The diverse nature of shift in the amount of cellular nutritional elements and nucleic acids as affected by the infection of different isolates of Papaya Ring Spot Virus-Papaya strain (PRSV-P) was studied in this experimentation. The symptomatic isolates used in the present study were mild mosaic, mosaic, fern leaf, severe mosaic, vein clearing, leaf distortion and chlorotic leaf spot. Parameters measured to quantify the alteration of cellular components comprised different nutritional cellular elements (C, N, P and K) and nucleic acids (DNA and RNA). In all occasion of measured parameter, the highest alteration was found in leaf distortion. Almost in all cases the lowest effect was determined with the Mild Mosaic infected plants followed by the mosaic, severe mosaic, vein clearing, chlorotic leaf spot, fern leaf and leaf distortion. Infection of seven different symptomatic isolates of PRSV-P created striking and responsive variability in all parameters studied. And the dependency of the cellular nutritional elements and nucleic acid on seven symptomatic variants of PRSV-P was found significantly correlated in respect to the corresponding yield.