal health status. While the aging characteristics differ across ethnic groups, the specific changes in skin aging within the Chinese population have been underexplored. Moreover, investigating the similarity of aging skin characteristics between parent-offspring pairs remains uncharted territory. This study aims to fill these gaps by examining the skin aging features of Chinese women and assessing the similarity in aging skin characteristics between mother-daughter pairs. A total of 40 mother-daughter pairs were recruited and analyzed. The perceived ages of the participants were evaluated, and their aging skin traits were systematically graded. Statistical methods were employed to discern the trends of the aging skin characteristics. By introducing a novel similarity parameter, we compared whether various skin aging characteristics have similar patterns between mothers and daughters. Our findings indicate that age 50 represents a pivotal point in skin aging. Beyond this age, the increase in rhytides and laxity scores accelerated noticeably, whereas the escalation in dyschromia scores became less marked. By introducing similar parameters between mother-daughter pairs and the radar map, we discovered that the skin aging characteristics are remarkably consistent between mother-daughter pairs. Understanding the main aging skin characteristics of different age groups can allow caregivers to devise treatments for preventing skin aging in women of various ages. The mother's skin aging trend is also significant for the daughter's skin aging prevention.

Familial Resemblance of Bone Health in Maternal Lineage Pairs and Triads: A Scoping Review.

Female bone health is influenced by familial resemblance, health parameters and maturational periods (puberty and menopause); this combination has been researched using familial multi-generational cross-sectional studies. This scoping review aimed to compile bone health research which uses sexually mature (grandmother-) mother-daughter pairs (and triads) and to determine the trends in its methodologies and familial comparisons. The Joanna Briggs Institute methodology for scoping reviews was used. Extraction included study and population characteristics, methodology (with an emphasis on imaging) and family-based results. Twenty-nine studies were included, and their generations were categorized into four developmental categories: late adolescent to young adult, pre-menopause, mixed-menopause, and post-menopause. Eleven different pair/triad combinations were observed; the most common was pre-menopausal daughters and post-menopausal mothers. Dual-energy X-ray absorptiometry (DXA) was the most utilized imaging modality, and the hip was the most imaged region of interest (ROI). Regardless of pairing, imaging modality and ROI, there was often a trend toward significant familial resemblance and heritability (h2 and h2L). This scoping review highlights the trends in bone health linked to familial resemblance, as well as the importance of menopause and late adolescence. This review compiles the commonalities and challenges within these studies to inform future research.

Capturing the fusion of two ancestries and kinship structures in Merovingian Flanders

The Merovingian period (5th to 8th cc AD) was a time of demographic, socioeconomic, cultural, and political realignment in Western Europe. Here, we report the whole-genome shotgun sequence data of 30 human skeletal remains from a coastal Late Merovingian site of Koksijde (675 to 750 AD), alongside 18 remains from two Early to Late Medieval sites in present-day Flanders, Belgium. We find two distinct ancestries, one shared with Early Medieval England and the Netherlands, while the other, minor component, reflecting likely continental Gaulish ancestry. Kinship analyses identified no large pedigrees characteristic to elite burials revealing instead a high modularity of distant relationships among individuals of the main ancestry group. In contrast, individuals with >90% Gaulish ancestry had no kinship links among sampled individuals. Evidence for population structure and major differences in the extent of Gaulish ancestry in the main group, including in a mother-daughter pair, suggests ongoing admixture in the community at the time of their burial. The isotopic and genetic evidence combined supports a model by which the burials, representing an established coastal nonelite community, had incorporated migrants from inland populations. The main group of burials at Koksijde shows an abundance of >5 cM long shared allelic intervals with the High Medieval site nearby, implying long-term continuity and suggesting that similarly to Britain, the Early Medieval ancestry shifts left a significant and long-lasting impact on the genetic makeup of the Flemish population. We find substantial allele frequency differences between the two ancestry groups in pigmentation and diet-associated variants, including those linked with lactase persistence, likely reflecting ancestry change rather than local adaptation.

‘Master Said He Was Over All the Magistrates’: Intimacy, Belonging, and Power Struggle within a Jamaican Houseful

ABSTRACT This article examines the struggle of an enslaved mother, Catherine Whitfield, and adult daughter, Ann King, to seek legal redress for their abuse while working as domestic servants to a leading Jamaican magistrate. While well-publicized in its time, this case was often narrated through framings which emphasized spectacular violence and suffering and minimized attentions to Whitfield’s and King’s own strategies of resistance and survival. Centring the women’s agency allows a nuanced analysis of modalities of resistance specific to their situation as a mother-daughter pair, as enslaved domestic servants, and as women.

Short Cilia, Immunodeficiency, and Cystic Fibrosis in a Mother-Daughter Pair

Patients with chronic rhinosinusitis (CRS) that is refractory to maximal medical and surgical therapy should be evaluated for other primary conditions. Cystic fibrosis (CF), primary immunodeficiency (PID), and primary ciliary dyskinesia (PCD) are potential risk factors for refractory CRS. These conditions present with variable disease severity and diagnosis may be delayed into adulthood. We report a case of a mother-daughter pair with CRS refractory to maximal medical management. The patients were further evaluated and found to have features consistent with CF, PID, and PCD. All 3 are rare disorders and thought to cause CRS in isolation. Patients with refractory CRS should be further evaluated to identify alternative diagnoses and ensure proper management. Refractory CRS may be multifactorial, with different risk factors simultaneously contributing to its persistence.

Parent-child correlation in energy and macronutrient intakes: A meta-analysis and systematic review.

In the current study, we aimed to review the evidence from twin and family-based studies that have assessed the familial similarity in intakes of energy and macronutrients among various parent-child pairs. The online literature databases, including Web of Science, PubMed, and Scopus, were searched up to December 2022 to find potentially eligible studies. We converted Pearson's, Spearman's, or intra-class correlation coefficients to z's using Fisher's z transformation to obtain approximate normality and then calculated a mean and standard error (SE) of transformed correlation weighted by the sample sizes in the studies. We reported pooled r and 95% CI as our final results in five groups, including parent-child, mother-daughter, mother-son, father-daughter, and father-son. Twenty-one eligible studies were included in this meta-analysis, in which the sample size ranged from 33 and 4310. Our analysis showed that family resemblance in the intake of energy and macronutrients in various parent-offspring pairs was weak to moderate which could be different based on family pairs, nutrients, and studies. The highest similarity in dietary intakes was observed among the mother-daughter pair, which was for carbohydrate and protein intake, respectively. The lowest correlations in dietary intakes were found between mother-son or father-son pairs. Our meta-analysis suggested that family similarity for intakes of energy and macronutrients was not strong in parent-child pairs. The highest correlation in dietary intake was mostly found in mother-daughter pairs. The weak similarities in dietary intake among parent-child pairs indicate the noticeable effect of the environment outside the family on individuals' dietary choices.

<i>ABCC8</i> haploinsufficiency in a mother-daughter pair with young-onset diabetes with and without neonatal hypoglycemia

<i>ABCC8</i> haploinsufficiency in a mother-daughter pair with young-onset diabetes with and without neonatal hypoglycemia

MILK PRODUCTIVITY OF COWS OF THE UKRAINIAN RED-AND-WHITE DAIRY BREED DEPENDS ON THE ORIGIN AND COMPATIBILITY OF THE BULLS

We studied the effectiveness of the bulls selection to the cows of the Ukrainian Red-and-White dairy breed (n = 490 mother-daughter pairs) different bloodlines and related groups. The level of milk productivity of first-borns cows (n = 490 mother-daughter pairs) for 305 days of the first lactation, obtained as a result of the compatibility of the bulls. The parents of the first-borns cows were four breeding bulls (bloodline Regal 352882, RG Valiant 1650414 and R. Sovereign 198998) of the Ukrainian Red-and-White dairy breed and one bull (Jornado Red 114386106, RG Chief 1427381) of the Holstein breed, and their mothers – from 11 bulls of three origin bloodlines (Dynemik 359742, Leader 1926780 and Hanover 1629391) and 4 related groups. A total of 29 combinations of interbloodline selection were investigated. The highest level of milk productivity was characterized by the daughters of bull Viter 4444 of the bloodline Regal 352882 (7191.5 ± 75.90), Jornado Red 114386106 of the Holstein breed of foreign selection, which belonged to the related group Chief 1427381 (the milk yield for 305 days of the first lactation was 7188.7 ± 31.05 kg), and Artek 344 related group Valiant 1650414 (the yield for 305 days of the first lactation was 7052.5 ± 75.51 kg). A statistically significant difference was established between milk yield indicators for 305 days of the first lactation between the groups of cows of the bull Jornado Red (related group Chief 14273381) and Luchnov 471 (r. g. R. Sovereign 198998) – +380 kg (td = 4.22 p < 0.001) in favor Jornado Red. Between cows of the bull Viter 4444 (bloodline Regal 352882) and Luchnov 471 (R. Sovereign 198998) – +383 kg (td = 3.38 p < 0.001) in favor of Viter 4444. Animals of the bulls Kanzler and Viter 4444 have the highest fat content in milk (3.71%), and cows of the related groups Valiant 1650414 characterized by the lowest fat content in milk (3.68%). A statistically significant difference was established between the amount of total milk fat and protein in the milk of cows of different bulls.
 A total 20 successful combinations of bulls were found, the first-borns cows of which were characterized by an increased milk yield on average across all successful compatibility by +96 kg (1.5%), milk fat yield – by +6,1 kg (2.3%) and total protein – by +5.3 kg (2.3%) from the average level of phenotypic manifestation of milk productivity traits of the daughters of all 5 evaluated bulls. The increasing of daughters milk yield of some successful combinations was from +42 kg (0.6%, sire Jornado 114386106 RG Chief 1427381) up to +296 kg (4.1%, sire Viter 4444,), milk fat from +2 kg (0.7%, sire Artek 344, RG Valiant) up to +8 kg (3%, sire Viter 4444) and protein from +1 kg (0.4%, sire Artek 344) up to +12 kg (5%, sire Viter 4444). The data, which we received, confirm the influence of the origin of cows by father on the level of their milk productivity and the high combining ability of individual improver bulls with the mothers of other genealogical formations.

Shared Minds, Shared Feedback: tracing the influence of parental feedback on shared neural patterns.

Parental feedback affects children in multiple ways. However, little is known about how children, family, and feedback types affect parental feedback neural mechanisms. The current study used functional near-infrared spectroscopy-based hyperscanning to observe 47 mother-daughter pairs's (mean age of mothers: 35.95 ± 3.99yr old; mean age of daughters: 6.97 ± 0.75yr old) brain synchronization in a jigsaw game under various conditions. Between parental negative feedback and praise conditions, mother-daughter brain in supramarginal gyrus, left dorsolateral prefrontal cortex, right inferior frontal gyrus, and right primary somatic (S1) differed. When criticized, conformity family-communication-patterned families had much worse brain synchronization in S1, left dorsolateral prefrontal cortex, and right Wernicke's region than conversational families. Resilient children had better mother-child supramarginal gyrus synchronicity under negative feedback. This study supports the importance of studying children's neurological development in nurturing environments to assess their psychological development.

Family aggregation and prevalence of other autoimmune diseases in SAPHO syndrome

ObjectiveSAPHO (Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) syndrome is a heterogeneous disease that clinically manifests as chronic inflammatory osteoarticular and dermatological lesions. Few reports have described familial clustering of SAPHO syndrome cases. This research aimed to illustrate the family aggregation of SAPHO syndrome and investigate the prevalence of autoimmune disorders among SAPHO syndrome patients and first-degree relatives in a large cohort. MethodsWe retrospectively reviewed the medical records of 233 SAPHO patients diagnosed at Peking Union Medical College Hospital. Direct phone calls were made to each first-degree relatives. All relatives of the patients who reported SAPHO syndrome were asked for a detailed outpatient evaluation. ResultsA total of 233 patients and 1227 first-degree relatives were recruited. Six (2.6 %) patients had positive SAPHO family history, including four mother-daughter pairs and two sister pairs. Twenty-one (9.0 %) patients presented at least one kind of autoimmune disease, including 12 rheumatoid arthritis and 4 ulcerative colitis cases. Fifty-eight (24.9 %) SAPHO syndrome patients had 68 (5.5 %) first-degree relatives with at least one autoimmune disorder. The palmoplantar pustulosis, psoriasis vulgaris, and rheumatoid arthritis prevalence in our subjects were each higher than reference rates. ConclusionThis is the first evaluation of familial aggregation for SAPHO syndrome in a large cohort. SAPHO syndrome has a weak familial aggregation. There is a relatively high prevalence of coexisting autoimmune disease among patients with SAPHO syndrome and their first-degree relatives. These results would prompt physicians to screen SAPHO syndrome patients and their family members for concomitant autoimmune diseases. KeypointsThis study suggesting a potential genetic component in the pathogenesis of SAPHO syndrome. This study is the first to evaluate the family aggregation of SAPHO syndrome in a large cohort.

Familial immune-mediated aplastic anaemia in six different families.

We studied the pathophysiology of aplastic anaemia (AA) in six different pairs of relatives without a family history of hematologic disorders or congenital AA. Five and four of the six pairs shared the HLA-DRB1*15:01 and B*40:02 alleles, respectively. Glycosylphosphatidylinositol-anchored protein-deficient blood cells were detected in eight of the 10 patients evaluated. In a mother-daughter pair from one family, flow cytometry detected leukocytes lacking HLA-A2 due to loss of heterogeneity in chromosome 6p. Whole-exome sequencing of the family pair revealed a missense mutation in MYSM1. These results suggest that genetic inheritance of immune traits might underlie familial AA in some patients.

Age But Not Menopausal Status Is Linked to Lower Resting Energy Expenditure.

It remains uncertain whether aging before late adulthood and menopause are associated with fat-free mass and fat mass-adjusted resting energy expenditure (REEadj). We investigated whether REEadj differs between middle-aged and younger women and between middle-aged women with different menopausal statuses. We repeated the age group comparison between middle-aged mothers and their daughters to partially control for genotype. We also explored whether serum estradiol and FSH concentrations explain REEadj in midlife. We divided 120 women, including 16 mother-daughter pairs, into age groups; group I (n = 26) consisted of participants aged 17 to 21, group II (n = 35) of those aged 22 to 38, and group III (n = 59) of those aged 41 to 58 years. The women in group III were further categorized as pre- or perimenopausal (n = 19), postmenopausal (n = 30), or postmenopausal hormone therapy users (n = 10). REE was assessed using indirect calorimetry, body composition using dual-energy X-ray absorptiometry, and hormones using immunoassays. The REEadj of group I was 126 kcal/day [95% confidence interval (CI): 93-160] higher than that of group III, and the REEadj of group II was 88 kcal/day (95% CI: 49-127) higher. Furthermore, daughters had a 100 kcal/day (95% CI: 63-138 kcal/day) higher REEadj than their middle-aged mothers (all P < .001). In group III, REEadj was not lower in postmenopausal women and did not vary by sex hormone concentrations. We demonstrated that REEadj declines with age in women before late adulthood, also when controlling partially for genetic background, and that menopause may not contribute to this decline.

Decline in the Age of Menarche in İstanbul Schoolgirls Over the Last 12 Years.

Menarche is the endpoint of a sequence of maturational events of female puberty. The timing of menarche is a strongly heritable trait. However, secular trends suggest that lifestyle and environmental factors are important. To assess the trend in age at menarche (AAM), and its associated factors in Istanbul over the last 12 years. A cross-sectional study was carried out between March and April 2022 on schoolgirls aged 9-18 years. A predesigned and self-administered questionnaire was filled out anonymously by the students. The data of AAM was included in the statistical analysis if the time of AAM is remembered for months and years. A probit model was used to calculate the median AAM. The findings were compared with those from the study performed 12 years ago in the same region of Istanbul. Among 9000 girls to whom the questionnaire was distributed, 1749 (19.5%) responded. The median AAM of 1374 girls whose AAM information was considered valid was 12.04 years (95% CI 12.01-12.13), 0.7 years lower than was reported 12 years ago (p<0.0001). AAM was correlated positively with maternal AAM, and negatively with body mass index (BMI) SDS and maternal educational status (p<0.0001, <0.0001, 0.002), respectively. There was no correlation between the AAM and birth weight. Girls with BMI percentile ≥85% (n=251) had earlier menarche than the ones with BMI percentile <85% (n=1072) (11.5 vs. 12.1 years, p<0.0001). Among the mother-daughter pairs (n=1162), AAM of girls was 0.91 years (median 0.94 years) earlier than their mothers. The present study demonstrates a significant downward trend in the menarcheal age in Istanbul over the last decade. Our findings support a strong contribution of genetic factors and BMI on AAM.

Sub-Rayleigh to supershear transition of dynamic mode-II cracks

The Sub-Rayleigh to supershear transition is commonly accepted to be governed by the Burridge-Andrews mechanism. Such a mechanism predicts the direct nucleation of a secondary intersonic crack (daughter crack), which is triggered ahead of the main crack front due to a developing shear stress peak. Yet, some research shows that the supershear transition is not always accompanied by a daughter crack. And to our knowledge, mother-daughter crack pairs are rarely reported with visual observations. By conducting numerical experiments for pre-strained PMMA plates, the mother-daughter crack mechanism is successfully observed in phase-field fracture modeling for the first time. On this basis, both the supershear transition with and without the daughter crack are discussed in terms of the stress field and prestress level. Our results reveal a critical prestress level, below which no supershear transition can be accomplished from the Sub-Rayleigh crack propagation. Furthermore, we also presented the criteria for predicting the occurrence of daughter crack through systematic simulations.

Childhood growth, current age, and waist circumference predict biological reserve capacity, physical performance, and rapid aging in Bangladeshi women

Background: The UK Bangladeshi community is socially disadvantaged, and many adults suffer from obesity, diabetes, and other chronic illnesses. Rapid aging has been noted.&#x0D; Objectives: Analyse biosocial trade-offs in growth, adult body composition, and reproduction, which are risk factors for age-related decline in physical performance, more rapid aging, frailty, and death.&#x0D; Methods: Sample: 40 Bangladeshi mothers (40-70 years old), one of their adult daughters (N=37, 18-36 years old) in the United Kingdom (UK), and 22 mother-daughter pairs of the same age range in Bangladesh (BD). Measurements: anthropometry, including knee height, migration, demographic history, education level, current menstruation (yes/no), and a 7-component lower body physical function score (PFS). Analysis: ridge regression and St Nikolas House Analysis (SNHA).&#x0D; Results: All the women are of short stature (x̄=150cm), with especially low knee height. Daughters who migrated to the UK have shorter knee height than daughters born in the UK. Marriage age was 16-18 years and total pregnancies of ~6 per mother, ~3 per daughter. UK mothers have higher fatness and lower PFS than BD women. Greater knee height predicts greater PFS, and that greater waist circumference and older age predict a lower PFS. SNHA finds that knee height is the most direct predictor of PFS.&#x0D; Conclusion: Adult knee height may serve as a sensitive indicator of early life physical and emotional well-being and predict physical performance, a risk factor for frailty and death. International migration of daughters is associated with poorer health status and physical performance at later ages.

Long-Term Olfactory Memory in African Elephants.

African elephants are capable of discriminating scents up to a single changed molecule and show the largest reported repertoire of olfactory receptor genes. Olfaction plays an important role in family bonding. However, to the best of our knowledge, no empirical data exist on their ability to remember familiar scents long-term. In an ethological experiment, two mother-daughter pairs were presented with feces of absent kin, absent non-kin, and present non-kin. Video recordings showed reactions of elephants recognizing kin after long-term separation but only minor reactions to non-kin. Results give the empirical implication that elephants have an olfactory memory longer than 1 year and up to 12 years and can distinguish between kin and non-kin just by scent. These findings confirm the significance of scent for family bonds in African elephants.

Heritability of body mass index and physical activity in Ukrainian adolescents

The article analyzed the lifestyle and physical development of Ukrainian adolescents and their parents and estimated the familial aggregation and heritability of body mass index and physical activity. 408 nuclear families were examined (1216 people with complete information). Anthropometric measures such as weight, height were measured following standardized procedures of WHO. Questionnaires were used to estimate the levels of physical activity. The method of genetic epidemiology research was used to explore heritability (h2) and family aggregation (ρ). Analysis was performed using the software product S.A.G.E. The study showed that 12.0±1.6% of children were overweight or obese, 6.4±1.2% were underweight and 81.6±1.9% with normal weight. It was found that among adolescents aged 12-15 years, 17.5±3.1% of boys and 32.7±2.9% of girls were physically inactive. Body mass index values higher than 25.0 kg/m2 were found in 34.3±2.4 mothers and in 70.6±2.3% of fathers. The proportion of physically inactive persons was 45.7±2.5% among mothers and 51.1±2.7% among fathers. Heritability values were significant for both body mass index (h2 =0.41±0.09; p&lt;0.001) and physical activity (h2 =0.23±0.07; p&lt;0.001). Significant familial correlations were obtained between parents-offspring for physical activity (ρ=0.20±0.04; p&lt;0.001) and body mass index (ρ=0.25±0.03; p&lt;0.001). The study estimated that the familial correlations for physical activity between mother-son and mother-daughter pairs were higher than in father-son and father-daughter pairs. The highest is the mother-daughter aggregation (ρ = 0.29 ± 0.06; p &lt;0.001), the lowest is the father-son (ρ=0.19±0.08; p&lt;0.05) by body mass index. As physical inactivity and overweight increase the risk of non-communicable diseases development, the data obtained should be taken into account while planning preventive measures.

Relaxed territoriality amid female trickery in a solitary carnivore

Territoriality (the defence of exclusive home ranges) is a strategy utilized within mammal populations to maximize individual fitness by monopolizing available resources. There is a trade-off, however, between acquiring the resources necessary for survival and reproduction and the cost of defending their exclusive use. Clarifying the sociospatial organization of wildlife populations is vital for understanding intraspecific competition and reproductive behaviour and, ultimately, conserving vulnerable or endangered species. We evaluated territorial behaviour in a solitary carnivore, the African leopard, Panthera pardus, under high-density conditions. We also assessed the influence of resource availability, sex-specific mating tactics and kinship on space sharing within the observed sociospatial structure. Both male and female leopards exhibited relaxed territoriality, with considerable intrasexual overlap occurring among both sexes, indicative of a risk aversion strategy. The risk of serious injury or death due to frequent territorial altercations in such a high-density system negated the benefits of strict spatial boundaries. Space sharing occurred more frequently in resource-rich areas: males overlapped more commonly in areas with high female density, and males and females overlapped more commonly in areas of high prey density. Males competed for access to females rather than monopoly of their home ranges; we hypothesize that the extralimital mating excursions undertaken by female leopards probably reduce the benefit of female monopoly (and consequently, of female defence) in this polygamous species. Space sharing among females was primarily driven by kinship; related females exhibited greater overlap than unrelated females, suggesting kinship benefits to space sharing among mother–daughter pairs. The contributions of resource availability, sex-specific mating tactics and kinship towards creating conditions permitting relaxed territoriality illustrate the complexity of ecological, demographic and behavioural factors involved in the sociospatial organization of solitary carnivores. • Male and female leopards display relaxed territoriality indicative of risk aversion. • Considerable intrasexual overlap occurred among male and female leopards. • For males, space sharing occurred more often in areas with high female density. • Males competed for access to females rather than monopoly of their home ranges. • Space sharing among females was primarily driven by kinship.

Transcriptional Fluctuations Govern the Serum-Dependent Cell Cycle Duration Heterogeneities in Mammalian Cells.

Mammalian cells exhibit a high degree of intercellular variability in cell cycle period and phase durations. However, the factors orchestrating the cell cycle duration heterogeneities remain unclear. Herein, by combining cell cycle network-based mathematical models with live single-cell imaging studies under varied serum conditions, we demonstrate that fluctuating transcription rates of cell cycle regulatory genes across cell lineages and during cell cycle progression in mammalian cells majorly govern the robust correlation patterns of cell cycle period and phase durations among sister, cousin, and mother-daughter lineage pairs. However, for the overall cellular population, alteration in the serum level modulates the fluctuation and correlation patterns of cell cycle period and phase durations in a correlated manner. These heterogeneities at the population level can be fine-tuned under limited serum conditions by perturbing the cell cycle network using a p38-signaling inhibitor without affecting the robust lineage-level correlations. Overall, our approach identifies transcriptional fluctuations as the key controlling factor for the cell cycle duration heterogeneities and predicts ways to reduce cell-to-cell variabilities by perturbing the cell cycle network regulations.